Article
Physiology
Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama
Summary: Respiratory muscle endurance training has beneficial effects on whole-body endurance performance. A novel high-intensity interval (HII) protocol is found to enhance the efficacy of respiratory muscle training programs.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jaakko Haverinen, Ahmed Badr, Markus Eskelinen, Matti Vornanen
Summary: The acclimatization of certain ectothermic vertebrates to winter conditions involves reduced energy consumption, achieved through decreased movement activity, depression of cellular functions, or switching to anaerobic energy production. This study on crucian carp showed that winter-acclimatized fish exhibited lower metabolic rates and a shift to anaerobic energy production during anoxia. Winter dormancy in crucian carp is achieved through active reduction of energy consumption, a slowed metabolic rate, and a direct response to oxygen absence.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Obstetrics & Gynecology
Hang Chen, Feng Jiang, Wanlin Chen, Ying Feng, Shali Chen, Jiajun Miao, Cuicui Jiao, Xinzhong Chen
Summary: This study investigates the use of a novel parameter called falling scaled slope (FSS) based on photoplethysmographic pulse waves (PPGW) to diagnose preeclampsia (PE). The results show that FSS outperforms previous parameters in distinguishing PE, with an AUC value of 0.924, a threshold of 0.498, a sensitivity of 84.1%, and a specificity of 89.2%. Additionally, the use of machine learning algorithm for data analysis has advantages over conventional statistical methods, as indicated by the AUC values of 0.878 and 0.749, respectively.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Ghasem Azizi-Tabesh, Hossein Sadeghi, Arezoo Farhadi, Mohammad Foad Heidari, Aghdas Safari, Mehdi Shakouri Khomartash, Javad Behroozi, Saeid Doaei, Maryam Gholamalizadeh
Summary: This study aimed to investigate the possible association between FTO gene rs9939609 and the risk of preeclampsia (PE) in Iranian pregnant women. The results showed that pregnant women carrying the AA genotype had a significantly reduced risk of PE. Therefore, the rs9939609 polymorphism in the FTO gene may play a protective role against PE.
HYPERTENSION IN PREGNANCY
(2023)
Review
Obstetrics & Gynecology
Alice Tassi, Alessia Sala, Ilaria Mazzera, Stefano Restaino, Giuseppe Vizzielli, Lorenza Driul
Summary: Hypertensive pregnancy disorders (HDP) affect 10% of pregnancies and increase the future risk of heart disease, chronic hypertension, kidney dysfunction, diabetes, and thromboembolism. The mechanisms are not well understood, but endothelial dysfunction, pro-inflammatory and procoagulant states seem to persist in women with a history of preeclampsia. The number and severity of complications differ according to the type of HDP. Lifestyle modifications and long-term follow-up are essential for reducing the risk of future diseases.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Sakurako Mishima, Takashi Mitsui, Kazumasa Tani, Jota Maki, Eriko Eto, Kei Hayata, Yosuke Washio, Junko Yoshimoto, Hirokazu Tsukahara, Hisashi Masuyama
Summary: This study aims to investigate the incidence and risk factors of small-for-gestational age (SGA) short stature at 2 and 3 years of age in SGA offspring born to women with hypertensive disorders of pregnancy (HDP). The results showed that 41.2% of the offspring were diagnosed with SGA short stature, and prematurity before 32 weeks of gestation was the most significant factor for catch-up growth failure. Therefore, the incidence of SGA short stature is high in SGA offspring born to women with HDP, and prematurity is the main risk factor.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Sha Su, Linlin Zhong, Shijin Huang, Lingjie Deng, Lihong Pang
Summary: This study investigated the role of the miR-494/SIRT1 axis in preeclampsia (PE) and found that SIRT1 expression was decreased and miR-494 expression was increased in PE patients. Premature placental aging was observed in PE patients. Experimental validation confirmed the targeting relationship between miR-494 and SIRT1. Overexpression of miR-494 resulted in cell senescence, impaired migration, decreased ATP synthesis, increased ROS levels, and upregulated expression of inflammatory molecules, while overexpression of SIRT1 partially reversed these effects.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Niraj N. N. Mahajan, Shweta Kesarwani, Padmaja Kumbhar, Periyasamy Kuppusamy, Madhura Pophalkar, Pratiksha Thamke, Ruchi Asawa, Saumya Sharan, Smita D. Mahale, Rahul K. Gajbhiye
Summary: This study aims to estimate the incidence and risk of early and late-onset preeclampsia in pregnant women with COVID-19. The results showed that pregnant women with symptomatic COVID-19 had a higher risk of early onset preeclampsia compared to asymptomatic women, with a risk eight times higher.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Lasse Gronningsaeter, Mette-Elise Estensen, Helge Skulstad, Eldrid Langesaeter, Elisabeth Edvardsen
Summary: This study aimed to objectively study cardiorespiratory fitness and physical activity, and to evaluate the limiting factors of exercise intolerance after severe pre-eclampsia. The results showed significantly lower cardiorespiratory fitness and physical activity levels in patients who had severe pre-eclampsia. In addition, one third of the patients had cardiovascular limitations, highlighting the need for clinical follow-up and exercise interventions.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Timothy Gesner, Joshua Fogel, Lennox Bryson
Summary: This study examined the use of blood pressure medication in preeclampsia patients and found that low-dose medication was associated with increased risk of readmission. It is recommended that clinicians consider the potential risk of readmission when reducing the dose of blood pressure medication.
HYPERTENSION IN PREGNANCY
(2023)
Review
Obstetrics & Gynecology
Minghui Ou, Futao Zhang, Shichao Cui, Shibo Zhao, Yan Yu
Summary: This study compared the efficacy of oral nifedipine and intravenous labetalol in the treatment of acute severe hypertension in pregnancy. The results showed no difference in systolic blood pressure, diastolic blood pressure, and adverse events between the two drugs. However, oral nifedipine achieved the target blood pressure faster and required a lower number of doses.
HYPERTENSION IN PREGNANCY
(2023)
Review
Obstetrics & Gynecology
Petra M. van Baar, Jeske M. Bij M. de Weg, Eibert A. ten Hove, Linda J. Schoonmade, Lidewij van de Mheen, Eva Pajkrt, Christianne J. M. de Groot, Marjon A. de Boer
Summary: This systematic review found that multifetal pregnancy reduction (MFPR) from triplet to twin is associated with a lower risk of hypertensive disorders of pregnancy (HDP) compared to ongoing triplets. The risk of HDP is also decreased after MFPR from higher-order to twin pregnancies. These findings can inform the decision-making process of MFPR by considering individual risk factors of HDP.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Hid Felizardo Cordero-Franco, Ana Maria Salinas-Martinez, Luis Angel Garza-de Hoyos, Sofia Denisse Gonzalez-Rueda, Joaquin Dario Trevino Baez, Francisco Javier de la Garza
Summary: This study found no association between ABO blood group and preeclampsia in Mexican women, based on a case-control study including patients with and without preeclampsia/eclampsia.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Elizabeth Fronek, Summer Martins, Stephen Contag
Summary: This retrospective study included 4,702,468 pregnancies to estimate the prevalence of hypertensive disorder of pregnancy (HDP) at term. The study found that the rate of HDP increased from 4.5% in 2014 to 6.0% in 2018. HDP was more common among black individuals, obese individuals, those with gestational or pregestational diabetes. HDP was associated with increased risks for transfusion, intensive care unit admission, and unplanned hysterectomy. The study highlights the increased risks for maternal and neonatal complications related to the development of HDP at or beyond 39 weeks among nulliparous women.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Rui Ma, Liping Huang, Yanmin Wang, Tingting Zhao, Shi Chen, Yingdong He
Summary: This retrospective study describes the variations in manifestations and outcomes of hypertensive disorders in pregnancy (HDPs) among different regions in China. It suggests that region-specific perinatal management guidelines should be developed to improve perinatal health care and reduce the incidence of HDP.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
D. Aoulad Fares, R. E. Wiegel, A. J. Eggink, J. B. J. van Meurs, S. P. Willemsen, A. H. J. Danser, R. P. M. Steegers-Theunissen
Summary: This study aimed to investigate the associations between maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation in the first trimester and telomere length (TL) in pregnancies conceived naturally and after IVF/ICSI. Renin, prorenin, and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA) in 145 pregnancies of the Rotterdam Periconception cohort. TL was measured using qPCR at 20 weeks GA. The results showed a significantly negative correlation between renin and TL, which was attenuated for prorenin and not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after IVF/ICSI compared to natural pregnancies.
Conclusion: The negative association between first-trimester maternal renin and maternal TL, as well as the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Sadia Mahmood, Amna Younus, Sammar Nathaniel, Hooria Younas
Summary: This study aimed to investigate the genetic association between MTHFR (A1298C) SNP and preeclampsia (PE) in Punjab, Pakistan. A sample of 80 pregnant women (40 healthy pregnant women and 40 with PE) was genotyped for MTHFR A1298C polymorphism using tetra-primer ARMS PCR. The AC genotype and C allele of MTHFR A1298C were found to be associated with decreased risk of PE.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Yueqi Li, Jen Jen Chang, Ruikun Zuo, Hong Xian, Darcell Scharff
Summary: This study investigates the individual and joint effects of hypertension and depression during pregnancy on infant birth outcomes. The results show that when both hypertension and depression are present during pregnancy, the risks of preterm birth and low birth weight are increased, although lower than the expected joint risk effect.
HYPERTENSION IN PREGNANCY
(2023)
Article
Obstetrics & Gynecology
Zhenhua Cao, Li Ma, Wei Cai, Xiulong Niu, Ning Yang, Jianmei Ni, Xiaojing Wang, Maoti Wei, Shaobo Chen, Yuming Li
Summary: In this study, rs13210237 and rs13176432 were identified as potential novel genetic factors associated with preeclampsia susceptibility in the Chinese Han population. However, there was no association between the onset of preeclampsia and these genotypes.
HYPERTENSION IN PREGNANCY
(2023)
Review
Obstetrics & Gynecology
Min Yao, Lijie Chen, Puchao Peng, Zhiwei Zhong
Summary: This review pooled data from various studies and found a reduced risk of breast cancer in women with preeclampsia. However, the risk reduction is minimal and may not have significant clinical implications. The study is limited by high heterogeneity among studies and the lack of adjustment for all possible confounders.
HYPERTENSION IN PREGNANCY
(2023)
