Peripheral Vascular Disease

Letter Hematology

Identification of two de novo variants causing inherited antithrombin deficiency by quantitative analysis of variant alleles

Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita

THROMBOSIS RESEARCH (2024)

Letter Surgery

Ethical Concerns Regarding the Use of Large Language Models in Healthcare

Fabien Lareyre, Juliette Raffort

EJVES VASCULAR FORUM (2024)

Article Surgery

Percutaneous Closure Based on Physiological Assessment of an Arteriovenous Fistula in a Patient With Chronic Limb Threatening Ischaemia

Keisuke Shoji, Michitaka Kitamura, Shiori Yoshida, Kenshi Ono, Naotoshi Wada, Tetsuya Nomura, Natsuya Keira, Tetsuya Tatsumi

Summary: This study reported a case of arteriovenous fistula (AVF) and steal syndrome in a 90-year-old female patient during endovascular therapy. Physiological assessment using laser Doppler flowmetry showed improved peripheral perfusion and accelerated wound healing after AVF closure. Therefore, preoperative evaluation of peripheral perfusion before AVF closure is of clinical significance.

EJVES VASCULAR FORUM (2024)

Review Pharmacology & Pharmacy

Clinical presentation and diagnostic evaluation of pheochromocytoma: case series and literature review

Panagiota Anyfanti, Konstantinos Mastrogiannis, Antonios Lazaridis, Konstantinos Tasios, Despoina Vasilakou, Anastasia Kyriazidou, Fotios Aroutsidis, Olga Pavlidou, Eleni Papoutsopoulou, Athina Tiritidou, Vasileios Kotsis, Areti Triantafyllou, Ioannis Zarifis, Stella Douma, Eugenia Gkaliagkousi

Summary: This study presents a case series of pheochromocytoma, emphasizing the importance of patients' specific characteristics, clinical presentation, and diagnostic evaluation. The study also briefly reviews relevant literature and current guidelines to summarize the screening and diagnostic procedures for pheochromocytoma.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2023)

Article Obstetrics & Gynecology

Distinguishing preeclampsia using the falling scaled slope (FSS) -- a novel photoplethysmographic morphological parameter

Hang Chen, Feng Jiang, Wanlin Chen, Ying Feng, Shali Chen, Jiajun Miao, Cuicui Jiao, Xinzhong Chen

Summary: This study investigates the use of a novel parameter called falling scaled slope (FSS) based on photoplethysmographic pulse waves (PPGW) to diagnose preeclampsia (PE). The results show that FSS outperforms previous parameters in distinguishing PE, with an AUC value of 0.924, a threshold of 0.498, a sensitivity of 84.1%, and a specificity of 89.2%. Additionally, the use of machine learning algorithm for data analysis has advantages over conventional statistical methods, as indicated by the AUC values of 0.878 and 0.749, respectively.

HYPERTENSION IN PREGNANCY (2023)

Article Obstetrics & Gynecology

The obesity associated FTO gene polymorphism and the risk of preeclampsia in Iranian women: A case-control study

Ghasem Azizi-Tabesh, Hossein Sadeghi, Arezoo Farhadi, Mohammad Foad Heidari, Aghdas Safari, Mehdi Shakouri Khomartash, Javad Behroozi, Saeid Doaei, Maryam Gholamalizadeh

Summary: This study aimed to investigate the possible association between FTO gene rs9939609 and the risk of preeclampsia (PE) in Iranian pregnant women. The results showed that pregnant women carrying the AA genotype had a significantly reduced risk of PE. Therefore, the rs9939609 polymorphism in the FTO gene may play a protective role against PE.

HYPERTENSION IN PREGNANCY (2023)

Review Obstetrics & Gynecology

Long-term outcomes of patients with preeclampsia, a review of the literature

Alice Tassi, Alessia Sala, Ilaria Mazzera, Stefano Restaino, Giuseppe Vizzielli, Lorenza Driul

Summary: Hypertensive pregnancy disorders (HDP) affect 10% of pregnancies and increase the future risk of heart disease, chronic hypertension, kidney dysfunction, diabetes, and thromboembolism. The mechanisms are not well understood, but endothelial dysfunction, pro-inflammatory and procoagulant states seem to persist in women with a history of preeclampsia. The number and severity of complications differ according to the type of HDP. Lifestyle modifications and long-term follow-up are essential for reducing the risk of future diseases.

HYPERTENSION IN PREGNANCY (2023)

Article Obstetrics & Gynecology

Short stature in small-for-gestational-age offspring born to mothers with hypertensive disorders of pregnancy

Sakurako Mishima, Takashi Mitsui, Kazumasa Tani, Jota Maki, Eriko Eto, Kei Hayata, Yosuke Washio, Junko Yoshimoto, Hirokazu Tsukahara, Hisashi Masuyama

Summary: This study aims to investigate the incidence and risk factors of small-for-gestational age (SGA) short stature at 2 and 3 years of age in SGA offspring born to women with hypertensive disorders of pregnancy (HDP). The results showed that 41.2% of the offspring were diagnosed with SGA short stature, and prematurity before 32 weeks of gestation was the most significant factor for catch-up growth failure. Therefore, the incidence of SGA short stature is high in SGA offspring born to women with HDP, and prematurity is the main risk factor.

HYPERTENSION IN PREGNANCY (2023)

Article Obstetrics & Gynecology

MiRNA-494 induces trophoblast senescence by targeting SIRT1

Sha Su, Linlin Zhong, Shijin Huang, Lingjie Deng, Lihong Pang

Summary: This study investigated the role of the miR-494/SIRT1 axis in preeclampsia (PE) and found that SIRT1 expression was decreased and miR-494 expression was increased in PE patients. Premature placental aging was observed in PE patients. Experimental validation confirmed the targeting relationship between miR-494 and SIRT1. Overexpression of miR-494 resulted in cell senescence, impaired migration, decreased ATP synthesis, increased ROS levels, and upregulated expression of inflammatory molecules, while overexpression of SIRT1 partially reversed these effects.

HYPERTENSION IN PREGNANCY (2023)

Article Obstetrics & Gynecology

Increased risk of early-onset preeclampsia in pregnant women with COVID-19

Niraj N. N. Mahajan, Shweta Kesarwani, Padmaja Kumbhar, Periyasamy Kuppusamy, Madhura Pophalkar, Pratiksha Thamke, Ruchi Asawa, Saumya Sharan, Smita D. Mahale, Rahul K. Gajbhiye

Summary: This study aims to estimate the incidence and risk of early and late-onset preeclampsia in pregnant women with COVID-19. The results showed that pregnant women with symptomatic COVID-19 had a higher risk of early onset preeclampsia compared to asymptomatic women, with a risk eight times higher.

HYPERTENSION IN PREGNANCY (2023)

Article Obstetrics & Gynecology

Cardiorespiratory fitness in women after severe pre-eclampsia

Lasse Gronningsaeter, Mette-Elise Estensen, Helge Skulstad, Eldrid Langesaeter, Elisabeth Edvardsen

Summary: This study aimed to objectively study cardiorespiratory fitness and physical activity, and to evaluate the limiting factors of exercise intolerance after severe pre-eclampsia. The results showed significantly lower cardiorespiratory fitness and physical activity levels in patients who had severe pre-eclampsia. In addition, one third of the patients had cardiovascular limitations, highlighting the need for clinical follow-up and exercise interventions.

HYPERTENSION IN PREGNANCY (2023)

Article Obstetrics & Gynecology

Blood pressure medication use and postpartum hospital readmission among preeclampsia patients

Timothy Gesner, Joshua Fogel, Lennox Bryson

Summary: This study examined the use of blood pressure medication in preeclampsia patients and found that low-dose medication was associated with increased risk of readmission. It is recommended that clinicians consider the potential risk of readmission when reducing the dose of blood pressure medication.

HYPERTENSION IN PREGNANCY (2023)

Review Obstetrics & Gynecology

Oral nifedipine may be a preferential option for treating acute severe hypertension during pregnancy: a meta-analysis

Minghui Ou, Futao Zhang, Shichao Cui, Shibo Zhao, Yan Yu

Summary: This study compared the efficacy of oral nifedipine and intravenous labetalol in the treatment of acute severe hypertension in pregnancy. The results showed no difference in systolic blood pressure, diastolic blood pressure, and adverse events between the two drugs. However, oral nifedipine achieved the target blood pressure faster and required a lower number of doses.

HYPERTENSION IN PREGNANCY (2023)

Article Peripheral Vascular Disease

Beliefs about medications when treating hypertension in primary health care: results from PERson-centredness in hypertension management using information Technology (PERHIT)

Rasmus Hermansson-Borrebaeck, Ulrika Andersson, Ulf Jakobsson, Patrik Midlov

Summary: This study found a significant association between beliefs about medication and blood pressure levels in hypertensive patients in Swedish primary care setting, but the intervention had no significant effect on changing patients' beliefs about medication. Further emphasis on patients' beliefs about medications could be useful in the clinical setting.

BLOOD PRESSURE (2023)

Editorial Material Peripheral Vascular Disease

Twenty-four-hour ambulatory blood pressure monitoring-from silent to whispering brain damage

Teodora Yaneva-Sirakova, Ivo Petrov, Latchezar Traykov, Antonio Coca, Pedro. G. G. Cunha, Dariusz Gasecki, Bushra Farukh, Vasilios Kotsis, Augusto Vicario, Efstathis Manios, Cristina Sierra, Dagmara Hering

BLOOD PRESSURE (2023)

Review Peripheral Vascular Disease

What is resistant arterial hypertension?

Evgeniya V. Shalaeva, Franz H. Messerli

Summary: Resistant arterial hypertension refers to above-goal elevated blood pressure despite the use of 3 or more classes of antihypertensive medications at maximum doses. It should be distinguished from refractory hypertension, which is when blood pressure remains uncontrolled on maximal therapy with 5 or more antihypertensive agents. Timely diagnosis and treatment of resistant arterial hypertension are crucial for reducing the risk of cardiovascular complications and improving the prognosis.

BLOOD PRESSURE (2023)

Review Peripheral Vascular Disease

Novel approaches: targeting sympathetic outflow in the carotid sinus

Dagmara Hering, Krzysztof Narkiewicz

Summary: Systemic hypertension is a major global health issue, leading to premature death and contributing to disease burden. Despite available treatments, many patients fail to achieve target blood pressure levels. Device-based therapies that target sympathetic neural mechanisms have shown promise in treating poorly controlled hypertension. However, the effectiveness of these therapies varies and further research is needed. Increased focus on device-based approaches could provide alternative or additional treatment options for hypertension.

BLOOD PRESSURE (2023)

Article Peripheral Vascular Disease

Serum uric acid: a futile bystander in endothelial function?

Benjamin De Becker, Philippe Van De Borne

Summary: This study investigates the relationship between serum uric acid levels and endothelial function, oxidative stress, and hemodynamic parameters. The study finds no significant correlation between uric acid levels and these parameters.

BLOOD PRESSURE (2023)

News Item Peripheral Vascular Disease

European Society of Hypertension - general practitioners' program hypertension management: focus on general practice

Rosa de Pinho, Fabiolucio Albini, Janos Nemcsik, Michael Doumas, Reinhold Kreutz

BLOOD PRESSURE (2023)

Review Peripheral Vascular Disease

The Hypertension Excellence Centre programme of the European Society of Hypertension - current status, activities and reshaping for the future

Thomas Weber, Michael Doumas, Christian Delles, Bojan Jelakovic, Margus Viigimaa, Krzysztof Narkiewicz, Andrzej Januszewicz, Reinhold Kreutz, Guido Grassi, Giuseppe Mancia

Summary: This article describes the history, achievements, and future developments of the Excellence Centre (EC) programme of the European Society of Hypertension (ESH) since its inception in 2006.

BLOOD PRESSURE (2023)