Oncology 类别的文章 - Peeref

Article Oncology

Subspecialty Breast Imaging Education in Tanzania; Clinical, Infrastructure, and Logistical Paradigms for Best Practices in the Low- and Middle-Income Settings

Toma S. Omofoye, Anganile Kalinga, Ramapriya Ganti, Frank J. Minja, Timothy B. Rooney

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

Diagnostic plasma small extracellular vesicles miRNA signatures for pancreatic cancer using machine learning methods

Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia

Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.

TRANSLATIONAL ONCOLOGY (2024)

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Article Oncology

Characterizing heterogeneity along EMT and metabolic axes in colorectal cancer reveals underlying consensus molecular subtype-specific trends

Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly

Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.

TRANSLATIONAL ONCOLOGY (2024)

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Article Oncology

Support needs of carers of cancer patients and the effects of the patient's age and cancer type on their needs

Irem Gul, Ismail Toygar, Oznur Usta Yesilbalkan

Summary: This study investigated the support needs of carers of cancer patients and how the patient's age and cancer type affect their needs. The study found that carers of older adults and patients with hematological malignancies require more support in various aspects of caregiving.

EUROPEAN JOURNAL OF ONCOLOGY NURSING (2024)

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Article Oncology

Using machine learning algorithms to predict the prognosis of advanced nasopharyngeal carcinoma after intensity-modulated radiotherapy

Dan Hu, Ying Wang, Genxin Ji, Yu Liu

Summary: This study constructed prognostic models for advanced NPC patients treated with IMRT using machine learning algorithms. Random forest (RF) showed the best predictive performance and identified the most important predictors. RF was proposed as a simple and accurate tool for evaluating the prognosis of advanced NPC patients.

CURRENT PROBLEMS IN CANCER (2024)

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Article Oncology

Silencing of PD-1 combined with EBV-specific killer T cells for the treatment of EBV-associated B lymphoma

Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang

Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.

TRANSLATIONAL ONCOLOGY (2024)

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Article Oncology

Smart Solutions to Address the Global Gap in Radiation Oncology Through Trainee Engagement and Partnerships with Industry

Cecilia Felix Penido Mendes de Sousa, Jared Pasetsky, Gustavo Nader Marta, Megan Kassick, Fabio Ynoe Moraes, Luqman K. Dad

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

Breast Cancer Disparities and Innovations A Focus on Kosovo

Mary D. Chamberlin, Dafina Ademi Islami, Shqiptar Demaci, Richard J. Barth Jr

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

More Drugs Versus More Data: The Tug of War on Cancer in Low- and Middle-Income Countries

Mary Chamberlin, Christopher Booth, Gabriel A. Brooks, Achille Manirakiza, Fidel Rubagumya, Verna Vanderpuye

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Review Oncology

Breast Cancer and Lifestyle Factors: Umbrella Review

Ilir Hoxha, Fitim Sadiku, Lot Hoxha, Midhet Nasim, Marie Anne Christine Buteau, Krenare Grezda, Mary D. Chamberlin

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

Quality of life, distress and psychological adjustment in patients with colon cancer

Diomidis Antoniadis, Alexander Giakoustidis, Vasileios Papadopoulos, Konstantinos N. Fountoulakis, Maggie Watson

Summary: The purpose of this study was to investigate the relationships between distress, psychological adjustment, and quality of life in patients with colon cancer. The results showed that quality of life was positively correlated with fighting spirit, cognitive avoidance, and fatalism, and negatively correlated with helplessness and hopelessness, and anxious preoccupation.

EUROPEAN JOURNAL OF ONCOLOGY NURSING (2024)

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Article Oncology

Ceramide metabolism-related prognostic signature and immunosuppressive function of ST3GAL1 in osteosarcoma

Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie

Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.

TRANSLATIONAL ONCOLOGY (2024)

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Review Oncology

Lung Cancer and Lifestyle Factors: Umbrella Review

Jeta Bunjaku, Arber Lama, Tawanda Pesanayi, Jeton Shatri, Mary Chamberlin, Ilir Hoxha

Summary: The evidence suggests that lifestyle factors such as alcohol and coffee intake may increase the risk of lung cancer, while tea intake may have a protective effect. However, the quality of evidence is currently low and further research is needed.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

Education and Training Models for Remote Learning

Victoria E. Forbes, Mary D. Chamberlin, Vincent Dusabejambo, Tim Walker, Steve P. Bensen, Norrisa Haynes, Kathryn Nunes, Veauthyelau Saint-Joy, Frederick L. Makrauer

Summary: Global health education needs to adapt to the challenges we face, such as inequities and pandemics. Virtual teaching models are effective in delivering global health education and improving outcomes through bidirectional learning and equitable partnerships.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

Diagnostic Accuracy of Biomarkers and International Ovarian Tumor Analysis Simple Rules in Diagnosis of Ovarian Cancer

Tefta Isufaj Haliti, Ilir Hoxha, Rubena Mojsiu, Rohini Mandal, Goksu Goc, Kreshnike Dedushi Hoti

Summary: The IOTA Simple Rules have high diagnostic performance in distinguishing between benign and malignant adnexal masses, providing a reliable tool for early diagnosis of ovarian cancer.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

Disparities in Cancer Control in Central America and the Caribbean

Anne Christine Buteau, Alicia Castelo-Loureiro, Regina Barragan-Carrillo, Suyapa Bejarano, Alba J. Kihn-Alarcon, Enrique Soto-Perez-de-Celis

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

Detection of circulating normal and tumor plasma cells in newly diagnosed patients of multiple myeloma and their associations with clinical and laboratory parameters

Leena Gupta, Pratibha Suku, Aishwarya Dash, Parveen Bose, Praveen Sharma, Nabhajit Mallik, Sreejesh Sreedharanunni, Neelam Varma, Aditya Jandial, Pankaj Malhotra, Man Updesh Singh Sachdeva

Summary: This study evaluated the load and characteristics of circulating tumor plasma cells (CTPCs) and circulating normal plasma cells (CNPCs) in newly diagnosed multiple myeloma patients using flow cytometry. Increased burden of CTPCs was associated with poor prognostic markers and poor response to therapy. CNPCs were lower in patients with thrombocytopenia and hypoalbuminemia.

CURRENT PROBLEMS IN CANCER (2024)

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Article Oncology

Transcriptionally activates CCL28 expression to inhibit M2 polarization of macrophages and prevent immune escape in colorectal cancer cells

Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu

Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.

TRANSLATIONAL ONCOLOGY (2024)

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Article Oncology

Breast Cancer in India Screening, Detection, and Management

Prarthna V. Bhardwaj, Renuka Dulala, Senthil Rajappa, Chandravathi Loke

Summary: The management of breast cancers in India needs greater emphasis on awareness, early detection, standard pathologic testing, and cost-effective solutions. With standardized management, outcomes similar to those of developed countries can be expected. Additionally, clinical trials aimed at a more diverse population in LMICs like India should be undertaken.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

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Article Oncology

HMGB1 in the interplay between autophagy and apoptosis in cancer

Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang

Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.

CANCER LETTERS (2024)

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