Physiology

Article Physiology

A Methodological Comparison of Protocols and Analytical Techniques to Assess the Outcome Measures of Submaximal Fitness Tests

Tzlil Shushan, Ric Lovell, Shaun J. McLaren, Steve Barrett, Martin Buchheit, Tannath J. Scott, Dean Norris

Summary: This study examined the test-retest reliability of submaximal fitness test (SMFT) outcome measures derived from different protocols and analytical techniques. The results showed that exercise heart rate, vertical PlayerLoad, and contact time had the highest degrees of reliability, regardless of the SMFT protocol or analytical approach.

INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE (2023)

Article Neurosciences

Oscillatory vs. non-oscillatory subthalamic beta activity in Parkinson's disease

Jesus Pardo-Valencia, Carla Fernandez-Garcia, Fernando Alonso-Frech, Guglielmo Foffani

Summary: Parkinson's disease is characterized by exaggerated beta activity in the cortico-basal ganglia motor loops. This study investigates the relative contribution, dopamine dependency, and clinical correlations of oscillatory vs. non-oscillatory beta activity. The results suggest that the oscillatory component of beta activity is dopamine dependent and may play a role in the pathophysiology and progression of Parkinson's disease.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

Review Nutrition & Dietetics

Is low-volume high-intensity interval training a time-efficient strategy to improve cardiometabolic health and body composition? A meta-analysis

Mingyue Yin, Hansen Li, Mingyang Bai, Hengxian Liu, Zhili Chen, Jianfeng Deng, Shengji Deng, Chuan Meng, Niels B. J. Vollaard, Jonathan P. Little, Yongming Li

Summary: The present meta-analysis examined the effects of low-volume high-intensity interval training (LV-HIIT) on cardiometabolic health and body composition. The results showed that LV-HIIT can improve cardiorespiratory fitness, lower blood pressure, and reduce fat mass, with no significant differences compared to moderate-intensity continuous training and high-volume HIIT.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2023)

Article Nutrition & Dietetics

Associations between cooking skills, cooking with processed foods, and health: a cross-sectional study

Melissa A. Fernandez, Katerina Maximova, Jayne A. Fulkerson, Kim D. Raine

Summary: This study investigated the impact of cooking skills and cooking with processed foods on health and diet outcomes. The findings suggest that individuals with poor cooking skills are less likely to have adequate fruit and vegetable intake and are more likely to have obesity. It also indicates that in addition to improving cooking skills, reducing the use of processed foods is important for promoting better health and diet outcomes.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2023)

Article Cell Biology

Changes in the fecal gut microbiome of home healthcare patients with disabilities through consumption of malted rice amazake

Suzumi Kageyama, Rikako Inoue, Jonguk Park, Koji Hosomi, Hitomi Yumioka, Tomo Suka, Kazuaki Teramoto, A. Yasmin Syauki, Miki Doi, Haruka Sakaue, Miyuu Miyake, Kenji Mizuguchi, Jun Kunisawa, Yasuyuki Irie

Summary: This study investigated the changes in the gut microbiome of in-home healthcare patients after consuming MR-Amazake. The results showed that MR-Amazake alleviated constipation symptoms and caused significant changes in the gut microbiome in some patients, primarily associated with Bifidobacterium. These changes were observed only during MR-Amazake intake, and the gut microbiome returned to its original state after discontinuation. Continuous consumption of MR-Amazake is necessary to sustain these changes.

PHYSIOLOGICAL GENOMICS (2023)

Article Behavioral Sciences

A formative journal for a formative career: a personal recollection of how JCPA has inspired and guided my research life

Eric J. Warrant

Summary: This article describes the author's fateful decision and advice from a professor that shaped their career, as well as the crucial role played by the Journal of Comparative Physiology A.

JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY (2023)

Article Nutrition & Dietetics

Lack of change in blood pressure and arterial stiffness after high dairy intake in hyperinsulinemic subjects: a cross-over randomized controlled trial

Hana Arghavani, Sarah O'Connor, Catherine Fortier, Iwona Rudkowska

Summary: For hyperinsulinemic subjects, consuming adequate or high dairy intake did not have an effect on blood pressure or arterial stiffness after 6 weeks.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2023)

Article Biology

Children and chrono-exercise: Timing of physical activity on school and weekend days depends on sex and obesity status

Ryan E. R. Reid, Melanie Henderson, Tracie A. Barnett, Lisa Kakinami, Angelo Tremblay, Marie-Eve Mathieu

Summary: This study describes the timing of physical activity for children on school and weekend days and explores the differences in timing across sex and body mass index categories. The results suggest that normal weight boys are more active than boys with obesity, while girls' physical activity levels are similar across different BMI categories. Additionally, there are timing differences in physical activity on school days and weekends.

CHRONOBIOLOGY INTERNATIONAL (2023)

Article Psychology, Biological

Dynamic alpha power modulations and slow negative potentials track natural shifts of spatio-temporal attention

Charline Peylo, Carola Romberg-Taylor, Larissa Behnke, Paul Sauseng

Summary: This study investigated the characteristics of spatio-temporal attention using electroencephalography. The results showed that dynamic alpha power modulations and slow negative potentials were correlated with subsequent memory performance, indicating a preferential allocation of attention to task-relevant locations and time points. This study provides important insights into the key signatures of spatio-temporal top-down attention.

PSYCHOPHYSIOLOGY (2023)

Review Cell Biology

Fibrosis in burns: an overview of mechanisms and therapies

Sara Faour, Mahmoud Farahat, Ayesha Aijaz, Marc G. Jeschke

Summary: The development of scars after burns is a common and significant healthcare challenge that affects the lives of many patients. This review discusses the different forms of fibrosis that occur after burns, highlighting the impact of burn severity on scar development, and exploring the systemic response induced by burns and the role of fibroblasts in skin healing.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2023)

Article Cell Biology

Single-cell reconstruction and mutation enrichment analysis identifies dysregulated cardiomyocyte and endothelial cells in congenital heart disease

Richa Tambi, Binte Zehra, Sharon Nandkishore, Shermin Sharafat, Faiza Kader, Nasna Nassir, Nesrin Mohamed, Awab Ahmed, Reem Abdel Hameid, Samah Alasrawi, Martina Brueckner, Wolfgang M. Kuebler, Wendy K. Chung, Alawi Alsheikh-Ali, Roberto M. Di Donato, Mohammed Uddin, Bakhrom K. Berdiev

Summary: This study conducted a comprehensive meta-analysis to identify the most frequently mutated genes in congenital heart disease (CHD) and revealed the heterogeneity of CHD genes. It also identified cardiomyocytes and endocardial cells as major cell types related to CHD.

PHYSIOLOGICAL GENOMICS (2023)

Review Cell Biology

Decoding fibrosis in the human central nervous system

Daniel Holl, Christian Goeritz

Summary: Fibrotic scarring is a common response to various lesions in the central nervous system, where perivascular cells give rise to stromal fibroblasts. This review summarizes the current understanding of fibrotic scar formation and provides an evaluation of perivascular cells using human single-cell gene expression datasets.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2023)

Article Psychology, Biological

The power of personal control: Task choice attenuates the effect of implicit sadness on sympathetically mediated cardiac response

David Framorando, Johanna R. Falk, Peter M. Gollwitzer, Gabriele Oettingen, Guido H. E. Gendolla

Summary: Implicitly processed facial expressions of emotions have been found to influence cardiovascular reactivity. This study demonstrates that personal choice in action can immunize against the implicit affective influences on effort.

PSYCHOPHYSIOLOGY (2023)

Article Physiology

ERG potassium channels and T-type calcium channels contribute to the pacemaker and atrioventricular conduction in zebrafish larvae

Jussep Salgado-Almario, Yillcer Molina, Manuel Vicente, Antonio Martinez-Sielva, Raul Rodriguez-Garcia, Pierre Vincent, Beatriz Domingo, Juan Llopis

Summary: This study investigates the contributions of ERG channels and TTCCs to the pacemaker and atrioventricular conduction in zebrafish larvae and explores the mechanisms causing atrioventricular block. The zebrafish lines expressing Ca2+ biosensors in the heart provide a valuable model for studying physiological feedback mechanisms and complex arrhythmias.

ACTA PHYSIOLOGICA (2023)

Review Physiology

Myocardial steatosis across the spectrum of human health and disease

Andrew P. Oneglia, Lidia S. Szczepaniak, Vlad G. Zaha, Michael D. Nelson

Summary: This brief review summarizes recent observations on the impact of myocardial steatosis on cardiac morphology and function. Research suggests that myocardial steatosis leads to adverse cardiac remodelling and left ventricular dysfunction. The use of 1H magnetic resonance spectroscopy for clinical translation in this field is discussed.

EXPERIMENTAL PHYSIOLOGY (2023)

Article Physiology

FTO and MC4R polymorphisms, and selected pre-, peri- and postnatal factors as determinants of body mass index and fatness in children: a thorough analysis of the associations

Ewa Bryl, Paula Szczesniewska, Agata Dutkiewicz, Agnieszka Slopien, Monika Dmitrzak-Weglarz, Tomasz Hanc

Summary: The contribution of environmental factors is more strongly related to changes in body composition than genetic ones. Additionally, the presence of the risk allele combined with unfavorable environmental factors like ACEs leads to visible interaction effects, resulting in increased BMI z scores and FMI z scores in children.

JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY (2023)

Review Pediatrics

Youths Are Less Susceptible to Exercise-Induced Muscle Damage Than Adults: A Systematic Review With Meta-Analysis

John F. T. Fernandes, Lawrence D. Hayes, Amelia F. Dingley, Sylvia Moeskops, Jon L. Oliver, Jorge Arede, Craig Twist, Laura J. Wilson

Summary: This meta-analysis compared the peak changes in indirect markers of exercise-induced muscle damage (EIMD) in youths versus adults and found that the magnitude of EIMD is substantially less in youths, especially in the upper limbs for muscle soreness. These findings are important for guiding the potential impact of EIMD on youth athletes during training.

PEDIATRIC EXERCISE SCIENCE (2023)

Review Neurosciences

Mountains of research: Where and whom high-altitude physiology has overlooked

Joshua C. Tremblay

Summary: High altitude is a natural environment for studying human acclimatization and adaptation. However, there is a mismatch between high-altitude populations and the countries where high-altitude research has been conducted. The majority of research has focused on lowlanders visiting high altitude rather than high-altitude natives, and there is under-representation of females in high-altitude physiology research.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

Article Physiology

The reproducibility of dendritic cell and T cell counts to a 30-min high-intensity cycling protocol as a tool to highlight overtraining

Carla Baker, Jessica Piasecki, John A. Hunt, John Hough

Summary: An exercise stress test was developed to induce reproducible changes in dendritic cell and T cell counts, providing a valuable tool to examine immune cell counts as potential biomarkers in highlighting the negative states of overtraining.

EXPERIMENTAL PHYSIOLOGY (2023)

Article Physiology

State-independent inhibition of the oncogenic Kv10.1 channel by desethylamiodarone, a comparison with amiodarone

F. Gomez-Lagunas, C. Barriga-Montoya, J. P. Pardo

Summary: Kv10.1 is a voltage-dependent K channel associated with human cancers, and its structure-function properties are not well understood. In this study, we examined the interaction between the antiarrhythmic drug desethylamiodarone (desAd) and Kv10.1. We found that desAd binds to both closed and open channels, with most inhibition occurring from the open state. The affinity of desAd is approximately five times smaller than that of amiodarone. Additionally, desAd does not inhibit the Kv10.1 Cole-Moore shift, suggesting that a hydrophobic interaction between amiodarone and Kv10.1 is involved in the inhibition of the Cole-Moore shift, which is lost with desAd.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2023)