Pathology 类别的文章

Article Pathology

Use of the Afirma Xpression Atlas for cytologically indeterminate, Afirma Genomic Sequencing Classifier suspicious thyroid nodules: Clinicopathologic analysis with postoperative molecular testing

Carlos A. Munoz-Zuluaga, Jonas J. Heymann, James P. Solomon, Ami Patel, Momin T. Siddiqui, Theresa Scognamiglio, Hamza N. Gokozan

Summary: This study evaluated the performance of Afirma XA in risk stratification and found that it improved the assessment of potential malignancy risk in Afirma GSC suspicious nodules.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2023)

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Article Pathology

Mutated ASXL1 upregulates mTOR expression in renal cell carcinoma with fibromyomatous stroma

Yang Liu, Luting Zhou, Haimin Xu, Yijin Gu, Lei Dong, Xiaoqun Yang, Chaofu Wang

Summary: Renal cell carcinoma with fibromyomatous stroma (RCC FMS) is a unique type of kidney cancer characterized by the presence of a fibromyomatous stroma. This study presented a case of RCC FMS in a 28-year-old woman, which showed distinct gene mutations and suggested the involvement of altered mTOR expression in the pathogenesis of this tumor.

VIRCHOWS ARCHIV (2023)

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Review Dermatology

TEMPI syndrome: A clinical, light-microscopic and phenotypic evaluation with review of the literature

Taylor A. Kalomeris, Marc E. Grossman, Jeffrey Tepler, Cynthia M. Magro

Summary: TEMPI syndrome is a rare multisystemic disease with unknown pathogenesis and etiology. This study aimed to further characterize TEMPI syndrome through the evaluation of a skin biopsy, as skin biopsies are rarely performed in this disorder.

JOURNAL OF CUTANEOUS PATHOLOGY (2023)

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Article Medical Laboratory Technology

Disseminated thymoma in pleural fluid: An unusual case

Kate Berry, Caroline Cooper

Summary: We report a case of a 77-year-old woman with pleural dissemination of type B2/B3 thymoma, presenting with a pleural effusion. Cytological evaluation revealed numerous lymphocytes and admixed mesothelial cells, without an epithelial component. Immunohistochemical staining confirmed the lymphocytes as CD3-positive T cells, consistent with immature lymphocytes of thymic origin. Despite the absence of an epithelial component, the case was diagnosed as suspicious for recurrent/metastatic thymoma.

DIAGNOSTIC CYTOPATHOLOGY (2023)

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Article Medicine, Legal

Cat and dog scavenging at indoor forensic scenes: strategies for documentation and detection

Lara Indra, Christian Schyma, Sandra Loesch

Summary: Scavenging on human remains by vertebrates is occasionally observed at indoor forensic scenes, especially when pets have access to the body and their deceased owners were socially distanced. Researchers present new cases from Switzerland with cat and/or dog involvement and provide a flowchart guide for systematic data collection in suspected scavenging scenarios.

FORENSIC SCIENCE MEDICINE AND PATHOLOGY (2023)

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Article Dermatology

Can angiotropism and lymphovascular invasion refine the current cutaneous melanoma staging system?

Patricia Namubiru, William Dalleywater, Shaimaa Lashin, Somaia Elsheikh

Summary: This study investigates the frequency of angiotropism and lymphovascular invasion in primary cutaneous melanoma and their relationship with patient prognosis. The results show that angiotropism occurs more frequently than lymphovascular invasion, and both are closely associated with other clinicopathological parameters. Moreover, both angiotropism and lymphovascular invasion can predict lymph node metastasis. Multivariate analysis identifies lymph node metastasis, tumor thickness, lymphovascular invasion, and angiotropism as predictors of overall survival.

JOURNAL OF CUTANEOUS PATHOLOGY (2023)

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Article Clinical Neurology

Sprouting of afferent and efferent inputs to pelvic organs after spinal cord injury

Shunyi Zhao, Chuanxi Tang, Jeremy Weinberger, Dianshuai Gao, Shaoping Hou

Summary: Neural plasticity occurs within the central and peripheral nervous systems after spinal cord injury, leading to morphological changes in afferent and efferent fibers in pelvic viscera. This may contribute to functional adaptation or maladaptation.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2023)

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Article Clinical Neurology

Pituitary apoplexy in endocrinologically silent adenoma during somatostatin analog administration for pancreatic neuroendocrine tumor: A case report

Keitaro Shiraishi, Takuya Akai, Takahiro Tomita, Ryuji Hayashi, Takashi Minamisaka, Satoshi Kuroda

Summary: This case report highlights the risk of pituitary apoplexy in an endocrinologically silent adenoma during lanreotide administration. The patient, previously diagnosed with a pancreatic neuroendocrine tumor, developed pituitary apoplexy after two years of lanreotide treatment. The tumor was confirmed as a pit1-lineage plurihormonal adenoma and expressed somatostatin receptor 2. These findings suggest that lanreotide treatment increases the risk of pituitary apoplexy, even in asymptomatic adenomas.

NEUROPATHOLOGY (2023)

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Article Cell Biology

Embryonal and pineal tumours

Joseph Reznicek, Nima Sharifai, Pouya Jamshidi, Nitin Wadhwani, Jared T. Ahrendsen

Summary: This article summarizes the cytologic and histologic features of CNS embryonal and pineal tumors, and highlights diagnostically relevant molecular alterations within each tumor type.

CYTOPATHOLOGY (2023)

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Article Oncology

ATF3-induced activation of NF-κB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinoma

Yang Liu, Yizhi Cao, Pengyi Liu, Shuyu Zhai, Yihao Liu, Xiaomei Tang, Jiayu Lin, Minmin Shi, Debin Qi, Xiaxing Deng, Youwei Zhu, Weishen Wang, Baiyong Shen

Summary: Experiments in vitro and in vivo indicate ATF3 enhances olaparib resistance through the NF-kappa B signaling pathway, suggesting that ATF3 could be employed as an olaparib sensitivity and prognostic indicator in patients with pancreatic cancer.

CELLULAR ONCOLOGY (2023)

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Article Hematology

Immunocytochemistry on frozen-embedded cell block for the diagnosis of hematolymphoid cytology specimen: a straightforward alternative to the conventional cell block

Youjeong Seo, Sanzida Alam Prome, Lucia Kim, Jee Young Han, Joon Mee Kim, Suk Jin Choi

Summary: The agarose-based cell block (CB) technique can be combined with the frozen section technique to prepare a high-quality frozen-embedded CB (F-CB) for the immunocharacterization and diagnosis of hematolymphoid cells. The use of CB-ICC on F-CB allows for the differential diagnosis of large cell hematologic malignancies and small B-cell lymphomas in effusion or fine-needle aspiration (FNA) cytology samples.

JOURNAL OF HEMATOPATHOLOGY (2023)

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Review Pathology

Molecular features for timely cancer diagnosis and treatment - tumors of the ovary, fallopian tube and endometrium

Sonia Gatius, Xavier Matias Guiu, Ben Davidson

Summary: Gynecologic pathology has rapidly evolved from lacking molecular testing to becoming a routine diagnostic discipline with the relevance of molecular characterization to treatment choice. Molecular testing is expanding as a tool for diagnosing rare tumors and improving reproducible diagnoses and genetic disease consultation. Despite challenges in studying rare cancers, increased knowledge may lead to new therapeutic options for malignant rare cancers.

VIRCHOWS ARCHIV (2023)

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Letter Pathology

Qualitative Immunodetection of Hsp70 in Nasal Samples of Children With Allergic Rhinitis

Francesca Simoncelli, Anna Fagotti, Ines Di Rosa, Livia Lucentini, Leonardo Brustenga, Giuseppe Di Cara

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY (2023)

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Article Cell Biology

The urgency of Burkitt lymphoma diagnosis in fluid cytology-A tertiary care experience

Soundarya Ravi, Anu K. Devi, Prabhu Manivannan, Debasis Gochhait, Rakhee Kar, Neelaiah Siddaraju

CYTOPATHOLOGY (2023)

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Article Immunology

Short communication: first case of bacteraemia caused by Dielma fastidiosa in a patient hospitalized with diverticulitis

Barbara Forman-Ankjaer, Frederik Hvid-Jensen, Carl Mathias Kobel, Thomas Greve

Summary: This study reports the first case of bacteremia caused by D. fastidiosa and confirms it as a possible pathogen through whole-genome sequencing and phylogenetic analysis.

APMIS (2023)

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Review Oncology

DNA repair in tumor radioresistance: insights from fruit flies genetics

Antonella Porrazzo, Matteo Cassandri, Andrea D'Alessandro, Patrizia Morciano, Rossella Rota, Francesco Marampon, Giovanni Cenci

Summary: In this article, we briefly review the role of genetic and epigenetic factors in DNA repair and damage response that promote radioresistance. We also discuss how recent research on the effects of low dose rate ionizing radiation on Drosophila melanogaster can help identify conserved factors involved in tumor resistance to radiation therapy.

CELLULAR ONCOLOGY (2023)

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Article Pathology

Fetal and Neonatal Autopsy in the Molecular Age: Exploring Tissue Selection for Testing Success

Elizabeth S. Doughty, Miriam D. Post

Summary: This study examines the feasibility of using molecular analysis as an ancillary tool to determine cause of demise in the fetal and neonatal population. The success of the testing methods and tissue selection is crucial for obtaining informative genetic results.

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY (2023)

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Article Medical Laboratory Technology

Two-tier subclassification of the Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance) in thyroid cytology

Jay Alden, Denise Lambrou, Jack Yang

Summary: In Bethesda category III, cases with nuclear atypia have a significantly higher risk of malignancy compared to cases with architectural atypia. Sub-classifying these two subgroups may better stratify the risk of malignancy.

DIAGNOSTIC CYTOPATHOLOGY (2023)

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Article Immunology

Evaluation of transcription factors and cytokine expressions of T-cell subsets in CD19 deficiency and their possible relationship with autoimmune disease

Serkan Kueccuektuerk, Mehmet Ali Karaselek, Tugce Duran, Ismail Reisli

Summary: CD19 deficiency is associated with altered expression of transcription factors and cytokines in T-cell subsets, particularly with downregulation of Th1 factors and upregulation of IFN-gamma. This suggests a potential role of CD19 deficiency in autoimmune diseases.

APMIS (2023)

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Article Pathology

Absence of Ductus Venosus: A Comparison of 2 Distinctive Fetal Autopsy Cases and Embryologic Perspectives

Elaine S. Chan, Ian Suchet, Weiming Yu, David Somerset, Nancy Soliman, Verena Kuret, Rati Chadha

Summary: This article presents two cases of ADV fetuses diagnosed through prenatal imaging studies. These cases highlight the heterogeneity of vascular anomalies and embryologic origins captured by the term ADV, as well as the misleading terminology in some ADV cases.

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY (2023)

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Pathology

Use of the Afirma Xpression Atlas for cytologically indeterminate, Afirma Genomic Sequencing Classifier suspicious thyroid nodules: Clinicopathologic analysis with postoperative molecular testing

Mutated ASXL1 upregulates mTOR expression in renal cell carcinoma with fibromyomatous stroma

TEMPI syndrome: A clinical, light-microscopic and phenotypic evaluation with review of the literature

Disseminated thymoma in pleural fluid: An unusual case

Cat and dog scavenging at indoor forensic scenes: strategies for documentation and detection

Can angiotropism and lymphovascular invasion refine the current cutaneous melanoma staging system?

Sprouting of afferent and efferent inputs to pelvic organs after spinal cord injury

Pituitary apoplexy in endocrinologically silent adenoma during somatostatin analog administration for pancreatic neuroendocrine tumor: A case report

Embryonal and pineal tumours

ATF3-induced activation of NF-κB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinoma

Immunocytochemistry on frozen-embedded cell block for the diagnosis of hematolymphoid cytology specimen: a straightforward alternative to the conventional cell block

Molecular features for timely cancer diagnosis and treatment - tumors of the ovary, fallopian tube and endometrium

Qualitative Immunodetection of Hsp70 in Nasal Samples of Children With Allergic Rhinitis

The urgency of Burkitt lymphoma diagnosis in fluid cytology-A tertiary care experience

Short communication: first case of bacteraemia caused by Dielma fastidiosa in a patient hospitalized with diverticulitis

DNA repair in tumor radioresistance: insights from fruit flies genetics

Fetal and Neonatal Autopsy in the Molecular Age: Exploring Tissue Selection for Testing Success

Two-tier subclassification of the Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance) in thyroid cytology

Evaluation of transcription factors and cytokine expressions of T-cell subsets in CD19 deficiency and their possible relationship with autoimmune disease

Absence of Ductus Venosus: A Comparison of 2 Distinctive Fetal Autopsy Cases and Embryologic Perspectives

Related Categories

Top Journals

Annual Review of Pathology-Mechanisms of Disease

ENDOCRINE PATHOLOGY

Seminars in Immunopathology

MODERN PATHOLOGY

BRAIN PATHOLOGY

JOURNAL OF PATHOLOGY

ADVANCES IN ANATOMIC PATHOLOGY

AMERICAN JOURNAL OF PATHOLOGY

AMERICAN JOURNAL OF SURGICAL PATHOLOGY