Obstetrics & Gynecology

Review Obstetrics & Gynecology

Placental energy metabolism in health and disease-significance of development and implications for preeclampsia

Irving L. M. H. Aye, Catherine E. Aiken, D. Stephen Charnock-Jones, Gordon C. S. Smith

Summary: This article discusses the metabolic basis for placental dysfunction and proposes that alterations in energy metabolism may explain various placental phenotypes in preeclampsia. It also suggests that placental metabolic reprogramming may be associated with severe preeclampsia phenotypes.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

Review Obstetrics & Gynecology

Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

Reyon Dcunha, Reda S. Hussein, Hanumappa Ananda, Sandhya Kumari, Satish Kumar Adiga, Nagarajan Kannan, Yulian Zhao, Guruprasad Kalthur

Summary: This review discusses the physiology of sperm, molecular pathways regulating sperm motility, risk factors affecting sperm motility, and the role of sperm motility in fertility outcomes. It also explores various pharmacological agents and biomolecules that can enhance sperm motility to improve assisted reproductive technology outcomes.

REPRODUCTIVE SCIENCES (2022)

Article Nursing

Midwives' experiences of providing maternity care during the COVID-19 pandemic in Australia

Zoe Bradfield, Yvonne Hauck, Caroline S. E. Homer, Linda Sweet, Alyce N. Wilson, Rebecca A. Szabo, Karen Wynter, Vidanka Vasilevski, Lesley Kuliukas

Summary: This study explores the experiences of Australian midwives in providing maternity care during the COVID-19 pandemic. The findings reveal that many midwives shifted to telehealth appointments and faced challenges in providing support during labor and postnatal visits. The study also highlights the coping strategies used by midwives to deal with rapid changes and challenges to woman-centered care.

WOMEN AND BIRTH (2022)

Review Obstetrics & Gynecology

Complement activation and regulation in preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome

Richard M. Burwick, Bruce B. Feinberg

Summary: The complement system plays a crucial role in host defense and immunity during pregnancy. Imbalanced complement activation and regulation are associated with complications like preeclampsia. Inhibiting the terminal complement pathway, possibly through C5 blockade, may be an effective strategy for treating these complications.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

Article Public, Environmental & Occupational Health

Sex-Related Differences in Long-COVID-19 Syndrome

Giovanna Pela, Matteo Goldoni, Emila Solinas, Chiara Cavalli, Sara Tagliaferri, Silvia Ranzieri, Annalisa Frizzelli, Laura Marchi, Pier Anselmo Mori, Maria Majori, Marina Aiello, Massimo Corradi, Alfredo Chetta

Summary: Studies have shown that there are sex differences in COVID-19, with women being less prone to severe disease. However, few studies have examined sex differences in Long-COVID-19 syndrome. This study found that women had more symptoms both in the acute phase and during follow-up. Sex was found to be an important determinant of Long-COVID-19 syndrome, with women more likely to experience persistent symptoms. These findings highlight the need for long-term follow-up and personalized treatment strategies from a sex perspective.

JOURNAL OF WOMENS HEALTH (2022)

Article Obstetrics & Gynecology

Projected Implications of Overturning Roe v Wade on Abortion Training in US Obstetrics and Gynecology Residency Programs

Kavita Vinekar, Aishwarya Karlapudi, Lauren Nathan, Jema K. Turk, Radhika Rible, Jody Steinauer

Summary: If Roe v Wade is overturned, it is projected that several states will ban abortion, posing significant implications for obstetrics and gynecology residency training and patient access to abortion care.

OBSTETRICS AND GYNECOLOGY (2022)

Review Obstetrics & Gynecology

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino, Roxanne Hastie, Fiona Brownfoot, Catherine Cluver, Natalie Hannan

Summary: Research on therapeutic agents for preeclampsia focuses on molecular mechanisms affecting disease pathophysiology, with pravastatin receiving significant interest. Other drugs with potential in clinical trials include proton-pump inhibitors and metformin. Natural compounds and novel molecular-targeted strategies also show promise in treating preeclampsia.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

Article Psychology, Clinical

Managing endometriosis: a cross-sectional survey of women in Australia

Rebecca O'Hara, Heather Rowe, Jane Fisher

Summary: A study involving 620 women with endometriosis found an average delay in diagnosis of 6.4 years, with a majority of patients still experiencing pain symptoms despite treatment. Therefore, establishing a chronic disease management plan may help in coordinating multidisciplinary care for these patients.

JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY (2022)

Article Nursing

Perceived social support and prenatal wellbeing; The mediating effects of loneliness and repetitive negative thinking on anxiety and depression during the COVID-19 pandemic

Virginia Harrison, Michelle L. Moulds, Katie Jones

Summary: This study investigated the relationship between perceived social support and anxiety/depression in UK-based pregnant women during the COVID-19 pandemic. It also examined two mediators, repetitive negative thinking and loneliness. The results showed that perceived social support was negatively associated with anxiety, depression, loneliness, and repetitive negative thinking. Repetitive negative thinking and loneliness mediated the relationship between perceived social support and anxiety/depression. Additionally, perceived social support and loneliness were associated with specific online behaviors.

WOMEN AND BIRTH (2022)

Article Obstetrics & Gynecology

SARS-CoV-2 infection among hospitalised pregnant women and impact of different viral strains on COVID-19 severity in Italy: a national prospective population-based cohort study

S. Donati, E. Corsi, A. Maraschini, M. A. Salvatore

Summary: The study found that the majority of pregnant women infected with the virus were asymptomatic, while a small percentage required treatment for pneumonia or ventilatory support. Risk factors for developing pneumonia included age, citizenship from countries with high migration pressure, previous comorbidities, and obesity. Preterm birth rates increased compared to the pre-pandemic period, while stillbirths and maternal and neonatal deaths remained stable. The need for ventilatory support and/or ICU admission increased during the Alpha-variant period compared to the wild-type period.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2022)

Review Obstetrics & Gynecology

Pregnancy and COVID-19: a systematic review of maternal, obstetric and neonatal outcomes

Vera Trocado, Joana Silvestre-Machado, Lidia Azevedo, Alexandra Miranda, Cristina Nogueira-Silva

Summary: This systematic review evaluates the impact of COVID-19 during pregnancy. It found that pregnant women with COVID-19 commonly experience symptoms such as fever, cough, and fatigue, and a portion of them have a history of exposure to the virus. Most deliveries were cesarean sections, and there were cases of preterm births. Among neonates, a percentage had low birth weight and very few tested positive for Sars-CoV-2, with no cases of severe neonatal asphyxia.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

Review Obstetrics & Gynecology

Vertical transmission of SARS CoV-2: a systematic review

Melis Deniz, Hasan Tezer

Summary: This study aims to review the current evidence on the vertical transmission of SARS CoV-2 and found that some newborns tested positive for the virus. The results suggest the potential transmission of SARS CoV-2 through placenta, breast milk, and amniotic fluid. Further testing is needed to confirm these findings.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

Article Nursing

Perspectives of pregnant women during the COVID-19 pandemic: A qualitative study

Kiran Atmuri, Mahbub Sarkar, Efe Obudu, Arunaz Kumar

Summary: This qualitative research in Australia explored the impacts of the COVID-19 pandemic on pregnant women, identifying major themes such as positive support experiences, changes in pregnancy preparedness, facing uncertainties, and maintaining resilience and optimism.

WOMEN AND BIRTH (2022)

Article Obstetrics & Gynecology

Psychological status of postpartum women under the COVID-19 pandemic in Japan

Shunji Suzuki

Summary: Under the COVID-19 pandemic, limitations may lead to psychosocial problems for postpartum women, affecting mother-infant bonding.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

Article Nursing

The impact of COVID-19 on the provision of respectful maternity care: Findings from a global survey of health workers

Anteneh Asefa, Aline Semaan, Therese Delvaux, Elise Huysmans, Anna Galle, Emma Sacks, Meghan A. Bohren, Alison Morgan, Michelle Sadler, Saraswathi Vedam, Lenka Benova

Summary: The COVID-19 pandemic has had a negative impact on frontline health workers' ability to provide respectful maternity care globally, resulting in reduced family involvement, decreased emotional and physical support for women, compromised care standards, and increased medically unjustified caesarean sections.

WOMEN AND BIRTH (2022)

Article Acoustics

Performance of IOTA Simple Rules, Simple Rules risk assessment, ADNEX model and O-RADS in differentiating between benign and malignant adnexal lesions in North American women

A. K. Hiett, J. D. Sonek, M. Guy, T. J. Reid

Summary: This study aimed to compare the performance of IOTA Simple Rules, SRR assessment, ADNEX model, and O-RADS in preoperative discrimination between malignant and benign adnexal lesions. The results showed that these models had similar sensitivity, but the IOTA models had higher specificity and did not require the use of magnetic resonance imaging.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2022)

Review Oncology

Factors influencing five-year adherence to adjuvant endocrine therapy in breast cancer patients: A systematic review

Izzati Yussof, Nor Asyikin Mohd Tahir, Ernieda Hatah, Noraida Mohamed Shah

Summary: This systematic review aimed to determine the rate and correlates of adherence and persistence in female breast cancer patients receiving adjuvant endocrine therapy over a five-year period. The results showed that the average adherence rate at five years was 66.2% and the average persistence rate was 66.8%. Adherence decreased by 25.5% from the first to fifth year. Factors associated with lower adherence included age, comorbidity index, depression, and adverse effects, while the use of aromatase inhibitors, chemotherapy, and prior medication were associated with improved adherence.

BREAST (2022)

Review Obstetrics & Gynecology

Clinical interpretation and implementation of the sFlt-1/PlGF ratio in the prediction, diagnosis and management of preeclampsia

Stefan Verlohren, Shaun P. Brennecke, Alberto Galindo, S. Ananth Karumanchi, Ljiljana B. Mirkovic, Dietmar Schlembach, Holger Stepan, Manu Vatish, Harald Zeisler, Sarosh Rana

Summary: Preeclampsia poses significant morbidity and mortality risks for both mother and baby. The discovery of circulating angiogenic factors in preeclampsia pathogenesis has advanced diagnosis and prognosis, but there is currently no consensus or clear guidance on their practical use in routine clinical practice.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2022)

Letter Obstetrics & Gynecology

Pregnant women in the exposure to COVID-19 infection outbreak: the unseen risk factors and preventive healthcare patterns

Monirsadat Mirzadeh, Leila Khedmat

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

Article Obstetrics & Gynecology

Does mRNA SARS-CoV-2 vaccine detrimentally affect male fertility, as reflected by semen analysis?

Dror Lifshitz, Jigal Haas, Oshrit Lebovitz, Gil Raviv, Raoul Orvieto, Adva Aizer

Summary: This study found no detrimental effects on semen analysis parameters following Pfizer's COVID-19 vaccination. Most participants had normal semen parameters within 1-2 months after vaccination. The results support the safety of Pfizer's vaccine and recommend it for men who wish to conceive.

REPRODUCTIVE BIOMEDICINE ONLINE (2022)