Rheumatology

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Article Rheumatology

TET1 Regulates Skeletal Stem-Cell Mediated Cartilage Regeneration

Akshay Pandey, Malachia Hoover, Mamta Singla, Yudhishtar Bedi, Hunter Storaci, Stuart B. Goodman, Charles Chan, Nidhi Bhutani

Summary: This study investigates how the DNA hydroxymethylase Tet1 regulates the function of adult skeletal stem cells (SSCs) in osteoarthritis (OA). It was found that loss of Tet1 expands the SSC pool and enhances their chondrogenic potential. Inhibiting Tet1 also enhances chondrogenesis in human SSCs and chondroprogenitors. Furthermore, the use of melatonin, a hormone, can mimic the inhibition ability of Tet1 and improve cartilage health.

ARTHRITIS & RHEUMATOLOGY (2023)

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Article Rheumatology

Adalimumab Effectively Decreases Inflammation Downstream of TNFα Signaling in Synoviocytes from Extended Oligoarticular Juvenile Idiopathic Arthritis

Megan M. Simonds, Samuel T. Freer, Lina Al-Jaberi, AnneMarie C. Brescia

Summary: This study examines the effects of inhibiting TNF alpha signaling with adalimumab on fibroblast-like synoviocytes (FLS) isolated from synovial fluid of patients with juvenile idiopathic arthritis (JIA). The results suggest that adalimumab can reduce inflammation in FLS associated with TNF alpha.

RHEUMATOLOGY AND THERAPY (2023)

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Letter Rheumatology

Case report: Successful treatment with canakinumab of a patient with active ileitis associated with familial Mediterranean fever

Dai Kishida, Ryosuke Hara, Takanori Ichikawa, Mai Iwaya, Yasuhiro Shimojima, Yoshiki Sekijima

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2023)

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Article Rheumatology

Epidemiological data and medical care situation of patients with chronic inflammatory diseases in Germany: Real-world evidence on prevalence, disease combinations, care

Gabriela Riemekasten, Renate Schmelz, Knut Schaekel, Diamant Thaci, Stefan Schreiber, Marit Roecken, Holger Bartz, Tina Ploner, Ximing Liao, Valeria Weber, Karina C. Manz, Harald Burkhardt, Jan Leipe

Summary: This study analyzed epidemiological data and utilization of care services in patients with chronic inflammatory diseases (IMID), and found that combinations of different diseases were common. Patients with IMID had higher rates of hospitalizations and outpatient visits to various disciplines compared to the reference population.

ZEITSCHRIFT FUR RHEUMATOLOGIE (2023)

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Article Rheumatology

Advancing physiotherapy practice: A quality improvement project to train advanced practice physiotherapists to deliver caudal epidurals in a community setting

Stephanie Griffiths

MUSCULOSKELETAL CARE (2023)

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Article Rheumatology

Neuro-Behçet's disease with atypical subcortical nodular lesions: A case report and treatment approach

Kiyomi Yoshimoto, Tadanao Kobayashi, Hidetoshi Matsuoka, Nobushiro Nishimura, Hiromasa Kawashima, Ryo Yoneima, Emiko Tsushima, Shiro Ono, Kenji Nishio

Summary: This article reports a rare case of Neuro-Behcet's disease (NB) presenting with multiple subcortical nodular brain lesions but without involvement of the brainstem, thalamus, or basal ganglia. The diagnostic challenge of distinguishing between NB and tuberculosis based on imaging alone is highlighted, and the potential efficacy of high-dose steroid therapy in steroid-resistant NB with subcortical nodular brain lesions is demonstrated.

MODERN RHEUMATOLOGY CASE REPORTS (2023)

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Article Rheumatology

Long-Term Efficacy and Safety of Canakinumab in Patients With Tumor Necrosis Factor Receptor-Associated Periodic Syndrome: Results From a Phase III Trial

Marco Gattorno, Laura Obici, Inmaculada Calvo Penades, Tilmann Kallinich, Susanne Benseler, Elise Dekker, Jeremy Levy, Fabrizio De Benedetti, Helen Lachmann

Summary: This study assessed the efficacy, safety, and tolerability of canakinumab in TRAPS patients during a 72-week long-term, open-label extension. The results showed that long-term canakinumab treatment effectively controlled disease activity and reduced flare incidence in TRAPS patients. No new safety concerns were identified.

ARTHRITIS & RHEUMATOLOGY (2023)

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Article Rheumatology

Aggressive multi-combination therapy for anti-MDA5 antibody-positive dermatomyositis-rapidly progressive interstitial lung disease

Kenichiro Hata, Takuya Kotani, Shogo Matsuda, Youhei Fujiki, Takayasu Suzuka, Takao Kiboshi, Yumiko Wada, Hideyuki Shiba, Takeshi Shoda, Maki Kagitani, Tohru Takeuchi

Summary: Aggressive multi-combination therapy may improve the survival outcome of patients with anti-MDA5 antibody-positive DM-RPILD. Group B exhibited a lower corticosteroid dose during the treatment period compared to Group A.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2023)

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Article Rheumatology

Use of transient elastography to assess hepatic steatosis and fibrosis in patients with juvenile idiopathic arthritis during methotrexate treatment

Chayakamon Niyasom, Sirisucha Soponkanaporn, Soamarat Vilaiyuk, Chatmanee Lertudomphonwanit, Songpon Getsuwan, Pornthep Tanpawpong, Piyaporn Kaewduang, Abhasnee Sobhonslidsuk

Summary: Hepatic steatosis is common among patients with juvenile idiopathic arthritis (JIA) receiving methotrexate treatment, but none had transient elastography-defined hepatic fibrosis. Overweight/obese JIA adolescents and patients with a high cumulative dose of methotrexate are at risk for hepatic steatosis.

CLINICAL RHEUMATOLOGY (2023)

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Article Rheumatology

Real-world safety and effectiveness of mepolizumab for patients with eosinophilic granulomatosis with polyangiitis in Japan: A 48-week interim analysis of the MARS study

Tomonori Ishii, Hideaki Kunishige, Tamami Kobayashi, Etsuko Hayashi, Masaki Komatsubara, Takeo Ishii, Rafael Alfonso-Cristancho, Jun Tamaoki, Peter Howarth

Summary: The study aims to evaluate the long-term safety and effectiveness of mepolizumab for eosinophilic granulomatosis with polyangiitis (EGPA) in Japan. The results show that mepolizumab treatment for 144 weeks led to a significant reduction in oral corticosteroid dose and improvement in clinical symptoms. The treatment demonstrated good safety profile and improved disease control among EGPA patients.

MODERN RHEUMATOLOGY (2023)

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Letter Rheumatology

Massive abdominal haemorrhage due to sequential omental vasculitis and ruptured aneurysms in a patient with granulomatosis with polyangiitis

M. Guerini, D. Sorace, F. Bobbio Pallavicini, V Codullo, M. Lucioni, S. Fraticelli, J. Vigano, P. Quaretti, P. Delvino

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2023)

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Article Rheumatology

Identification of discriminatory factors and construction of nomograms for differentiating AOSD and sepsis

Songlou Yin, Fei Luo, Jingzhi Xie, Yanzhen Zeng, Quanquan Fang, Juan Zong, Lina Cao, Hanqiu Yin, Lili Duan, Dongmei Zhou

Summary: The nomogram prediction models developed in this study can be used as useful tools for differentiating between adult-onset Still's disease (AOSD) and sepsis, providing guidance for clinical practice.

CLINICAL RHEUMATOLOGY (2023)

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Review Rheumatology

Immunohistochemical expression of perforin in adult systemic lupus erythematosus associated macrophage activation syndrome: Clinicohematological correlation and literature review

Bakialakshmi Velayutham, Somanath Padhi, Sujata Devi, Susama Patra, Chinmayee Panigrahi, Mathan Kumar Ramasubbu, Rajesh Kumar, Samiur Raheman

Summary: This study aimed to investigate the immunohistomorphological characteristics of bone marrow in adult SLE-MAS patients. The results showed that MAS was more common in patients who had prior immunosuppressive therapy, involvement of three or more systems, lower fibrinogen, increased triglyceride, and increased bone marrow hemophagocytosis. Fibrinogen, hemophagocytosis score, and MAS probability score were useful in discriminating between MAS and non-MAS patients.

LUPUS (2023)

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Letter Rheumatology

Seropositive polyarthritis and diffuse lymphadenopathy associated with PRKCD mutation

Riccardo Papa, Francesca Schena, Anna Corcione, Paola Bocca, Enrico Drago, Clara Malattia, Alice Grossi, Isabella Ceccherini, Marco Gattorno

RHEUMATOLOGY (2023)

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Article Rheumatology

Expert Perspective: Diagnostic Approach to the Autoinflammatory Diseases

Riccardo Papa, Roberta Caorsi, Stefano Volpi, Marco Gattorno

ARTHRITIS & RHEUMATOLOGY (2023)

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Letter Rheumatology

Correspondence on hearing loss in ankylosing spondylitis

Hsin-Tien Wu, Renin Chang

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2023)

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Letter Rheumatology

MEFV gene test-Who's ordering them and why? A retrospective study from an Australian referrals center

Sam Shan, Mueed Mian

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2023)

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Review Rheumatology

Calcinosis in Juvenile Dermatomyositis-Epidemiology, Pathogenesis, Clinical Features, and Treatment: A Systematic Review

Jucier Goncalves Junior, Samuel Katsuyuki Shinjo

Summary: Calcinosis is common in female children with around five years of age and three years of disease duration. The pathogenesis involves interleukin 1 and 6, tumor necrosis factor alpha, and innate immunity dysregulation. Treatment with anti-NXP-2, anti-MDA-5, and anti-Mi-2 autoantibodies remains controversial, and further studies are needed to evaluate treatment protocols.

CURRENT RHEUMATOLOGY REPORTS (2023)

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Article Rheumatology

Safety and effectiveness of peficitinib 100 mg/day in patients achieving clinical remission from a long-term open-label extension study in Japan, Korea, and Taiwan (RAJ2)

Yoshiya Tanaka, Tsutomu Takeuchi, Yoshiaki Morita, Yuichiro Kaneko, Wataru Terada

Summary: This study assessed the long-term safety and effectiveness of peficitinib 100 mg/day for the treatment of rheumatoid arthritis. The results showed that long-term treatment with 100 mg/day of peficitinib was well tolerated and maintained effectiveness for 48 weeks.

MODERN RHEUMATOLOGY (2023)

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Article Rheumatology

Evaluation of discontinuation for adverse events of JAK inhibitors and bDMARDs in an international collaboration of rheumatoid arthritis registers (the 'JAK-pot' study)

Romain Aymon, Denis Mongin, Sytske Anne Bergstra, Denis Choquette, Catalin Codreanu, Diederik De Cock, Lene Dreyer, Ori Elkayam, Doreen Huschek, Kimme L. Hyrich, Florenzo Iannone, Nevsun Inanc, Lianne Kearsley-Fleet, Suleyman Serdar Koca, Tore K. Kvien, Burkhard F. Leeb, Galina Lukina, Dan C. Nordstrom, Karel Pavelka, Manuel Pombo-Suarez, Ana Rodrigues, Ziga Rotar, Anja Strangfeld, Patrick Verschueren, Rasmus Westermann, Jakub Zavada, Delphine Sophie Courvoisier, Axel Finckh, Kim Lauper

Summary: In an international real-world RA population, treatment discontinuations for adverse events were compared among second-line therapies including JAKi, TNFi, and other mode of action biologicals. While overall JAKi were not associated with more treatment discontinuations for adverse events, subgroup analyses revealed varying patterns with specific JAKi drugs like tofacitinib.

ANNALS OF THE RHEUMATIC DISEASES (2023)

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