Article
Peripheral Vascular Disease
D. Radovanovic, F. Muggli, M. Bianchetti, A. Gallino, G. Parati, P. M. Suter, R. Schoenenberger-Berzins, P. Erne, A. W. Schoenenberger
Summary: This study compared the use of OBPM, HBPM, and ABPM in individuals with elevated blood pressure. The findings showed that ABPM and HBPM are more accurate in confirming hypertension, while relying solely on OBPM may result in underdiagnosis and uncontrolled hypertension. For the younger working population, ABPM should be prioritized over HBPM for hypertension confirmation.
Article
Peripheral Vascular Disease
Tomas L. Bothe, Martin Hulpke-Wette, Boris Barbarics, Andreas Patzak, Niklas Pilz
Summary: This study aimed to assess the clinical validity of a cuff-less blood pressure measurement device in 24-hour measurements in children and adolescents. The results showed that the cuff-less device had a minor measurement deviation compared to the traditional cuff-based device and could alleviate discomfort and arousal reactions. This study encourages further research to promote the broad clinical application of cuff-less blood pressure measurement.
Review
Peripheral Vascular Disease
Jingjing Hu, Yidan Zhou
Summary: This meta-analysis of four randomized controlled trials involving 20,747 hypertensive patients suggested that intensive blood pressure lowering should be initiated as soon as possible for optimal control and prevention of left ventricular hypertrophy, especially in patients at high cardiovascular risk. However, caution is needed when treating hypertensive patients with existing left ventricular hypertrophy to systolic blood pressure targets below 130 mm Hg.
Article
Peripheral Vascular Disease
A. Jujic, C. Kenneback, M. Johansson, P. M. Nilsson, H. Holm
Summary: This study investigates the relationship between age and endothelial dysfunction (ED) in a large population-based cohort. The study finds that the proposed cut-off of RHI < 1.67 for prevalent ED may not be applicable to individuals under the age of 30, as young and healthy arteries may have limited ability to dilate post-occlusion, resulting in low RHI values that do not necessarily indicate true ED.
Article
Peripheral Vascular Disease
Henrik Wistrand, Teemu Niiranen, Niina E. Kaartinen, Ville L. Langen
Summary: This study found positive associations between urine sodium concentration and dietary salt intake with home blood pressure and hypertension, but these associations were not statistically significant after adjustments. This highlights the challenge of accurately estimating sodium intake in epidemiology.
Article
Peripheral Vascular Disease
Annabel Eide Ohldieck, Ester Kringeland, Helga Midtbo, Grethe S. Tell, Eva Gerdts
Summary: This study aimed to identify modifiable risk factors in early midlife associated with incident hypertension 26 years later in women and men. The results showed that high-normal blood pressure in midlife was a significantly stronger risk factor for the development of hypertension in women than in men during follow-up, independent of body mass index.
Review
Peripheral Vascular Disease
Isabella Sudano, Paolo Suter, Felix Beuschlein
Summary: The prevalence of secondary hypertension is 5-10% of hypertensive patients (lower in the whole population, higher in patients with therapy-resistant hypertension). Patient history, physical examination, and laboratory results are crucial for identifying suspected cases of secondary hypertension. Referral to specialist medical clarification is recommended after preliminary screening. Be vigilant for secondary hypertension in young patients, individuals without a family history of hypertension, those with late onset or worsening of previously well-controlled hypertension, and those with difficult-to-treat hypertension. Secondary hypertension is caused by a known and/or potentially treatable underlying disease. Despite the prevalence of primary hypertension accounting for 90-95% of cases, the prevalence of secondary hypertension is significantly higher in certain patient groups. Targeted diagnostics for identifying and treating secondary hypertension is of great importance as it can result in normalization or improvement of elevated blood pressure in many cases.
Article
Peripheral Vascular Disease
Ning Xia, Hao Wang, Lin Zhang, Xiao-Jun Fan, Xiu-Hong Nie
Summary: The study aims to investigate the association between decreased slow wave sleep (SWS) and elevated office blood pressure (BP) in non-hypertensive obstructive sleep apnea (OSA) patients. The results show that decreased SWS is associated with elevated office BP in non-hypertensive OSA patients.
Article
Peripheral Vascular Disease
Erika Kahonen, Satu Korpimaki, Markus Juonala, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Olli T. Raitakari, Mika Kivimaki, Jussi Vahtera
Summary: Limited data is available on the association between neighbourhood deprivation and arterial stiffening. This study found that neighbourhood deprivation in childhood and adulthood predicts arterial stiffness indicated by pulse wave velocity (PWV). These findings suggest that neighbourhood deprivation and low adulthood socioeconomic status are independent risk factors for increased arterial stiffness in adulthood.
Review
Peripheral Vascular Disease
Michal Pac, Lukasz Obrycki, Jan Koziej, Krzysztof Skoczynski, Anna Starnawska-Bojsza, Mieczyslaw Litwin
Summary: Arterial hypertension is a serious condition that can lead to increased cardiovascular risk and hypertension mediated organ damage (HMOD). Currently used methods of HMOD assessment include echocardiography, electrocardiography, eye fundus examination, evaluation of kidney function, and microalbuminuria. Recent studies also indicate cognitive impairment in hypertensive children. Assessment of HMOD in children and adolescents with arterial hypertension is important for decision-making process and long-term clinical outcomes monitoring.
Article
Pharmacology & Pharmacy
Yuehai Wang, Yuqiang Zhang, Yan Wang, Changpeng Zhai, Jie Gao, Guangyong Huang, Shengjun Ma
Summary: This case report describes a patient who was mistakenly diagnosed with ST-elevation acute myocardial infarction but actually had pulmonary embolism. The patient presented with chest pain and ST-elevation in multiple leads, along with other abnormal electrocardiographic findings. Multi-site pulmonary embolism can lead to a special type of myocardial infarction through various pathological mechanisms.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Xia Wu, Fei Yang, Lili Sun
Summary: This study evaluated the characteristics and influencing factors of computed tomography myocardial perfusion imaging (CT-MPI) in patients with left ventricular hypertrophy (LVH) caused by hypertension. The results showed that patients with LVH had lower myocardial blood flow but stable myocardial blood volume. In hypertensive patients, decreased myocardial blood flow was significantly correlated with increased left ventricular mass index.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Chen Dai, Meng Tan, Xiaopan Meng, Jian Dong, Yuanming Zhang
Summary: This study examined the roles of Kv1.3 and KCa3.1 potassium channels in peripheral blood T lymphocytes of Kazakh hypertensive patients. The gene silencing of Kv1.3 and KCa3.1 inhibited T cell proliferation and decreased the expression levels of NFAT, IL-6, and IFN-gamma. The activation of these potassium channels may contribute to micro-inflammatory responses and the development of hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Juan Deng, Yuan Hu, Yindi Zhang, Fadong Yu
Summary: In this study, it was found that ghrelin can improve endothelial function and lower blood pressure in Ang II-induced hypertensive mice. This protective effect is likely achieved through the reduction of oxidative stress, the increase in NO production, and the activation of the AMPK signaling pathway.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Xiaoqing Dai, Huimin Zhang, Bin Wu, Wenwen Ning, Yijie Chen, Yiming Chen
Summary: A retrospective cohort study was conducted to analyze the data of 22,574 pregnant women, and it was found that elevated maternal serum AFP in the second trimester is associated with ischemic placental disease (IPD). Elevated maternal serum AFP levels are associated with adverse maternal pregnancy outcomes such as IUGR, PROM, and placenta previa.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Yan Luo, Yan Tang, Wenchao Huang, Shiqiang Xiong, Yu Long, Hanxiong Liu
Summary: The clinical risk factors associated with late recurrence in patients with non-valvular atrial fibrillation (AF) undergoing radiofrequency catheter ablation (RFCA) remain unknown. The Age, creatinine, and ejection fraction (ACEF) score is a useful risk score for cardiovascular morbidity and mortality. Pre-ablation ACEF score is a valuable risk score for assessing late AF recurrence after RFCA in patients with NVAF, along with left atrial diameter (LAD).
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Tingchun Wu, Yuhua Zheng, Qianqian Huang, Shui Tian
Summary: Paeonol, a phenolic compound extracted from Moutan Cortex, has been found to reduce oxidative stress and lower blood pressure in spontaneous hypertension rats (SHRs) by improving the functions of angiotensin II type 1 receptors (AT(1)R) in the kidney and mesenteric artery.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Haiyan Qian, Zebo Zhang, Zhenbo Tao, Yanqing Xie, Yueqi Yin, Wenming He, Lina Zhang
Summary: Three circRNAs were found to be associated with carotid plaque, suggesting their potential as biomarkers for essential hypertension with carotid plaque.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Shengkai Xu, Yishan Ge, Xuebin Wang, Wei Yin, Xiaoqing Zhu, Jie Wang, Shigang Qiao
Summary: Endothelial pyroptosis is a pathological mechanism of atherosclerosis, and circular RNA (circRNA) plays a vital role in this progression. This study aimed to investigate the role of circ-USP9x in regulating pyroptosis of endothelial cells and its molecular mechanism in atherosclerosis development. The results showed that circ-USP9x was upregulated in atherosclerosis and ox-LDL-treated HUVECs. Knockdown of circ-USP9x suppressed ox-LDL-induced pyroptosis in HUVECs. Mechanistically, circ-USP9x interacted with EIF4A3 in the cytoplasm, which then affected the stability of GSDMD. Overexpression of EIF4A3 rescued cell pyroptosis induced by circ-USP9x depletion. In conclusion, circ-USP9x enhances GSDMD stability by interacting with EIF4A3 and promotes ox-LDL-induced pyroptosis in HUVECs, suggesting its potential as a therapeutic target for atherosclerosis.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Wen Jiang, Yuxiang Zhang, Wei Zhang, Xiaomei Pan, Jieyu Liu, Qiang Chen, Junhui Chen
Summary: Acute myocardial infarction (AMI) is the leading cause of death worldwide. Ischemia-reperfusion (I/R) injury is a common contributor to AMI. Hirsutine has been shown to protect cardiomyocytes against hypoxic injury. In this study, hirsutine pre-treatment improved myocardial I/R injury by reducing infarct size, enhancing cardiac function, inhibiting cell apoptosis, and balancing mitochondrial dynamics. Mechanistically, hirsutine inhibited mitochondrial-mediated apoptosis by blocking the AKT/ASK-1/p38 MAPK pathway. This study provides a promising therapeutic intervention for myocardial I/R injury.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
