Physiology

Article Biology

Cryopreserved red blood cells maintain allosteric control of oxygen binding when utilizing trehalose as a cryoprotectant

Charles A. Elder, Jensen S. Smith, Mustafa Almosawi, Ethan Mills, Brett R. Janis, Jonathan A. Kopechek, Willem F. Wolkers, Michael A. Menze

Summary: By using a biomimetics approach and trehalose as a cryoprotective agent, red blood cells can be successfully preserved for long-term storage without the need for time-consuming washing steps.

CRYOBIOLOGY (2024)

Article Biochemistry & Molecular Biology

Crustacean cardioactive peptide signaling system in the gastropod mollusk Pacific abalone

Sang Hyuck Lee, Mi Ae Kim, Young Chang Sohn

Summary: This study characterized the CCAP signaling system in Pacific abalone and revealed its relationship with the calcium/PKC and cAMP/PKA signal transduction pathways. It provides new insights into the evolutionary origins of the NPS and OT/VP signaling systems in protostomes.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2024)

Article Physiology

Cardiorespiratory coupling is associated with exercise capacity in athletes: A cross-sectional study

Raphael Martins de Abreu, Beatrice Cairo, Patricia Rehder-Santos, Claudio Donisete da Silva, Etore De Favari Signini, Juliana Cristina Milan-Mattos, Camila Akemi Sakaguchi, Aparecida Maria Catai, Alberto Porta

Summary: The purpose of this study was to determine the association between exercise capacity based on peak oxygen uptake (VO2peak) and resting cardiorespiratory coupling (CRC) levels. The results showed that resting CRC values were associated with exercise capacity in athletes but not in non-athletes.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Physiology

Low level CO2 supplementation maintains isocapnia and reveals ventilatory long-term facilitation in rats

Shawn Miller Jr, Edgar Juarez Lopez, Jessica M. L. Grittner, Brendan J. Dougherty

Summary: This study tested the impact of CO2 supplementation at different concentrations on ventilatory long-term facilitation (vLTF) in rats and found that 2% CO2 supplementation during and after acute, intermittent hypoxia (AIH) was sufficient to maintain isocapnia and induce significant vLTF.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Physiology

In-vivo optogenetic identification and electrophysiology of glycinergic neurons in pre-Botzinger complex of mice

Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Huelsmann

Summary: The preBo·tzinger Complex (preBo·tC) in the brainstem plays a critical role in generating respiratory rhythm. This study aimed to investigate the activity of inhibitory glycinergic neurons in the preBo·tC of anesthetized mice. Using juxtacellular recordings and optogenetic activation, the researchers were able to identify and characterize the activity pattern of these inhibitory neurons in relation to the breathing rhythm.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Physiology

Disinhibition does not play a role in endomorphin-2-induced changes in inspiratory motoneuron output produced by in vitro neonatal rat preparations

Stephen M. Johnson, Maia G. Gumnit, Sarah M. Johnson, Tracy L. Baker, Jyoti J. Watters

Summary: Low-level activation of mu-opioid receptors can increase the amplitude of inspiratory bursts in neonatal rat brainstem-spinal cord preparations. Endomorphin-2, an endogenous ligand for these receptors, was found to have similar effects. Disinhibition of inhibitory synaptic transmission may not be involved in the changes induced by endomorphin-2, and different mechanisms may underlie the increase in burst amplitude and decrease in burst frequency.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Physiology

Closed-loop cervical epidural stimulation partially restores ipsilesional diaphragm EMG after acute C2 hemisection

Alyssa R. Mickle, Jesus D. Penaloza-Aponte, Richard Coffey, Natale A. Hall, David Baekey, Erica A. Dale

Summary: Closed-loop epidural stimulation (CL-ES) can improve respiratory deficits caused by cervical spinal cord injury, restoring diaphragm activity and enhancing contralateral activity. This treatment has the potential to lead to lasting recovery and device independence.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Psychology, Biological

Frequent media multitasking modulates the temporal dynamics of resting-state electroencephalography networks

Jie Zhang, Xiyan Li, Shiwei Liu, Can Xu, Zhijie Zhang

Summary: In this study, electroencephalogram data was analyzed to compare the resting network activation between heavy media multitaskers (HMM) and light media multitaskers (LMM). The results showed that HMM had weaker activation in the attention network, but enhanced activation in the salience network. They also had an enhanced visual network and may feel less comfortable during resting-state periods. This suggests that chronic media multitasking leads to a bottom-up or stimulus-driven allocation of attention for HMM, while LMM use a top-down approach.

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2024)

Article Biochemistry & Molecular Biology

Cardiovascular physiology of embryonic neotropic cormorants (Phalacrocorax brasilianus)

James B. Cummins, Dane A. Crossley II

Summary: This study focuses on cardiovascular development in altricial bird species, which has been less studied compared to precocial species. The researchers investigated the cholinergic and adrenergic receptor mediated control of arterial blood pressure and heart rate in the neotropic cormorant. The findings suggest that both cholinergic and adrenergic tone play a role in cardiovascular regulation in embryonic birds.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2024)

Review Physiology

Physical exercise plays a role in rebalancing the bile acids of enterohepatic axis in non-alcoholic fatty liver disease

Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang

Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.

ACTA PHYSIOLOGICA (2024)

Article Biochemistry & Molecular Biology

Links between reproduction and immunity in two sympatric wild marine fishes

Maria Cruz Sueiro, Cynthia A. Awruch, Gustavo M. Somoza, Walter S. Svagelj, Maria G. Palacios

Summary: According to life-history theory, there might be different immunological strategies between reproductive and non-reproductive periods due to limited resources. Our study on two sympatric marine fish species, rockfish and sandperch, found that reproductive individuals showed lower immune function, but higher levels of natural antibodies in rockfish females, compared to their non-reproductive counterparts. On the other hand, reproductively active sandperch males showed lower levels of natural antibodies and higher neutrophil to lymphocyte ratio and spleen index compared to non-reproductive males. The study highlights the species-specific patterns of immunity and the potential influence of resource limitation and abiotic factors on immune trade-offs in fish.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2024)

Article Physiology

Effects of body postures on respiratory muscle force and coughing in healthy people

Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi

Summary: Body postures significantly influence respiratory muscle force, cough pressure, subjective ease of coughing, and pulmonary function. The 60-degree semi-recumbent posture and sitting posture show better results compared to the supine posture.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Biochemistry & Molecular Biology

Molecular cloning and tissue distribution of glucokinase and glucose-6-phosphatase catalytic subunit paralogs in largemouth bass Micropterus salmoides: Regulation by dietary starch levels and a glucose load

Ru Xia, Hong-Kang Liu, Xi-Feng Liu, Xin Deng, Chuan-Jie Qin, Yuan-Fa He, Shi-Mei Lin, Yong-Jun Chen

Summary: This study cloned the genes encoding glucokinase and glucose-6-phosphatase catalytic subunit in largemouth bass, revealing their distribution and transcriptional regulation. The results showed that the functions of G6pc and Gck in LMB were highly conserved in evolution, and the interconversion of glucose and G6P in the liver was well regulated at the transcript level under high starch diet, but a futile cycle was induced after a glucose load.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2024)

Article Physiology

Physiological responses during static apnoea efforts in elite and novice breath-hold divers before and after two weeks of dry apnoea training

Dimitrios I. Bourdas, Nickos D. Geladas

Summary: This study examined the effects of breath-hold training on the performance of novice and elite breath-hold divers. The results showed that breath-hold training significantly improved red blood cell concentration, hemoglobin oxygen saturation steady state duration, and breath-hold time in novice divers. Elite divers had better breath-hold performance and higher peak mean arterial pressure compared to novices. The study suggests that breath-hold training can enhance the performance of divers.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Physiology

Insights into exercise-induced rhinitis based on nasal aerodynamics induced by airway morphology

Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito

Summary: This study aimed to characterize the response of different nasal morphologies to airflow-related variables during rapid/deep inspiration. The results showed that notched nasal vestibules had higher resistance values and airflow velocities, while standard nasal vestibules had higher mucosal heat flux. Different nasal phenotypes may predispose individuals to exercise-induced rhinitis.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Physiology

Cough and swallow after laparotomy in anesthetized cats

Ivan Poliacek, Lukas Martvon, Michal Simera, Marcel Veternik, Jakub Misek, Lucia Cibulkova, Kimberly E. Iceman, Donald C. Bolser, Teresa Pitts

Summary: An animal model study evaluated the effects of an abdominal incision on cough and swallow, revealing that abdominal wall manipulations can increase pharyngeal muscle activity during swallow without affecting the cough reflex. Swallowing tended to occur more during the inspiratory phase. The results highlight the important role of abdominal wall sensory feedback in regulating swallow motor patterns.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)

Article Biochemistry & Molecular Biology

Daily thermal variability does not modify long-term gene expression relative to stable thermal environments: A case study of a tropical fish

Hanna Scheuffele, Erica V. Todd, John A. Donald, Timothy D. Clark

Summary: Global warming is causing an increase in extreme weather events, affecting ecosystems and the behavior of ectotherms. More research is needed to understand the impact of diurnal thermal variability and improve climate change predictions.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2024)

Article Psychology, Biological

Neural basis underlying the relation between internet addiction tendency and sleep quality: The intrinsic default-mode network connectivity pathways

Youling Bai, Jianguo Qu, Dan Li, Huazhan Yin

Summary: This study used resting-state functional connectivity analysis to investigate the neural pathways between internet addiction tendency and sleep quality, and found a positive correlation between internet addiction tendency and the strength of functional connectivity within the default-mode network. Furthermore, internet addiction tendency mediated the relationship between these functional couplings and sleep quality.

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2024)

Correction Physiology

The course of lung inflation alters the central pattern of tracheobronchial cough in cat - The evidence for volume feedback during cough (vol 229, pg 43, 2016)

Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2024)