Peripheral Vascular Disease

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Review Cardiac & Cardiovascular Systems

Social Determinants of Cardiovascular Disease

Tiffany M. Powell-Wiley, Yvonne Baumer, Foster Osei Baah, Andrew S. Baez, Nicole Farmer, Christa T. Mahlobo, Mario A. Pita, Kameswari A. Potharaju, Kosuke Tamura, Gwenyth R. Wallen

Summary: Social determinants of health have a significant impact on the development of cardiovascular disease and its outcomes, but their influence is not fully understood. This review aims to further investigate the relationship between social determinants of health and cardiovascular disease, and provide a framework for future research and interventions.

CIRCULATION RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Post-Stroke Cognitive Impairment and Dementia

Natalia S. Rost, Amy Brodtmann, Matthew P. Pase, Susanne J. van Veluw, Alessandro Biffi, Marco Duering, Jason D. Hinman, Martin Dichgans

Summary: Poststroke cognitive impairment and dementia is a common problem among stroke patients, influenced by factors such as age, education level, preexisting cognitive decline, and history of prior stroke. Manifestations of cerebral small vessel disease also contribute to cognitive outcomes. Understanding the interaction between acute stroke events and preexisting brain pathology is crucial for personalized prediction, prevention, targeted interventions, and rehabilitation.

CIRCULATION RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults: Suspected Myocarditis After COVID-19 Vaccination

Dongngan T. Truong, Audrey Dionne, Juan Carlos Muniz, Kimberly E. McHugh, Michael A. Portman, Linda M. Lambert, Deepika Thacker, Matthew D. Elias, Jennifer S. Li, Olga H. Toro-Salazar, Brett R. Anderson, Andrew M. Atz, C. Monique Bohun, M. Jay Campbell, Maryanne Chrisant, Laura D'Addese, Kirsten B. Dummer, Daniel Forsha, Lowell H. Frank, Olivia H. Frosch, Sarah K. Gelehrter, Therese M. Giglia, Camden Hebson, Supriya S. Jain, Pace Johnston, Anita Krishnan, Kristin C. Lombardi, Brian W. McCrindle, Elizabeth C. Mitchell, Koichi Miyata, Trent Mizzi, Robert M. Parker, Jyoti K. Patel, Christina Ronai, Arash A. Sabati, Jenna Schauer, S. Kristen Sexson Tejtel, J. Ryan Shea, Lara S. Shekerdemian, Shubhika Srivastava, Jodie K. Votava-Smith, Sarah White, Jane W. Newburger

Summary: This study retrospectively analyzed the clinical characteristics and short-term outcomes of young individuals with suspected myocarditis after COVID-19 vaccination. The results showed that most cases of suspected myocarditis had a mild clinical course with rapid resolution of symptoms, and abnormal findings on cardiac MRI were frequent.

CIRCULATION (2022)

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Article Peripheral Vascular Disease

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)

Giuseppe Mancia, Reinhold Kreutz, Mattias Brunstrom, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Maria Lorenza Muiesan, Konstantinos Tsioufis, Enrico Agabiti-Rosei, Engi Abd Elhady Algharably, Michel Azizi, Athanase Benetos, Claudio Borghi, Jana Brguljan Hitij, Renata Cifkova, Antonio Coca, Veronique Cornelissen, J. Kennedy Cruickshank, Pedro G. Cunha, A. H. Jan Danser, Rosa Maria de Pinho, Christian Delles, Anna F. Dominiczak, Maria Dorobantu, Michalis Doumas, Maria S. Fernandez-Alfonso, Jean-Michel Halimi, Zoltan Jarai, Bojan Jelakovic, Jens Jordan, Tatiana Kuznetsova, Stephane Laurent, Dragan Lovic, Empar Lurbe, Felix Mahfoud, Athanasios Manolis, Marius Miglinas, Krzystof Narkiewicz, Teemu Niiranen, Paolo Palatini, Gianfranco Parati, Atul Pathak, Alexandre Persu, Jorge Polonia, Josep Redon, Pantelis Sarafidis, Roland Schmieder, Bart Spronck, Stella Stabouli, George Stergiou, Stefano Taddei, Costas Thomopoulos, Maciej Tomaszewski, Philippe Van de Borne, Christoph Wanner, Thomas Weber, Bryan Williams, Zhen-Yu Zhang, Sverre E. Kjeldsen, Int Soc Hypertension ISH, European Renal Assoc ERA

Summary: This is an article introducing a list of document reviewers from various countries such as Mexico, Greece, Turkey, Brazil, Lebanon, and more.

JOURNAL OF HYPERTENSION (2023)

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Article Pharmacology & Pharmacy

Gender difference in the relationship between lipid accumulation product index and pulse pressure in nondiabetic Korean adults: The Korean National Health and Nutrition Examination Survey 2013-2014

Hyun Ho Sung, Mi Young Gi, Ju Ae Cha, Hye Eun Cho, Ae Eun Moon, Hyun Yoon

Summary: The study found that in nondiabetic Korean adults, pulse pressure was positively associated with lipid accumulation product index in women but not in men.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2022)

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Article Cardiac & Cardiovascular Systems

Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial

Marko Banovic, Svetozar Putnik, Martin Penicka, Gheorghe Doros, Marek A. Deja, Radka Kockova, Martin Kotrc, Sigita Glaveckaite, Hrvoje Gasparovic, Nikola Pavlovic, Lazar Velicki, Stefano Salizzoni, Wojtek Wojakowski, Guy Van Camp, Serge D. Nikolic, Bernard Iung, Jozef Bartunek

Summary: This international randomized controlled trial evaluated the safety and efficacy of early surgical treatment in asymptomatic patients with severe aortic stenosis. The results showed that early surgery reduced the primary composite end point of all-cause death, acute myocardial infarction, stroke, or unplanned hospitalization for heart failure compared with conservative treatment.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial

Javed Butler, Gerasimos Filippatos, Tariq Jamal Siddiqi, Martina Brueckmann, Michael Bohm, Vijay K. Chopra, Joao Pedro Ferreira, James L. Januzzi, Sanjay Kaul, Ileana L. Pina, Piotr Ponikowski, Sanjiv J. Shah, Michele Senni, Ola Vedin, Subodh Verma, Barbara Peil, Stuart J. Pocock, Faiez Zannad, Milton Packer, Stefan D. Anker

Summary: This study evaluated the impact of Empagliflozin on health-related quality of life in patients with heart failure and preserved ejection fraction. The results showed that Empagliflozin reduced the risk of major heart failure outcomes and improved health-related quality of life. The effects were consistent across different levels of baseline health status.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Prevalence, Characteristics, and Outcomes of COVID-19-Associated Acute Myocarditis

Enrico Ammirati, Laura Lupi, Matteo Palazzini, Nicholas S. Hendren, Justin L. Grodin, Carlo Cannistraci, Matthieu Schmidt, Guillaume Hekimian, Giovanni Peretto, Thomas Bochaton, Ahmad Hayek, Nicolas Piriou, Sergio Leonardi, Stefania Guida, Annalisa Turco, Simone Sala, Aitor Uribarri, Caroline M. Van de Heyning, Massimo Mapelli, Jeness Campodonico, Patrizia Pedrotti, Maria Isabel Barrionuevo Sanchez, Albert Ariza Sole, Marco Marini, Maria Vittoria Matassini, Mickael Vourc'h, Antonio Cannata, Daniel Bromage, Daniele Briguglia, Jorge Salamanca, Pablo Diez-Villanueva, Jukka Lehtonen, Florent Huang, Stephanie Russel, Francesco Soriano, Fabrizio Turrini, Manlio Cipriani, Manuela Bramerio, Mattia Di Pasquale, Aurelia Grosu, Michele Senni, Davide Farina, Piergiuseppe Agostoni, Stefania Rizzo, Monica De Gaspari, Francesca Marzo, Jason M. Duran, Eric D. Adler, Cristina Giannattasio, Cristina Basso, Theresa McDonagh, Mathieu Kerneis, Alain Combes, Paolo G. Camici, James A. de Lemos, Marco Metra

Summary: The prevalence of acute myocarditis (AM) in COVID-19 patients is estimated to be between 2.4 and 4.1 per 1000 hospitalized patients. Most cases of AM occur in the absence of pneumonia and are often complicated by hemodynamic instability.

CIRCULATION (2022)

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Article Hematology

Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association

P. Barton Duell, Francine K. Welty, Michael Miller, Alan Chait, Gmerice Hammond, Zahid Ahmad, David E. Cohen, Jay D. Horton, Gregg S. Pressman, Peter P. Toth

Summary: Nonalcoholic fatty liver disease is a common chronic condition that is often undetected until it progresses to serious complications, such as liver cirrhosis and hepatocellular carcinoma. It is also a risk factor for atherosclerotic cardiovascular disease.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2022)

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Article Hematology

ISTH guidelines for antithrombotic treatment in COVID-19

Sam Schulman, Michelle Sholzberg, Alex C. Spyropoulos, Ryan Zarychanski, Helaine E. Resnick, Charlotte A. Bradbury, Lisa Broxmeyer, Jean Marie Connors, Anna Falanga, Toshiaki Iba, Scott Kaatz, Jerrold H. Levy, Saskia Middeldorp, Tracy Minichiello, Eduardo Ramacciotti, Charles Marc Samama, Jecko Thachil

Summary: Antithrombotic agents, particularly heparins, are recommended for patients with COVID-19 to reduce thromboembolism risk. The optimal dosing and timing of these treatments, as well as the benefits of other antithrombotic agents, are still unclear. A panel of experts developed 12 recommendations based on high- to moderate-quality evidence, including the use of prophylactic or therapeutic dose heparin for different patient groups. Additional weak recommendations were made for the use of sulodexide, adding antiplatelet agents, and prophylactic rivaroxaban in select patients. Future updates will incorporate new evidence and may modify these recommendations.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Cardiac & Cardiovascular Systems

The Impact of Sex and Gender on Stroke

Kathryn M. Rexrode, Tracy E. Madsen, Amy Y. X. Yu, Cheryl Carcel, Judith H. Lichtman, Eliza C. Miller

Summary: Women bear a disproportionate burden of stroke mortality and disability. Both biological sex and sociocultural gender contribute to differences in stroke risk factors, assessment, treatment, and outcomes. This review outlines the current knowledge of the impact of sex and gender on stroke, while also identifying research gaps and areas for future inquiry.

CIRCULATION RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People With Type 2 Diabetes: A Meta-Analysis of Individual Participant Data From Randomized, Controlled Trials

Brendon L. Neuen, Megumi Oshima, Rajiv Agarwal, Clare Arnott, David Z. Cherney, Robert Edwards, Anna Maria Langkilde, Kenneth W. Mahaffey, Darren K. McGuire, Bruce Neal, Vlado Perkovic, Annpey Pong, Marc S. Sabatine, Itamar Raz, Tadashi Toyama, Christoph Wanner, David C. Wheeler, Stephen D. Wiviott, Bernard Zinman, Hiddo J. L. Heerspink

Summary: SGLT2 inhibitors reduce the risk of serious hyperkalemia in people with type 2 diabetes at high cardiovascular risk or with chronic kidney disease without increasing the risk of hypokalemia.

CIRCULATION (2022)

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Article Hematology

Vaccine-induced immune thrombotic thrombocytopenia (VITT): Update on diagnosis and management considering different resources

Andreas Greinacher, Florian Langer, Mike Makris, Menaka Pai, Sue Pavord, Huyen Tran, Theodore E. Warkentin

Summary: VITT is a rare but severe immunological reaction to non-replicable adenoviral vector-based COVID-19 vaccines, causing extreme activation of platelets and the coagulation system, increasing the risk of death. The World Health Organization provided guidelines for the diagnosis and management of VITT, and authors summarized new clinically relevant information with recommendations for low resource environments.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Cardiac & Cardiovascular Systems

Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex

Anthony P. Carnicelli, Hwanhee Hong, Stuart J. Connolly, John Eikelboom, Robert P. Giugliano, David A. Morrow, Manesh R. Patel, Lars Wallentin, John H. Alexander, M. Cecilia Bahit, Alexander P. Benz, Erin A. Bohula, Tze-Fan Chao, Leanne Dyal, Michael Ezekowitz, Keith A.a. Fox, Baris Gencer, Jonathan L. Halperin, Ziad Hijazi, Stefan H. Hohnloser, Kaiyuan Hua, Elaine Hylek, Eri Toda Kato, Julia Kuder, Renato D. Lopes, Kenneth W. Mahaffey, Jonas Oldgren, Jonathan P. Piccini, Christian T. Ruff, Jan Steffel, Daniel Wojdyla, Christopher B. Granger

Summary: DOACs have more favorable efficacy and safety profiles compared to warfarin in patients with atrial fibrillation, showing significant advantages in terms of stroke, systemic embolism, and bleeding.

CIRCULATION (2022)

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Article Surgery

Editor's Choice - European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease

Ross Naylor, Barbara Rantner, Stefano Ancetti, Gert J. de Borst, Marco De Carlo, Alison Halliday, Stavros K. Kakkos, Hugh S. Markus, Dominick J. H. McCabe, Henrik Sillesen, Jos C. van den Berg, Melina Vega de Ceniga, Maarit A. Venermo, Frank E. G. Vermassen

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY (2023)

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Article Peripheral Vascular Disease

Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association

Niteesh K. Choudhry, Ian M. Kronish, Wanpen Vongpatanasin, Keith C. Ferdinand, Valory N. Pavlik, Brent M. Egan, Antoinette Schoenthaler, Nancy Houston Miller, David J. Hyman

Summary: The widespread treatment of hypertension and improvements in blood pressure have led to a decline in heart disease and stroke, but there is still a gap between public health targets and actual blood pressure control rates. Medication nonadherence is a key factor contributing to this gap, and the scientific statement aims to summarize its impact and strategies for improving adherence.

HYPERTENSION (2022)

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Article Cardiac & Cardiovascular Systems

Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease

Michelle L. O'Donoghue, Robert P. Giugliano, Stephen D. Wiviott, Dan Atar, Anthony Keech, Julia F. Kuder, KyungAh Im, Sabina A. Murphy, Jose H. Flores-Arredondo, J. Antonio G. Lopez, Mary Elliott-Davey, Bei Wang, Maria Laura Monsalvo, Siddique Abbasi, Marc S. Sabatine

Summary: Long-term use of evolocumab to lower LDL-C levels is associated with low rates of adverse events, which do not exceed those in the placebo group. Over time, the use of evolocumab also leads to further reduction in cardiovascular events.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications

Trisha Singh, Hilal Khan, David T. Gamble, Caroline Scally, David E. Newby, Dana Dawson

Summary: “Takotsubo syndrome is an acute condition with transient dysfunction of the left ventricle, which is challenging to differentiate from acute myocardial infarction. Recent studies have shown that patients with this syndrome have persistent cardiac dysfunction and limiting symptoms. They also have a substantial burden of morbidity and mortality, similar to patients with acute coronary syndrome. The underlying pathophysiology of this condition remains unclear, and further research is needed to inform evidence-based management strategies.”

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales

Rochelle Knight, Venexia Walker, Samantha Ip, Jennifer A. Cooper, Thomas Bolton, Spencer Keene, Rachel Denholm, Ashley Akbari, Hoda Abbasizanjani, Fatemeh Torabi, Efosa Omigie, Sam Hollings, Teri-Louise North, Renin Toms, Xiyun Jiang, Emanuele Di Angelantonio, Spiros Denaxas, Johan H. Thygesen, Christopher Tomlinson, Ben Bray, Craig J. Smith, Mark Barber, Kamlesh Khunti, George Davey Smith, Nishi Chaturvedi, Cathie Sudlow, William N. Whiteley, Angela M. Wood, Jonathan A. C. Sterne

Summary: Incidence of vascular diseases remains elevated up to 49 weeks after COVID-19 diagnosis, with a faster decline for arterial thromboses than VTEs. Patients hospitalized with COVID-19, non-White individuals, and those without previous events are at higher risk. Policies to prevent severe COVID-19, including vaccination, early post-discharge review, risk factor control, and secondary preventive agents, are supported by these findings.

CIRCULATION (2022)

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Letter Cardiac & Cardiovascular Systems

Rise in Blood Pressure Observed Among US Adults During the COVID-19 Pandemic

Luke J. Laffin, Harvey W. Kaufman, Zhen Chen, Justin K. Niles, Andre R. Arellano, Lance A. Bare, Stanley L. Hazen

CIRCULATION (2022)

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