Medicine, General & Internal

The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels

Marina Romanello, Claudia Di Napoli, Paul Drummond, Carole Green, Harry Kennard, Pete Lampard, Daniel Scamman, Nigel Arnell, Sonja Ayeb-Karlsson, Lea Berrang Ford, Kristine Belesova, Kathryn Bowen, Wenjia Cai, Max Callaghan, Diarmid Campbell-Lendrum, Jonathan Chambers, Kim R. van Daalen, Carole Dalin, Niheer Dasandi, Shouro Dasgupta, Michael Davies, Paula Dominguez-Salas, Robert Dubrow, Kristie L. Ebi, Matthew Eckelman, Paul Ekins, Luis E. Escobar, Lucien Georgeson, Hilary Graham, Samuel H. Gunther, Ian Hamilton, Yun Hang, Risto Hanninen, Stella Hartinger, Kehan He, Jeremy J. Hess, Shih-Che Hsu, Slava Jankin, Louis Jamart, Ollie Jay, Ilan Kelman, Gregor Kiesewetter, Patrick Kinney, Tord Kjellstrom, Dominic Kniveton, Jason K. W. Lee, Bruno Lemke, Yang Liu, Zhao Liu, Melissa Lott, Martin Lotto Batista, Rachel Lowe, Frances MacGuire, Maquins Odhiambo Sewe, Jaime Martinez-Urtaza, Mark Maslin, Lucy McAllister, Alice McGushin, Celia McMichael, Zhifu Mi, James Milner, Kelton Minor, Jan C. Minx, Nahid Mohajeri, Maziar Moradi-Lakeh, Karyn Morrissey, Simon Munzert, Kris A. Murray, Tara Neville, Maria Nilsson, Nick Obradovich, Megan B. O'Hare, Tadj Oreszczyn, Matthias Otto, Fereidoon Owfi, Olivia Pearman, Mahnaz Rabbaniha, Elizabeth J. Z. Robinson, Joacim Rocklov, Renee N. Salas, Jan C. Semenza, Jodi D. Sherman, Liuhua Shi, Joy Shumake-Guillemot, Grant Silbert, Mikhail Sofiev, Marco Springmann, Jennifer Stowell, Meisam Tabatabaei, Jonathon Taylor, Joaquin Trinanes, Fabian Wagner, Paul Wilkinson, Matthew Winning, Marisol Yglesias-Gonzalez, Shihui Zhang, Peng Gong, Hugh Montgomery, Anthony Costello

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

Jeanne Tie, Joshua D. Cohen, Kamel Lahouel, Serigne N. Lo, Yuxuan Wang, Suzanne Kosmider, Rachel Wong, Jeremy Shapiro, Margaret Lee, Sam Harris, Adnan Khattak, Matthew Burge, Marion Harris, James Lynam, Louise Nott, Fiona Day, Theresa Hayes, Sue-Anne McLachlan, Belinda Lee, Janine Ptak, Natalie Silliman, Lisa Dobbyn, Maria Popoli, Ralph Hruban, Anne Marie Lennon, Nicholas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Cristian Tomasetti, Peter Gibbs

Genetically Modified Porcine-to-Human Cardiac Xenotransplantation

Bartley P. Griffith, Corbin E. Goerlich, Avneesh K. Singh, Martine Rothblatt, Christine L. Lau, Aakash Shah, Marc Lorber, Alison Grazioli, Kapil K. Saharia, Susie N. Hong, Susan M. Joseph, David Ayares, Muhammad M. Mohiuddin

Covid-19 Vaccine Effectiveness in New York State

Eli S. Rosenberg, Vajeera Dorabawila, Delia Easton, Ursula E. Bauer, Jessica Kumar, Rebecca Hoen, Dina Hoefer, Meng Wu, Emily Lutterloh, Mary Beth Conroy, Danielle Greene, Howard A. Zucker

Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation

Ildiko Lingvay, Priya Sumithran, Ricardo Cohen, Carel W. le Roux

Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2

Michela Antonelli, Joan Capdevila Pujol, Tim D. Spector, Sebastien Ourselin, Claire J. Steves

Global, regional, and national prevalence estimates of physical or sexual, or both, intimate partner violence against women in 2018

Lynnmarie Sardinha, Mathieu Maheu-Giroux, Heidi Stockl, Sarah Rachel Meyer, Claudia Garcia-Moreno

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Peter W. Horby, Marion Mafham, Leon Peto, Mark Campbell, Guilherme Pessoa-Amorim, Enti Spata, Natalie Staplin, Jonathan R. Emberson, Benjamin Prudon, Paul Hine, Thomas Brown, Christopher A. Green, Rahuldeb Sarkar, Purav Desai, Bryan Yates, Tom Bewick, Simon Tiberi, Tim Felton, J. Kenneth Baillie, Maya H. Bitch, Lucy C. Chappell, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, David M. Weinreich, Richard Haynes, Martin J. Landray

The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

Tom H. Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J. Hutchinson, Bruno Sangro, Natasha K. Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y. Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J. Verkade, Ekkehard Sturm, Giulio Marchesini, Hannele Yki-Jarvinen, Chris D. Byrne, Giovanni Targher, Aviad Tur-Sinai, Damon Barrett, Michael Ninburg, Tatjana Reic, Alison Taylor, Tim Rhodes, Carla Treloar, Claus Petersen, Christoph Schramm, Robert Flisiak, Marieta Y. Simonova, Albert Pares, Philip Johnson, Alessandro Cucchetti, Isabel Graupera, Christos Lionis, Elisa Pose, Nuria Fabrellas, Ann T. Ma, Juan M. Mendive, Vincenzo Mazzaferro, Harry Rutter, Helena Cortez-Pinto, Deirdre Kelly, Robyn Burton, Jeffrey Lazarus, Pere Gines, Maria Buti, Philip N. Newsome, Patrizia Burra, Michael P. Manns

Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial

Jason J. Luke, Piotr Rutkowski, Paola Queirolo, Michele Del Vecchio, Jacek Mackiewicz, Vanna Chiarion-Sileni, Luis de la Cruz-Merino, Muhammad A. Khattak, Dirk Schadendorf, Georgina Long, Paolo A. Ascierto, Mario Mandala, Federica De Galitiis, Andrew Haydon, Reinhard Dummer, Jean-Jacques Grob, Caroline Robert, Matteo S. Carlino, Peter Mohr, Andrew Poklepovic, Vernon K. Sondak, Richard A. Scolyer, John M. Kirkwood, Ke Chen, Scott J. Diede, Sama Ahsan, Nageatte Ibrahim, Alexander M. M. Eggermont

Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2

Yair Goldberg, Micha Mandel, Yinon M. Bar-On, Omri Bodenheimer, Laurence S. Freedman, Nachman Ash, Sharon Alroy-Preis, Amit Huppert, Ron Milo

Teclistamab in Relapsed or Refractory Multiple Myeloma

Philippe Moreau, Alfred L. Garfall, Niels W. C. J. van de Donk, Hareth Nahi, Jesus F. San-Miguel, Albert Oriol, Ajay K. Nooka, Thomas Martin, Laura Rosinol, Ajai Chari, Lionel Karlin, Lotfi Benboubker, Maria-Victoria Mateos, Nizar Bahlis, Rakesh Popat, Britta Besemer, Joaquin Martinez-Lopez, Surbhi Sidana, Michel Delforge, Lixia Pei, Danielle Trancucci, Raluca Verona, Suzette Girgis, Shun X. W. Lin, Yunsi Olyslager, Mindy Jaffe, Clarissa Uhlar, Tara Stephenson, Rian Van Rampelbergh, Arnob Banerjee, Jenna D. Goldberg, Rachel Kobos, Amrita Krishnan, Saad Z. Usmani

Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2

Emi Takashita, Noriko Kinoshita, Seiya Yamayoshi, Yuko Sakai-Tagawa, Seiichiro Fujisaki, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Peter Halfmann, Shinji Watanabe, Kenji Maeda, Masaki Imai, Hiroaki Mitsuya, Norio Ohmagari, Makoto Takeda, Hideki Hasegawa, Yoshihiro Kawaoka

Effectiveness of Covid-19 Vaccines over a 9-Month Period in North Carolina

Dan-Yu Lin, Yu Gu, Bradford Wheeler, Hayley Young, Shannon Holloway, Shadia-Khan Sunny, Zack Moore, Donglin Zeng

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants

Laura L. Hammitt, Ron Dagan, Yuan Yuan, Manuel Baca Cots, Miroslava Bosheva, Shabir A. Madhi, William J. Muller, Heather J. Zar, Dennis Brooks, Amy Grenham, Ulrika Wahlby Hamren, Vaishali S. Mankad, Pin Ren, Therese Takas, Michael E. Abram, Amanda Leach, M. Pamela Griffin, Tonya Villafana

Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial

Manali Kamdar, Scott R. Solomon, Jon Arnason, Patrick B. Johnston, Bertram Glass, Veronika Bachanova, Sami Ibrahimi, Stephan Mielke, Pim Mutsaers, Francisco Hernandez-Ilizaliturri, Koji Izutsu, Franck Morschhauser, Matthew Lunning, David G. Maloney, Alessandro Crotta, Sandrine Montheard, Alessandro Previtali, Lara Stepan, Ken Ogasawara, Timothy Mack, Jeremy S. Abramson

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19 The RECOVERY-RS Randomized Clinical Trial

Gavin D. Perkins, Chen Ji, Bronwen A. Connolly, Keith Couper, Ranjit Lall, J. Kenneth Baillie, Judy M. Bradley, Paul Dark, Chirag Dave, Anthony De Soyza, Anna Dennis, Anne Devrell, Sara Fairbairn, Hakim Ghani, Ellen A. Gorman, Christopher A. Green, Nicholas Hart, Siew Wan Hee, Zoe Kimbley, Shyam Madathil, Nicola McGowan, Benjamin Messer, Jay Naisbitt, Chloe Norman, Dhruv Parekh, Emma M. Parkin, Jaimin Patel, Scott E. Regan, Clare Ross, Anthony J. Rostron, Mohammad Saim, Anita K. Simonds, Emma Skilton, Nigel Stallard, Michael Steiner, Rama Vancheeswaran, Joyce Yeung, Daniel F. McAuley

Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in the US, 2013-2018

Edward F. Bell, Susan R. Hintz, Nellie Hansen, Carla M. Bann, Myra H. Wyckoff, Sara B. DeMauro, Michele C. Walsh, Betty R. Vohr, Barbara J. Stoll, Waldemar A. Carlo, Krisa P. Van Meurs, Matthew A. Rysavy, Ravi M. Patel, Stephanie L. Merhar, Pablo J. Sanchez, Abbot R. Laptook, Anna Maria Hibbs, C. Michael Cotten, Carl T. D'Angio, Sarah Winter, Janell Fuller, Abhik Das