Article
Urology & Nephrology
Minghao Liang, Xiuhong Ren, Di Huang, Zhishen Ruan, Xianhai Chen, Zhanjun Qiu
Summary: In this retrospective cohort study, the lactate dehydrogenase to serum albumin ratio (LAR) was found to be associated with prognosis in patients with sepsis-associated acute kidney injury (SA-AKI). Higher LAR was significantly correlated with higher 28-day, 90-day, and in-hospital mortality rates.
Article
Urology & Nephrology
Li Zhu, Xun-Liang Li, Rui Shi, De-Guang Wang
Summary: This study examined the differences in the prevalence and severity of unpleasant symptoms among hemodialysis patients with different dialysis vintages. The results showed that patients with longer dialysis vintages had significantly higher prevalence and severity of unpleasant symptoms compared to those with shorter dialysis vintages. These findings highlight the need for further research on symptom burden in chronic kidney disease patients.
Article
Urology & Nephrology
Zhongdi Liu, Yifan Chen, Zhe Du, Fengxue Zhu, Wei Huang
Summary: This study aimed to investigate the protective effect of ischemic postconditioning (I-PostC) against acute kidney injury (AKI) induced by limb ischemia-reperfusion (LIR) and the potential involvement of high-mobility group box 1 protein (HMGB1) and autophagy. The results showed that I-PostC significantly reduced the levels of HMGB1, Beclin1, LC3-II/LC3-I, and inflammatory cytokines in renal tissues and improved renal function. The protective effect of I-PostC against LIR-induced AKI was reversed by rapamycin (autophagy activator) treatment. In conclusion, I-PostC could play a protective role against AKI by regulating the release of HMGB1 and inhibiting autophagy activation.
Article
Urology & Nephrology
Yun Xia Zhang, Juan Lv, Jun Yuan Bai, XiaoWei Pu, En Lai Dai
Summary: The study aimed to identify key biomarkers of glomeruli in focal glomerulosclerosis (FSGS) and analyze their relationship with immune cell infiltration. Gene expression profiles were obtained and analyzed using GSEA, MCODE, and WGCNA. Key genes were identified using LASSO regression, and their diagnostic accuracy was evaluated using ROC curves. Transcription factors of key biomarkers were predicted using the IRegulon plugin. Immune cell infiltration and its correlation with key biomarkers were analyzed. TGFB1 and NOTCH1 were found to be potential key glomerular biomarkers in FSGS, and T-cell infiltration played a crucial role in the FSGS lesion process.
Article
Urology & Nephrology
Ping Zhang, Shilong Xiang, Bicheng Liu, Xiaohui Wang, Xiaoping Yang, Chaoyang Ye, Zunsong Wang, Yanlin Li, Li Zhou, Caili Wang, Hongbo Li, Jian Huang, Ai Peng, Xiaoping Wang, Deguang Wang, Jie Xiao, Wenli Chen, Hong Cheng, Nan Mao, Jianqin Wang, Lin Yang, Jianghua Chen
Summary: This study aimed to evaluate the efficacy and safety of nalfurafine in treating refractory CKD-aP in Chinese patients. The results showed that nalfurafine effectively reduced itching and had low incidence of adverse drug reactions.
Letter
Urology & Nephrology
Jun Li, Zhiying Li, Tao Su
Article
Urology & Nephrology
Zeping Gui, Xiang Zhang, Qianguang Han, Zhou Hang, Ruoyun Tan, Min Gu, Zijie Wang
Summary: Our research investigates the role of M1 macrophage polarization in endothelium-to-myofibroblast transition (EndMT) and chronic allograft dysfunction (CAD). We collected and studied transplanted nephrectomy specimens from CAD patients to explore the infiltration of M1 and M2 macrophages. We also established a co-culture model of M1 macrophages and aortic endothelial cells to test EndMT. Our findings suggest that M1 macrophages play a significant role in the development of EndMT and CAD.
Article
Urology & Nephrology
Zhenzhou Li, Mengjie Weng, Lizhao Lin, Yi Chen, Jiaqun Lin, Jiong Cui, Dewen Jiang, Binbin Fu, Guifen Li, Caiming Chen, Yanfang Xu, Jianxin Wan
Summary: This study investigated the association of multiple variables with AKI in patients with IMN. The results showed that the incidence of AKI was higher in males than females, and the AKI group had higher uric acid levels, lower serum PLA2R antibody positive rates, and worse baseline kidney function. Binary logistic regression analysis indicated that uric acid and baseline eGFR were independent risk factors for AKI in patients with IMN. The study demonstrated that AKI increases the risk of poor prognosis in IMN patients.
Article
Urology & Nephrology
Zhe Li, Weibo Le, Haitao Zhang, Dacheng Chen, Wencui Chen, Shuhua Zhu, Ke Zuo
Summary: This cohort study analyzed the prevalence, clinical features, and prognosis of anemia in membranous nephropathy (MN) patients. The results showed that the anemia experienced by MN patients was mainly mild and moderate normocytic anemia. Acute renal tubule injury, protein level, cholesterol level, hypokalemia, and hypophosphatemia were identified as independent risk factors for anemia in MN patients. The rate of complete remission and renal endpoint events differed among anemia patients with different treatment outcomes.
Article
Urology & Nephrology
Jiandong Zhou, Weijie Yuan, Yunshan Guo, Yongfang Wang, Yuyang Dai, Ying Shen, Xuan Liu
Summary: The study investigated the relationship between asprosin and metabolic syndrome in hemodialysis patients. Higher levels of asprosin were associated with an increased risk of metabolic syndrome. Fasting serum asprosin could be an independent risk factor for metabolic syndrome in these patients.
Article
Urology & Nephrology
Jiakun Tian, Rong Zhang, Nan Zhu, Lijie Gu, Yunshan Guo, Weijie Yuan
Summary: In this study of 76 peritoneal dialysis patients, it was found that a decrease in sT beta 4 levels is associated with the occurrence of MIA syndrome. Increasing sT beta 4 levels can improve the prognosis of PD patients and reduce the incidence of MIA syndrome.
Article
Urology & Nephrology
Ying Ding, Li Wan, Zhou-cang Zhang, Qing-hua Yang, Jia-xiang Ding, Zhen Qu, Feng Yu
Summary: This study investigated the effect of angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril-valsartan (SV) on patients undergoing dialysis. The results showed that SV might have a cardio-protective role in patients with end-stage kidney disease (ESRD) undergoing dialysis, especially in peritoneal dialysis (PD) patients.
Article
Urology & Nephrology
Wei Chen, Ying Xu, Zheng-Hao Li, Ya-Chen Si, Hai-Yan Wang, Xiao-Lu Bian, Lu Li, Zhi-Yong Guo, Xue-Li Lai
Summary: This study aims to identify biomarkers and reveal the underlying mechanisms of Excessive Daytime Sleepiness (EDS) in peritoneal dialysis patients. Using UHPLC-Q-TOF/MS, 39 differential metabolites were found between EDS and non-EDS groups, and 9 of them were correlated with disease severity. The EDS-metabolite-target network and protein-protein interaction network were constructed, providing new insights into the early diagnosis and mechanisms of EDS in PD patients.
Article
Urology & Nephrology
Ziman Chen, Tin Cheung Ying, Jiaxin Chen, Chaoqun Wu, Liujun Li, Hui Chen, Ting Xiao, Yongquan Huang, Xuehua Chen, Jun Jiang, Yingli Wang, Wuzhu Lu, Zhongzhen Su
Summary: A multilayer perceptron model was developed and validated for assessing the severity of renal fibrosis in patients with chronic kidney disease using real-time two-dimensional shear wave elastography and clinical variables. The model demonstrated good discrimination and calibration, and showed potential for clinical management and treatment decision-making.
Article
Urology & Nephrology
Yunxian Chen, Xiwen Zhou, Zhixin Chen, Jue Xia, Fenglei Guan, Yue Li, Yanrong Li, Yicai Chen, Yuanlin Zhao, Huayun Qiu, Jiarong Liang, Liangqiu Tang
Summary: High-sensitivity cardiac troponin T (hs-cTnT) and creatine kinase (CK)-MB are commonly used biomarkers for the diagnosis and prognosis of acute myocardial infarction (AMI). This study aimed to compare the prognostic value of hs-cTnT and CK-MB in AMI patients with chronic kidney disease (CKD). The results showed that hs-cTnT and CK-MB had higher predictive value in AMI patients with CKD, while only CK-MB had predictive ability in patients with normal renal function. Moreover, the hs-cTnT/CK-MB ratio may assist in risk stratification of AMI patients with CKD.
Article
Endocrinology & Metabolism
Jong Seung Lee, Seung-ho Hong, Hwa Yeon Sun, Hyungseung Jin, Byung Yeon Yu, Yong-jin Cho, Jin young Chang, Byung Wook Yoo
Summary: This study examined the effect of daily low-dose tadalafil on patients with type 2 diabetes and erectile dysfunction. The results showed that daily tadalafil use significantly improved erectile reliability and blood circulation, supporting its safe administration for patients with diabetes.
Article
Endocrinology & Metabolism
Fei Wu, Hao Ning, Yang Sun, Haihu Wu, Jiaju Lyu
Summary: This study comprehensively analyzed single-cell RNA sequencing, bulk-RNA sequencing, and microarray data to explore the inter-relational mechanism between benign prostate hyperplasia (BPH) and prostate cancer (CaP). The identified hub genes, including DDA1, ERG28, OGFOD1, and OXA1L, may serve as potential therapeutic targets for immunotherapy in prostate cancer.
Review
Endocrinology & Metabolism
Kai K. Kummer, Barbara Mangweth-Matzek
Summary: While eating disorders have long been seen as predominantly affecting females, it is now recognized that men are also impacted. However, limited research exists on eating disorders in men, particularly in older age groups. This focused review aims to provide an update on disordered eating and eating disorders in middle-aged and older males, including the relationship between excessive exercising as a purging method and the influences of age-related hormonal imbalances.
Article
Endocrinology & Metabolism
E. E. Besong, P. J. Ashonibare, O. O. Obembe, M. A. Folawiyo, D. H. Adeyemi, M. A. Hamed, T. M. Akhigbe, R. E. Akhigbe
Summary: This study investigated the impact of lead exposure on testicular function, and found that lead exposure resulted in decreased sperm count, viability and motility, as well as abnormal sperm morphology. Lead exposure also caused oxidative stress, apoptosis, inflammation, and degenerative changes in testicular tissues. However, co-administration of zinc was able to protect against lead-induced testicular injury by mitigating oxidative stress, apoptosis, and inflammation.
Article
Endocrinology & Metabolism
Qianying Ou, Wei Jin, Leweihua Lin, Danhong Lin, Kaining Chen, Huibiao Quan
Summary: This study aimed to establish a practical nomogram for predicting the risk incidence of prediabetes and prediabetes conversion to diabetes. The LASSO algorithm was found to be superior to other algorithms for diabetes risk prediction. The nomogram for prediabetes included Age, FH, Insulin_F, hypertension, Tgab, HDL-C, Proinsulin_F, and TG, and the nomogram for prediabetes to diabetes included Age, FH, Proinsulin_E, and HDL-C. Both models demonstrated good discrimination and calibration.
