Review
Transplantation
Jean Kanitakis
Summary: This review discusses the diagnosis and related changes of chronic rejection in vascularized composite tissue allografts. Currently, diagnosis mainly relies on clinical and pathological findings, although recent advances in non-invasive techniques have shown promising results but still require further studies.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2023)
Review
Transplantation
Aaron Ahearn
Summary: This review evaluates the ethical implications of the changes in the US liver transplant community, focusing on the competing ethical principles of urgency vs. utility and justice vs. pragmatism.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2023)
Review
Transplantation
Joseph Scarpa
Summary: The entire set of molecular omics data, known as the transplant-ome, can be used to tailor perioperative care for individual liver transplant patients. Recent findings indicate that elements of the transplant-ome can predict complications and point to novel interventions. Monitoring molecular networks continuously and noninvasively offers new opportunities to optimize perioperative management.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2023)
Review
Transplantation
Yoshiko Toyoda, L. Scott Levin
Summary: The field of vascularized composite allotransplantation (VCA) has made significant progress, but has yet to become mainstream. To ensure long-term sustainability, continued clinical developments of VCA, public support, improved policy and financial support, and bridging to the future of transplant surgery are important.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2023)
Review
Transplantation
Megan K. Morales, Lara Danziger-Isakov, Saman Nematollahi
Summary: This review provides an overview of the evolution of transplant infectious diseases training programs, essential elements of training, as well as future needs. It also discusses gaps in the current curriculum and suggests areas for continued development and expansion in training.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2023)
Article
Immunology
Samuel J. Tingle, Rebecca Bramley, Michael Goodfellow, Emily R. Thompson, Stuart Mcpherson, Steve A. White, Colin H. Wilson
Summary: This study found that donor liver transaminase levels do not predict transplant outcomes. Liver transplantation from donors with elevated transaminases can be accepted and transplanted confidently when other factors are favorable. This finding is important for improving organ utilization decision-making and preventing unnecessary organ discard.
Review
Immunology
Chandrashekar Annamalai, Vivek Kute, Carl Sheridan, Ahmed Halawa
Summary: This study reviews the safety and effectiveness of immune tolerance induction strategies in living-donor kidney transplantation, including chimerism-based and non-chimerism-based approaches. Chimerism-based strategies foster immune tolerance and allow for withdrawal of immunosuppressive medications, while non-chimerism-based cell therapy mainly minimizes immunosuppression without inducing tolerance. Further validation and refinement of tolerogenic protocols are needed, with attention to patient selection, cost implications, and immune monitoring techniques.
TRANSPLANTATION REVIEWS
(2023)
Review
Immunology
Changli Han, Qin Zeng, Libing He, Zonghui Luan, Ruyue Liu, Guohui Zhang, Weixin Liu
Summary: Ovaries are important organs in women, and ovarian tissue cryopreservation and transplantation technology can solve fertility problems and improve endocrine issues. However, follicle loss after transplantation is a key challenge that requires further research on its mechanisms.
TRANSPLANT IMMUNOLOGY
(2023)
Review
Immunology
Reshma Rana Magar, Simon R. Knight, Umberto Maggiore, Jeffrey A. Lafranca, Frank J. M. F. Dor, Liset H. M. Pengel
Summary: The study found that patients who undergo preemptive kidney transplant (PKT) have a lower risk of patient death and graft loss compared to non-preemptive kidney transplantation (nPKT) patients, especially in living donor (LD) transplants.
TRANSPLANTATION REVIEWS
(2023)
Review
Immunology
Felix Thibeault, Guillaume Plourde, Massine Fellouah, Daniela Ziegler, Francois Martin Carrier
Summary: This systematic review examined the association between preoperative fibrinogen level and intraoperative blood products transfusion, blood loss, and clinical outcomes in patients undergoing orthotopic liver transplantation (OLT). The findings suggest that a higher preoperative fibrinogen level is associated with reduced intraoperative blood transfusion requirements and lower blood loss, but also with higher mortality.
TRANSPLANTATION REVIEWS
(2023)
Review
Immunology
Thor S. Stead, Hilliard T. Brydges, Matteo Laspro, Ogechukwu C. Onuh, Bachar F. Chaya, Piul S. Rabbani, Catherine P. Lu, Daniel J. Ceradini, Bruce E. Gelb, Eduardo D. Rodriguez
Summary: Rejection following Vascularized Composite Allotransplantation (VCA) is a common and harmful issue. Current monitoring and diagnostic methods are subjective and invasive. This review explored nonand minimally invasive modalities (NIMMs) for diagnosing and monitoring rejection in VCA. NIMMs, such as imaging, liquid biomarkers, epidermal sampling, clinical grading scales, and introduction of additional donor tissue, have shown promise for improved monitoring and diagnosis. However, further research is needed and a multimodal algorithmic approach should be explored.
TRANSPLANTATION REVIEWS
(2023)
Article
Immunology
Rajni Chauhan, Aseem Kumar Tiwari, Geet Aggarwal, L. Gowri Suresh, Mohit Kumar, Shyam Bihari Bansal
Summary: In solid organ transplantation, compatibility testing prior to transplantation is crucial for successful outcomes. Indian laboratories have adopted test algorithms for risk stratification, but reclassification may be necessary for sensitized patients with low MFI DSAs. Our case studies suggest the possibility of antibody-mediated rejection in low MFI DSA patients.
TRANSPLANT IMMUNOLOGY
(2023)
Article
Immunology
Zhuo Deng, Qi Zhou, Tai-Guang Zhou
Summary: This article presents a comprehensive review and analysis of a clinical case of Alport syndrome in a child, where nephrotic syndrome was the primary manifestation. The identification of a novel mutation locus adds valuable information to the existing knowledge of the genetic mutation spectrum of Alport syndrome.
TRANSPLANT IMMUNOLOGY
(2023)
Article
Immunology
Bruno A. Lima, Filipe Reis, Helena Alves, Teresa S. Henriques
Summary: This study presents a kidney allocation system based on an equity matrix that balances utility and justice. Comparisons were made between the Eurotransplant (ET) kidney allocation system and the proposed Equity Matrix (EQM) allocation system. The EQM model outperforms established practices.
TRANSPLANT IMMUNOLOGY
(2023)
Review
Immunology
Haowen Jiang, Wenmei Fan
Summary: With advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has become a popular treatment option for end-stage diseases. However, despite significant breakthroughs and progress in immunosuppression, there are still adverse reactions and complications associated with this procedure. Therefore, there is a need to explore new immunological approaches to provide fresh insights and guidance for clinical transplantation.
TRANSPLANT IMMUNOLOGY
(2023)
Article
Immunology
Can Boga, Eylem Eliacik, Cigdem Yalcin, Nazim Emrah Kocer, Emre Durdag, Cigdem Gereklioglu
Summary: Transplant physicians should be aware of immune deviation-related clinical conditions in allogeneic hematopoietic stem cell transplantation. Diagnosis of immune reconstitution inflammatory syndrome (IRIS) in patients with chronic graft-versus-host disease (GVHD) poses challenges due to overlapping clinical immunological conditions.
TRANSPLANT IMMUNOLOGY
(2023)
Review
Immunology
Maria Jose Perez-Saez, Nuria Montero, Laia Oliveras, Dolores Redondo-Pachon, David Martinez-Simon, Daniel Abramovicz, Umberto Maggiore, Christophe Mariat, Geir Mjoen, Gabriel C. Oniscu, Licia Peruzzi, Mehmet Sukru Severi, Bruno Watschingerj, Arzu Velioglu, Erol Demir, Ilaria Gandolfini, Rachel Hellemans, Luuk Hilbrands, Julio Pascual, Marta Crespo
Summary: There is a lack of sufficient evidence to support specific immunosuppression treatments for HLA identical sibling kidney transplant recipients. The current research mainly focuses on comparing different immunosuppression strategies and assessing patients with different immunological risks. However, the evidence from these studies is relatively poor and there is a lack of evaluation using modern immunological risk assessment tools.
TRANSPLANTATION REVIEWS
(2023)
Article
Immunology
Perla R. Colunga-Pedraza, Luz Maria Barbosa-Castillo, Edgar Ulises Coronado-Alejandro, Hector Alejandro Vaquera-Alfaro, Ingrid Gabriela Lopez-Reyna, Julia E. Colunga-Pedraza, David Gomez-Almaguer
Summary: Low-dose rituximab is a safe and effective option for the treatment of steroid-refractory chronic graft-versus-host disease in middle-income regions.
TRANSPLANT IMMUNOLOGY
(2023)
Article
Hematology
Fangfang Yuan, Gangping Li, Minghui Li, Xudong Wei, Yuewen Fu
Summary: This study compared the clinical outcomes of different graft-versus-host disease (GVHD) prophylaxis strategies in acute leukemia patients. The results showed that haplo-cord HSCT with low-dose ATG had faster neutrophil recovery and lower rates of acute and chronic GVHD compared to haplo-HSCT with higher-dose ATG.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Jana Doering, Markus Perl, Daniela Weber, Bernhard Banas, Christian Schulz, Okka W. Hamer, Klemens Angstwurm, Ernst Holler, Wolfgang Herr, Matthias Edinger, Daniel Wolff, Matthias A. Fante
Summary: Chronic graft-versus-host disease (cGVHD) is a major cause of late nonrelapse mortality (NRM) after allogeneic hematopoietic stem cell transplantation (alloHSCT) with certain risk factors. Atypical cGVHD is more common than previously estimated and has similarities and differences compared to classical cGVHD. Atypical cGVHD increases the risk of mortality but is associated with better overall survival.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
