Urology & Nephrology

567K Papers

Follow See full results

Review Urology & Nephrology

Impact of Clinicopathological Features on Survival in Patients Treated with First-line Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors for Renal Cell Carcinoma: A Meta-analysis of Randomized Clinical Trials

Alessandro Rizzo, Veronica Mollica, Matteo Santoni, Angela Dalia Ricci, Matteo Rosellini, Andrea Marchetti, Rodolfo Montironi, Andrea Ardizzoni, Francesco Massari

Summary: This study conducted a meta-analysis to explore the predictive value of immune checkpoint inhibitors (ICI) plus tyrosine kinase inhibitors (TKI) in the treatment of metastatic renal cell carcinoma (mRCC) patients. The results showed that the combination therapy had significant survival benefits in different clinicopathological subgroups.

EUROPEAN UROLOGY FOCUS (2022)

添加到收藏夹

Editorial Material Urology & Nephrology

Re: Global Burden of Bacterial Antimicrobial Resistance in 2019: A Systematic Analysis

Florian M. E. Wagenlehner, Florian Dittmar

EUROPEAN UROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy

Jonathan Barratt, Richard Lafayette, Jens Kristensen, Andrew Stone, Daniel Cattran, Jurgen Floege, Vladimir Tesar, Hernan Trimarchi, Hong Zhang, Necmi Eren, Alexander Paliege, Brad H. Rovin

Summary: The clinical trial (NefIgArd) of a novel targeted-release formulation of oral budesonide (Nefecon) for the treatment of IgA nephropathy (IgAN) demonstrated significant improvements in proteinuria and glomerular filtration rate, with good tolerability.

KIDNEY INTERNATIONAL (2023)

添加到收藏夹

Review Urology & Nephrology

European Association of Urology Guidelines on the Diagnosis and Management of Female Non-neurogenic Lower Urinary Tract Symptoms. Part 1: Diagnostics, Overactive Bladder, Stress Urinary Incontinence, and Mixed Urinary Incontinence

Arjun K. Nambiar, Salvador Arlandis, Kari Bo, Hanny Cobussen-Boekhorst, Elisabetta Costantini, Monica de Heide, Fawzy Farag, Jan Groen, Markos Karavitakis, Marie Carmela Lapitan, Margarida Manso, Serenella Monagas Arteaga, Aisling Nic An Riogh, Eabhann O'Connor, Muhammad Imran Omar, Benoit Peyronnet, Veronique Phe, Vasileios Sakalis, Neha Sihra, Lazaros Tzelves, Mary-Lynne van Poelgeest-Pomfret, Tine W. L. van den Bos, Huub van der Vaart, Christopher K. Harding

Summary: This article summarizes the guidelines from the European Association of Urology on non-neurogenic female lower urinary tract symptoms and diseases. It provides recommendations for the diagnosis and management of female overactive bladder, stress urinary incontinence, and mixed urinary incontinence.

EUROPEAN UROLOGY (2022)

添加到收藏夹

Review Urology & Nephrology

Epidemiology of haemodialysis outcomes

Aminu K. Bello, Ikechi G. Okpechi, Mohamed A. Osman, Yeoungjee Cho, Htay Htay, Vivekanand Jha, Marina Wainstein, David W. Johnson

Summary: Haemodialysis is the most common form of kidney replacement therapy worldwide, but its availability, accessibility, cost, and outcomes vary across regions. Cardiovascular disease is the major cause of morbidity and mortality in haemodialysis patients. Understanding the epidemiology of haemodialysis outcomes and finding strategies for improvement are crucial.

NATURE REVIEWS NEPHROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Finerenone in Predominantly Advanced CKD and Type 2 Diabetes With or Without Sodium-Glucose Cotransporter-2 Inhibitor Therapy

Peter Rossing, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, Bertram Pitt, Luis M. Ruilope, Juliana C. N. Chan, Adriaan Kooy, Kieran McCafferty, Guntram Schernthaner, Christoph Wanner, Amer Joseph, Markus F. Scheerer, Charlie Scott, George L. Bakris

Summary: The FIDELIO-DKD study investigated the treatment effect of finerenone in patients with CKD and T2D, showing that finerenone can improve UACR and have beneficial effects on kidney and cardiovascular outcomes, regardless of whether patients were also using SGLT-2i.

KIDNEY INTERNATIONAL REPORTS (2022)

添加到收藏夹

Review Urology & Nephrology

COVID-19 and chronic kidney disease: an updated overview of reviews

Sara S. Jdiaa, Razan Mansour, Abdallah El Alayli, Archana Gautam, Preston Thomas, Reem A. Mustafa

Summary: This review focuses on the impact of Chronic Kidney Disease (CKD) on the poor outcomes of COVID-19 and highlights the importance of identifying strategies to prevent COVID-19 infection among patients with CKD.

JOURNAL OF NEPHROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis

Maxime Espi, Xavier Charmetant, Thomas Barba, Cyrille Mathieu, Caroline Pelletier, Laetitia Koppe, Elodie Chalencon, Emilie Kalbacher, Virginie Mathias, Anne Ovize, Emmanuelle Cart-Tanneur, Christine Bouz, Laurence Pellegrina, Emmanuel Morelon, Laurent Juillard, Denis Fouque, Cecile Couchoud, Olivier Thaunat

Summary: The level of protection provided by two doses of COVID-19 mRNA vaccines in patients receiving maintenance hemodialysis (MHD) is uncertain. This study found that vaccination significantly reduced the incidence and severity of COVID-19, but 11% of patients infected after two doses still died. Lack of protection in SARS-CoV-2-naive patients could be due to defective T-cell response and failure to generate sufficient neutralizing antibodies after vaccination. Administering a third dose of vaccine improved protection in low/no responders. High responders did not show an increase in antibodies after the third dose but experienced more side effects. The antibody and T-cell response after two doses can guide personalized administration of the third dose in MHD patients.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Review Urology & Nephrology

Molecular mechanisms and therapeutic targets for diabetic kidney disease

Katherine R. Tuttle, Rajiv Agarwal, Charles E. Alpers, George L. Bakris, Frank C. Brosius, Peter Kolkhof, Jaime Uribarri

Summary: Diabetic kidney disease is a global burden that increases the risk of kidney failure and cardiovascular events. There is a need to understand the molecular mechanisms of the disease and find new therapies. Inflammatory and fibrotic mediators play important roles in the pathophysiology of the disease. Recent clinical trials have shown promising drug therapies and dietary strategies for treating diabetic kidney disease.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Review Urology & Nephrology

COVID-19 in dialysis: clinical impact, immune response, prevention, and treatment

Khalil El Karoui, An S. De Vriese

Summary: The COVID-19 pandemic has had significant negative impacts on dialysis patients, increasing their risk of infection and mortality. Vaccination can provide partial protection against infection and severe disease, but immune responses in these patients may be suboptimal. Booster doses and primary prophylaxis strategies may be necessary for persistent poor vaccine responses. Specific therapeutic strategies for established COVID-19 in dialysis patients need further investigation.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Article Transplantation

Design, recruitment, and baseline characteristics of the EMPA-KIDNEY trial

William G. Herrington, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Natalie Staplin, David Preiss, Will Stevens, Karl Wallendszus, Rejive Dayanandan, Carol Knott, Michael Hill, Jonathan Emberson, Susanne Brenner, Vladimir Cejka, Alfred K. Cheung, Zhihong Liu, Jing Li, Peiling Chen, Laiseong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Roberto Pontremoli, Aldo Pietro Maggioni, Shinya Goto, Aiko Tomita, Rajat Deo, Katherine Tuttle, Jens Eilbracht, Stefan Hantel, Mark Hopley, Martin J. Landray, Colin Baigent, Richard Haynes

Summary: The EMPA-KIDNEY trial aims to evaluate the effects of empagliflozin on the risk of kidney disease progression or cardiovascular death in patients with chronic kidney disease. The trial includes a widely generalizable population of CKD patients and uses a streamlined design with minimal data collection. Results are anticipated in 2022.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

添加到收藏夹

Article Urology & Nephrology

Nivolumab in Combination with Stereotactic Body Radiotherapy in Pretreated Patients with Metastatic Renal Cell Carcinoma. Results of the Phase II NIVES Study

Cristina Masini, Cinzia Iotti, Ugo De Giorgi, Roberto Salvatore Bellia, Sebastiano Buti, Francesco Salaroli, Ilaria Zampiva, Renzo Mazzarotto, Claudia Mucciarini, Maria Giuseppa Vitale, Alessio Bruni, Frank Lohr, Giuseppe Procopio, Orazio Caffo, Franco Nole, Franco Morelli, Susanne Baier, Consuelo Buttigliero, Patrizia Ciammella, Giorgia Timon, Emanuela Fantinel, Gabriele Carlinfante, Annalisa Berselli, Carmine Pinto

Summary: This study evaluated the efficacy and safety of stereotactic body radiotherapy (SBRT) in combination with nivolumab in second- and third-line metastatic renal cell carcinoma (mRCC) patients. The results showed that the combination treatment did not provide additional clinical benefits but was safe and showed a good response in the irradiated lesions.

EUROPEAN UROLOGY (2022)

添加到收藏夹

Review Urology & Nephrology

Radiomics in prostate cancer: an up-to-date review

Matteo Ferro, Ottavio de Cobelli, Gennaro Musi, Francesco del Giudice, Giuseppe Carrieri, Gian Maria Busetto, Ugo Giovanni Falagario, Alessandro Sciarra, Martina Maggi, Felice Crocetto, Biagio Barone, Vincenzo Francesco Caputo, Michele Marchioni, Giuseppe Lucarelli, Ciro Imbimbo, Francesco Alessandro Mistretta, Stefano Luzzago, Mihai Dorin Vartolomei, Luigi Cormio, Riccardo Autorino, Octavian Sabin Tataru

Summary: This article provides an overview of the application of radiomics in prostate cancer patients, emphasizing its potential for personalized treatment and future applications.

THERAPEUTIC ADVANCES IN UROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Open Radical Cystectomy versus Robot-Assisted Radical Cystectomy with Intracorporeal Urinary Diversion: Early Outcomes of a Single-Center Randomized Controlled Trial

Riccardo Mastroianni, Mariaconsiglia Ferriero, Gabriele Tuderti, Umberto Anceschi, Alfredo Maria Bove, Aldo Brassetti, Leonardo Misuraca, Ashanti Zampa, Giulia Torregiani, Edoardo Ghiani, Diana Giannarelli, Salvatore Guaglianone, Michele Gallucci, Giuseppe Simone

Summary: This study compared perioperative and 6-month outcomes between open radical cystectomy (ORC) and robot-assisted radical cystectomy (RARC) with totally intracorporeal urinary diversion (UD). Results showed that RARC with intracorporeal UD had a significantly lower overall perioperative transfusion rate compared to ORC. However, perioperative complications, hospital stay, and 6-month health-related quality of life were similar between the two groups. Long-term follow-up is needed to assess oncologic and functional outcomes.

JOURNAL OF UROLOGY (2022)

添加到收藏夹

Review Urology & Nephrology

Health inequities and the inappropriate use of race in nephrology

Nwamaka D. Eneanya, L. Ebony Boulware, Jennifer Tsai, Marino A. Bruce, Chandra L. Ford, Christina Harris, Leo S. Morales, Michael J. Ryan, Peter P. Reese, Roland J. Thorpe, Michelle Morse, Valencia Walker, Fatiu A. Arogundade, Antonio A. Lopes, Keith C. Norris

Summary: The authors discuss how structural racism contributes to health disparities in minority racial groups and analyze the impact of using race coefficients in estimating glomerular filtration rate on health inequities in Black patients with kidney disease. Concerns have been raised regarding the use of race in assessing kidney disease, with emphasis on the role of race and racism in medicine. It is important to recognize and address the nuances of racism in healthcare to avoid perpetuating historical racist concepts that exacerbate health inequities in marginalized populations.

NATURE REVIEWS NEPHROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Executive summary of the KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease: an update based on rapidly emerging new evidence

Peter Rossing, M. Luiza Caramori, Juliana C. N. Chan, Hiddo J. L. Heerspink, Clint Hurst, Kamlesh Khunti, Adrian Liew, Erin D. Michos, Sankar D. Navaneethan, Wasiu A. Olowu, Tami Sadusky, Nikhil Tandon, Katherine R. Tuttle, Christoph Wanner, Katy G. Wilkens, Sophia Zoungas, Jonathan C. Craig, David J. Tunnicliffe, Marcello A. Tonelli, Michael Cheung, Amy Earley, Ian H. de Boer

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Review Urology & Nephrology

Therapeutic advances in COVID-19

Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey, Lorenzo Del Sorbo, Patrick R. Lawler, Meghan E. Sise, David E. Leaf

Summary: This article evaluates different types of therapies for treating COVID-19, with a particular focus on their relevance to patients with kidney failure and kidney transplant recipients. The research finds that anti-inflammatory and antiviral agents have a stronger evidence base and greater benefits compared to other therapeutic approaches.

NATURE REVIEWS NEPHROLOGY (2023)

添加到收藏夹

Article Urology & Nephrology

Stereotactic Radiotherapy and Short-course Pembrolizumab for Oligometastatic Renal Cell Carcinoma-The RAPPORT Trial

Shankar Siva, Mathias Bressel, Simon T. Wood, Mark G. Shaw, Sherene Loi, Shahneen K. Sandhu, Ben Tran, Arun A. Azad, Jeremy H. Lewin, Katharine E. Cuff, Howard Y. Liu, Daniel Moon, Jeremy Goad, Lih-Ming Wong, Michael LimJoon, Jennifer Mooi, Sarat Chander, Declan G. Murphy, Nathan Lawrentschuk, David Pryor

Summary: The RAPPORT trial investigated the combination of high-dose precision radiotherapy and a short course of immunotherapy in patients with low-volume metastatic kidney cancer. The results showed that this treatment regimen was well tolerated, with excellent cancer control in known disease sites, and a proportion of patients were free from cancer relapse in the longer term. These findings are encouraging and warrant further investigation.

EUROPEAN UROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Safety, pharmacodynamics, and exposure-response modeling results from a first-in-human phase 1 study of nedosiran (PHYOX1) in primary hyperoxaluria

Bernd Hoppe, Annelize Koch, Pierre Cochat, Sander F. Garrelfs, Michelle A. Baum, Jaap W. Groothoff, Graham Lipkin, Martin Coenen, Gesa Schalk, Aniruddha Amrite, David McDougall, Kelly Barrios, Craig B. Langman

Summary: This study evaluated the safety, pharmacokinetics, pharmacodynamics, and dose-response relationship of Nedosiran in healthy individuals and patients with PH. The results showed that single-dose Nedosiran demonstrated acceptable safety and evidence of pharmacodynamic effect in both PH1 and PH2 subpopulations.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Article Urology & Nephrology

Robot-assisted Radical Prostatectomy with the Novel Hugo Robotic System: Initial Experience and Optimal Surgical Set-up at a Tertiary Referral Robotic Center

Carlo A. Bravi, Marco Paciotti, Luca Sarchi, Angelo Mottaran, Luigi Nocera, Rui Farinha, Pieter De Backer, Marie-Helene Vinckier, Geert De Naeyer, Frederiek D'Hondt, Ruben De Groote, Alexandre Mottrie

Summary: This study describes the first five robot-assisted radical prostatectomies performed with the new Hugo RAS system in Europe. The procedures were completed successfully without any complications or technical failures. The study demonstrates the safety and feasibility of RARP with the Hugo RAS system.

EUROPEAN UROLOGY (2022)

添加到收藏夹

«
1
2
3
4
5
»

See full results

Related Categories

Anesthesiology (212.5K) Audiology & Speech-Language Pathology (1.7K) Clinical Neurology (1.3M) Critical Care Medicine (338.4K) Dentistry, Oral Surgery & Medicine (340.8K) Dermatology (413.6K) Emergency Medicine (142.9K) Endocrinology & Metabolism (751.7K) Gastroenterology & Hepatology (856.4K) Geriatrics & Gerontology (226.3K) Gerontology (158.2K) Health Care Sciences & Services (433.8K) Hematology (653.3K) Immunology (896.7K) Infectious Diseases (453.2K) Integrative & Complementary Medicine (99.8K) Medical Ethics (26.6K) Medical Informatics (100.5K) Medical Laboratory Technology (108K) Medicine, General & Internal (1.3M) Medicine, Legal (48.4K) Medicine, Research & Experimental (710K) Nursing (297.8K) Obstetrics & Gynecology (559.8K) Oncology (1.8M) Ophthalmology (452.2K) Orthopedics (359.5K) Otorhinolaryngology (166K) Pediatrics (655.3K) Peripheral Vascular Disease (595.7K) Pharmacology & Pharmacy (1.3M) Primary Health Care (59.2K) Psychiatry (755.1K) Radiology, Nuclear Medicine & Medical Imaging (799.4K) Rehabilitation (249.2K) Rheumatology (300.3K) Surgery (1.3M) Toxicology (333.1K) Transplantation (309.7K) Tropical Medicine (112.2K) Veterinary Sciences (455.3K)

© Peeref 2019-2024. All rights reserved.