Transplantation

309.7K Papers

Article Surgery

Evolution of HLA-sensitization according to immunosuppressive therapy management among kidney transplant patients returning to dialysis between 2008 and 2019: A French retrospective study

Kevin Ferrari, Alice Aarnink, Carole Ayav, Luc Frimat, Cecile Couchoud, Benoit Audry, Corinne Antoine, Sophie Girerd

Summary: Continuation of immunosuppressive therapy after kidney allograft failure is associated with less change in HLA-sensitization and does not increase patient mortality.

CLINICAL TRANSPLANTATION (2024)

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Article Surgery

Lung transplantation in primary pulmonary arterial hypertension and pulmonary venous hypertension

Sandeep Sainathan, John Ryan, Leonardo Mullinari, Pablo Sanchez

Summary: Patients undergoing lung transplantation for pulmonary venous-occlusive disease (PVOD) had better initial survival compared to those with primary pulmonary hypertension (PPHTN), but this advantage disappeared after 1 year. The use of donation after circulatory death donors was associated with lower short-term survival rates.

CLINICAL TRANSPLANTATION (2024)

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Article Immunology

A low thrombospondin-1 serum concentration is related to increased bacteremia risk in lymphoma patients treated with BeEAM/BEAM conditioning regimen and autologous stem cell transplantation

Kacper Koscielny, Damian Mikulski, Mateusz Nowicki, Krystyna Wyka, Malgorzata Misiewicz, Ewelina Perdas, Agnieszka Wierzbowska, Wojciech Fendler

Summary: This study examined the potential use of THBS-1 serum levels as a biomarker for predicting bacteremia in AHSCT recipients. The findings showed that patients with lower THBS-1 concentrations had a higher risk of bacteremia and experienced febrile neutropenia sooner.

TRANSPLANT INFECTIOUS DISEASE (2023)

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Letter Biophysics

KyoTox-e score; prediction of post-CAR-T prolonged thrombocytopenia using peripheral blood data before apheresis

Tomoyasu Jo, Yasuyuki Arai, Toshio Kitawaki, Naokazu Nakamura, Momoko Nishikori, Chisaki Mizumoto, Junya Kanda, Kouhei Yamashita, Miki Nagao, Akifumi Takaori-Kondo

BONE MARROW TRANSPLANTATION (2023)

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Article Engineering, Biomedical

Investigation of the role of von Willebrand factor in shear-induced platelet activation and functional alteration under high non-physiological shear stress

Dong Han, Wenji Sun, Kiersten P. Clark, Bartley P. Griffith, Zhongjun J. Wu

Summary: High levels of non-physiological shear stress mainly activate platelets by enhancing the vWF-GPIb alpha interaction. Shear-induced platelet activation and receptor shedding occur through distinct pathways.

ARTIFICIAL ORGANS (2023)

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Article Medicine, Research & Experimental

Alteration of γδ T cell subsets in non-human primates transplanted with GGTA1 gene-deficient porcine blood vessels

Sujin Lee, Yun Shin Chung, Kyo Won Lee, Miran Choi, Chung Hee Sonn, Won Jun Oh, Hun Gi Hong, Joohyun Shim, Kimyung Choi, Sung Joo Kim, Jae Berm Park, Tae Jin Kim

Summary: The involvement of gamma delta T cells in xenograft rejection was investigated in a study on cynomolgus monkeys transplanted with vessel xenografts from pigs. The study found that the gamma: delta TCR repertoire was significantly altered post-xenotransplantation, suggesting the important role of gamma delta T cells in sustained xenoreactive immune responses.

XENOTRANSPLANTATION (2023)

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Article Immunology

Twelve-month kidney and liver outcomes of kidney transplantation from Hepatitis C Viremic deceased donors to aviremic recipients

Laura A. Binari, Peter Thorne, Scott A. Rega, Irene D. Feurer, Saed Shawar, Ruchi Naik, Kelly A. Birdwell, J. Harold Helderman, Anthony Langone, Bonnie Ann Sarrell, Heidi Schaefer, Bernard John DuBray, Kareem Eid, Laura Hickman, David Shaffer, Beatrice P. Concepcion, Rachel C. Forbes

Summary: Utilization of hepatitis C viremic deceased donor kidneys for aviremic recipients shows excellent short-term outcomes, and this study aims to understand longer-term outcomes. The study found no significant differences in kidney and liver function between recipients of HCV+ and HCV- kidneys in the first year posttransplant.

TRANSPLANT INFECTIOUS DISEASE (2023)

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Letter Biophysics

Abatacept treatment for autoimmune hemolytic anemia occurring post hematopoietic stem cell transplantation

Maria Gabelli, Antonio Perez-Martinez, David Bueno Sanchez, Giovanna Lucchini, Louis-Philippe Grenier, Felix Couture, Emily Limerick, Victoria Bernaud, Maria Trabazo del Castillo, Alexander Ngwube

BONE MARROW TRANSPLANTATION (2023)

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Article Biophysics

Allogeneic hematopoietic cell transplantation for acute myeloid leukemia with hyperdiploid complex karyotype

Xavier Poire, Myriam Labopin, Emmanuelle Polge, Arnold Ganser, Gerard Socie, Tobias Gedde-Dahl, Edouard Forcade, Juergen Finke, Yves Chalandon, Claude-Eric Bulabois, Ibrahim Yakoub-Agha, Mahmoud Aljurf, Nicolaus Kroeger, Igor Wolfgang Blau, Arnon Nagler, Jordi Esteve, Mohamad Mohty

Summary: Allogeneic hematopoietic cell transplantation remains the best consolidation strategy for acute myeloid leukemia with complex karyotype. AML with pure hyperdiploid karyotype may have a distinct prognosis after allo-HCT compared to non-pure hyperdiploid CK AML.

BONE MARROW TRANSPLANTATION (2023)

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Article Surgery

Impact of Share 35 liver transplantation allocation in Australia and New Zealand

Michael A. Fink, Paul J. Gow, Geoffrey W. Mccaughan, Peter Hodgkinson, John Chen, John Mccall, Bryon Jaques, Michael Crawford, Simone I. Strasser, Winita Hardikar, Mark Brooke-Smith, Graham Starkey, Gary P. Jeffrey, Ed Gane, Michael Stormon, Helen Evans, Caroline Tallis, Amanda J. Byrne, Robert M. Jones

Summary: The implementation of Share 35 policy in Australia and New Zealand has significantly reduced waiting list mortality for patients with high MELD scores. There were no significant differences in post-transplant patient and graft survival between the Share 35 group and the Pre-Share 35 group. However, the intention-to-treat survival was improved in the Share 35 group.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

Have a Heart: Tie It Off - Update on Recommendations Regarding Vascular Access Ligation After Successful Renal Transplant

Alyssa Stetson, Brianna Bangert, Saad Ahmad, Lulu Zhang, Alex Chang, Shalini Bumb, Madison Cuffy, Latifa Silski

Summary: The purpose of this review is to explore whether the complications and negative physiological effects of arteriovenous fistulas (AVF) in kidney transplant patients outweigh the benefits. Studies have shown that fistula ligation can decrease left ventricular mass and cardiac output, and improve symptoms of right heart failure. Current research is investigating the impact of AVF on quality of life and whether fistula flow can predict the benefits of ligation.

CURRENT TRANSPLANTATION REPORTS (2023)

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Letter Surgery

A single center experience of the first 100 next-generation sequencing renal gene panel testing during kidney transplant evaluation

Sridhar R. Allam, Saravanan Balamuthusamy, Machaiah M. Madhrira, Imran A. Memon, Balamurugan P. Sankarapandian, Nikhil A. Reddy, Traci Salas, Kathryn Lozano, Anna Curtis, Ashraf I. Reyad

CLINICAL TRANSPLANTATION (2023)

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Article Engineering, Biomedical

Bone implant substitutes from synthetic polymer and reduced graphene oxide: Current perspective

Rethinam Senthil

Summary: In this study, bone implant materials (BIM) were developed with excellent mechanical properties, bioactivity, antimicrobial characteristics, and biocompatibility. BIM showed significant deposition of bone tube apatite crystals after immersion in a simulated body fluids (SBF) solution. The results suggest that BIM has the potential to be tested as a bone implant material in large animals.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2023)

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Letter Biophysics

Clinical outcomes of early defibrotide discontinuation: a single-center case series

Rachael D. Baggett, Katie S. Gatwood

BONE MARROW TRANSPLANTATION (2023)

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Article Engineering, Biomedical

An arteriovenous mock circulatory loop and accompanying bond graph model for in vitro study of peripheral intravascular bioartificial organs

Jarrett C. Moyer, Venkat Keshav Chivukula, Parsa Taheri-Tehrani, Sukhveer Sandhu, Charles Blaha, William H. Fissell, Shuvo Roy

Summary: This study developed a compact and cost-effective mock circulatory loop (MCL) to refine and test implantable bioartificial organs and blood-interfacing membranes. The MCL successfully replicated the flow rates and pressures consistent with pulsatile arteriovenous shunts measured in swine.

ARTIFICIAL ORGANS (2023)

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Review Surgery

Graft survival and postoperative complications following orthotopic renal transplantation

Angelo Territo, Ismail Selvi, Aydan Malcok, Romain Boissier, Riccardo Campi, Thomas Prudhomme, Alessio Pecoraro, Alberto Piana, Alicia Lopez-Abad, Beatriz Banuelos Marco, Alberto Breda, M. Irfan Donmez

Summary: This narrative review provides an update on the clinical outcomes after orthotopic renal transplantation, finding comparable survival rates in both recipients and renal grafts, as well as lower complication rates compared to heterotopic renal transplantation. These results may encourage transplant centers to reevaluate their policies and consider orthotopic renal transplantation as an alternative technique.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

A change of heart: Characteristics and outcomes of multiple cardiac retransplant recipients

Jaya Batra, Ersilia M. Defilippis, Kevin Clerkin, David Bae, Kyung Taek Oh, Dor Lotan, Veli K. Topkara, Sun Hi Lee, Farhana Latif, Paolo Colombo, Melana Yuzefpolskaya, Jayant Raikhelkar, David T. Majure, Gabriel Sayer, Nir Uriel

Summary: This study aimed to investigate the outcomes of patients who underwent a third heart transplant and compare them with patients who underwent primary and second heart transplant. The results showed that third heart transplant was associated with higher morbidity and mortality rates.

CLINICAL TRANSPLANTATION (2023)

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Article Immunology

Clinical impact of preservation fluid contamination on kidney transplant patients

Natalia Picola Brau, Maria Fiol Riera, Begona Etcheverry Giadrosich, Lluis Riera Canals, Edoardo Melilli, Nuria Sabe Fernandez, Manel Castells Esteve, Francesc Vigues Julia

Summary: This study retrospectively evaluated the contamination rate of preservation solution in patients who underwent cadaveric renal transplant and found common microbial contamination. However, the risk of infection transmission from donor to recipient was minimal, possibly due to early targeted preemptive therapy.

TRANSPLANT INFECTIOUS DISEASE (2023)

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Letter Biophysics

Belumosudil and ruxolitinib combination for treatment of refractory chronic graft-versus-host disease

Iskra Pusic, Catherine Lee, Muthu Veeraputhiran, Chelsea Minor, John F. Dipersio

BONE MARROW TRANSPLANTATION (2023)

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Article Pediatrics

Effect of serum panel reactive antibodies on allogeneic hematopoietic stem cell transplantation in pediatric thalassemia patients: A single-center experience

Baris Malbora, Hakan Sarbay, Zeynep Dogusan, Abdullah Avni Atay

Summary: This study assessed the impact of serum panel reactive antibodies (PRA) on the outcomes of HSCT in pediatric thalassemia patients. The results showed that PRA-positive patients had higher rates of blood product transfusion requirements, but no statistical significance was observed. Therefore, identifying patients with high PRA levels can assist in optimizing transplant strategies and post-transplant care, leading to improved outcomes for the patients.

PEDIATRIC TRANSPLANTATION (2023)

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Transplantation

Evolution of HLA-sensitization according to immunosuppressive therapy management among kidney transplant patients returning to dialysis between 2008 and 2019: A French retrospective study

Lung transplantation in primary pulmonary arterial hypertension and pulmonary venous hypertension

A low thrombospondin-1 serum concentration is related to increased bacteremia risk in lymphoma patients treated with BeEAM/BEAM conditioning regimen and autologous stem cell transplantation

KyoTox-e score; prediction of post-CAR-T prolonged thrombocytopenia using peripheral blood data before apheresis

Investigation of the role of von Willebrand factor in shear-induced platelet activation and functional alteration under high non-physiological shear stress

Alteration of γδ T cell subsets in non-human primates transplanted with GGTA1 gene-deficient porcine blood vessels

Twelve-month kidney and liver outcomes of kidney transplantation from Hepatitis C Viremic deceased donors to aviremic recipients

Abatacept treatment for autoimmune hemolytic anemia occurring post hematopoietic stem cell transplantation

Allogeneic hematopoietic cell transplantation for acute myeloid leukemia with hyperdiploid complex karyotype

Impact of Share 35 liver transplantation allocation in Australia and New Zealand

Have a Heart: Tie It Off - Update on Recommendations Regarding Vascular Access Ligation After Successful Renal Transplant

A single center experience of the first 100 next-generation sequencing renal gene panel testing during kidney transplant evaluation

Bone implant substitutes from synthetic polymer and reduced graphene oxide: Current perspective

Clinical outcomes of early defibrotide discontinuation: a single-center case series

An arteriovenous mock circulatory loop and accompanying bond graph model for in vitro study of peripheral intravascular bioartificial organs

Graft survival and postoperative complications following orthotopic renal transplantation

A change of heart: Characteristics and outcomes of multiple cardiac retransplant recipients

Clinical impact of preservation fluid contamination on kidney transplant patients

Belumosudil and ruxolitinib combination for treatment of refractory chronic graft-versus-host disease

Effect of serum panel reactive antibodies on allogeneic hematopoietic stem cell transplantation in pediatric thalassemia patients: A single-center experience

Related Categories

Top Journals

AMERICAN JOURNAL OF TRANSPLANTATION

NEPHROLOGY DIALYSIS TRANSPLANTATION

BONE MARROW TRANSPLANTATION

STEM CELLS AND DEVELOPMENT

CLINICAL TRANSPLANTATION

Current Opinion in Organ Transplantation

Experimental and Clinical Transplantation