Oncology

Letter Oncology

Pancreatic cancer care: Lighting the way with the torch of staging laparoscopy and advanced imaging

Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella

Article Oncology

Stentless florence robotic intracorporeal neobladder (FloRIN), a feasibility prospective randomized clinical trial

Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini

Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article Oncology

Neoadjuvant chemotherapy followed by surgery for HPV-associated tonsillar cancer: Does imaging reflect the pathological response?

Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun

Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Letter Oncology

Osimertinib-induced urticarial vasculitis in a patient with lung cancer: A rare cutaneous toxicity

Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng

EUROPEAN JOURNAL OF CANCER (2024)

Article Oncology

Deep learning based histological classification of adnex tumors

Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank

Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.

EUROPEAN JOURNAL OF CANCER (2024)

Article Oncology

A pragmatic approach improves the clinical management of stage IV gastric cancer: Comparison between the Meta-Gastro results and the GIRCG's retrospective series

Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio

Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article Oncology

Impact of colorectal cancer screening on survival after metachronous metastasis

Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman

Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.

EUROPEAN JOURNAL OF CANCER (2024)

Review Oncology

Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet candidate for immunotherapy of human malignancies

Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak

Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2024)

Review Oncology

Uterine transposition versus uterine ventrofixation before radiotherapy as a fertility sparing option in young women with pelvic malignancies: Systematic review of the literature and dose simulation

Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu

Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article Oncology

Outcomes following hypofractionated radiation therapy alone for surgically unfit early esophageal squamous cell carcinoma patients; a retrospective single center analysis

Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn

Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.

RADIOTHERAPY AND ONCOLOGY (2024)

Article Oncology

ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway

Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato

Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.

MOLECULAR ONCOLOGY (2024)

Article Oncology

Association of Internal and External Motion Based on Cine MR Images Acquired During Real-Time Treatment on MRI-Guided Linear Accelerator for Patients With Lung Cancer

Weihua Mao, Joshua Kim, Indrin J. Chetty

Summary: This study investigated the association between lung tumor, diaphragm, and external skin movement during lung cancer treatment using MR cine imaging. The results showed a strong correlation between belly and diaphragmatic motions and large amplitude lung tumor motion in the longitudinal axis.

ADVANCES IN RADIATION ONCOLOGY (2024)

Article Oncology

Clinical identification of malignant pleural effusions

Jianlong Jia, Antonia Marazioti, Apostolos Voulgaridis, Ioannis Psallidas, Anne-Sophie Lamort, Marianthi Iliopoulou, Anthi C. Krontira, Ioannis Lilis, Rachelle Asciak, Nikolaos I. Kanellakis, Najib M. Rahman, Kyriakos Karkoulias, Konstantinos Spiropoulos, Ruonan Liu, Jan-Christian Kaiser, Georgios T. Stathopoulos

Summary: The MAPED score, developed in this study, accurately identifies malignant pleural effusions and complements cytology, providing valuable assistance in streamlining diagnostic decisions.

TRANSLATIONAL ONCOLOGY (2024)

Article Oncology

Gene expression profiles (GEPs) of immuno-oncologic pathways as predictors of response to checkpoint inhibitors in advanced NSCLC

Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis

Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.

TRANSLATIONAL ONCOLOGY (2024)

Review Oncology

Paediatric CBCT protocols for image-guided radiotherapy; outcome of a survey across SIOP Europe affiliated countries and literature review

Daniella Elisabet Ostergaard, Abigail Bryce-Atkinson, Mikkel Skaarup, Bob Smulders, Lucy Siew Chen Davies, Gillian Whitfield, Geert O. Janssens, Lisa Lyngsie Hjalgrim, Ivan Vogelius Richter, Marcel van Herk, Marianne Aznar, Maja Vestmo Maraldo

RADIOTHERAPY AND ONCOLOGY (2024)

Article Oncology

Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models

Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao

Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.

TRANSLATIONAL ONCOLOGY (2024)

Article Oncology

CT-based deep learning radiomics and hematological biomarkers in the assessment of pathological complete response to neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma: A two-center study

Meng Zhang, Yukun Lu, Hongfu Sun, Chuanke Hou, Zichun Zhou, Xiao Liu, Qichao Zhou, Zhenjiang Li, Yong Yin

Summary: This study developed a LR-based model using CT-based models and hematological biomarkers to assess the prediction of pathological complete response (pCR) in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemoradiotherapy (nCRT). The model showed good performance in both internal and external validation sets.

TRANSLATIONAL ONCOLOGY (2024)

Article Oncology

CYB5R1 is a potential biomarker that correlates with stemness and drug resistance in gastric cancer

Qin Zhang, Yufan Ma, Yongfeng Yan, Lu Zhang, Yajun Zhang

Summary: This study identifies CYB5R1 as a potential biomarker for stemness and drug resistance in gastric cancer, suggesting the possibility of targeted therapy through the CYB5R1-NFS1 signaling pathway.

TRANSLATIONAL ONCOLOGY (2024)

Article Oncology

Primary metaplastic breast carcinoma or breast metastasis of a poorly differentiated squamous cell carcinoma from the lung? Distinction not always clear

Yoldez Houcine, Ines Houissa, Amira Hmidi, Mohammed Ali Ayadi, Montacer Ghalleb, Fethia Abidi, Asma Zidi, Maha Driss

Summary: Diagnosing primary triple-negative breast cancer with lung metastases or primary TTF1negative lung carcinoma can be difficult due to lack of a TNBC standard immunoprofile. We report a rare case of a woman with a lung squamous cell carcinoma diagnosis confirmed through confrontation with radiology and clinical presentation.

REVISTA DE SENOLOGIA Y PATOLOGIA MAMARIA (2024)

Article Oncology

Optimal Liver Transplantation Criteria for Hepatocellular Carcinoma

Mignote Yilma, Neil Mehta

Summary: Liver transplantation (LT) remains the optimal treatment for hepatocellular carcinoma (HCC), but considerations must be given to organ availability and risk of recurrence. In the United States, Milan criteria have been used to maximize the benefit of LT compared to alternative treatments. Advances in local regional therapy (LRT) have allowed us to downstage patients to meet Milan criteria, and newer selection criteria incorporating biomarkers and imaging are being developed to further optimize LT for HCC patients.

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2024)