Tropical Medicine

112.2K Papers

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Article Infectious Diseases

Prevalence of G6PD deficiency and submicroscopic malaria parasites carriage in malaria hotspot area in Northwest, Tanzania

Alphaxard Manjurano, Eric Lyimo, Coleman Kishamawe, Justin Omolo, Jacklin Mosha, Miyaye Donald, Paul Kazyoba, Saidi Kapiga, John Changalucha

Summary: A retrospective cross-sectional study was conducted in a malaria hotspot area in Tanzania to determine the prevalence of G6PD deficiency. The study revealed that 16.4% of the population in this area carry the G6PD A- mutation, similar to other parts of Africa. This suggests that primaquine could be valuable for malaria control and elimination in this region, but further research on G6PD deficiency mapping in Tanzania is needed.

MALARIA JOURNAL (2023)

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Article Pediatrics

Antimicrobial resistance and epidemic clustering of late-onset neonatal infections in a Brazilian intensive care unit

Felipe Teixeira de Mello Freitas, Marcela Santos Correa da Costa, Kaylla Heduarda Rodrigues da Costa, Everton Giovanni Alves

Summary: Clusters of infections are common in a Brazilian NICU, indicating the transmission of multidrug-resistant pathogens and the need for intensified surveillance and infection control measures.

JOURNAL OF TROPICAL PEDIATRICS (2023)

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Article Pediatrics

The new Xpert Mycobacterium tuberculosis/rifampicin (MTB/Rif) Ultra assay in comparison to Xpert MTB/Rif assay for diagnosis of tuberculosis in children and adolescents

Harveen Kaur, Vishal Guglani, Lipika Singhal, Shivani Randev, Pankaj Kumar, Varsha Gupta

Summary: The study found that Xpert Ultra is more sensitive than Xpert in detecting Mycobacterium tuberculosis in children, supporting the use of Xpert Ultra as an initial rapid molecular diagnostic test in children being evaluated for TB.

JOURNAL OF TROPICAL PEDIATRICS (2023)

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Article Pediatrics

Risk factors for mortality in an African pediatric emergency department: case of Sourô Sanou Hospital, a prospective, cross-sectional study

Makoura Barro, Cheick Ahmed Ouattara, Bintou Sanogo, Abdel Aziz Baby, Ad Bafa Ibrahim Ouattara, Fatimata Sahoura Nacro, Isidore Tiandiogo Traore, Angele Kalmogho, Alain Saga Ouermi, Rene Souanguimpari Ouoba, Klangboro Raymond Cessouma, Boubacar Nacro

Summary: This study assessed the causes and associated factors of pediatric emergency mortality at the Souro Sanou University Hospital in Bobo-Dioulasso, sub-Saharan Africa. The study found that infant mortality rates remain high and are significantly associated with younger maternal age, delay in consultation, and incomplete vaccination status.

JOURNAL OF TROPICAL PEDIATRICS (2023)

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Article Pediatrics

Tumor necrosis factor alpha gene polymorphism affects the pattern of idiopathic nephrotic syndrome in Kuwaiti Arab children

Amal A. Al-Eisa, Maysoun Al Rushood, Sumedha Kashyap, Mohammad Z. Haider

Summary: The AG genotype of TNF-α gene polymorphisms may be considered a suitable marker for INS disease among Kuwaiti children. Both AA and AG genotypes may be useful in predicting steroid responsiveness among these cases of Arab ethnicity.

JOURNAL OF TROPICAL PEDIATRICS (2023)

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Article Public, Environmental & Occupational Health

International health regulations and pre-travel health practices of international travelers at Nigerian airport: a cross-sectional study

Oluwatosin Samson Jegede, Grace Ijitade, Oyedoyin Aanu Fatoye, Timilehin Mercy Jegede, Nicholas Aderinto, Oluwafunmilayo Adenike Oguntoye, Oluwatosin Oluwagbenga Oguntoye, Oluwatosin Ruth Ilori, Olugbemiga Lanre Abodunrin, Adenike Iyanuoluwa Olugbenga-Bello, James Bamidele, Dauda Bayo Parakoyi

Summary: This study reveals a low prevalence of good pre-travel health practices among participants. Educational level and endemicity of yellow fever at the destination were predictors of pre-travel health practices. Introducing topics on travelers' health into schools' curriculums may have a positive ripple effect on health practices among international travelers. Furthermore, there is a need for public enlightenment programs on pre-travel health practices using social media platforms.

TROPICAL DISEASES TRAVEL MEDICINE AND VACCINES (2023)

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Article Parasitology

Integrative taxonomy of Metastrongylus spp. in wild boars from Brazil

Wilson Junior Oliveira, Patricia Parreira Perin, Carmen Andrea Arias Pacheco, Talita Oliveira Mendonca, Andressa de Souza Pollo, Renan Bressianini do Amaral, Natalia de Oliveira Zolla, Livia de Oliveira Andrade, Jonathan Silvestre Gomes, Vitoria Maximiana Soares dos Santos, Adrian Felipe de Moraes Ferreira, Estevam Guilherme Lux Hoppe

Summary: This study characterized Metastrongylus spp. from wild boars in Brazil using morphological description and genetic sequences. The results showed that Metastrongylus salmi was the most prevalent and abundant species. The phylogenetic analysis identified ITS2 region and cox-1 mtDNA as the most suitable genetic markers for Metastrongylus species characterization.

PARASITES & VECTORS (2023)

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Article Infectious Diseases

Examining the disparities of anti-malarial drug consumption among children under the age of five: a study of 5 malaria-endemic countries

Md Sabbir Hossain, Talha Sheikh Ahmed, Nahid Sultana, Muhammad Abdul Baker Chowdhury, Md Jamal Uddin

Summary: This study investigates the disparities in anti-malarial drug consumption for malaria among children under the age of five in low- and middle-income countries. The findings reveal shockingly low usage of anti-malarial drugs for treating malaria in some countries.

MALARIA JOURNAL (2023)

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Article Infectious Diseases

Estimated distribution of malaria cases among children in sub-Saharan Africa by specified age categories using data from the Global Burden of Diseases 2019

Olorunfemi A. Oshagbemi, Pedro Lopez-Romero, Cornelis Winnips, Katalin R. Csermak, Guoqin Su, Elodie Aubrun

Summary: This study estimated the disease burden and distribution of Plasmodium falciparum malaria among children in sub-Saharan Africa, with a detailed analysis based on age categories. The results have important implications for ensuring appropriate representation of children in clinical trials and other interventions.

MALARIA JOURNAL (2023)

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Article Public, Environmental & Occupational Health

Impact of lamivudine treatment in late pregnancy on the development of the foetal immune response to hepatitis B virus: a meta-analysis in R with the metafor package

Peng Zhao, Ying Zhao, Minmin Du, Xiuying Chen, Yongchao Lu

Summary: This study evaluated the impact of antiretroviral therapy (ART) on the immune response to Hepatitis B virus (HBV) in foetuses and infants. The results showed that lamivudine treatment in late pregnancy can boost the foetal immune response to HBV in utero and enhance the neonatal immune response to HBV vaccine after birth.

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2023)

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Article Parasitology

Borrelia puertoricensis in opossums (Didelphis marsupialis) from Colombia

Yesica Lopez, Alvaro A. Faccini-Martinez, Sebastian Munoz-Leal, Veronica Contreras, Alfonso Calderon, Ricardo Rivero, Marina Munoz, Juan David Ramirez, Salim Mattar

Summary: This study provides the first molecular evidence of Borrelia puertoricensis in Colombia, specifically in opossums, and the first detection of this spirochete in a vertebrate host since its isolation from Ornithodoros puertoricensis in Panama. The detection is also significant due to the epidemiological importance of opossums as reservoirs of zoonotic diseases to humans.

PARASITES & VECTORS (2023)

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Article Infectious Diseases

Human monoclonal antibodies inhibit invasion of transgenic Plasmodium knowlesi expressing Plasmodium vivax Duffy binding protein

Quentin D. Watson, Lenore L. Carias, Alyssa Malachin, Karli R. Redinger, Juergen Bosch, Martino Bardelli, Lea Baldor, Lionel Brice Feufack-Donfack, Jean Popovici, Robert W. Moon, Simon J. Draper, Peter A. Zimmerman, Christopher L. King

Summary: This study evaluated the invasion and growth inhibition of human monoclonal antibodies targeting PvDBP using a transgenic parasite model. Results showed that PvDBP-specific antibodies could effectively inhibit the invasion of P. vivax, but there was no significant synergistic effect observed in combinations of different antibodies.

MALARIA JOURNAL (2023)

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Review Public, Environmental & Occupational Health

Use of point-of-care haemoglobin tests to diagnose childhood anaemia in low- and middle-income countries: A systematic review

Rebecca Brehm, Annabelle South, Elizabeth C. George

Summary: Anaemia is a major cause of mortality and transfusion in children in low- and middle-income countries. Point-of-care haemoglobin tests could provide rapid and affordable results, improving patient outcomes and resource utilization. However, challenges exist in the use of POC(Hb)Ts in LMICs.

TROPICAL MEDICINE & INTERNATIONAL HEALTH (2023)

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Letter Public, Environmental & Occupational Health

Sterilisation of some improvised suture materials for external tissue apposition

Richard Okafor, John Elijah, Sheriff Idris

TROPICAL DOCTOR (2023)

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Letter Public, Environmental & Occupational Health

Löffler's syndrome associated with cutaneous larva migrans

Kaushiki Hajra, Uddalak Chakraborty, Atanu Chandra

TROPICAL DOCTOR (2023)

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Article Parasitology

Rapid insecticide resistance bioassays for three major urban insects in Taiwan

Hsiu-Hua Pai, Chun-Yung Chang, Kai-Chen Lin, Err-Lieh Hsu

Summary: Taiwan's warm and humid climate and dense population provide a suitable environment for pest breeding. House flies, cockroaches, and mosquitoes are the three major urban pests in Taiwan. Selecting the most effective insecticide is crucial in cases where a disease outbreak or high pest density necessitates chemical control, and rapid resistance assessment is required.

PARASITES & VECTORS (2023)

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Article Parasitology

Efficacy of an oral formulation of afoxolaner and milbemycin oxime against Tunga penetrans in naturally infected dogs

Katharine Costa dos Santos, Eric Tielemans, Andre Antonio Cutolo, Paula Elisa Brandao Guedes, Tatiani Vitor Harvey, Jamille Bispo de Carvalho Teixeira, Rebeca Costa Vitor, Anaia da Paixao Seva, Adan William de Melo Navarro, Ana Carolina Ribeiro Lima, Karin Denise Botteon, Thammy Vieira Bittar, George Rego Albuquerque, Fernando de Almeida Borges, Frederic Beugnet, Renata Santiago Alberto Carlos

Summary: This study assessed the efficacy of NexGard Spectra (R) against canine tungiasis and proved its high effectiveness. In addition to benefiting the health and welfare of treated dogs, the use of this product may have a one-health benefit on human cases by controlling the main reservoir of sand fleas.

PARASITES & VECTORS (2023)

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Article Parasitology

The role of apoptosis and oxidative stress in the pathophysiology of Acanthamoeba spp. infection in the kidneys of hosts with different immunological status

Karolina Kot, Patrycja Kupnicka, Maciej Tarnowski, Patrycja Tomasiak, Danuta Kosik-Bogacka, Natalia Lanocha-Arendarczyk

Summary: This study analyzes the gene expression and protein concentration of NADPH oxidase 2 and 4 (NOX2 and NOX4) and nuclear erythroid 2-related factor (Nrf2) in the kidneys of hosts with systemic acanthamoebiasis. The results show increased expression and/or concentration of NOX2 and NOX4 in infected mice, as well as higher expression of Nrf2 in immunocompetent mice. The study also reveals different strategies of Acanthamoeba spp. in relation to apoptosis, inhibiting apoptosis in immunocompetent hosts and increasing apoptosis in immunosuppressed hosts.

PARASITES & VECTORS (2023)

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Article Infectious Diseases

13-Valent pneumococcal conjugate vaccines vaccination innovative strategy in Weifang City, China: a case study

Jiachen Wang, Yujue Wang, Ruoyu Xu, Ting Zhang, Yanyan Jiang, Yuanyuan Wang, Yi Wang, Yuanze Du, Wenxue Sun, Kai Deng, Weizhong Yang, Zengwu Wang, Luzhao Feng, Chunping Wang

Summary: Weifang City implemented an innovative strategy for PCV13 vaccination, providing free vaccines and reducing prices to increase vaccination coverage. However, the coverage is still lower than that in developed countries. To further promote PCV13 vaccination, Weifang City should continue to implement this strategy and explore appropriate financing channels.

INFECTIOUS DISEASES OF POVERTY (2023)

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Article Toxicology

Echinometra lucunter molecules reduce Aβ42-induced neurotoxicity in SH-SY5Y neuron- like cells: effects on disaggregation and oxidative stress

Amanda Gomes da Silva, Mariana da Mata Alves, Admilson Aparecido da Cunha, Giovanna Arruda Caires, Irina Kerkis, Hugo Vigerelli, Juliana Mozer Sciani

Summary: The coelomic fluid of Echinometra lucunter and its fractions show potential in preventing and treating neurotoxicity caused by A1342o and oxidative stress, indicating their therapeutic potential in treating neurodegenerative diseases.

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES (2023)

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