Plant Sciences

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Article Plant Sciences

Black mulberry extract inhibits hepatic adipogenesis through AMPK/mTOR signaling pathway in T2DM mice

Yudi Yao, Yang Chen, Huijian Chen, Xin Pan, Xiaojun Li, Wenqi Liu, Yerlan Bahetjan, Binan Lu, Kejian Pang, Xinzhou Yang, Zongran Pang

Summary: This study aimed to investigate the potential of Morus nigra L. fruit ethyl acetate extract (MNF-EA) in reducing blood sugar levels by preventing the production of hepatic lipogenesis, and to provide more evidence for its use as an adjuvant therapy for type 2 diabetes mellitus (T2DM).

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Panax Quinquefolium Saponins enhances angiogenesis in rats with diabetes and myocardial infarction

Deng Pan, Lin Xu, Pengfei Chen, Lina Miao, Yi Tian, Dazhuo Shi, Ming Guo

Summary: PQS improves blood glucose, enhances cardiac function, mitigates cardiac damage, and boosts arteriolar density. The angiogenic impact of PQS appears to be, at least partially, due to its modulation of the PKC delta-mediated VEGF/PI3K-Akt/eNOS signaling pathway in rats with diabetes and myocardial infarction.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Gastroprotective potential of red onion (Allium cepa L.) peel in ethanol-induced gastric injury in rats: Involvement of Nrf2/HO-1 and HMGB-1/NF-κB trajectories

Nermeen B. Ali, Sherihan Salaheldin Abdelhamid Ibrahim, Muhammad A. Alsherbiny, Eman Sheta, Riham A. El-Shiekh, Rehab M. Ashour, Amira A. El-Gazar, Ghada M. Ragab, Sabah H. El-Gayed, Chun Guang Li, Essam Abdel-Sattar

Summary: Red onion peels have potential in treating gastric ulcers by modulating the Nrf2/HO-1 and HMGB-1/NF-kappa B pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Sceletium tortuosum-derived mesembrine significantly contributes to the anxiolytic effect of Zembrin®, but its anti-depressant effect may require synergy of multiple plant constituents

Johane Gericke, Brian H. Harvey, Lesha Pretorius, Tracey Ollewagen, Rohan M. Benecke, Carine Smith

Summary: This study determined the effective concentration of a Sceletium tortuosum (ST) extract with anxiolytic and antidepressant effects using zebrafish larvae as a model. The results showed that the alkaloid mesembrine contributed significantly to the anxiolytic effects of the extract. However, the contribution of individual alkaloids to the antidepressant effects could not be determined. Further investigation into the mechanisms of action and potential synergistic effects of ST alkaloids is warranted.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Xihuang pill ameliorates colitis in mice by improving mucosal barrier injury and inhibiting inflammatory cell filtration through network regulation

Meng-Lei Hu, Qian-Zan Liao, Bo-Tong Liu, Kai Sun, Chun-Shui Pan, Xiao-Yi Wang, Li Yan, Xin-Mei Huo, Xian-Qun Zheng, Yuan Wang, Li-Jun Zhong, Jian Liu, Lin He, Jing-Yan Han

Summary: Xihuang pill (XHP), a traditional Chinese medicine formula, has been shown to have anti-inflammatory properties against colitis. This study aimed to investigate the potential impact of XHP on colitis and uncover the underlying mechanisms involved. The results showed that XHP improved weight loss, colonic shortening, and mucosal barrier injury, while reducing the number of infiltrating immune cells and pro-inflammatory cytokines in the colon tissue. Additionally, pharmacokinetic analysis revealed that XHP contained multiple prototype ingredients that regulated proteins linked to mucosal barrier injury and inflammation.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

An Andrographis paniculata Burm. Nees extract standardized for three main Andrographolides prevents house dust mite-induced airway inflammation, remodeling, and hyperreactivity by regulating Th1/Th2 gene expression in mice

Ibrahim Sulaiman, Emmanuel Oshiogwe Okwuofu, Norhafizah Mohtarrudin, Jonathan Chee Woei Lim, Johnson Stanslas

Summary: The standardized Andrographis paniculata 50% ethanol extract (APEE50) showed anti-inflammatory effects in a mouse asthma model by down-regulating Th2 cytokine gene expression and oxidative stress levels.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

The Qi Yin San Liang San decoction enhances anti-CD19 CAR-T cell function in the treatment of B-cell lymphomas

Shi Dong, Peipei Wang, Liubo Zhang, Xiaotian Zhang, Xiaorui Li, Jiali Wang, Xinming Cui, Ting Lan, Can Gao, Yuanyuan Shi, Weijia Wang, Jianxun Wang, Miao Jiang

Summary: SLS can potentially enhance the function of anti-CD19 CAR T cells in treating B-cell lymphoma by improving their killing ability and reducing the risk associated with inflammation. The mechanism of SLS involves the apoptosis and IL-17 signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Fagopyrum tataricum (L.) Gaertn interacts with Gsk-3β/Nrf-2 signalling to protect neurotoxicity in a zebrafish model

Shubham Nilkanth Rahmatkar, Anil Kumar Rana, Rajneesh Kumar, Damanpreet Singh

Summary: This study investigated the neuroprotective effects of Fagopyrum tataricum seed extract against acrylamide-induced neurotoxicity. The extract showed anti-inflammatory and antioxidant properties, improved locomotor deficits, and reduced oxidative stress. It prevented neurotoxicity by suppressing Gsk-3 beta-mediated oxidative stress.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Inhibition of pro-inflammatory cytokines by selected southern African medicinal plants in LPS-stimulated RAW 264.7 macrophages

Gugulethu P. Khumalo, Thanh Nguyen, Ben-Erik Van Wyk, Yunjiang Feng, Ian E. Cock

Summary: In this study, the immunomodulatory and anti-inflammatory properties of bark from ten important southern African plants were evaluated. It was found that most of these plants exhibited cytokine inhibitory effects, providing new insights into the mechanisms by which they regulate inflammation.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Rhei Radix et Rhizoma in Xuanbai-Chengqi decoction strengthens the intestinal barrier function and promotes lung barrier repair in preventing severe viral pneumonia induced by influenza A virus

Linfeng Guo, Weilian Bao, Shuiyuan Yang, Yang Liu, Jiaren Lyu, Ting Wang, Yan Lu, Hong Li, Haiyan Zhu, Daofeng Chen

Summary: This study aims to investigate the protective effect and mechanism of Xuanbai-Chengqi decoction (XCD) on the pulmonary/intestinal barrier guided by the theory of gut-lung concurrent treatment. Moreover, the compatibility mechanism of rhubarb in XCD was elucidated.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Modified Shoutai Pill inhibited ferroptosis to alleviate recurrent pregnancy loss

Yuling Lai, Yu Zhang, Huimin Zhang, Zhenyue Chen, Lihua Zeng, Gaopi Deng, Songping Luo, Jie Gao

Summary: This study explores the potential molecular mechanism of Modified Shoutai Pill (JSP) in treating recurrent pregnancy loss (RPL). The findings suggest that JSP alleviates RPL symptoms by inhibiting ferroptosis.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Multi-omics revealed the mechanisms of Codonopsis pilosula aqueous extract in improving UC through blocking abnormal activation of PI3K/Akt signaling pathway

Fang Li, Yanping Yang, Junli Ge, Chunxia Wang, Zhengjun Chen, Qin Li, Fude Yang

Summary: Codonopsis pilosula (DS) has preventive and therapeutic effects in improving ulcerative colitis (UC) by inhibiting abnormal inflammatory responses and promoting antioxidant capacity. DS can restore metabolic disorders and alleviate colonal inflammation by inhibiting PI3K/Akt signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

The effect and mechanism of Qingre Huashi formula in the treatment of chronic hepatitis B with Gan-dan-shi-Re syndrome: An integrated transcriptomic and targeted metabolomic analysis

Yiyu Lu, Chaoqun Zhao, Chengbao Wang, Hong Cai, Yuting Hu, Long Chen, Shanghai Yu, Huiming Zhu, Ping Liu, Wang Wan'e, Hua Zhang

Summary: This study aimed to explore the molecular basis of Gan-Dan-Shi-Re syndrome (GDSR) in chronic hepatitis B (CHB) and to investigate the mechanism of the Qingre Huashi (QRHS) formula in treating GDSR. Transcriptomics and metabolomics techniques were used to detect the transcriptome and metabolome of CHB patients with GDSR. Potential biomarkers and dysregulated metabolic pathways were identified. The QRHS formula was found to significantly improve clinical indexes and correct disturbed biomarkers.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Diuretic activity evaluation and chemical composition analysis of Hedyotis scandens extract from Mizoram, India, in rat models

Elizabeth Vanlalruati Ngamlai, R. B. Pradhan, P. C. Lalbiaknii, Vanlalhruaii Ralte, F. Lalnunmawia, P. C. Vanlalhluna, S. K. Mehta

Summary: Hedyotis scandens extract demonstrated significant diuretic effects and was found to be safe for consumption. This study confirms the traditional use of this plant as a diuretic in the Mizoram region. The GC-MS analysis identified several bioactive compounds, including phytol, which is associated with diuretic properties.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms

Houpan Song, Meng Xiong, Chang Yu, Baoping Ren, Meiqi Zhong, Shunhua Zhou, Qing Gao, Chen Ou, Xiaojuan Wang, Jing Lu, Meiyan Zeng, Xiong Cai, Qinghua Peng

Summary: In this study, the gastroprotective potential of Huang-Qi-Jian-Zhong-Tang (HQJZT) in a rat model of indomethacin-induced gastric ulcer was investigated. The results showed that HQJZT effectively protected the stomach from ulceration by suppressing gastric acid secretion, enhancing antioxidant defenses and blood flow, mitigating proinflammatory cytokines, and inhibiting the activation of NF-kappa B and STAT signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Revealing the mechanism of Zanthoxylum armatum DC. extract-induced liver injury in mice based on lipidomics

Nannan Yang, Jian Zhang, Jiafu Guo, Qiwen Xiang, Yan Huang, Jiayu Wen, Qiuyan Liu, Tingting Hu, Yan Chen, Chaolong Rao

Summary: This study aimed to investigate the potential hepatotoxic mechanism of Z. armatum by analyzing hepatic lipid levels, lipid metabolites and metabolic pathways using lipidomics.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Annickia affinis (Exell) Versteegh & Sosef methanol stem bark extract, potent fractions and isolated Berberine alkaloid target both blood and liver stages of malaria parasites

Nekpen Erhunse, Surekha Kumari, Pooja Anmol, Pooja Singh, Ehimwenma Sheena Omoregie, Agam Prasad Singh, Upendra Sharma, Dinkar Sahal

Summary: This study identified the specialized metabolites responsible for the antiplasmodial activity of Annickia affinis, finding that protoberberine alkaloids isolated from the plant showed excellent antiplasmodial activity, particularly against the blood-stage malaria parasite. Additionally, these compounds also exhibited promising activity against the liver-stage malaria parasite.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury

Annu Bangar, Heena Khan, Amarjot Kaur, Kamal Dua, Thakur Gurjeet Singh

Summary: This study aims to gather and highlight the traditional understanding of therapeutic plants and their efficacy in cerebral ischemia-reperfusion injury. It also provides a concise summary and explanation of herbal drugs and their role in improving neuroplasticity. The review of pharmacological activity of polyherbal formulations produced from some of the frequently referenced botanicals for the treatment of cerebral ischemia damage was conducted.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

The anti-liver fibrosis effect of Tibetan medicine (Qiwei Tiexie capsule) is related to the inhibition of NLRP3 inflammasome activation in vivo and in vitro

Shanshan Wang, Fei Ye, Qingjia Ren, Shengnan Sun, Weina Xia, Zhuwei Wang, Haolin Guo, Han Li, Shujing Zhang, Scott Lowe, Meng Chen, Qinghong Du, Weihong Li

Summary: This study confirms the significant anti-liver fibrosis effect of Tibetan medicine QWTX and reveals its mechanism through the inhibition of NLRP3 inflammasome activation.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Essential oil from Ligusticum chuanxiong Hort. Alleviates lipopolysaccharide-induced neuroinflammation: Integrating network pharmacology and molecular mechanism evaluation

Jing Zuo, Tian-Hao Zhang, Cheng Peng, Bin-Jie Xu, Ou Dai, Yan Lu, Qin-Mei Zhou, Liang Xiong

Summary: Chuanxiong essential oil alleviates neuroinflammation through the NF-kappa B signaling pathway, providing a theoretical foundation for the clinical application of Chuanxiong essential oil in migraine treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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