Oncology 类别的文章 - Peeref

Article Oncology

Longitudinal changes in cognitive and physical function and health-related quality of life in older adults with acute myeloid leukemia

Vijaya R. Bhatt, Christopher Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Ann Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu

Summary: A study on older adults with AML receiving chemotherapy showed significant comorbidity burden and functional impairments at baseline, but cognitive and physical function improvements or stability, as well as improved depression scores, were observed in a high proportion of patients at three months post-treatment, indicating success of treatment.

JOURNAL OF GERIATRIC ONCOLOGY (2024)

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Article Oncology

Risk of dementia among older patients with lymphoma: A Danish nationwide matched cohort study

Eva Futtrup Maksten, Lasse Hjort Jakobsen, Boris Modrau, Hilde Jensvoll, Kristian Hay Kragholm, Judit Meszaros Jorgensen, Michael Roost Clausen, Robert Schou Pedersen, Andriette Dessau-Arp, Thomas Stauffer Larsen, Christian Bjorn Poulsen, Anne Ortved Gang, Peter Brown, Tarec C. El-Galaly, Marianne Tang Severinsen

Summary: The risk of developing dementia is not increased after lymphoma treatment among patients.

JOURNAL OF GERIATRIC ONCOLOGY (2024)

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Article Oncology

Real-time motion management in MRI-guided radiotherapy: Current status and AI-enabled prospects

Elia Lombardo, Jennifer Dhont, Denis Page, Cristina Garibaldi, Luise A. Kuenzel, Coen Hurkmans, Rob H. N. Tijssen, Chiara Paganelli, Paul Z. Y. Liu, Paul J. Keall, Marco Riboldi, Christopher Kurz, Guillaume Landry, Davide Cusumano, Marco Fusella, Lorenzo Placidi

Summary: This paper describes the steps and available solutions for intra-fractional motion management in MRIgRT, and proposes a 3D compensation method for motion-induced over- or under-dosage with minimal impact on radiotherapy treatment time. Artificial intelligence is emphasized as a fast and accurate alternative to conventional algorithms.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

Pilot applications of GPT-4 in radiation oncology: Summarizing patient symptom intake and targeted chatbot applications

David J. H. Wu, Jean-Emmanuel Bibault

Summary: This study examines the use of GPT-4 in monitoring radiation toxicity during prostate cancer treatments. Two methods, summarization and chatbot interface, were tested. Radiation oncologists surveyed preferred the summarization method for its accuracy and potential for adoption, and both methods saved time.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

A feasibility trial of skin surface motion-gated stereotactic body radiotherapy for treatment of upper abdominal or lower thoracic targets using a novel O-ring gantry

Kendall Kiser, Joshua Schiff, Eric Laugeman, Taeho Kim, Olga Green, Casey Hatscher, Hyun Kim, Shahed Badiyan, Matthew Spraker, Pamela Samson, Clifford Robinson, Alex Price, Lauren Henke

Summary: This study evaluated the feasibility of optical skin surface-guided gating for SBRT treatment, achieving successful breath-hold in 92% of treatments. After three months, no local recurrences or acute grade >= 3 toxicities were observed.

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY (2024)

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Article Oncology

Meta-analysis of 5-day preoperative radiotherapy for soft tissue sarcoma (5D-PREORTS)

Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes

Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.

RADIOTHERAPY AND ONCOLOGY (2024)

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Review Oncology

Self-reported electronic symptom monitoring in older patients with multimorbidity treated for cancer: Development of a core dataset based on expert consensus, literature review, and quality of life questionnaires

P. A. L. Nelleke Seghers, Marije E. Hamaker, Shane O'Hanlon, Johanneke E. A. Portielje, Hans Wildiers, Pierre Soubeyran, Annemarie Coolbrandt, Siri Rostoft

Summary: This study identified a core set of symptoms to monitor in older patients with multimorbidity treated for cancer. These symptoms include those related to cancer, treatment side effects, functional decline, and destabilization of comorbidities. The results provide a basis for guiding symptom monitoring during cancer treatment.

JOURNAL OF GERIATRIC ONCOLOGY (2024)

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Article Oncology

A case of a shrunken multilocular mediastinal cyst that developed into thymic carcinoma with lung metastases 13 years later

Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima

Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.

THORACIC CANCER (2024)

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Article Oncology

Exploring published and novel pre-treatment CT and PET radiomics to stratify risk of progression among early-stage non-small cell lung cancer patients treated with stereotactic radiation

Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner

Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

CT-based online adaptive radiotherapy improves target coverage and organ at risk (OAR) avoidance in stereotactic body radiation therapy (SBRT) for prostate cancer

Michael Waters, Alex Price, Eric Laugeman, Lauren Henke, Geoff Hugo, Hayley Stowe, Neal Andruska, Randall Brenneman, Yao Hao, Olga Green, Clifford Robinson, Hiram Gay, Jeff Michalski, Brian C. Baumann

Summary: The study evaluated the clinical utility of an AI-augmented CT-based adaptive SBRT system for prostate cancer treatment. Results showed that adaptive treatment plans significantly improved target coverage and reduced dose to critical organs.

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY (2024)

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Article Oncology

Comparative effectiveness of new treatment modalities for localized prostate cancer through patient-reported outcome measures

Victor Zamora, Olatz Garin, Jose Francisco Suarez, Cristina Gutierrez, Ferran Guedea, Patricia Cabrera, Manuel Castells, Ismael Herruzo, Lluis Fumado, Pilar Samper, Carlos Ferrer, Lucas Regis, Angels Pont, Montse Ferrer

Summary: There is a lack of comparative effectiveness research on new treatment modalities for localized prostate cancer. This study aimed to compare the impact of active surveillance, robot-assisted radical prostatectomy (RARP), intensity-modulated radiotherapy (IMRT), and real-time brachytherapy using Patient-Reported Outcome Measures (PROMs). The results showed that active surveillance had the fewest side effects, but led to significant deterioration in sexual and physical health, while showing moderate improvement in mental health. RARP had greater urinary incontinence, and IMRT and real-time brachytherapy were associated with worse bowel symptoms. Most side effects seemed to be limited to short-term deteriorations.

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY (2024)

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Article Oncology

Mammary actinomycosis: Presentation of a clinical case

Mirian E. Pinto Paz, Clariza Biminchumo Sagastegui, Jose Somocurcio Peralta, Victor Gomez Ponce

Summary: Breast actinomycosis is a rare chronic infection characterized by external fistulas on the skin of the breasts. This article presents a clinical case of a 71-year-old female patient who experienced a hard tumor, intense pain, limited mobility of the left upper limb, and significant weight loss. The thoracic tomography report initially suspected a malignant breast neoplasm, but the pathology study revealed mammary actinomycosis.

REVISTA DE SENOLOGIA Y PATOLOGIA MAMARIA (2024)

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Review Oncology

Enhancing radiotherapy outcomes in rectal cancer: A systematic review of targeting hypoxia-induced radioresistance

Matthew Fok, Rhianna Hill, Hayley Fowler, Rachael Clifford, Aaron Kler, Jayanma Uzzi-Daniel, Sonia Rocha, Gabrielle Grundy, Jason Parsons, Dale Vimalachandran

Summary: This systematic review evaluates the potential effectiveness of targeting hypoxia-induced radioresistance in rectal cancer and highlights the importance of further research in this area. There is a need for more preclinical and clinical studies to fully understand the mechanism behind this radioresistance. Promising targets have been identified, but more research is needed.

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY (2024)

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Article Oncology

Bulky glycocalyx shields cancer cells from invasion-associated stresses

Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen

Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.

TRANSLATIONAL ONCOLOGY (2024)

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Article Oncology

Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer

Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang

Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.

TRANSLATIONAL ONCOLOGY (2024)

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Article Oncology

Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression

Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.

MOLECULAR ONCOLOGY (2024)

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Article Oncology

What is the predictive value of RECIST criteria following stereotactic lung radiation?

Stephanie Gulstene, Pencilla Lang, Melody Qu, Joanna M. Laba, Brian P. Yaremko, George B. Rodrigues, Edward Yu, Mehdi Qiabi, Rahul Nayak, Richard A. Malthaner, Dalilah Fortin, Andrew Warner, Richard I. Inculet, David A. Palma

Summary: Purpose: This study evaluates the frequency of progressive disease (PD) as determined by the Response Evaluation Criteria in Solid Tumors (RECIST) following lung stereotactic ablative radiotherapy (SABR), and correlates this with actual treatment outcomes. The results show that most lesions identified as PD by RECIST criteria do not represent recurrence, highlighting the limitations of RECIST in this setting.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

The rise of negative portrayals of radiation oncology: A textual analysis of media news

Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka

Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

Curative carbon ion radiotherapy in a head and neck mucosal melanoma series: Facing the future within multidisciplinarity

Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni

Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.

RADIOTHERAPY AND ONCOLOGY (2024)

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Review Oncology

Advances in new targets for immunotherapy of small cell lung cancer

Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu

Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.

THORACIC CANCER (2024)

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