Review
Plant Sciences
Lirong Wang, Shujing Chen, Suyi Liu, Abdulmumin Muhammad Biu, Yuli Han, Xingyue Jin, Chunxiao Liang, Yang Liu, Jin Li, Shiming Fang, Yanxu Chang
Summary: This review comprehensively summarizes the research progress in botany, traditional medical use, processing method, phytochemistry, pharmacological activity, quality control, pharmacokinetics, and toxicology of Gardeniae Fructus (GF), providing a scientific basis for its rational application and future research. More than 215 compounds have been isolated and identified from GF, with various pharmacological effects. Improved processing methods can alleviate side effects and toxic reactions. GF has a wide range of potential applications in treating diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chien-Yun Hsiang, Hsin-Yi Lo, Guan-Ling Lu, Pei-Yung Liao, Tin-Yun Ho
Summary: This study identified a novel heat-stable ACE inhibitory peptide, CS-1, in corn silk extract. CS-1 interacted with the zinc-binding motif of ACE, leading to the inhibition of ACE activity and a subsequent decrease in blood pressure in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiaqi Fu, Yuqin Liang, Donghua Yu, Yu Wang, Fang Lu, Shumin Liu
Summary: This study aimed to investigate the role of Radix Saposhnikoviae (RS), which is designed as a guide drug for Huangqi Chifeng decoction (HQCF), in improving lipid metabolism in atherosclerosis (AS) patients. The results showed that HQCF can reduce atherosclerotic lesions in the aorta and lipid accumulation in the liver, potentially by activating the AMPK pathway to regulate lipid transport and metabolic function. These effects can be attributed to the guidance and synergism of RS.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kathrin Ganz, Cesar Morales-Molino, Erika Gobet, Dmytro Kiosak, Nadezhda Kotova, Jacqueline van Leeuwen, Sergey Makhortykh, Christoph Schworer, Willy Tinner
Summary: This study presents a palaeoecological reinvestigation from the Kardashynskyi mire in southern Ukraine, reconstructing the vegetation dynamics, fire history, and land use for the past 8300 years. The results show that both climate and human activities have driven the vegetation changes, and the remaining special vegetation types are severely threatened under current conditions.
REVIEW OF PALAEOBOTANY AND PALYNOLOGY
(2024)
Article
Plant Sciences
Seyedeh Fatemeh Borghei, Ali Azizi, Seyyed Hossein Pourhosseini, Marziye Rahimi-Rizi
Summary: This study assessed the morphological traits, essential oil content, and genetic diversity of seven populations of Dracocephalum moldavica in Northwest Iran. Significant variations in morphological traits and essential oil composition were observed among populations, suggesting the potential for selective breeding programs. High genetic diversity was also observed, revealing distinct genetic clusters among populations.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2024)
Article
Biochemistry & Molecular Biology
Cong Guan, Wei Li, Guoliang Wang, Ruimei Yang, Jinglei Zhang, Jinhong Zhang, Bo Wu, Run Gao, Chunlin Jia
Summary: This study characterized the expression profiles of mRNAs and ncRNAs in switchgrass under drought stress. The up-regulated mRNAs were enriched in starch and sucrose metabolism pathway, while the differentially expressed lncRNAs potentially regulated protein-coding genes. The study also constructed regulatory networks and validated the functionality of the target gene PvSS4 in enhancing drought tolerance.
Article
Plant Sciences
Murat Ozdemir, Veranur Gungor, Mehmet Melikoglu, Coskun Aydiner
Summary: This study aimed to identify the appropriate extraction solvent and investigate the effect of various extraction conditions on the content of phenolic compounds in galangal extracts. The study found that ethanol/water (50%) was the most suitable solvent for extraction. The optimal extraction conditions were determined to be temperature of 25 degrees C, extraction time of 20 min, ethanol/water concentration of 50%, solvent/solid ratio of 10, ultrasound power of 50% and ultrasound cycle of 5. The study also revealed significant correlations between the content of phenolic compounds and antioxidant activity in galangal extracts.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Hanane Oublid, Mohamed Ait Hamza, Hassan Boubaker, Abdellah El Hamdaoui, Mohamed El Yaagoubi, Imane Abbad, Mina El Moutaouakil, Fouad Msanda
Summary: This study assessed the environmental requirements for the germination of Thymus satureioides and found that dry heat treatment improved germination parameters, while salt and water stress inhibited germination.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Pei Liu, Xiao-ying Tan, Huang-qin Zhang, Ke-lei Su, Er-xin Shang, Qing-ling Xiao, Sheng Guo, Jin-ao Duan
Summary: The study aims to investigate the optimal combination ratio of Trichosanthis Pericarpium - Trichosanthis Radix (TP-TR) and its anti-inflammatory active ingredients in the treatment of cough. Through zebrafish and mouse models, the study found that TP-TR at a ratio of 1:2 exhibited superior anti-inflammatory effects and identified several anti-inflammatory active ingredients. Furthermore, network pharmacology and intestinal flora sequencing validated the anti-inflammatory components of TP-TR and revealed its potential regulatory effects on gut microbes.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Song-Yi Lin, Chia-Lin Chang, Kuo-Tong Liou, Yao-Kai Kao, Yea-Hwey Wang, Cher-Chia Chang, Terry B. J. Kuo, Hung-Tse Huang, Cheryl C. H. Yang, Chia-Ching Liaw, Yuh-Chiang Shen
Summary: This study investigates the molecular mechanisms of the action of Achyranthes aspera using an integrative approach and aims to provide a comprehensive understanding of its protective effects and underlying signaling networks.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chang-chang Wang, Le Kang, Bei-lei Zuo, Xin Peng, Hong-wei Li, Ning Zhou, Kai Li
Summary: The study elucidated the mechanisms of action of GF&JF against chronic bronchitis through network pharmacology and experimental verification, showing that the combination effectively inhibits the inflammatory response and regulates the expression of the AGE-RAGE signaling pathway. Quercetin and stigmasterol are identified as the main active ingredients in the treatment of chronic bronchitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
De Zhao Kong, Peng Sun, Yi Lu, Ye Yang, Dong Yu Min, Si Cheng Zheng, Yi Yang, Zhe Zhang, Guan Lin Yang, Jun Wen Jiang
Summary: Yi Mai granule (YMG) has therapeutic effects in improving mitochondrial autophagy and alleviating cardiovascular disease possibly by regulating the Pink1-Mfn2-Parkin pathway via miRNA-125a-5p and regulating proinflammatory factors, vasoconstriction cytokines, and blood lipids to alleviate atherosclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo
Summary: BJP-IVb suppressed iron overload-mediated dopaminergic neuron ferroptosis and improved motor dysfunctions in PD, providing a potential drug candidate for the treatment of PD.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Fanghao Zheng, Tingting Zhao, Zhenyang Liu
Summary: This study aimed to investigate the acute and long-term toxicity of Shang-Ke-Huang-Shui lotion (SKHS) in rabbits using topical administration. The results suggest that topical administration of SKHS can be considered relatively safe and did not reveal any severe toxicity or side effects in this study.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Peng Wang, YiQing Shen, Anatol Manaenko, FangYu Liu, WenSong Yang, ZhongSong Xiao, PeiZheng Li, YuXin Ran, RuoZhi Dang, Yong He, QingYuan Wu, Peng Xie, Qi Li
Summary: This study investigated the potential mechanism of Tenuigenin (TNG) in treating intracerebral hemorrhage (ICH) using animal experiments and proteomics analysis. The results showed that TNG could improve neurological functions, reduce cerebral edema and hematoma volume in ICH. The therapeutic effects of TNG on ICH were found to be closely associated with the complement system.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Sheng Zhang, Xianwei Zhang, Jiayin Du, Wei Wang, Xitian Pi
Summary: The study aims to develop an AI framework to classify multi-target meridians through the topological structure of phytochemicals. A total of 354 anti-cancer herbs, their corresponding TCM meridians and 5471 ingredient compounds were collected for analysis. A deep learning hybrid model named GRMC consisting of graph convolutional network (GCN) and recurrent neural network (RNN) was employed to generate the meridian multi-label sequences based on molecular graph. The proposed method outperforms several comparison methods and provides a basis for understanding the molecular scientific evidence of TCM meridians.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Xinyue Liu, Lele Chen, Peng Sun, Zhaoshuang Zhan, Jiafeng Wang
Summary: Guizhi Fuling Formulation (GF), a traditional Chinese medicine prescription, has significant value in the treatment of gynecological diseases and tumors. However, research on GF still faces challenges in terms of quality control, pharmacological and pharmacokinetic processes, and clinical safety.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
