Article
Urology & Nephrology
Xiaoyu Yang, Ailing Kang, Yuanyue Lu, Yafeng Li, Lili Guo, Rongshan Li, Xiaoshuang Zhou
Summary: Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), and the injury and repair of renal tubular epithelial cells play a critical role in the pathological process of IR-AKI. Metabolomics was used to detect cell metabolism alterations and metabolic reprogramming in different stages of human renal proximal tubular cells (HK-2 cells) after IRI induction, providing insights for the clinical prevention and treatment of IRI-induced AKI.
Article
Urology & Nephrology
Yanan Wang, Jin Li, Wenjun Liu, Ying Zhang, Qing Li, Fan He
Summary: A novel surgical approach named NILLINR was used to treat high-flow vascular access in hemodialysis patients. The study included 26 patients who showed a significant decrease in blood flow volume after the operation and continued to maintain an acceptable range at 6 months and 1 year follow-up. The procedure was safe, effective, and time-saving with no complications.
Article
Urology & Nephrology
Chenlei Lv, Tianyang Cheng, Bingbing Zhang, Ke Sun, Keda Lu
Summary: This study found that triptolide improved podocyte injury in diabetic nephropathy (DN) by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway. The in vivo experiments confirmed the beneficial effects of TP on renal function and histopathological injury in DN mice, as well as its inhibition of podocyte injury, oxidative stress, and inflammation. In vitro experiments further demonstrated that TP exerted its effects by mediating the Nrf2/HO-1 and NLRP3 inflammasome pathways to inhibit oxidative stress and pyroptosis.
Article
Urology & Nephrology
Lei Liu, Jia Guo, Xin-lu Pang, Wen-jun Shang, Zhi-gang Wang, Jun-xiang Wang, Xian-lei Yang, Gui-wen Feng
Summary: This study confirms that tacrolimus upregulates NORAD to compete with miR-136-5p, resulting in the downregulation of miR-136-5p expression, which activates the TGF-beta 1/Smad3 pathway and ultimately aggravates renal fibrosis.
Article
Urology & Nephrology
Yufen Zhou, Muyin Zhang, Xiaojing Wu, Xin Li, Xu Hao, Lili Xu, Hao Li, Panpan Qiao, Ping Chen, Weiming Wang
Summary: The objective of this study was to develop clinical scores to predict the risk of ICU admission in patients with ESKD and COVID-19. Clinical characteristics and liver function changes were analyzed in 100 patients, and ROC curves were plotted to identify predictive scores. Patients transferred to the ICU commonly experienced symptoms such as shortness of breath and gastrointestinal bleeding. The PALBI and NLR scores showed good predictive value for ICU admission risk.
Article
Urology & Nephrology
Xiaomin Liu, Sijie Chen, Caifei Liu, Xilong Dang, Meng Wei, Xia Xin, Julin Gao
Summary: This study investigated the prevalence of falls in maintenance hemodialysis (MHD) patients and developed a nomogram model for assessing fall risk. A total of 303 MHD patients were enrolled, and their general data, as well as scores on various scales and occurrence of falls, were recorded. Logistic regression and receiver operating characteristic analysis were performed to validate the model. Higher depression scores and SPPB <= 6 were identified as independent risk factors for falls in MHD patients. The nomogram showed good accuracy and discrimination in predicting fall risk.
Review
Urology & Nephrology
Jialing Zhang, Qi Pang, Ting Zhou, Jiali Meng, Xingtong Dong, Zhe Wang, Aihua Zhang
Summary: This meta-analysis aimed to identify risk factors for the development of acute kidney injury (AKI) in COVID-19 patients. The results showed that age, male sex, obesity, black race, invasive ventilation, and the use of diuretics, steroids and vasopressors, as well as comorbidities such as hypertension, congestive heart failure, chronic kidney disease, acute respiratory distress syndrome, and diabetes, were significant risk factors for COVID-19-associated AKI.
Article
Urology & Nephrology
Yonghong Wan, Yihang Yu, Chengjun Yu, Jin Luo, Sheng Wen, Lianju Shen, Guanghui Wei, Yi Hua
Summary: Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) improve acute kidney injury (AKI) by inhibiting pyroptosis, according to this study.
Article
Urology & Nephrology
Yan Hong, Jidong Wang, Wenjuan Sun, Lai Zhang, Xuefang Xu, Kaiyue Zhang
Summary: This study aimed to test whether a combination of gallic acid and metformin can exert a synergistic effect on diabetic kidney disease in diabetic mice model. Our results demonstrated that compared to the untreated diabetic mice, all three strategies (gallic acid, metformin, and the combination of gallic acid and metformin) exhibited various effects on improving renal morphology and functions, reducing oxidative stress in kidney tissues, and restoring AMPK/SIRT1 signaling in kidney tissues. Notably, the combination strategy provided the most potent renal protection effects.
Article
Urology & Nephrology
Hong Ding, Jinhua Zhu, Ying Tian, Li Xu, Lei Song, Ying Shi, Dongxing Mu, Ruoxin Chen, Hong Liu, Bicheng Liu
Summary: In this study, the relationship between the TyG index and CAC in asymptomatic non-diabetic patients undergoing MHD was investigated. The results showed that the TyG index was independently associated with the presence of CAC and could be used to predict CAC in asymptomatic non-diabetic patients undergoing MHD.
Article
Urology & Nephrology
Qichen Liang, Huiping Zhao, Bei Wu, Qingyu Niu, Lixia Lu, Jie Qiao, Chuncui Men, Yuting He, Xinxin Chu, Li Zuo, Mei Wang
Summary: This study investigated the clinical characteristics and treatment outcomes of PD peritonitis in patients with different PD durations. The results showed that PD duration is an independent risk factor for poor prognosis in PD peritonitis, and emphasized the importance of preventing peritonitis in PD patients with long PD duration.
Article
Urology & Nephrology
Jiaqing Li, Dunlu Yuan, Qing Yang, Jingjing Huang, Zhu Zhou, Ruomei Li, Qing Li
Summary: The objective of this study was to investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients. Comparisons were made between two groups in terms of basic conditions, biochemical indicators, and serum serine levels to analyze the influencing factors of HI. The results showed that increased d-serine level and older age were risk factors for HI, while l-serine was a protective factor. The d-serine level had a predictive value for HI in uremic patients. The study recommends hearing assessment and estimation of d-serine levels for uremic patients along with early intervention.
Article
Urology & Nephrology
Xiaomeng Zheng, Yiyi Jin, Tao Xu, Hongbin Xu, Suyan Zhu
Summary: This cohort study aimed to investigate the effects of roxadustat and erythropoietin on thyroid function in patients with renal anemia. The results showed that roxadustat group had significantly lower levels of TSH, FT3, and FT4 compared to the erythropoietin group. Roxadustat was found to be an independent influencing factor for thyroid dysfunction.
Review
Urology & Nephrology
Qian Zeng, Yuanlong Zhong, Xiqiu Yu
Summary: This study analyzed the safety and efficacy of sevelamer compared to placebo, calcium carbonate (CC), or lanthanum carbonate (LC) in the treatment of chronic kidney disease (CKD) patients. A meta-analysis of 34 randomized controlled trials (RCTs) involving 2802 patients showed that sevelamer reduced all-cause mortality and vascular calcification score, and induced less hypercalcemia and hyperphosphatemia compared to Ca-based binders in CKD5D individuals. However, there were no significant differences in gastrointestinal adverse events (GAEs) incidence.
Article
Urology & Nephrology
Fenfen Liu, Yang Liu, Xueai Lv, Hengzhong Lun
Summary: This meta-analysis evaluated the effects of prebiotics, probiotics, and synbiotics on serum creatinine levels in non-dialysis patients. The results showed that supplementation with prebiotics, probiotics, or synbiotics did not significantly decrease serum creatinine levels compared to placebo in non-dialysis patients.
Article
Urology & Nephrology
Xin-Yi Gao, Yue-Ming Liu, Dan-Na Zheng, Yi-Wen Li, Hua Li, Xiao-Ling Xiong, Hong-Yu Chen, Hua Wang, Xiao-Yong Yu, Kai Qu, Juan Jin, Bo Lin, Qiang He
Summary: This study compared the efficacy and safety of indobufen and warfarin in preventing thromboembolic events in patients with nephrotic syndrome. The results showed that indobufen therapy provided equivalent effects in preventing thromboembolic events compared with warfarin therapy, while low dose of indobufen was associated with a reduced risk of bleeding events. Therefore, indobufen should be recommended for the prevention of thromboembolic events in clinical practice in patients with nephrotic syndrome.
Article
Urology & Nephrology
Jiuxu Bai, Aihong Zhang, Yanping Zhang, Kaiming Ren, Zhuo Ren, Chen Zhao, Qian Wang, Ning Cao
Summary: Abdominal aortic calcification (AAC) assessed by using standard lateral lumbar radiographs is a highly predictive marker for subsequent cardiovascular morbidity and mortality in hemodialysis (HD) patients. This retrospective cohort study aimed to determine the optimal AAC score cutoff values for predicting mortality among HD patients. The cutoff AAC value for mortality prediction was found to be 4.5, and HD patients with an AAC score > 4.5 had significantly higher all-cause and cardiovascular mortality rates. AAC was a better predictor than cardiac valve calcification for mortality in HD patients.
Review
Urology & Nephrology
Li Zhu, Lei Wang, Hongxia Shi, Lei Jiang, Xin Li, Chunying Shao, Yu Yan, Bao Dong, Wanzhong Zou, Li Zuo
Summary: This is a rare case of multiple myeloma combined with crystal-storing histiocytosis, light chain proximal tubulopathy, and light chain crystalline podocytopathy. Immunofixation electrophoresis showed elevated immunoglobulin G kappa and kappa light chain in both serum and urine. Bone marrow aspirate revealed 15% plasma cells with cytoplasmic granular inclusions and needle-shaped crystals. Renal biopsy confirmed the diagnosis, and the patient received two cycles of chemotherapy, with relatively stable renal function during follow-up.
Article
Urology & Nephrology
Zhen Li, Tao Zhen, Yong Zhao, Jianbin Zhang
Summary: The objective of this study was to develop a valid and reliable Nutritional Literacy Scale for patients with end-stage kidney disease (ESKD) receiving dialysis and evaluate the associations between nutrition literacy and quality of life. A total of 208 ESKD patients receiving dialysis were selected, and the Nutritional Literacy Scale was developed based on dietary guidelines for chronic kidney disease (CKD), literature reviews, and expert consultation. The scale showed high reliability and validity, and nutrition literacy was found to be influenced by various factors and associated with both nutritional status and quality of life.
Article
Urology & Nephrology
Liliana Gadola, Maria Jimena Cabrera, Mariela Garau, Ruben Coitino, Maria Haydee Aunchayna, Oscar Noboa, Maria Asuncion Alvarez, Sylvia Balardini, Graciela Desiderio, Nelson Dibello, Alejandro Ferreiro, Soledad Giro, Leonella Luzardo, Alfredo Maino, Lucia Orihuela, Maria Gabriela Ottati, Andres Urrestarazu
Summary: This study analyzed the long-term outcomes and treatment of IgA nephropathy (IgAN) and found that patients treated with immunosuppressive agents had more severe risk factors but achieved similar outcomes compared to those not receiving immunosuppressive treatment.
