Article
Ophthalmology
Kaleb Abbott, Kara S. Hanson, James Lally
Summary: This study retrospectively evaluated the prevalence of dry eye syndrome, meibomian gland dysfunction, and blepharitis among the low vision population. The findings showed a high prevalence of dry eye syndrome in this population, highlighting the importance of managing ocular comfort in individuals with complex visual needs.
JOURNAL OF OPTOMETRY
(2024)
Article
Ophthalmology
Anastasia Papachristou, Argiri Lambraki, Trisevgeni Giannakopoulou, Miltiadis K. Tsilimbaris, Sotiris Plainis
Summary: This study investigates the hypothesis that silicone oil causes insulation effects on the retina by affecting its response to light. Electrophysiological responses to a flash stimulus were recorded in patients who underwent surgery for retinal detachment, before and after silicone oil removal. The study found statistically significant differences in the amplitudes of the ERG responses and their corresponding ratios, indicating that silicone oil reduces the flash ERG responses.
JOURNAL OF OPTOMETRY
(2024)
Review
Ophthalmology
Lynne Loh, Mallika Prem-Senthil, Paul A. Constable
Summary: This systematic review evaluates the impact of vision impairment on reading and literacy levels in education. The included studies showed that students with vision impairment have lower reading speed compared to their normally sighted peers, but no difference in reading ability. Early intervention to enhance literacy skills can improve educational outcomes. Future research should focus on identifying specific obstacles to learning these students face and providing interventions to improve academic outcomes.
JOURNAL OF OPTOMETRY
(2024)
Article
Ophthalmology
Barry Tannen, Alina Sample, Kenneth J. Ciuffreda, Noah M. Tannen
Summary: The study aimed to determine if saccadic-related problems could be confirmed and extended using three common clinical reading-related eye movement tests in patients with visual snow syndrome (VSS). The results showed a high frequency of oculomotor deficits in these patients, consistent with previous findings.
JOURNAL OF OPTOMETRY
(2024)
Article
Ophthalmology
Jaxon J. Huang, Daniel A. Rodriguez, Susan H. Slifer, Eden R. Martin, Roy C. Levitt, Anat Galor
Summary: The purpose of this study was to identify genomic variants that may predispose to neuropathic ocular pain (NOP) development through a genome-wide association study (GWAS). The results revealed several significant genes and pathways associated with the development of NOP.
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Maximilian Hammer, Yvonne Heggemann, Gerd U. Auffarth
Summary: Dynamic stimulation aberrometry was used to investigate the dynamic accommodative ability after anterior iris-claw phakic intraocular lens (pIOL) implantation. The study found that pIOL implantation does not impair the accommodative ability but alters pupil dynamics during deaccommodation.
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Kotaro Tsuboi, Mehdi Mazloumi, Yukun Guo, Jie Wang, Christina J. Flaxel, Steven T. Bailey, David J. Wilson, David Huang, Yali Jia, Thomas S. Hwang
Summary: This study demonstrates that the combination of en face OCT and cross-sectional OCTA can identify subtle structural changes that precede clinically evident retinal neovascularization in eyes with diabetic retinopathy.
OPHTHALMOLOGY SCIENCE
(2024)
Review
Ophthalmology
Stela Vujosevic, Emily Chew, Leanne Labriola, Sobha Sivaprasad, Ecosse Lamoureux
Summary: This narrative review assessed the available PROMs used in research on diabetic retinal diseases and highlighted areas for improvement. The most commonly used PROM is NEI VFQ-25, but it lacks the ideal psychometric, responsiveness, and clinical setting digital administration requirements for inclusion in an updated DRD staging system.
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Siamak Yousefi, Xiaoqin Huang, Asma Poursoroush, Julek Majoor, Hans Lemij, Koen Vermeer, Tobias Elze, Mengyu Wang, Kouros Nouri-Mahdavi, Vahid Mohammadzadeh, Paolo Brusini, Chris Johnson
Summary: The purpose of this study was to develop an objective glaucoma damage severity classification system based on OCT measurements. An unsupervised machine learning algorithm was used to identify optimal RNFL thresholds for different severity levels. The proposed classification system demonstrated accuracy and feasibility, and could potentially enhance glaucoma research and clinical practice.
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Thomas S. Hwang, Merina Thomas, Michelle Hribar, Aiyin Chen, Elizabeth White
Summary: This study aims to determine the impact of documentation workflow on the accuracy of coded diagnoses in electronic health records (EHRs).
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Jyotirmay Biswas, Mudit Tyagi, Manisha Agarwal
Summary: The study shows that the intravitreal 0.2-mu g/day fluocinolone acetonide implant is effective in reducing the recurrence rate of noninfectious uveitis and prolonging the time to first recurrence. In addition, it helps control macular edema and maintain stable intraocular pressure levels but increases the risk of cataract formation.
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Daphne P. C. Vergouwen, Martijn Kolijn, Joeri de Hoog, Joke H. de Boer, Leonoor I. Los, Marlies Gijs, Roel J. Erckens, Pascal H. P. de Jong, Aniki Rothova, Josianne C. Ten Berge, Marco W. J. Schreurs
Summary: The purpose of this study was to gain insight into the disease process of scleritis and identify potential biomarker candidates. Extensive proteomics analysis was performed in serum and tear fluid samples, revealing significant differences in the levels of several proteins involved in neurogenesis, T-cell activation, disruption of epithelial barrier, and angiogenesis between patients with scleritis and control groups. These findings highlight the potential clinical relevance of MMP9 and NudC as biomarkers in scleritis.
OPHTHALMOLOGY SCIENCE
(2024)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jimmy S. Chen, Kyle V. Marra, Hailey K. Robles-Holmes, Kristine B. Ly, Joseph Miller, Guoqin Wei, Edith Aguilar, Felicitas Bucher, Yoichi Ideguchi, Aaron S. Coyner, Napoleone Ferrara, J. Peter Campbell, Martin Friedlander, Eric Nudleman
Summary: This study developed a generative adversarial network (GAN) to segment major blood vessels from retinal flat-mount images and demonstrated the utility of these GAN-generated vessel segmentations in quantifying vascular tortuosity. The results showed that GAN can accurately generate vessel map segmentations and have the potential to accelerate research in treatments for ischemic retinopathies.
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Maximilian Friedrich, Isabella D. Baur, Timur M. Yildirim, Victor A. Augustin, Ramin Khoramnia, Gerd U. Auffarth
Summary: This study found that increases in the vertical diameter of the IOL injector tip, the preoperative incision size, and the insertion depth, as well as a reduction in incision length, were all significantly associated with an increased final incision size. The findings suggest that minimizing the vertical diameter of the injector tip and insertion depth, while ensuring sufficient incision length, can help reduce the final incision size.
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Alyssa L. Lie, Xingzheng Pan, Ehsan Vaghefi, Thomas W. White, Paul J. Donaldson
Summary: This study investigates the association between water redistribution within the crystalline lens and the shape deformation during accommodation. Using magnetic resonance imaging, it was found that young adults exhibited an elastic shape deformation and an elevated, smoother free-water distribution in the anterior region of the lens during accommodation. In contrast, middle-aged adults with presbyopia showed an atypical shape deformation and a lowered free-water distribution in the anterior region of the lens during accommodation. No discernible changes to the lens total-water distribution were observed in response to the accommodative stimulus in either subject cohort.
OPHTHALMOLOGY SCIENCE
(2024)
