Pathology 类别的文章

Article Medicine, Legal

Acute disseminated encephalomyelitis (ADEM) following recent Oxford/AstraZeneca COVID-19 vaccination

Fiona Permezel, Branko Borojevic, Stephanie Lau, Hans H. de Boer

Summary: This report discusses the clinical context and autopsy findings of a fatal case of ADEM following vaccination with the Oxford/AstraZeneca COVID-19 vaccine. It highlights the rare risk of developing ADEM post COVID-19 vaccination.

FORENSIC SCIENCE MEDICINE AND PATHOLOGY (2022)

添加到收藏夹

Review Pathology

Atherosclerosis: Known and unknown

Jianglin Fan, Teruo Watanabe

Summary: Atherosclerotic disease is a global killer caused by multiple factors. While progress has been made in understanding its pathogenesis, further research is needed to develop new treatments.

PATHOLOGY INTERNATIONAL (2022)

添加到收藏夹

Review Clinical Neurology

White matter microglia heterogeneity in the CNS

Sandra Amor, Niamh B. McNamara, Emma Gerrits, Manuel C. Marzin, Susanne M. Kooistra, Veronique E. Miron, Erik Nutma

Summary: Microglia, the resident myeloid cells in the central nervous system, have diverse roles in maintaining homeostasis, responding to diseases, and promoting repair. Advances in technology have revealed the complexity of microglial functions in white matter health. Additionally, microglia are intricately linked to various diseases and disease mechanisms.

ACTA NEUROPATHOLOGICA (2022)

添加到收藏夹

Review Immunology

TNF in the liver: targeting a central player in inflammation

Gisa Tiegs, Andrea K. Horst

Summary: Tumour necrosis factor-alpha (TNF) is a multifunctional cytokine that plays important roles in immunopathogenesis and liver functions. Targeting TNF signalling through anti-TNF therapies could be a potential treatment for TNF-related diseases.

SEMINARS IN IMMUNOPATHOLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex

Valentina Perosa, Jan Oltmer, Leon P. Munting, Whitney M. Freeze, Corinne A. Auger, Ashley A. Scherlek, Andre J. van der Kouwe, Juan Eugenio Iglesias, Alessia Atzeni, Brian J. Bacskai, Anand Viswanathan, Matthew P. Frosch, Steven M. Greenberg, Susanne J. van Veluw

Summary: Enlarged perivascular spaces are associated with cerebral small vessel disease and cerebral amyloid angiopathy, impacting the pathophysiological processes related to arteriole perivascular clearance mechanisms.

ACTA NEUROPATHOLOGICA (2022)

添加到收藏夹

Review Cell Biology

Evolving classification of rhabdomyosarcoma

Narasimhan P. Agaram

Summary: This article discusses the evolution of the classification of rhabdomyosarcoma, the histomorphological and genetic features of each subtype, and the diagnostic approach to these tumors.

HISTOPATHOLOGY (2022)

添加到收藏夹

Review Pathology

Extrachromosomal DNA: An Emerging Hallmark in Human Cancer

Sihan Wu, Vineet Bafna, Howard Y. Chang, Paul S. Mischel

Summary: This review discusses the formation and function of circular, extrachromosomal pieces of DNA (ecDNA) found in cancer, as well as their contribution to tumor pathogenesis, drug resistance, and accelerated cancer evolution.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

添加到收藏夹

Article Oncology

Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology

Peter Leonard Schrammen, Narmin Ghaffari Laleh, Amelie Echle, Daniel Truhn, Volkmar Schulz, Titus J. Brinker, Hermann Brenner, Jenny Chang-Claude, Elizabeth Alwers, Alexander Brobeil, Matthias Kloor, Lara R. Heij, Dirk Jager, Christian Trautwein, Heike Grabsch, Philip Quirke, Nicholas P. West, Michael Hoffmeister, Jakob Nikolas Kather

Summary: SLAM is a simple yet powerful computational pathology method that utilizes a neural network to predict tumor presence and genetic alterations directly from histopathology slides, without the need for complex manual annotations. It demonstrates high reliability and accuracy in clinically relevant tasks, making it a valuable tool for disease analysis.

JOURNAL OF PATHOLOGY (2022)

添加到收藏夹

Article Medicine, Legal

Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α

Paolo Frisoni, Margherita Neri, Stefano D'Errico, Letizia Alfieri, Diana Bonuccelli, Mariano Cingolani, Marco di Paolo, Rosa Maria Gaudio, Maurizio Lestani, Matteo Marti, Massimo Martelloni, Carlo Moreschi, Alessandro Santurro, Matteo Scopetti, Ombretta Turriziani, Martina Zanon, Roberto Scendoni, Paola Frati, Vittorio Fineschi

Summary: The study involved histological analysis of autopsied samples from COVID-19-related deaths, revealing enhanced inflammatory cytokine response in COVID-19 patients, playing a significant role in the development of acute respiratory distress syndrome (ARDS) and multiple organ failure.

FORENSIC SCIENCE MEDICINE AND PATHOLOGY (2022)

添加到收藏夹

Review Pathology

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

Achim D. Gruber, Theresa C. Firsching, Jakob Trimpert, Kristina Dietert

Summary: Different hamster species can mimic different courses of COVID-19 manifestations in humans, with the Syrian hamster turning into the leading non-transgenic model under pandemic conditions, currently used in numerous studies aiming to combat the impact of the virus and its new variants.

VETERINARY PATHOLOGY (2022)

添加到收藏夹

Review Immunology

Genetics of rheumatoid arthritis

Leonid Padyukov

Summary: Rheumatoid arthritis is an inflammatory autoimmune disease with significant genetic associations and variations. Current research focuses on immune receptor binding, T cell activation, and cell signaling mechanisms. More than 150 candidate loci have been identified, with further discoveries expected in the future.

SEMINARS IN IMMUNOPATHOLOGY (2022)

添加到收藏夹

Review Pathology

HER2-Low Breast Cancers New Opportunities and Challenges

Huina Zhang, Hani Katerji, Bradley M. Turner, David G. Hicks

Summary: Recent clinical trials have shown benefits in treating breast cancer with low HER2 expression, raising concerns about current testing methodologies and accurately identifying such patients. The definition and reliable testing methods for HER2-low breast cancer need further clarification. New HER2-targeted therapies have shown promise in treating HER2-low breast cancers, potentially changing the clinical interpretation of HER2 status in breast cancer.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2022)

添加到收藏夹

Review Pathology

miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay-A review

Hesham A. El-Mahdy, Elsayed G. E. Elsakka, Ahmed A. El-Husseiny, Ahmed Ismail, Amr Mohamed Yehia, Nourhan M. Abdelmaksoud, Reham A. A. Elshimy, Mina Noshy, Ahmed S. Doghish

Summary: Bladder cancer is the 11th most popular cancer in females and 4th in males. Efforts have been made to improve BC patients' care, and new approaches have been developed to enhance the efficiency of BC diagnosis, prognosis, therapeutics, and monitoring.

PATHOLOGY RESEARCH AND PRACTICE (2023)

添加到收藏夹

Article Pathology

Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

Mai He, Priya Skaria, Kasey Kreutz, Ling Chen, Ian S. Hagemann, Ebony B. Carter, Indira U. Mysorekar, D. Michael Nelson, John Pfeifer, Louis P. Dehner

Summary: The study found that the maternal SARS-CoV-2 status does not have a significant effect on placental pathology, both in terms of pathological features and symptoms.

FETAL AND PEDIATRIC PATHOLOGY (2022)

添加到收藏夹

Article Pathology

Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney

Payal Kapur, Ming Gao, Hua Zhong, Suneetha Chintalapati, Midori Mitui, Spencer D. Barnes, Qinbo Zhou, Jeffrey Miyata, Deyssy Carrillo, Venkat S. Malladi, Dinesh Rakheja, Ivan Pedrosa, Lin Xu, Lisa Kinch, James Brugarolas

Summary: Low-grade oncocytic tumor (LOT) of the kidney is a distinct entity with characteristic features and mutations in the mTORC1 pathway. Gene expression analysis showed that LOT is separate from related entities, suggesting its unique biological behavior. Additionally, a germline TSC1 mutation was found in one patient with multiple bilateral LOTs, indicating a possible syndromic association.

MODERN PATHOLOGY (2022)

添加到收藏夹

Article Pathology

Deep learning trained on hematoxylin and eosin tumor region of Interest predicts HER2 status and trastuzumab treatment response in HER2+breast cancer

Saman Farahmand, Aileen Fernandez, Fahad Shabbir Ahmed, David L. Rimm, Jeffrey H. Chuang, Emily Reisenbichler, Kourosh Zarringhalam

Summary: This study presents a novel convolutional neural network (CNN) approach for predicting HER2 status on H&E images, achieving higher accuracy compared to previous methods. The classifier performed well, accurately predicting HER2 status and showing potential in predicting drug treatment response.

MODERN PATHOLOGY (2022)

添加到收藏夹

Article Pathology

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue

Susan Muller, Wanninayake M. Tilakaratne

Summary: The fifth chapter of the 2022 World Health Organization Classification of Tumours of the Head and Neck has undergone modifications, including the addition of a new section on Non-neoplastic Lesions and the separation of the Oral potentially malignant disorders and Oral epithelial dysplasia section. Carcinoma cuniculatum and verrucous carcinoma are now described in dedicated sections. This review summarizes these changes and highlights their clinical, histological, and molecular significance.

HEAD & NECK PATHOLOGY (2022)

添加到收藏夹

Review Pathology

NTRK insights: best practices for pathologists

Jaclyn F. Hechtman

Summary: Since the discovery of an oncogenic TRK fusion protein in the early 1980s, our understanding of NTRK fusions and methods to detect them has expanded significantly. The identification of these molecular alterations in cancer patient management has become increasingly important, with the emergence of effective TRK protein inhibitors. Insights into testing methods and implementation within healthcare teams are essential for optimal patient care.

MODERN PATHOLOGY (2022)

添加到收藏夹

Review Pathology

The role of miRNAs in liver diseases: Potential therapeutic and clinical applications

Ahmed S. Doghish, Mohammed S. Elballal, Ola Elazazy, Ahmed E. Elesawy, Mahmoud A. Elrebehy, Reem K. Shahin, Heba M. Midan, Al-Aliaa M. Sallam

PATHOLOGY RESEARCH AND PRACTICE (2023)

添加到收藏夹

Review Oncology

Artificial intelligence to identify genetic alterations in conventional histopathology

Didem Cifci, Sebastian Foersch, Jakob Nikolas Kather

Summary: Artificial intelligence methods can predict specific genetic alterations from conventional tissue slides, although they are currently less accurate than gold standard testing. These methods can serve as pre-screening tools to reduce the workload of genetic analyses. Certain genetic alterations in various tumor types can be predicted from histopathology slides, but more research is needed for other genetic alterations.

JOURNAL OF PATHOLOGY (2022)

添加到收藏夹

Pathology

Acute disseminated encephalomyelitis (ADEM) following recent Oxford/AstraZeneca COVID-19 vaccination

Atherosclerosis: Known and unknown

White matter microglia heterogeneity in the CNS

TNF in the liver: targeting a central player in inflammation

Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex

Evolving classification of rhabdomyosarcoma

Extrachromosomal DNA: An Emerging Hallmark in Human Cancer

Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology

Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

Genetics of rheumatoid arthritis

HER2-Low Breast Cancers New Opportunities and Challenges

miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay-A review

Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney

Deep learning trained on hematoxylin and eosin tumor region of Interest predicts HER2 status and trastuzumab treatment response in HER2+breast cancer

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue

NTRK insights: best practices for pathologists

The role of miRNAs in liver diseases: Potential therapeutic and clinical applications

Artificial intelligence to identify genetic alterations in conventional histopathology

Related Categories

Top Journals

Annual Review of Pathology-Mechanisms of Disease

ENDOCRINE PATHOLOGY

Seminars in Immunopathology

MODERN PATHOLOGY

BRAIN PATHOLOGY

JOURNAL OF PATHOLOGY

ADVANCES IN ANATOMIC PATHOLOGY

AMERICAN JOURNAL OF PATHOLOGY

AMERICAN JOURNAL OF SURGICAL PATHOLOGY