Article
Environmental Sciences
Lariah Edwards, Nathan L. McCray, Brianna N. VanNoy, Alice Yau, Ruth J. Geller, Gary Adamkiewicz, Ami R. Zota
Summary: DEHT was found at the highest concentrations in both foods and gloves, with DnBP and DEHP detected in the majority of food samples. These preliminary findings suggest that ortho-phthalates remain common in fast food and replacement plasticizers may also be prevalent.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Toxicology
Guoqing Chen, Faqiang Zhang, Long Wang, Zeguo Feng
Summary: Our study demonstrates that ISO pretreatment can significantly regulate miR-744 and its downstream target SIRT6 to mitigate myocardial injury induced by H/R. Elevated miR-744 weakens the protective effect of ISO on H/R-induced myocardial injury, leading to decreased cell viability, increased apoptosis, and elevated concentration of myocardial injury indicators.
TOXICOLOGY MECHANISMS AND METHODS
(2022)
Article
Environmental Sciences
Jianan Huang, Langjie Ye, Mingliang Fang, Guanyong Su
Summary: With the phase-out of traditional halogenated flame retardants, research interests have shifted to organophosphate flame retardants (OPFRs). This study conducted an extensive survey to identify the OPFRs currently being produced in factories and investigate their annual production volume (APV). Results indicate that there are at least 56 OPFR monomers and 62 OPFR mixtures being produced in 367 factories worldwide, with 201 of them located in Mainland China. The estimated APV of OPFRs is 598,422 metric tons, which may be underestimated due to limited information availability. The study also highlights the limited research on certain types of OPFRs and provides recommendations for future research in this area.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Food Science & Technology
Fariba Garkani Nejad, Iran Sheikhshoaie, Hadi Beitollahi
Summary: This study developed a new voltammetric sensor based on graphene oxide-Fe3O4 nanocomposite functionalized with fourth-generation poly(amidoamine) dendrimers and ionic liquid modified carbon paste electrode for the simultaneous detection of carmoisine and tartrazine in food samples. The sensor exhibited good electrocatalytic function and a linear response range, making it suitable for the determination of carmoisine and tartrazine in food samples.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Hessamaddin Sohrabi, Parya Salahshour Sani, Yasin Orooji, Mir Reza Majidi, Yeojoon Yoon, Alireza Khataee
Summary: This paper reviews the recent advances in sensing assays for pesticide detection based on the metal-organic framework structure. Optical biosensors and electrochemical sensors are discussed as effective methods for rapid and sensitive detection of pesticides in agricultural and food samples.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Toxicology
R. Raveesha, A. M. Anusuya, A. V. Raghu, K. Yogesh Kumar, M. G. Dileep Kumar, S. B. Benaka Prasad, M. K. Prashanth
Summary: A series of new thiazole derivatives were synthesized and their anticancer activities were investigated. The results showed good anticancer effects of these compounds in various cancer cell lines. The anticancer mechanisms were studied and evaluated by molecular docking with the HER2 receptor. The compounds were found to comply with Lipinski's rule of five and showed potential in terms of electronic properties.
COMPUTATIONAL TOXICOLOGY
(2022)
Article
Cell Biology
Shaowei Zhuang, Yan Ma, Yuxiao Zeng, Cheng Lu, Fenghua Yang, Nianxin Jiang, Junwei Ge, Haining Ju, Chunlin Zhong, Jiayi Wang, Jiehan Zhang, Shengyang Jiang
Summary: This study found that DOX induces myocardial injury by promoting ferroptosis. DOX treatment upregulates METTL14, increasing the sponge KCNQ1OT1 for miR-7-5p and inhibiting its activity. The lack of miR-7-5p expression leads to increased iron uptake and lipid reactive oxygen species production, demonstrating DOX-induced ferroptosis in AC16 cells.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jessica E. B. F. Lima, Natalia C. S. Moreira, Elza T. Sakamoto-Hojo
Summary: Type 2 diabetes is a complex disease influenced by genetic and environmental factors, with obesity, lifestyle, and aging being major risk factors. Hyperglycemia, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and inflammation play important roles in the development and complications of type 2 diabetes.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Environmental Sciences
Liang Zhao, Jianlong Fang, Song Tang, Fuchang Deng, Xiaohui Liu, Yu Shen, Yuanyuan Liu, Fanling Kong, Yanjun Du, Liangliang Cui, Wanying Shi, Yan Wang, Jiaonan Wang, Yingjian Zhang, Xiaoyan Dong, Ying Gao, Li Dong, Huichan Zhou, Qinghua Sun, Haoran Dong, Xiumiao Peng, Yi Zhang, Meng Cao, Yanwen Wang, Hong Zhi, Hang Du, Jingyang Zhou, Tiantian Li, Xiaoming Shi
Summary: This study investigated the associations between personal exposure to PM2.5 and insulin resistance (IR) index, systemic inflammation, and sphingolipid metabolism. The findings suggest that PM2.5 exposure is linked to higher IR index and altered functional biomarkers, and it may contribute to systemic inflammation and disrupted sphingolipid metabolism.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Jiawen Cui, Qin Zhou, Meijin Yu, Yuhao Liu, Xiaohua Teng, Xianhong Gu
Summary: In this study, we investigated the toxicity of 4-tert-butylphenol (4-tBP) to fish liver using in vivo and in vitro models. We found that 4-tBP caused liver damage, potentially through the process of ferroptosis. Furthermore, we observed oxidative stress, iron overload, and abnormal expression of ferroptosis-related factors following 4-tBP exposure. The ferroptosis inhibitor Fer-1 alleviated these changes, indicating its potential as a protective agent against 4-tBP toxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cardiac & Cardiovascular Systems
Mohammad Sheibani, Yaser Azizi, Maryam Shayan, Sadaf Nezamoleslami, Faezeh Eslami, Mohammad Hadi Farjoo, Ahmad Reza Dehpour
Summary: Doxorubicin is an effective chemotherapeutic agent used to treat solid tumors, but it can cause cardiotoxicity, particularly congestive heart failure. The mechanisms underlying doxorubicin-induced cardiotoxicity are not fully understood, but inflammatory cytokines, oxidative stress pathways, mitochondrial damage, and other factors and pathways play critical roles. Currently, there are few medications available for the treatment of doxorubicin-induced cardiotoxicity, and further research is needed to explore preventive treatments.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Environmental Sciences
M. Safiur Rahman, Zia Ahmed, Sirajum Munir Seefat, Rafiul Alam, Abu Reza Md Towfiqul Islam, Tasrina Rabia Choudhury, Bilkis Ara Begum, Abubakr M. Idris
Summary: The study evaluated the concentration of heavy metals in sediment samples from the Dhaleshwari River, discovering moderate to high levels of contamination of chromium and iron in some samples, with spatial distribution patterns showing high concentrations in certain areas. The environmental impact of heavy metals in sediment should be closely monitored and addressed.
ENVIRONMENTAL CHEMISTRY AND ECOTOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Terry Gordon, Emma Karey, Meghan E. Rebuli, Yael-Natalie H. Escobar, Ilona Jaspers, Lung Chi Chen
Summary: This review discusses the experimental and clinical evidence of the toxicity and deleterious health effects of e-cigarettes. The adverse health effects related to e-cigarette aerosols are influenced by factors such as e-liquid components, physical device factors, chemical changes, and user health conditions. Despite regulations governing e-cigarette flavors, manufacturing, distribution, and availability, the evolving e-cigarette landscape hinders progress in toxicological studies and the understanding of the long-term health consequences of e-cigarettes.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Environmental Sciences
Hussein K. Okoro, Sadanand Pandey, Clement O. Ogunkunle, Catherine J. Ngila, C. Zvinowanda, Ismaila Jimoh, Isiaka A. Lawal, Muyiwa M. Orosun, Adewale George Adeniyi
Summary: Organic pollutants pose serious environmental and health issues, and biosorption is a promising alternative strategy for their removal due to its simplicity of operation and high sorption capacity.
EMERGING CONTAMINANTS
(2022)
Review
Pharmacology & Pharmacy
Daniel Westaby, Maria de Los Dolores Fenor de La Maza, Alec Paschalis, Juan M. Jimenez-Vacas, Jon Welti, Johann de Bono, Adam Sharp
Summary: In the last two decades, there has been significant progress in the treatment of advanced prostate cancer by targeting androgen and the androgen receptor (AR). However, drug resistance remains a challenge that needs to be addressed for the development of future therapeutic strategies.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Toxicology
Said Muhammad, Qazi Ahmed Usman
Summary: The study revealed that heavy metal contamination in the water of Indus River and its tributaries in northern Pakistan is relatively low, with most water samples meeting the WHO drinking water guidelines. The bedrock geology plays a significant role in the distribution of heavy metals in the water of the study area.
Article
Cell Biology
Jian Chang, Hanjun Li, Zhongchao Zhu, Pei Mei, Weimin Hu, Xingcheng Xiong, Jing Tao
Summary: This research demonstrates that M2 macrophage-derived exosomal miR-21-5p promotes differentiation and activity of PaCa stem cells by targeting KLF3. downregulation of miR-21-5p in M2 macrophage-derived EVs inhibits key cancer stem cell functions in vitro and tumor-forming ability in vivo.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Toxicology
Carlos Martins-Gomes, Tania L. Silva, Tatiana Andreani, Amelia M. Silva
Summary: Glyphosate-based herbicide has been widely used for weed management due to its effectiveness and perceived low toxicity. However, recent studies have raised concerns about the persistence and toxicity of glyphosate and its metabolites, as well as the role of surfactants in herbicide formulations. It is important to analyze and review these studies to redefine safety levels for glyphosate exposure.
JOURNAL OF XENOBIOTICS
(2022)
Review
Biochemistry & Molecular Biology
Alexandrina-Stefania Curpan, Federica Impellitteri, Gabriel Plavan, Alin Ciobica, Caterina Faggio
Summary: The increasing level of pollution has become a pressing issue for humankind worldwide. While the direct effects of pollution such as decreased air quality and abnormal temperatures are often focused on, the unseen effects are frequently overlooked. In recent years, more attention has been given to the effects of pollution on living organisms and plants, and a model animal called Mytilus galloprovincialis has emerged. This species of mussel is capable of accumulating various xenobiotics and can be used for toxicological assessments. This paper aims to highlight the benefits of using M. galloprovincialis as an animal model for toxicological assays by reviewing relevant studies.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Immunology
Hayder M. Al-kuraishy, Gaber El-Saber Batiha, Hani Faidah, Ali Al-Gareeb, Hebatallah M. Saad, Jesus Simal-Gandara
Summary: Pirfenidone, an anti-fibrotic drug, has the potential to manage post-Covid-19 pulmonary fibrosis by inhibiting inflammatory cell accumulation, fibroblast proliferation, and extracellular matrix deposition. It also modulates signaling pathways involved in the pathogenesis of pulmonary fibrosis. Its anti-inflammatory and anti-fibrotic properties may attenuate post-Covid-19 pulmonary fibrosis.
INFLAMMOPHARMACOLOGY
(2022)
