Medicine, Research & Experimental

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Article Medicine, Research & Experimental

Trigonelline mitigates bleomycin-induced pulmonary inflammation and fibrosis: Insight into NLRP3 inflammasome and SPHK1/S1P/Hippo signaling modulation

Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy

Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.

LIFE SCIENCES (2024)

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Review Medicine, Research & Experimental

Review on chronic metabolic diseases surrounding bile acids and gut microbiota: What we have explored so far

Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun

Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

Involvement of CXC chemokines (CXCL1-CXCL17) in gastric cancer: Prognosis and therapeutic molecules

Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen

Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

TET1-mediated epigenetic regulation of tumor necrosis factor-α in trigeminal ganglia contributes to chronic temporomandibular joint pain

Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai

Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

Targeting HIF-1α alleviates the inflammatory responses and rebuilds the CD4+ T cell subsets balance in the experimental autoimmune myasthenia gravis inflammation model via regulating cellular and humoral immunity

Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu

Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

Potential role of bile acids in the pathogenesis of necrotizing enterocolitis

Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi

Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

Metabolomics study reveals increased deoxycholic acid contributes to deoxynivalenol-mediated intestinal barrier injury

Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu

Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta

Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo

Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

DCLK1 and its oncogenic functions: A promising therapeutic target for cancers

Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang

Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

Targeting the chromatin remodeling protein BRG1 in liver fibrosis: Mechanism and translational potential

Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv

Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.

LIFE SCIENCES (2024)

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Article Medicine, Research & Experimental

Alternative Tissue Fixation Protocols Dramatically Reduce the Impact of DNA Artifacts, Unraveling the Interpretation of Clinical Comprehensive Genomic Profiling

Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi

Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.

LABORATORY INVESTIGATION (2024)

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Article Nanoscience & Nanotechnology

Exploiting the ferroaddiction of pancreatic cancer cells using Fe-doped nanoparticles

Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel

Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2024)

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Article Medicine, Research & Experimental

Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice

Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma

Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.

MEDICAL HYPOTHESES (2024)

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Article Medicine, Research & Experimental

Hyperbaric oxygen therapy as a possible therapeutic candidate for sepsis-associated encephalopathy: A novel hypothesis

Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim

Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.

MEDICAL HYPOTHESES (2024)

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Article Medicine, Research & Experimental

Protocol of a patient randomized clinical trial to improve medication adherence in primary care

JoAnn M. Sperl-Hillen, Jacob L. Haapala, Steven P. Dehmer, Lilian N. Chumba, Heidi L. Ekstrom, Anjali R. Truitt, Stephen E. Asche, Ann M. Werner, Dan J. Rehrauer, Melissa A. Pankonin, Pamala A. Pawloski, Patrick J. O'Connor

Summary: This article describes the original and adapted protocols of a randomized trial to improve medication adherence for cardiometabolic conditions. Protocol adaptation became imperative in response to major implementation challenges.

CONTEMPORARY CLINICAL TRIALS (2024)

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Review Medicine, Research & Experimental

Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells

Weizhuo Lu, Zhiwu Chen, Jiyue Wen

Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.

BIOMEDICINE & PHARMACOTHERAPY (2024)

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Article Nanoscience & Nanotechnology

Therapeutic activity and biodistribution of a nano-sized polymer-dexamethasone conjugate intended for the targeted treatment of rheumatoid arthritis

Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala

Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2024)

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Article Medicine, Research & Experimental

Feasibility of implementing acupuncture in medically underserved breast cancer survivors (FAB): A protocol

Hongjin Li, Judith M. Schlaeger, Crystal L. Patil, Oana Danciu, Zhengjia Chen, Natalie Lif, Shuang Gao, Ardith Z. Doorenbos

Summary: Nearly 94% of breast cancer survivors experience symptoms or side effects during or after endocrine therapy, and acupuncture offers a comprehensive solution to address these issues. However, medically underserved breast cancer survivors often lack access to acupuncture. To promote equal access and evidence-based treatment, a randomized controlled trial is being conducted to investigate the effectiveness of acupuncture for symptom management among this population.

CONTEMPORARY CLINICAL TRIALS (2024)

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Article Medicine, Research & Experimental

Integration of RNA Sequencing, Whole Exome Sequencing, and Flow Cytometry Into Routine Diagnostic Workup of Pediatric Lymphomas

Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup

Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.

LABORATORY INVESTIGATION (2024)

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Article Medicine, Research & Experimental

Integrative Placental Multi-Omics Analysis Reveals Perturbed Pathways and Potential Prognostic Biomarkers in Gestational Hypertension

Bincy Varghese, Sreeranjini Babu, Aishwarya Jala, Panchanan Das, Rajesh Raju, Roshan M. Borkar, Ramu Adela

Summary: Through integrating next-generation sequencing and metabolomics multi-omics analysis of placenta, this study identified differentially expressed miRNAs, their target genes, altered metabolites, and metabolic pathways in gestational hypertension (GH) patients. The findings obtained from this study may contribute to further understanding of the molecular pathways associated with GH and the evaluation of prognostic markers.

ARCHIVES OF MEDICAL RESEARCH (2024)

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