Obstetrics & Gynecology

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Article Obstetrics & Gynecology

Pregnant and breastfeeding women's attitudes and fears regarding the COVID-19 vaccination

Nora K. Schaal, Janine Zoellkau, Philip Hepp, Tanja Fehm, Carsten Hagenbeck

Summary: The survey revealed that during pregnancy, the majority of women (57.4%) are not in favor of receiving the COVID-19 vaccine, while breastfeeding women show higher willingness (39.5% are in favor). The willingness to be vaccinated is significantly related to the women's anxiety levels of getting infected and developing disease symptoms, with main reasons for vaccination hesitancy including limited vaccine-specific information and scientific evidence on vaccine safety, as well as fear of harming the fetus or infant.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

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Article Obstetrics & Gynecology

Treatment for Mild Chronic Hypertension During Pregnancy

Alan T. Tita, Jeff M. Szychowski, Kim Boggess, Lorraine Dugoff, Baha Sibai, Kirsten Lawrence, Brenna L. Hughes, Joseph Bell, Kjersti Aagaard, Rodney K. Edwards, Kelly Gibson, David M. Haas, Lauren Plante, Torri Metz, Brian Casey, Sean Esplin, Sherri Longo, Matthew Hoffman, George R. Saade, Kara K. Hoppe, Janelle Foroutan, Methodius Tuuli, Michelle Y. Owens, Hyagriv N. Simhan, Heather Frey, Todd Rosen, Anna Palatnik, Susan Baker, Phyllis August, Uma M. Reddy, Wendy Kinzler, Emily Su, Iris Krishna, Nicki Nguyen, Mary E. Norton, Daniel Skupski, Yasser Y. El-Sayed, Dotum Ogunyemi, Zorina S. Galis, Lorie Harper, Namasivayam Ambalavanan, Nancy L. Geller, Suzanne Oparil, Gary R. Cutter, William W. Andrews

Summary: Chronic hypertension is a common condition in pregnancies in the United States, with a higher prevalence among Black women. Pregnant women with chronic hypertension have an increased risk of placental abruption, preeclampsia, preterm birth, small-for-gestational-age birthweight, and perinatal death.

OBSTETRICAL & GYNECOLOGICAL SURVEY (2022)

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Article Obstetrics & Gynecology

Fetal exome sequencing for isolated increased nuchal translucency: should we be doing it?

R. Mellis, R. Y. Eberhardt, S. J. Hamilton, D. J. McMullan, M. D. Kilby, E. R. Maher, M. E. Hurles, J. L. Giordano, V Aggarwal, D. B. Goldstein, R. J. Wapner, L. S. Chitty

Summary: Prenatal exome sequencing has a low diagnostic yield for fetuses with isolated increased nuchal translucency, but significantly higher when there are additional structural anomalies present. It may not be appropriate for truly isolated increased NT cases, but careful ultrasound scanning to identify other anomalies emerging later can direct testing to focus where there is a higher likelihood of diagnosis.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2022)

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Article Obstetrics & Gynecology

Women perception of SARS-CoV-2 vaccination during pregnancy and subsequent maternal anxiety: a prospective observational study

Ilenia Mappa, Maria Luviso, Flavia Adalgisa Distefano, Luigi Carbone, Giuseppe Maria Maruotti, Giuseppe Rizzo

Summary: The majority of pregnant women in Italy have a positive attitude towards the SARS-CoV-2 vaccine. However, vaccine campaigns seem to increase maternal anxiety levels, with a more pronounced increase among those with a negative attitude toward the vaccine.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Review Obstetrics & Gynecology

Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis

Hajra Khattak, Rosamund Malhas, Laurentiu Craciunas, Yousri Afifi, Christiani A. Amorim, Simon Fishel, Sherman Silber, Debra Gook, Isabelle Demeestere, Olga Bystrova, Alla Lisyanskaya, Georgy Manikhas, Laura Lotz, Ralf Dittrich, Lotte Berdiin Colmorn, Kirsten Tryde Macklon, Ina Marie Dueholm Hjorth, Stine Gry Kristensen, Ioannis Gallos, Arri Coomarasamy

Summary: Ovarian tissue cryopreservation and transplantation techniques have evolved over the past two decades with the aim of restoring fertility and hormonal function in women. Although evidence of success is largely based on case reports, studies demonstrate that this technology can restore reproductive and hormonal functions in women.

HUMAN REPRODUCTION UPDATE (2022)

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Article Oncology

SUCCOR cone study: conization before radical hysterectomy

Enrique Chacon, Nabil Manzour, Vanna Zanagnolo, Denis Querleu, Jorge M. Nunez-Cordoba, Nerea Martin-Calvo, Mihai Emil Capilna, Anna Fagotti, Ali Kucukmetin, Constantijne Mom, Galina Chakalova, Aliyev Shamistan, Antonio Gil Moreno, Mario Malzoni, Fabrice Narducci, Octavio Arencibia, Francesco Raspagliesi, Tayfun Toptas, David Cibula, Dilyara Kaidarova, Mehmet Mutlu Meydanli, Mariana Tavares, Dmytro Golub, Anna Myriam Perrone, Robert Poka, Dimitrios Tsolakidis, Goran Vujic, Marcin A. Jedryka, Petra L. M. Zusterzeel, Jogchum Jan Beltman, Frederic Goffin, Dimitrios Haidopoulos, Herman Haller, Robert Jach, Iryna Yezhova, Igor Berlev, Margarida Bernardino, Rasiah Bharathan, Maximilian Lanner, Minna M. Maenpaa, Vladyslav Sukhin, Jean-Guillaume Feron, Robert Fruscio, Kersti Kukk, Jordi Ponce, Jose Angel Minguez, Daniel Vazquez-Vicente, Teresa Castellanos, Felix Boria, Juan Luis Alcazar, Luis Chiva

Summary: This retrospective study evaluated the disease-free survival of patients with stage IB1 cervical cancer who underwent cervical conization prior to radical hysterectomy. The results showed a significantly lower risk of relapse and death for patients who had cervical conization before radical hysterectomy.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2022)

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Article Obstetrics & Gynecology

Guideline No. 426: Hypertensive Disorders of Pregnancy: Diagnosis, Prediction, Prevention, and Management

Laura A. Magee, Graeme N. Smith, Christine Bloch, Anne-Marie Cote, Venu Jain, Kara Nerenberg, Peter von Dadelszen, Michael Helewa, Evelyne Rey

Summary: This guideline reviews the diagnosis, evaluation, and management of hypertensive disorders of pregnancy (HDPs), prediction and prevention of preeclampsia, and postpartum care. The recommendations are based on a comprehensive literature review and prioritize randomized controlled trials and systematic reviews to support therapeutic recommendations. Implementation of these recommendations may reduce the incidence of HDPs and associated adverse outcomes.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA (2022)

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Review Obstetrics & Gynecology

The Role of Genetics, Epigenetics and Lifestyle in Polycystic Ovary Syndrome Development: the State of the Art

Vincenzina Bruni, Anna Capozzi, Stefano Lello

Summary: PCOS is a common endocrine-metabolic disease that may be associated with genetic, epigenetic, and lifestyle factors. Early identification and management of PCOS require an understanding of the patient's personal and family history, lifestyle, and nutritional habits.

REPRODUCTIVE SCIENCES (2022)

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Article Obstetrics & Gynecology

Spectrum of neonatal COVID-19 in Iran: 19 infants with SARS-CoV-2 perinatal infections with varying test results, clinical findings and outcomes

David A. Schwartz, Parisa Mohagheghi, Babak Beigi, Nazanin Zafaranloo, Fereshteh Moshfegh, Anita Yazdani

Summary: This study analyzed the epidemiology, diagnostic test results, and clinical findings of neonatal COVID-19 in Iran. The results showed significant variation in the cases, with some neonates initially testing negative but later becoming positive. Two neonates were highly suspicious for intrauterine vertical transmission. The study recommends repeat testing for neonates testing negative initially to avoid misdiagnosis.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Article Nursing

Effects of the COVID-19 pandemic on perinatal mental health in Spain: Positive and negative outcomes

Covadonga Chaves, Carlos Marchena, Beatriz Palacios, Alfonso Salgado, Almudena Duque

Summary: This study described the effects of the COVID-19 pandemic on maternal perinatal mental health in Spain, revealing high rates of psychological distress among women during the pandemic. Various predictors for life satisfaction during pregnancy and postpartum were identified.

WOMEN AND BIRTH (2022)

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Article Obstetrics & Gynecology

Management and implications of severe COVID-19 in pregnancy in the UK: data from the UK Obstetric Surveillance System national cohort

Nicola Vousden, Rema Ramakrishnan, Kathryn Bunch, Edward Morris, Nigel Simpson, Christopher Gale, Pat O'Brien, Maria Quigley, Peter Brocklehurst, Jennifer J. Kurinczuk, Marian Knight

Summary: Severe COVID-19 in pregnancy increases the risk of adverse outcomes. Factors such as age, overweight or obesity, mixed ethnicity, and gestational diabetes are associated with severe infection. Cesarean birth, preterm birth, stillbirth, and neonatal unit admission are more likely to occur in women with severe infection. Most women with severe infection who gave birth at a later admission delivered at 36 weeks or later, but rapid delivery may be warranted for those with severe infection at term.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2022)

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Article Obstetrics & Gynecology

Preparing an obstetric unit in the heart of the epidemic strike of COVID-19: quick reorganization tips

Federica Capanna, Ahmad Haydar, Catherine McCarey, Enrico Carri, Jose' Bartha Rasero, Valentina Tsibizova, Hanns Helmer, Alexander Makatsarya, Gian Carlo Di Renzo

Summary: The COVID-19 outbreak has greatly burdened healthcare systems, with many units being overwhelmed. This article aims to provide key strategies to be implemented in obstetric units without delay, based on practical experience and field feedback, in order to best respond to the upcoming wave.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Review Obstetrics & Gynecology

Progress in the understanding of the pathophysiology of immunologic maladaptation related to early-onset preeclampsia and metabolic syndrome related to late-onset preeclampsia

Pierre-Yves Robillard, Gustaaf Dekker, Marco Scioscia, Shigeru Saito

Summary: Human reproduction has two notable features: deep endovascular trophoblast invasion and preeclampsia. Regulatory T cells and sexual intercourse play important roles in maintaining pregnancy. Preeclampsia is associated with immune and cardiovascular metabolic factors. Preventative measures for preeclampsia include low-dose aspirin and controlling weight gain.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

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Article Nursing

The effects of the COVID 19 pandemic on vaccine decisions in pregnant women

Hatice Gencer, Sevgi Ozkan, Okan Vardar, Pinar Serceku

Summary: This study aims to understand the opinions of pregnant women on vaccinations during pregnancy and childhood, and the impact of the COVID-19 pandemic on these views. The results show that approximately 29.6% of pregnant women exhibited hesitant attitudes towards vaccinations when using forum websites. Vaccine hesitancy was found to be higher among pregnant women with lower economic levels and concerns about vaccination risks. The COVID-19 pandemic was reported to have decreased vaccine hesitancy in 28.9% of the participants.

WOMEN AND BIRTH (2022)

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Review Obstetrics & Gynecology

COVID-19 and maternal, fetal and neonatal mortality: a systematic review

Kamran Hessami, Nahid Homayoon, Atefe Hashemi, Homeira Vafaei, Maryam Kasraeian, Nasrin Asadi

Summary: This comprehensive review examines the available evidence on maternal, fetal, and neonatal mortality associated with COVID-19 infection. The results suggest that maternal mortality is more common in women with pre-existing conditions, while fetal and neonatal mortality may be a result of maternal infection severity or prematurity. However, further research is needed to determine the exact magnitude of these mortality rates.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Review Obstetrics & Gynecology

Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance

Michal Fishel Bartal, Marshall D. Lindheimer, Baha M. Sibai

Summary: In pregnancy, the measurement of urine protein excretion is common, and recent guidelines suggest that proteinuria alone is sufficient for the diagnosis of preeclampsia. While a 24-hour urine collection is the reference standard, the urine protein-to-creatinine ratio is a reasonable test to rule out proteinuria.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

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Review Obstetrics & Gynecology

Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review

Jingbo Guo, Jie Shao, Yuan Yang, Xiaodan Niu, Juan Liao, Qing Zhao, Donghui Wang, Shuaitong Li, Junping Hu

Summary: The relationship between gut microbiome and Polycystic Ovary Syndrome (PCOS) remains unclear, with existing studies showing differences in specific gut microbes between patients with PCOS and healthy controls. PCOS patients exhibit reduced alpha-diversity and significant differences in beta-diversity composition compared to healthy controls, with common bacterial alterations identified. More research is needed to determine the role of these microbes in the development of PCOS.

REPRODUCTIVE SCIENCES (2022)

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Letter Obstetrics & Gynecology

Maternal morbidity and fetal outcomes among pregnant women at 22 weeks' gestation or less with complications in 2 Texas hospitals after legislation on abortion

Anjali Nambiar, Shivani Patel, Patricia Santiago-Munoz, Catherine Y. Spong, David B. Nelson

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

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Review Obstetrics & Gynecology

Effectiveness and safety of available treatments for COVID-19 during pregnancy: a critical review

Alessandro Favilli, Marta Mattei Gentili, Francesca Raspa, Irene Giardina, Fabio Parazzini, Amerigo Vitagliano, Anna V. Borisova, Sandro Gerli

Summary: Clinical trials for COVID-19 treatment in pregnant women are lacking due to safety concerns, leading to a lack of knowledge on the effectiveness and safety of drugs used in the general population. This overview provides useful information for physicians on the management of COVID-19 during pregnancy in the current state of uncertainty and limited knowledge.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Review Obstetrics & Gynecology

Psychological variables in medically assisted reproduction: a systematic review

Sofia Burgio, Concetta Polizzi, Giovanni Buzzaccarini, Antonio Simone Lagana, Giuseppe Gullo, Giovanna Perricone, Antonino Perino, Gaspare Cucinella, Marianna Alesi

Summary: Medically assisted reproduction is a significant scientific progress in dealing with infertility, but it presents challenges to psychological well-being. While studies emphasize the importance of addressing psychological variables, further research is needed to evaluate the effectiveness of interventions and their implications on child development.

MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY (2022)

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