Respiratory System

Article Respiratory System

Expression of constitutively active TŞRI leads to attenuation of ovalbumin-induced allergic airway inflammation associated with augmented M2 polarization of alveolar macrophage

Panwadee Pluangnooch, Kitipong Soontrapa, Arnon Pudgerd, Somyoth Sridurongrit

Summary: This study demonstrates that TSRICA expression in alveolar macrophages promotes M2 polarization and ameliorates allergic airway inflammation in an ova-induced asthma mouse model.

RESPIRATORY INVESTIGATION (2024)

Article Oncology

IgG4-related retroperitoneal fibrosis induced by nivolumab and ipilimumab in a patient with non-small cell lung cancer: A case report

Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana

Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.

THORACIC CANCER (2024)

Article Respiratory System

Delayed iliopsoas abscess following COVID-19 pneumonia

Ryuichiro Takaki, Masaru Ando, Yoshio Satonaga, Michitoshi Yabe, Takamasa Kan, Erika Omote, Shoma Hirota, Sonoe Uchida, Toru Yamasaki, Kosaku Komiya, Kazufumi Hiramatsu

Summary: Bacterial co-infection can worsen the prognosis of patients with viral infections. This study reported two cases of iliopsoas abscess in patients with COVID-19, a comorbidity that has not been previously reported. The comorbidity of iliopsoas abscess may have been underestimated in these cases despite the use of immunosuppressive therapy for COVID-19 pneumonia.

RESPIRATORY INVESTIGATION (2024)

Correction Physiology

The course of lung inflation alters the central pattern of tracheobronchial cough in cat - The evidence for volume feedback during cough (vol 229, pg 43, 2016)

Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Review Cardiac & Cardiovascular Systems

Effects of rapid response team on patient outcomes: A systematic review

Qiuxia Zhang, Khuan Lee, Zawiah Mansor, Iskasymar Ismail, Yi Guo, Qiao Xiao, Poh Ying Lim

Summary: This study conducted a systematic review to understand the effect of rapid response teams (RRT) on patient outcomes. The results showed that, despite variation in context and intervention type, most studies demonstrated that RRT positively impacts patient outcomes.

HEART & LUNG (2024)

Article Cardiac & Cardiovascular Systems

Lung ultrasound score for monitoring the withdrawal of extracorporeal membrane oxygenation on neonatal acute respiratory distress syndrome

Hong-Lin Wu, Si-Jia Zhou, Xiu-Hua Chen, Hua Cao, Yi-Rong Zheng, Qiang Chen

Summary: This study aimed to evaluate the value of LUS score at VA-ECMO withdrawal in neonatal ARDS patients. The results showed that LUS score significantly improved during VA-ECMO treatment and could be used to evaluate various lung diagnostic signs. Additionally, LUS score was positively correlated with ECMO blood flow and could predict ECMO weaning success.

HEART & LUNG (2024)

Article Cardiac & Cardiovascular Systems

A family intervention to prevent postoperative delirium in patients undergoing cardiac valve surgery: A randomized controlled study

Lingyu Lin, Yanchun Peng, Xizhen Huang, Sailan Li, Liangwan Chen, Yanjuan Lin

Summary: This study aimed to investigate the effects of family intervention on the incidence of postoperative delirium (POD) and ICU prognoses of patients undergoing cardiac valve surgery. The results showed that family intervention could reduce the incidence of POD, shorten ICU stays, reduce the incidence of anxiety and depression in family caregivers, and improve their satisfaction. Therefore, family intervention is of significant importance for patients undergoing cardiac valve surgery.

HEART & LUNG (2024)

Article Physiology

Impact of high-intensity interval hyperpnea on aerobic energy release and inspiratory muscle fatigue

Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama

Summary: Respiratory muscle endurance training has beneficial effects on whole-body endurance performance. A novel high-intensity interval (HII) protocol is found to enhance the efficacy of respiratory muscle training programs.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Causal relationship between asthma and inflammatory bowel disease : A two-sample bidirectional mendelian randomization analysis

Jianxiong Lai, Bin Fang, Lirong Luo, Wenjie Xie, Yuanhui Xu, Jian Li

Summary: This study used two-sample bidirectional mendelian randomization to explore the causal link between asthma and inflammatory bowel disease. The researchers found a negative correlation between asthma and Crohn's disease. However, further research is needed to confirm this finding.

HEART & LUNG (2024)

Article Respiratory System

Minimal-Resource Home Exercise Program Improves Activities of Daily Living, Perceived Health Status, and Shortness of Breath in Individuals with COPD Stages GOLD II to IV

Vanessa Joaquim Ribeiro Moco, Aline Almeida Gulart, Agnaldo Jose Lopes, Arthur de Sa Ferreira, Luis Felipe da Fonseca Reis

Summary: Home exercises with minimal resources can improve activities of daily living, reduce dyspnea, and enhance health status and quality of life in individuals with COPD.

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2023)

Article Respiratory System

Pulmonary Vascular Volume by Quantitative CT in Dyspneic Smokers with Minor Emphysema

Amany F. F. Elbehairy, Sandra G. G. Vincent, Devin B. B. Phillips, Matthew D. D. James, Jenna Veugen, Grace Parraga, Denis E. E. O'donnell, J. Alberto Neder

Summary: Reduced lung diffusing capacity for carbon monoxide (DLCO) at rest and increased ventilation-carbon dioxide output during exercise are common findings in dyspneic smokers with preserved FEV1. It is unclear whether these abnormalities are solely due to emphysematous destruction or impaired pulmonary perfusion in non-emphysematous tissue.

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2023)

Article Respiratory System

PTD-FGF2 Attenuates Elastase Induced Emphysema in Mice and Alveolar Epithelial Cell Injury

Soojin Jang, Hanbyeol Lee, Jaehyun Park, Sang-Ryul Cha, Jooyeon Lee, Youngheon Park, Sang Ho Jang, Jeong-Ran Park, Seok-Ho Hong, Se-Ran Yang

Summary: This study investigated the effects of protein transduction domains (PTD) conjugated Basic Fibroblast Growth Factor (FGF2) (PTD-FGF2) on MLE-12 cells and porcine pancreatic elastase (PPE)-induced emphysematous mice in response to cigarette smoke extract (CSE). The results showed that PTD-FGF2 treatment significantly decreased alveolar epithelium inflammation and pro-inflammatory cytokines in PPE-induced mice, as well as reactive oxygen species (ROS) production and cytokine levels in MLE-12 cells.

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2023)

Article Respiratory System

LncRNA H19 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-181/PDCD4 Axis

Panpan Liu, Hongchang Gao, Yumeng Wang, Yujuan Li, Lei Zhao

Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, with over 3 million people dying from it each year. Despite progress in treating symptoms and preventing acute exacerbations, little has been done to slow disease progression or reduce mortality. This study aimed to uncover the therapeutic mechanism of exercise in COPD through both in vivo and in vitro experiments. The results showed that exercise improves COPD-induced lung injury by reducing oxidative stress, inflammation, and epithelial-mesenchymal transition (EMT). Additionally, the study found that the lncRNA H19 plays a role in smoke-related COPD by targeting the miR-181/PDCD4 Axis.

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2023)

Article Respiratory System

A retrospective study on immune-related pneumonitis in patients with non-small-cell lung cancer undergoing treatment with PD-1/PD-L1 inhibitors

Dorthe Yakymenko, Kristin Skougaard

Summary: This study aimed to explore the diagnosis and management of immune-related (ir-)pneumonitis in lung cancer patients undergoing treatment with immune checkpoint inhibitors (ICIs). Suspected ir-pneumonitis was frequent in this patient group, but diagnostic conclusions were often uncertain and treatment duration exceeded recommendations. Furthermore, pulmonologist involvement was rare. The study highlights the challenges in diagnosing and managing lung cancer patients presenting with pulmonary symptoms in daily clinical practice.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2023)

Article Respiratory System

Comorbid conditions as predictors of mortality in severe COPD - an eight-year follow-up cohort study

Gabriella Eliasson, Christer Janson, Gunnar Johansson, Kjell Larsson, Anders Linden, Claes-Goeran Loefdahl, Thomas Sandstroem, Josefin Sundh

Summary: Co-morbidities are common in COPD and are associated with increased morbidity and mortality. This study aimed to explore the prevalence of comorbid conditions in severe COPD and their associations with long-term mortality. Impaired kidney function was found to be the only comorbidity independently associated with increased all-cause and respiratory mortality.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2023)

Article Respiratory System

Agreement between reported questionnaire data and medical records on diagnosis and COVID-19 symptoms at onset

Marta A. Kisiel, Claes Kock, Josef Sultan, Helena Janols, Christer Janson, Ronnie Pingel

Summary: This study aimed to examine the agreement between self-reported data and medical records in terms of diagnoses and symptoms at COVID-19 onset, and to explore the impact of sociodemographic factors on this agreement. The results showed that there was moderate to substantial agreement between self-reported data and medical records for certain diagnoses, but only fair agreement for more difficult-to-define conditions. The agreement for symptoms was generally poor. The study also found that agreement varied across sociodemographic subgroups.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2023)

Article Respiratory System

Age at asthma diagnosis and onset of symptoms among adults with allergic and non-allergic asthma

Johanna Pakkasela, Petri Salmela, Pekka Juntunen, Jussi Karjalainen, Lauri Lehtimaki

Summary: This study found that the onset and diagnosis of symptoms occurred at a younger age among adults with allergic asthma compared to those with non-allergic asthma. Only a minority of adults with non-allergic asthma had already experienced symptoms in their youth.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2023)

Article Respiratory System

The effect of aerobic exercise training on asthma control in postmenopausal women (ATOM): a randomized controlled pilot study

Erik Soren Halvard Hansen, Hanne Kruuse Rasmusen, Morten Hostrup, Ylva Hellsten, Vibeke Backer

Summary: This study aimed to evaluate if high-intensity interval training could improve asthma control in overweight, postmenopausal women with uncontrolled, late-onset asthma. The results showed that high-intensity interval training significantly reduced body fat percentage and had a positive impact on asthma control.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2023)

Article Respiratory System

Introduction of a systematic examination framework for chronic cough: a before-after cohort study in a clinical setting

Allan Klitgaard, Anders Lokke, Jannie Frolund, Steffen Kristensen, Ole Hilberg

Summary: A systematic examination framework for diagnosing cough was introduced and found to reduce the number of appointments required to establish a diagnosis without compromising the diagnostic outcome.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2023)

Review Respiratory System

Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis

Karina Mayoral, Catalina Lizano-Barrantes, Victor Zamora, Angels Pont, Carme Miret, Cristina Barrufet, M. Araceli Caballero-Rabasco, Manuel Praena-Crespo, Alberto Bercedo, Laura Valdesoiro-Navarrete, Maria Teresa Guerra, Yolanda Pardo, Ma Jose Martinez Zapata, Olatz Garin, Montse Ferrer

Summary: This study aimed to assess the impact of montelukast on pediatric patients with asthma/allergic rhinitis and found that montelukast was effective in controlling asthma symptoms when compared with placebo, but inhaled corticosteroids were superior in controlling symptoms. These findings are consistent with current asthma treatment guidelines.

EUROPEAN RESPIRATORY REVIEW (2023)