Transplantation

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Article Hematology

American Society of Transplantation and Cellular Therapy Series: #7-Management of Respiratory Syncytial Virus Infections in Hematopoietic Cell Transplant Recipients

Firas El Chaer, Daniel R. Kaul, Janet A. Englund, Michael Boeckh, Marjorie V. Batista, Susan K. Seo, Paul A. Carpenter, David Navarro, Hans H. Hirsch, Michael G. Ison, Genovefa A. Papanicolaou, Roy F. Chemaly

Summary: The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to update the guidelines for hematopoietic cell transplantation. They adopted a new approach of publishing each topic in a concise format of FAQs, tables, and figures. In the seventh guideline, they focused on respiratory syncytial virus (RSV) and provided answers to FAQs regarding epidemiology, clinical diagnosis, prophylaxis, and treatment.

TRANSPLANTATION AND CELLULAR THERAPY (2023)

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Article Immunology

Kidney transplant outcomes in patients with antibodies to human neutrophil antigen 3a

Emma Cannon, Karen Stevenson, Ann-Margaret Little, David Mckenzie, Catherine Hastie, Anthony Calvert, Anthony Poles, Richard Battle, Sylvia Mcconnell, Paul J. Phelan, David Turner

Summary: The presence of HNA-3a antibodies may contribute to the development of ABMR in kidney transplant recipients without a known DSA. This finding suggests the importance of screening at-risk groups for HNA antibodies to guide immunosuppressive therapy.

TRANSPLANT IMMUNOLOGY (2023)

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Article Transplantation

Establishing a HOPE Program in a Real-life Setting: A Brazilian Case Series

Amanda P. C. S. Boteon, Marisa R. D. Lima, Bianca Della Guardia, Mauricio F. Carvalho, Andrea Schlegel, Yuri L. Boteon

Summary: This study describes the establishment of hypothermic oxygenated perfusion (HOPE) in a real-life setting in Brazil and demonstrates its successful application in challenging donor-recipient matching situations. These findings may provide valuable insights for implementing machine perfusion programs in settings with limited resources or complex transplant logistics.

TRANSPLANTATION DIRECT (2023)

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Article Immunology

HLA B eplet mismatches in the context of delayed graft function and low tacrolimus trough levels are risk factors influencing the generation of de novo donor-specific antibodies and acute rejection in the early stage after kidney transplantation

Shan Gao, Huilin Gong, Meihe Li, Ping Lan, Minyue Zhang, Peidan Kuang, Ying Zhang, Xiaojun Hu, Chenguang Ding, Yang Li, Xiaoming Ding, Wujun Xue, Jin Zheng

Summary: This study found that HLA B eplet mis-matching, delayed graft function, and tacrolimus trough levels at 12 months could affect the occurrence of dnDSA and AR in the early stage after kidney transplantation.

TRANSPLANT IMMUNOLOGY (2023)

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Article Transplantation

Evolving Trends in Kidney Transplant Outcomes Among Older Adults: A Comparative Analysis Before and During the COVID-19 Pandemic

Yiting Li, Gayathri Menon, Wenbo Wu, Amrusha Musunuru, Yusi Chen, Evelien E. Quint, Maya N. Clark-Cutaia, Laura B. Zeiser, Dorry L. Segev, Mara A. McAdams-DeMarco

Summary: A study examined the trends in post-kidney transplant outcomes for older and younger recipients over the past 30 years. It was found that there have been steady improvements in patient/graft survival, but these improvements were disrupted during the COVID-19 pandemic, particularly for older adults. The mortality rate among older adults during the pandemic reflected rates seen 20 years prior.

TRANSPLANTATION DIRECT (2023)

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Article Transplantation

Therapeutic Donor Kidney Transplant Outcomes: Comparing Early US Experiences Using Optimal Matching

Junji Yamauchi, Divya Raghavan, George Rofaiel, Michael Zimmerman, Vishnu S. Potluri, Talia Baker, Jeffrey Campsen, Isaac E. Hall, Miklos Z. Molnar

Summary: This study evaluated the outcomes of therapeutic donor kidney transplantation compared to non-therapeutic donor and deceased-donor kidney transplantation. The results showed no significant difference in early graft function among the groups, but therapeutic donor kidney transplantation had a higher risk of poor outcomes at 6 months. The findings suggest selective utilization of therapeutic donor kidneys, but further studies are needed for optimal utilization.

TRANSPLANTATION DIRECT (2023)

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Article Transplantation

Factors Associated With Sinoatrial Reinnervation After Heart Transplantation

Anders H. Christensen, Vegard B. B. Wyller, Sissel Nygaard, Katrine Rolid, Kari Nytroen, Lars Gullestad, Arnt Fiane, Erik Thaulow, J. Philip Saul, Gaute Dohlen

Summary: Sympathetic and parasympathetic sinoatrial reinnervation after heart transplantation increases over time. A pretransplant diagnosis of nonischemic cardiomyopathy and higher index visit handgrip strength are the main factors affecting sympathetic reinnervation, while recipient age, rejection episodes, and duration of extracorporeal circulation have no association. Recipients with higher levels of reinnervation have higher average handgrip strength, suggesting a link between reinnervation and improved frailty. Reinnervation may have an inhibitory effect on inflammation, possibly through enhanced function of the inflammatory reflex.

TRANSPLANTATION DIRECT (2023)

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Article Immunology

UNOS Decisions Impact Data Integrity of the OPTN Data Registry

Demetra S. Tsapepas, Kristen King, Syed Ali Husain, Miko E. Yu, Benjamin E. Hippen, Jesse D. Schold, Sumit Mohan

Summary: This article summarizes critical gaps in the OPTN/UNOS database and proposes ideas for improvement.

TRANSPLANTATION (2023)

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Editorial Material Immunology

Executive summary of the consensus statement of the group for the study of infection in transplantation and other immunocompromised host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the treatment of SARS-CoV-2 infection in solid organ transplant recipients

Sabina Herrera, Jose M. Aguado, Francisco Javier Candel, Elisa Cordero, Beatriz Dominguez-Gil, Mario Fernandez-Ruiz, Ibai Los Arcos, Oscar Len, M. Angeles Marcos, Elena Munez, Patricia Munoz, Isabel Rodriguez-Goncer, Javier Sanchez-Cespedes, Maricela Valerio, Marta Bodro

TRANSPLANTATION REVIEWS (2023)

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Review Immunology

The British transplantation society guidelines on organ donation from deceased donors after circulatory death

Stephen O'Neill, Ellie Asgari, Chris Callaghan, Dale Gardiner, Hermien Hartog, Satheesh Iype, Alex Manara, David Nasralla, Gabi C. Oniscu, Chris Watson

Summary: Recipient outcomes after transplantation with organs from donation after circulatory death (DCD) donors can be as good as or even comparable to those after transplantation with organs from donation after brain death donors. The key to success lies in establishing common practices and accepted protocols to safely utilize DCD organs and maximize the use of the DCD donor pool.

TRANSPLANTATION REVIEWS (2023)

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Correction Cardiac & Cardiovascular Systems

THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION/HEART FAILURE SOCIETY OF AMERICA GUIDELINE ON ACUTE MECHANICAL CIRCULATORY SUPPORT (vol 42, pg E1, 2023)

Alexander M. Bernhardt, Hannah Copeland, Anita Deswal, Jason Gluck, Michael M. Givertz

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2023)

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Article Hematology

Continuous Elotuzumab, Pomalidomide, and Dexamethasone Maintenance Following Second Autologous Transplantation for Multiple Myeloma: Results of a Prospective Phase 2 Multicenter Trial

Michael Slade, Mark A. Fiala, Marie Kirchmeyer, Jeff King, Feng Gao, Mark A. Schroeder, A. Keith Stewart, Keith Stockerl-Goldstein, Christine Chen, Ravi Vij

Summary: This study investigates the use of elotuzumab, pomalidomide, and dexamethasone (EPd) as salvage therapy prior to and maintenance after second autologous hematopoietic cell transplantation (AHCT2) for relapsed multiple myeloma. The results show that EPd maintenance after AHCT2 is safe and tolerable, with similar 1-year progression-free survival (PFS) and median PFS compared to previous studies.

TRANSPLANTATION AND CELLULAR THERAPY (2023)

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Article Hematology

Integration of Daily Patient-Reported Outcome Measures in Pediatric Stem Cell Transplantation

Benjamin Hetzer, Andreas Meryk, Gabriele Kropshofer, Christina Salvador, David Riedl, Jens Lehmann, Gerhard Rumpold, Alexandra Haid, Verena Schneeberger-Carta, Bernhard Holzner, Roman Crazzolara

Summary: This study aimed to evaluate the feasibility of capturing daily patient-reported health status during stem cell transplantation and proposed a method to integrate continuous feedback on health-related symptoms into daily clinical practice.

TRANSPLANTATION AND CELLULAR THERAPY (2023)

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Article Hematology

Short-Course Empiric Antibiotics in Children Undergoing Allogeneic Hematopoietic Cell Transplantation

Pratik A. Patel, Mehgan F. Teherani, Yijin Xiang, Valeria Bernardo, Shanmuganathan Chandrakasan, Kathryn P. Goggin, Ann Haight, Edwin Horwitz, Wayne H. Liang, Suhag H. Parikh, Michelle L. Schoettler, Kathleen Spencer, Elizabeth Stenger, Benjamin Watkins, Kirsten M. Williams, Kathryn Leung, Preeti Jaggi, Muna Qayed

Summary: This study successfully reduced the duration of broad-spectrum antibiotic use by limiting the time of antibiotic use in children undergoing hematopoietic cell transplantation. The results show promise in reducing antibiotic exposure in this patient population, but further clinical trials are needed to validate the findings.

TRANSPLANTATION AND CELLULAR THERAPY (2023)

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Review Transplantation

Transplant tourism - a missed opportunity

Hadar Merhav

Summary: This article discusses the resurgence of transplant tourism despite the reiteration of a declaration that prohibits it. As the demand for organ transplants continues to grow and the supply remains limited, novel approaches are needed to bridge the gap.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2023)

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Review Transplantation

Novel cell-based strategies for immunomodulation in vascularized composite allotransplantation

Maria Siemionow, Yalcin Kulahci, Fatih Zor

Summary: Cell-based therapies have emerged as a promising strategy for inducing tolerance in VCA, with preclinical studies and clinical trials showing safety and efficacy. However, further research is needed to develop novel cell-based immunosuppressive protocols for VCA.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2023)

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Article Cardiac & Cardiovascular Systems

Atypical infiltrates on endomyocardial biopsy are associated with adverse outcomes in pediatric heart transplantation

Kyle D. Hope, Shaine A. Morris, Debra L. Kearney, Kriti Puri, Swati Choudhry, Joseph A. Spinner, Hari P. Tunuguntla, Jack F. Price, William J. Dreyer, Sarah K. Nicholas, Susan W. Denfield

Summary: The presence of atypical infiltrates on endomyocardial biopsy (EMB) after pediatric heart transplant (HTx) is associated with worse post-HTx outcomes. Patients with atypical infiltrates by 1-year post-HTx have a higher risk of reaching the composite outcome.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2023)

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Article Cardiac & Cardiovascular Systems

How do mechanical circulatory support patients die? Autopsy findings for left-ventricular assist device/total artificial heart nonsurvivors

Nicole K. Bart, Desire Robson, Kavitha Muthiah, Paul C. Jansz, Christopher S. Hayward

Summary: This study aimed to determine the frequency and outcomes of autopsy investigations in patients who died prior to heart transplantation after receiving permanent mechanical circulatory support.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2023)

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Article Immunology

Identification of biomarkers of renal ischemia-reperfusion injury by bioinformatics analysis and single-cell sequencing analysis combined with in vivo validation

Qin Zhu, Shiqi Ren, Zhaoyang Sun, Jun Qin, Xiaoming Sheng

Summary: By analyzing the transcriptome and biological functions, this study identified cyp1a1 and pdk4 as key genes in renal ischemia-reperfusion injury (IRI), and demonstrated their diagnostic value and upregulated expression. This finding provides a new research basis for studying the pathogenesis and treatment of renal IRI.

TRANSPLANT IMMUNOLOGY (2023)

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Article Immunology

An analysis of the relationship between donor and recipient biomarkers and kidney graft function, dysfunction, and rejection

Yi-Jie Mao, Dong-Sheng Xu, Shuang-De Liu, Jie-Ke Yan, Xiao-Li Liu, Xu-Feng Zhang, Wen-Gu Pan, Chuan Tian

Summary: This study found that donor serum TIMP-2 and uNAG levels are useful predictive biomarkers for reduced graft function. They can provide donor-based prediction for RGF.

TRANSPLANT IMMUNOLOGY (2023)

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