Review
Biochemistry & Molecular Biology
Jianing Xing, Siyi Zhang, Miaolian Zhang, Jing Hou
Summary: This article reviews the presence and removal of bisphenol A (BPA) in the environment and consumer products, as well as its endocrine disrupting, neurotoxic, cytotoxic, reproductive, genotoxic, and carcinogenic effects. It is found that humans have been exposed to low concentrations of BPA for a long time, and future research should focus on the long-term exposure and the potential health risks associated with it. Developing safe, functional, and reproducible BPA analogs and studying its degradation products are also important areas of research.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Toxicology
Lin Wu, Wen Wen, Xiaofeng Wang, Danhua Huang, Jin Cao, Xueyong Qi, Song Shen
Summary: The study found that ultrasmall Fe3O4 nanoparticles have high toxicity, especially on the heart. The toxicity is related to both the iron element and particle size, providing new insights into the toxicology of ultrasmall Fe3O4 nanoparticles.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Environmental Sciences
Julia N. Moeller, Ingrid Heisel, Anna Satzger, Eva C. Vizsolyi, S. D. Jakob Oster, Seema Agarwal, Christian Laforsch, Martin G. J. Loeder
Summary: Microplastic pollution in soils is an emerging topic in scientific research, with limited information due to a lack of suitable analytical methods. A combination of various purification methods can effectively purify soil samples for reliable spectroscopic analysis.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Mohamed A. Farag, Mohamed Z. Gad
Summary: This article mainly introduces the pharmacological activities of omega-9 fatty acids in inflammation management. Multiple studies have shown that omega-9 fatty acids such as oleic acid can alleviate inflammation and play a role in physiological and pathological conditions such as wound healing and eye inflammation. In addition, this article compiles for the first time the action mechanisms of oleic acid as an anti-tumor agent in different types of cancer.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Ecology
Jie Cao, Chengyu Xie, Zhiru Hou
Summary: This study evaluates soil pollution in lead-zinc ore mine soils in rural China using the index of geoaccumulation and improved analytic hierarchy process. The results indicate severe pollution in mining areas, with mines being one of the main pollution sources.
Article
Toxicology
Nicholas Ball, Remi Bars, Philip A. Botham, Andreea Cuciureanu, Mark T. D. Cronin, John E. Doe, Tatsiana Dudzina, Timothy W. Gant, Marcel Leist, Bennard van Ravenzwaay
Summary: The long-term investment in new approach methodologies (NAMs) has led to a consensus on how to assess the safety of chemicals using in silico, in vitro, and targeted in vivo sources. However, the adoption of this methodology for regulatory purposes is slow. In this study, a framework incorporating these methods was developed to meet the requirements of REACH. The framework allows for a transparent and phased introduction of NAMs, providing the same level of public health protection using fewer animals, time, and resources.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Toxicology
Yi Xiang, Kathleen Miller, Jiaao Guan, Wisarut Kiratitanaporn, Min Tang, Shaochen Chen
Summary: This article introduces the application of 3D bio-printing technology in modeling complex human tissues. By controlling factors such as cell population, extracellular matrix, microenvironment, and microstructure, 3D bio-printing technology plays an important role in pharmacology and toxicology research. The article also mentions recent advancements in printing techniques and bio-ink sources, as well as specialized research in the fields of cancer, heart, muscle, and liver.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Maryam Nabati, Homa Parsaee
Summary: Remdesivir is currently the only authorized drug for COVID-19 treatment under emergency circumstances, but it may have cardiotoxic and proarrhythmic effects, especially more pronounced in patients with a history of cardiovascular diseases. Further clinical trials are needed to fully understand its safety profile and potential adverse cardiovascular effects.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Environmental Sciences
Cihan Gur, Ozge Kandemir, Fatih Mehmet Kandemir
Summary: In this study, it was found that hesperidin provided significant protection against chronic toxicity in testicular tissue caused by abamectin by exerting antioxidant, anti-inflammatory, antiapoptotic, and anti-autophagic effects, suggesting its potential as an alternative treatment option.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Neurosciences
Lorena Lopez-Suarez, Sana Al Awabdh, Xavier Coumoul, Caroline Chauvet
Summary: Investigating the toxicity of chemicals on the human brain traditionally relies on animal and cell models, which have limitations due to species differences, ethical concerns, and time/cost constraints. Human cell models, such as the SH-SY5Y cell line, offer a relevant alternative for studying neurotoxicity and prioritizing in vivo testing. This review examines the characteristics and use of the SH-SY5Y cell line for studying the effects of organic environmental pollutants on neurotoxicity, highlighting the impacts on cellular processes and neurotransmitter homeostasis.
Article
Environmental Sciences
Ping Fan, Wenbing Tan, Hong Yu
Summary: The study found that all three types of MPs (polyethylene, polystyrene, and polyvinyl chloride) stimulate soil enzyme activities and alter the composition of soil bacterial and fungal communities, with a stronger impact on fungi. The effects of different types and concentrations of MPs on soil microbial communities varied significantly.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Toxicology
Priyanka De, Supratik Kar, Pravin Ambure, Kunal Roy
Summary: This review discusses various validation tools for improving the quality and robustness of QSAR models, such as double cross-validation, small dataset modeler, intelligent consensus predictor, prediction reliability indicator, and quantitative read-across.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Environmental Sciences
Jia Li, Songguo Yu, Yufei Yu, Meiling Xu
Summary: This review summarizes the effects of microplastics on the growth and performance of higher plants, and discusses the mechanisms through which microplastics influence higher plants. The findings show that microplastics can inhibit the growth and performance of higher plants, with direct and indirect mechanisms involved.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Review
Environmental Sciences
Le Yang, Junbang Wang, Yongsheng Yang, Sha Li, Tongxin Wang, Patrik Oleksak, Zofia Chrienova, Qinghua Wu, Eugenie Nepovimova, Xiujuan Zhang, Kamil Kuca
Summary: By analyzing 1123 publications, this study provides insights into the global status and research hotspots of heavy metal pollution phytoremediation. China, India, Spain, Italy, and Pakistan are the top five contributors. The hot research topics include diversity, translocation, and enhanced phytoremediation, with a focus on cadmium as the most concerned heavy metal. Future research directions should focus on strengthening plant remediation ability, studying the molecular mechanisms of heavy metal damage to plants, and investigating the enrichment principle of heavy metals in plants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Zhifan Chen, Yongfeng Ding, Xingyuan Jiang, Haijing Duan, Xinling Ruan, Zhihong Li, Yipeng Li
Summary: This study successfully quantitatively identified the sources of heavy metals in agricultural soils in Kaifeng, China using various methods and techniques. The results showed that local anthropogenic pollution sources had a significant impact on heavy metal accumulation, with sewage irrigation and atmospheric deposition being the primary anthropogenic sources.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Saroj Bala, Diksha Garg, Banjagere Veerabhadrappa Thirumalesh, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj, Manikant Tripathi
Summary: Environmental pollution caused by xenobiotics and other recalcitrant compounds poses a significant risk to human health and the natural environment. Bioremediation, an effective technique for cleaning polluted environments, utilizes microorganisms to eliminate, degrade, detoxify, and immobilize hazardous wastes and pollutants. The goal of bioremediation is to degrade pollutants into less toxic forms. This review discusses the recent developments in bioremediation techniques, the breakdown of different pollutants by microorganisms, and the future of bioremediation in reducing pollution.
Review
Pharmacology & Pharmacy
Elizabeth M. Burnette, Steven J. Nieto, Erica N. Grodin, Lindsay R. Meredith, Brian Hurley, Karen Miotto, Artha J. Gillis, Lara A. Ray
Summary: Alcohol use disorder is a common but under-treated condition, with limited pharmacological options. This review explores the efficacy and potential of various pharmacotherapies for AUD, highlighting the need for new treatments and improved access to care.
Article
Chemistry, Multidisciplinary
Vasfiye Erseckin, Handan Mert, Kivanc Irak, Serkan Yildirim, Nihat Mert
Summary: This study investigates the effect of ferulic acid on nephrotoxicity induced by gentamicin. The results show that ferulic acid can reduce inflammation and oxidative stress, protecting the kidneys.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Review
Environmental Sciences
Fasih Ullah Haider, Xiukang Wang, Muhammad Farooq, Saddam Hussain, Sardar Alam Cheema, Noor Ul Ain, Ahmad Latif Virk, Mukkaram Ejaz, Uulzhan Janyshova, Cai Liqun
Summary: This review discusses the negative effects of trace metals stress on plant growth, physiology, and yield, and the potential of biochar in remediation of trace metal contamination in plants. Biochar application enhances plant productivity, biomass accumulation, and photosynthetic activity, while scavenging reactive oxygen species formation. Integrated application of biochar with other amendments further improves trace metal remediation and crop production.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Fatma Esam, Malik M. Khalafalla, Mahmoud S. Gewaily, Safaa Abdo, Aziza M. Hassan, Mahmoud A. O. Dawood
Summary: This study found that the combined exposure of ammonia and heat stress can cause histological changes in the gills and liver tissues of Nile tilapia, as well as affect the expression of immune and antioxidative related genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
