Review
Biochemistry & Molecular Biology
Marco Solmi, Joaquim Radua, Miriam Olivola, Enrico Croce, Livia Soardo, Gonzalo Salazar de Pablo, Jae Il Shin, James B. Kirkbride, Peter Jones, Jae Han Kim, Jong Yeob Kim, Andre F. Carvalho, Mary V. Seeman, Christoph U. Correll, Paolo Fusar-Poli
Summary: This study emphasizes the importance of promoting good mental health, prevention, and early intervention before the onset of mental disorders. It found that different types of mental disorders have different age at onset characteristics, providing valuable guidance for the timing of interventions for specific mental disorders.
MOLECULAR PSYCHIATRY
(2022)
Review
Immunology
Felicia Ceban, Susan Ling, Leanna M. W. Lui, Yena Lee, Hartej Gill, Kayla M. Teopiz, Nelson B. Rodrigues, Mehala Subramaniapillai, Joshua D. Di Vincenzo, Bing Cao, Kangguang Lin, Rodrigo B. Mansur, Roger C. Ho, Joshua D. Rosenblat, Kamilla W. Miskowiak, Maj Vinberg, Vladimir Maletic, Roger S. McIntyre
Summary: Post-COVID-19 syndrome, characterized by persistent symptoms after resolution of acute infection, is associated with significant fatigue and cognitive impairment. This study aimed to quantify the proportion of individuals experiencing fatigue and cognitive impairment 12 or more weeks after COVID-19 diagnosis, and to explore the inflammatory and functional consequences of post-COVID-19 syndrome. The results showed that a significant proportion of individuals continue to experience fatigue and cognitive impairment even after 12 or more weeks of COVID-19 diagnosis. Additionally, some individuals showed elevated levels of inflammatory markers and significant functional impairment.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Neurosciences
Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brone, Guy C. Brown, Oleg Butovsky, Monica J. Carson, Bernardo Castellano, Marco Colonna, Sally A. Cowley, Colm Cunningham, Dimitrios Davalos, Philip L. De Jager, Bart de Strooper, Adam Denes, Bart J. L. Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K. Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta Gonzalez, Siamon Gordon, Manuel B. Graeber, Andrew D. Greenhalgh, Pierre Gressens, Melanie Greter, David H. Gutmann, Christian Haass, Michael T. Heneka, Frank L. Heppner, Soyon Hong, David A. Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W. McColl, Veronique E. Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J. Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V. Hugh Perry, Phillip G. Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M. Ransohoff, Michael W. Salter, Anne Schaefer, Dorothy P. Schafer, Michal Schwartz, Mikael Simons, Cody J. Smith, Wolfgang J. Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valerie Wittamer, Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray
Summary: Microglial research has made significant progress, but the current classification system fails to accurately describe their diversity, leading to misconceptions about their functions. To address this issue, a group of multidisciplinary experts has proposed a naming framework and recommendations to help researchers better understand and describe the different states and functions of microglia.
Article
Psychology, Biological
Tal Yarkoni
Summary: Most theories and hypotheses in psychology are verbal in nature, yet their evaluation overwhelmingly relies on inferential statistical procedures. However, many applications of statistical inference in psychology fail to meet the basic condition of closely aligning verbal and statistical expressions, which results in limited generalizability of results, increased false-positive rates, and researchers drawing sweeping verbal generalizations without meaningful connection to statistical quantities.
BEHAVIORAL AND BRAIN SCIENCES
(2022)
Article
Anesthesiology
R. Jason Yong, Peter M. Mullins, Neil Bhattacharyya
Summary: Chronic pain is associated with reduced quality of life, increased medical expenditures, and significant economic costs. According to the latest data, more than one-fifth of adults in America experience chronic pain, indicating a need for increased attention and management.
Review
Neurosciences
Naomi P. Friedman, Trevor W. Robbins
Summary: Concepts of cognitive control and executive function are defined in relation to goal-directed behavior versus habits, controlled versus automatic processing, and the functions of the prefrontal cortex and related regions and networks. There is unity and diversity in cognitive control constructs, including general cognitive control and components specific to mental set shifting and working memory updating. The relationships of cognitive control with psychopathology, impulsivity, genetic studies, and psychiatric classification are also explored.
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Moncrieff, Ruth E. Cooper, Tom Stockmann, Simone Amendola, Michael P. Hengartner, Mark A. Horowitz
Summary: The serotonin hypothesis of depression, which suggests that depression is caused by lowered serotonin activity or concentrations, lacks consistent evidence based on the synthesis and evaluation of research in this field. This umbrella review found no substantial association between serotonin and depression, while suggesting that long-term antidepressant use may reduce serotonin concentration.
MOLECULAR PSYCHIATRY
(2023)
Review
Clinical Neurology
Lavienraj Premraj, Nivedha Kannapadi, Jack Briggs, Stella M. Seal, Denise Battaglini, Jonathon Fanning, Jacky Suen, Chiara Robba, John Fraser, Sung-Min Cho
Summary: Neurological and neuropsychiatric symptoms that persist or develop three months after the onset of COVID-19 pose a significant threat to the global healthcare system. A systematic review analyzed data from multiple studies and found that fatigue, cognitive dysfunction, and sleep disturbances were key features of post-COVID-19 syndrome. Psychiatric manifestations such as anxiety and depression were also common and increased in prevalence over time.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Longjian Liu, Stella L. Volpe, Jennifer A. Ross, Jessica A. Grimm, Elisabeth J. Van Bockstaele, Howard J. Eisen
Summary: This study found a significant association between excessive total sugar intake and AD risk in women, with lactose showing a stronger impact on AD risk.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Clinical Neurology
Jeffrey Cummings, Garam Lee, Pouyan Nahed, Mina Esmail Zadeh Nojoo Kambar, Kate Zhong, Jorge Fonseca, Kazem Taghva
Summary: Alzheimer's disease is a global health crisis, and there are numerous clinical trials and drugs in development to treat and improve the symptoms and progression of the disease. The pipeline of drug development includes a diverse array of treatments, including disease-modifying therapies, cognitive enhancing treatments, and drugs for neuropsychiatric symptoms. Advances in drug design, outcome measures, biomarker use, and trial conduct show promise in accelerating the delivery of new and improved treatments for Alzheimer's disease patients.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Review
Neurosciences
Giovanni B. Frisoni, Daniele Altomare, Dietmar Rudolf Thal, Federica Ribaldi, Rik van der Kant, Rik Ossenkoppele, Kaj Blennow, Jeffrey Cummings, Cornelia van Duijn, Peter M. Nilsson, Pierre-Yves Dietrich, Philip Scheltens, Bruno Dubois
Summary: The amyloid hypothesis has long been the leading model for the pathogenesis of Alzheimer's disease, but a probabilistic model is proposed as an alternative due to the increasing understanding of the complex biology of Alzheimer's disease. This new model suggests that genetic factors, environmental exposures, and lower-risk genes play significant roles in different types of Alzheimer's disease, leading to a better understanding of disease pathophysiology and potentially accelerating the development of prevention and treatment strategies.
NATURE REVIEWS NEUROSCIENCE
(2022)
Article
Neurosciences
Ju-Hyun Lee, Dun-Sheng Yang, Chris N. Goulbourne, Eunju Im, Philip Stavrides, Anna Pensalfini, Han Chan, Cedric Bouchet-Marquis, Cynthia Bleiwas, Martin J. Berg, Chunfeng Huo, James Peddy, Monika Pawlik, Efrat Levy, Mala Rao, Mathias Staufenbiel, Ralph A. Nixon
Summary: This study reveals unique autophagy dysregulation within neurons in Alzheimer's disease mouse models, particularly deficient autolysosome acidification, leading to the accumulation of autophagic vacuoles and the formation of flower-like structures called "PANTHOS," which may contribute to the development of senile plaques in Alzheimer's disease.
NATURE NEUROSCIENCE
(2022)
Review
Clinical Neurology
Lars Jacob Stovner, Knut Hagen, Mattias Linde, Timothy J. Steiner
Summary: This article summarizes the epidemiological studies of headache disorders globally, finding that headache disorders remain highly prevalent worldwide, and identifies methodological factors explaining the large variation between study findings. While migraine prevalence estimates increased over time, estimates for all headache types varied between world regions.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Psychology, Biological
Longqi Yang, David Holtz, Sonia Jaffe, Siddharth Suri, Shilpi Sinha, Jeffrey Weston, Connor Joyce, Neha Shah, Kevin Sherman, Brent Hecht, Jaime Teevan
Summary: The COVID-19 pandemic has resulted in a rapid increase in full-time remote work, causing collaboration networks to become more static and fragmented. Asynchronous communication has increased while synchronous communication has decreased, making it more challenging for employees to acquire and share new information.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Cell Biology
Walter J. Lukiw, Aileen Pogue, James M. Hill
Summary: The novel coronavirus SARS-CoV-2 enters human host cells through the ACE2 receptor, allowing it to attack multiple cell types simultaneously and cause harm to various tissues and organ systems. This study found that ACE2 is highly expressed not only in respiratory, digestive, renal-excretory, and reproductive cells, but also in regions of the brain such as the amygdala, cerebral cortex, and brainstem. The high expression of ACE2 in the brainstem, particularly in the respiratory centers, may explain the susceptibility of COVID-19 patients to severe respiratory distress.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Yaojun Ju, Kin Yip Tam
Summary: Alzheimer's disease is a complex neurodegenerative disease characterized by synaptic dysfunctions and neurotransmitter deficiencies. The pathological features of Alzheimer's disease include changes in β-amyloid and tau proteins. Aging and other factors are also risk factors for the disease. Therefore, developing treatment strategies that target different pathological factors is crucial.
NEURAL REGENERATION RESEARCH
(2022)
Article
Computer Science, Artificial Intelligence
Ahmad Ali, Yanmin Zhu, Muhammad Zakarya
Summary: The study proposes a unified dynamic deep spatio-temporal neural network model for predicting crowd flows in different regions of a city. By combining the influences of different time granularities and external properties, the model shows exceptional performance in prediction accuracy, outperforming other methods.
Review
Geriatrics & Gerontology
Shenrui Guo, Hui Wang, Yafu Yin
Summary: Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases, and microglia can be categorized into M1 and M2 types with opposite functions. Modulating microglia M1/M2 polarization shows promising therapeutic potential in neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Computer Science, Artificial Intelligence
Dongrui Wu, Yifan Xu, Bao-Liang Lu
Summary: This article reviews journal publications on transfer learning approaches in EEG-based BCIs since 2016. TL methods applied to different paradigms and applications, such as motor imagery and event-related potentials, are reviewed in the context of cross-subject/session and cross-device/task settings. Observations and conclusions provide insights for future research directions.
IEEE TRANSACTIONS ON COGNITIVE AND DEVELOPMENTAL SYSTEMS
(2022)
Review
Psychology, Biological
Christopher D. Chambers, Loukia Tzavella
Summary: Registered Reports were introduced a decade ago to improve the rigour and credibility of confirmatory research by peer reviewing study proposals before research is undertaken. While they are not a universal solution for irreproducibility, early evidence suggests that Registered Reports are working as intended and are promoting reproducibility, transparency, and self-correction across disciplines. The policies and practices surrounding Registered Reports are evolving to address limitations and adapt to new challenges.
NATURE HUMAN BEHAVIOUR
(2022)
