Transplantation

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Article Surgery

The liver frailty index is a predictor of healthcare utilization after liver transplantation in older adults

Melinda Wang, Amy M. Shui, Jessica Ruck, Elizabeth King, Robert Rahimi, Matthew Kappus, Michael L. Volk, Daniel R. Ganger, Daniela P. Ladner, Andres Duarte-Rojo, Chiung-Yu Huang, Elizabeth C. Verna, Jennifer C. Lai

Summary: The study evaluated the Liver Frailty Index as a potential tool for healthcare utilization in older adults post-liver transplantation, and found that frailty was associated with increased hospitalized days post-transplantation.

CLINICAL TRANSPLANTATION (2023)

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Article Pediatrics

Cardiac magnetic resonance imaging in detection of progressive graft dysfunction in pediatric heart transplantation

Kae Watanabe, Nicoleta C. Arva, Joshua D. Robinson, Cynthia Rigsby, Michael Markl, Melanie Sojka, Paul Tannous, Jennifer Arzu, Nazia Husain

Summary: CMR has the potential to be used as a screening method for CGF in PHT, as it can identify ventricular remodeling and abnormalities in myocardial structure.

PEDIATRIC TRANSPLANTATION (2023)

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Review Surgery

Human cytomegalovirus-related gastrointestinal disease after kidney transplantation: A systematic review

Ilaria Elena Zais, Alessandro Sirotti, Samuele Iesari, Edoardo Campioli, Andrea Costantino, Serena Delbue, Andrea Collini, Andrea Guarneri, Federico Ambrogi, Roberto Cacciola, Mariano Ferraresso, Evaldo Favi

Summary: Human-cytomegalovirus (hCMV) infection involving the gastrointestinal tract is a leading cause of morbidity and mortality among kidney transplant recipients. The signs and symptoms of the disease are variable, making it necessary for complex diagnostic procedures to confirm the preliminary diagnosis. Prompt antiviral therapy and immunosuppression modification are crucial for effective management. However, there is a lack of solid evidence and guidelines in this specific area.

CLINICAL TRANSPLANTATION (2023)

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Article Engineering, Biomedical

First in human implantation of the CorLog device for postoperative intravascular pressure sensing in left ventricular assist device patients

Zurab Darbaidze, Jasmin S. Hanke, Guenes Dogan, Bastian Schmack, Arjang Ruhparwar, Jan D. Schmitto

ARTIFICIAL ORGANS (2023)

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Letter Surgery

Limitation of transient elastography in living donor liver transplant setting - A new insight

Shekhar Poudel, Priyank Dhiman, Shekhar Singh Jadaun, Gaurav Kumar Maurya, Sarker Mohammad Shohel Rana, Subash Gupta, Sanjiv Saigal

CLINICAL TRANSPLANTATION (2023)

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Review Pediatrics

Pediatric heart transplantation: Looking forward after five decades of learning

Anne I. Dipchand, Steven A. Webber

Summary: Heart transplantation is the standard treatment for pediatric patients with end-stage heart disease. Short-term outcomes have consistently improved over the past few decades, but chronic allograft vasculopathy remains a major cause of graft loss beyond the first year. Acute rejection, graft failure, and infection are also significant concerns. Key challenges for the future include improving donor utilization rates, developing non-invasive biomarkers for rejection, mitigating long-term effects of immunosuppression, and preventing chronic allograft vasculopathy.

PEDIATRIC TRANSPLANTATION (2023)

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Article Surgery

An international survey of venous thromboembolic events and current practices of peri-operative VTE prophylaxis after living donor hepatectomy

Mettu Srinivas Reddy, Mureo Kasahara, Toru Ikegami, Kwang-Woong Lee

Summary: This study investigated the practices and incidence of venous thromboembolism after live donor hepatectomy in centers performing living donor liver transplantation worldwide. The results revealed variations in practice and a significant incidence of thromboembolic events, which are an important cause of morbidity for liver donors. Therefore, evidence-based guidelines for risk assessment and peri-operative prophylaxis are needed.

CLINICAL TRANSPLANTATION (2023)

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Review Surgery

Blood salvage and autotransfusion during orthotopic liver transplantation for hepatocellular carcinoma: A systematic review and meta-analysis

David E. Hinojosa-Gonzalez, Gustavo Salgado-Garza, Eduardo Tellez-Garcia, Jaime A. Escarcega-Bordagaray, Luis Carlos Bueno-Gutierrez, Katheryne Madrazo-Aguirre, Monica I. Munoz-Hibert, Karla G. Diaz-Garza, Isabela Ramirez-Mulhern, Rodrigo Alvarez de la Reguera-babb, Eduardo Flores-Villalba, Mario Rodarte-Shade, Mauricio Gonzalez-Urquijo

Summary: In this study, the long-term oncologic outcomes of patients undergoing liver transplantation for HCC with and without IBS-AT were analyzed. The results suggest that the use of IBS-AT is not associated with an increased risk of recurrence in liver transplant for HCC, and both operative and postoperative outcomes are similar between groups.

CLINICAL TRANSPLANTATION (2023)

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Article Immunology

Difference in immunosuppressant dose requirement when transitioning to isavuconazole from other azoles in thoracic transplant recipients

Jade M. Kozuch, Carrie Burt, Kamyar Afshar, Saima Aslam, Gordon Yung, Mark Mariski, Eugene Golts, Ashley Feist

Summary: This study evaluated the effect of using isavuconazole in solid organ transplant recipients. It found that there were changes in immunosuppressant concentrations and dose requirements when starting isavuconazole or transitioning from other azoles in these patients.

TRANSPLANT INFECTIOUS DISEASE (2023)

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Review Pediatrics

Combined liver-kidney transplantation in pediatric patients

Nam-Joon Yi, Jiyoung Kim, Su Young Hong, Hee Gyung Kang

Summary: Combined liver-kidney transplantation is a surgical procedure commonly used to treat pediatric patients with congenital diseases. The procedure has shown high survival rates and is dependent on factors such as dominant organ failure and the availability of organs. However, there are challenges surrounding organ allocation and accessibility to advanced medical technologies.

PEDIATRIC TRANSPLANTATION (2023)

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Article Pediatrics

Changes over time in self-efficacy and the allocation of responsibility for health management tasks in pediatric liver transplant recipients: Targets to improve the transition process

Jacob L. Bilhartz, M. James Lopez, Sally J. Eder, John C. Magee, Kelly Rea, Julie Sturza, Emily M. Fredericks

Summary: This study found that self-efficacy and parent-proxy self-efficacy are dynamic concepts that change over time spent in a focused transition program. There was disagreement between patient and parent responses on the survey. The changes in self-efficacy and parent-proxy self-efficacy were found to have a relationship with adherence.

PEDIATRIC TRANSPLANTATION (2023)

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Article Biophysics

The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party

Lars Klingen Gjaerde, Tapani Ruutu, Christophe Peczynski, William Boreland, Nicolaus Kroeger, Didier Blaise, Thomas Schroeder, Regis Peffault de Latour, Tobias Gedde-Dahl, Aleksandr Kulagin, Henrik Sengelov, Ibrahim Yakoub-Agha, Juergen Finke, Matthias Eder, Grzegorz Basak, Ivan Moiseev, Helene Schoemans, Christian Koenecke, Olaf Penack, Zinaida Peric

Summary: Obesity and diabetes do not increase the risk of acute graft-versus-host disease (GvHD) after allogeneic hematopoietic cell transplantation (HCT), but they are associated with poorer survival. The presence of obesity and diabetes may modulate immune responses and impact HCT outcomes.

BONE MARROW TRANSPLANTATION (2023)

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Article Pediatrics

Immediate extubation after pediatric liver transplantation: Update on a single-center experience

P. Nina Scalise, Donna C. Koo, Steven J. Staffa, Alex G. Cuenca, Pete G. Kovatsis, Heung Bae Kim, Eliza J. Lee

Summary: This study reviews the experience of immediate extubation (IE) in children following liver transplantation (LT) and identifies factors predictive of successful IE and its effects on post-operative outcomes. The study finds that IE is safe and leads to shorter ICU and hospital lengths of stay. Pre-transplant ICU requirement, high PELD/MELD score, intraoperative transfusion, cold ischemia time, and pressor requirements are risk factors against IE. The proportion of patients undergoing IE has increased over time, highlighting the importance of clinical experience and the transplant team learning curve.

PEDIATRIC TRANSPLANTATION (2023)

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Article Pediatrics

Pediatric living donor liver transplant for Budd-Chiari syndrome using a cryopreserved pulmonary vein graft for retro-hepatic vena cava reconstruction: A case report

Xin Yu Yang, Annie Le-Nguyen, Fernando Alvarez, Zhi Xia Rong, Daniel Borsuk, Nelson Piche, Michel Lallier, Mona Beaunoyer

Summary: This case report presents a pediatric patient with BCS who underwent LDLT with IVC reconstruction using a cryopreserved pulmonary vein graft. The patient experienced some postoperative complications but eventually recovered well. The report highlights the importance of multidisciplinary teamwork and early referral in the management of pediatric patients with BCS.

PEDIATRIC TRANSPLANTATION (2023)

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Article Immunology

Stopping antibacterial prophylaxis in pediatric allogeneic hematopoietic cell transplantation: An internal audit

Nina Wintjes, Katja Kraemer, Hedwig Kolve, Daniela Mohring, Frieder Schaumburg, Claudia Rossig, Birgit Burkhardt, Andreas H. Groll

Summary: In this single-center study, discontinuing routine antibacterial prophylaxis had no effect on the occurrence of fever and bacterial infections in pediatric allogeneic HCT recipients. Overall antibiotic use was significantly reduced, and survival was noninferior to the historical control cohort.

TRANSPLANT INFECTIOUS DISEASE (2023)

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Article Immunology

Heart of the matter-infection and xenotransplantation

Kapil K. Saharia, Victoria G. Hall, Supavit Chesdachai, Paige Porrett, Jay A. Fishman, Stephanie M. Pouch

Summary: This clinicopathological conference discussed a case of a patient with nonischemic cardiomyopathy who received a heart transplant from a genetically modified pig source animal. The patient experienced complications including the detection of porcine cytomegalovirus and subsequent xenograft failure. The objectives of the session were to discuss immunosuppressive regimens, prophylactic antimicrobials, infectious disease risk assessment, and screening and therapeutic strategies for xenograft-related infections.

TRANSPLANT INFECTIOUS DISEASE (2023)

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Article Engineering, Biomedical

Cardiogenic shock etiology and exit strategy impact survival in patients with Impella 5.5

Mckenzie Sicke, Shan Modi, Yeahwa Hong, Michael Bashline, Wyatt Klass, Ed Horn, Barinder S. Hansra, Raj Ramanan, Jeffrey Fowler, Nikita Sumzin, Ryan M. Rivosecchi, Rahul Chaudhary, Luke A. Ziegler, Nicholas R. Hess, Nishant Agrawal, David J. Kaczorowski, Gavin W. Hickey

Summary: This study found differences in survival and post-support destination between acute myocardial infarction (AMI) cardiogenic shock (CS) patients and acute decompensated heart failure (ADHF) CS patients receiving Impella 5.5 support. ADHF-CS patients had a higher survival rate and were more likely to be successfully bridged to heart transplantation.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2023)

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Article Surgery

Survival Outcomes After Double-Lung Transplantation for Refractory Lung-Limited Cancers and Incidence of Post-Transplant Lung Cancer

Jeeyeon Lee, Maria Jose Aguilera Chuchuca, Jisang Yu, Liam Il-Young Chung, Ankit Bharat, Young Kwang Chae

Summary: This study assessed the role of double-lung transplantation (DLT) for lung cancer treatment and found promising survival outcomes for patients. The study also evaluated the incidence of de novo lung cancer after DLT and observed a low occurrence rate.

ANNALS OF TRANSPLANTATION (2023)

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Article Engineering, Biomedical

Inter-institutional analysis of the outcome after postcardiotomy veno-arterial extracorporeal membrane oxygenation

Fausto Biancari, Timo Makikallio, Antonio Loforte, Alexander Kaserer, Vito G. Ruggieri, Sung-Min Cho, Jin Kook Kang, Magnus Dalen, Henryk Welp, Kristjan Jonsson, Sigurdur Ragnarsson, Francisco J. Hernandez Perez, Giuseppe Gatti, Khalid Alkhamees, Antonio Fiore, Andrea Lechiancole, Stefano Rosato, Cristiano Spadaccio, Matteo Pettinari, Andrea Perrotti, Sebastian D. Sahli, Camilla L'Acqua, Amr A. Arafat, Monirah A. Albabtain, Mohammed M. Albarak, Mohamed Laimoud, Ilija Djordjevic, Ihor Krasivskyi, Robertas Samalavicius, Agne Jankuviene, Marta Alonso-Fernandez-Gatta, Markus J. Wilhelm, Tatu Juvonen, Giovanni Mariscalco

Summary: This study evaluated whether there were interinstitutional differences in the outcomes of postcardiotomy V-A-ECMO. The results showed significant variations in in-hospital mortality rates between different hospitals, suggesting the need for improvement in the results of postcardiotomy V-A-ECMO in many centers.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2023)

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Article Engineering, Biomedical

Extracorporeal membrane oxygenation in diabetic ketoacidosis-related cardiac and respiratory failure

Ammar Sharif, J. Michael Brewer, Aly El Banayosy, Mircea R. Mihu, Zachary Reaves, Laura Swant, Robert S. Schoaps, Clayne Benson, Malik Ibithaj Khalid, Marc O. Maybauer

Summary: This retrospective study analyzed the clinical presentation and outcomes of patients with DKA who received ECMO treatment. The results suggest that ECMO is a viable support option for managing these patients and has excellent outcomes.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2023)

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