Medicine, General & Internal

Review Medicine, General & Internal

Pulmonary fibrosis: Is stem cell therapy the way forward?

Muhammad Ikrama, Muhammad Usama, Shifa Israr, Maryam Humayon

Summary: Pulmonary fibrosis is a complex disease involving various factors, and current treatments have limited effectiveness. Stem cell therapy has emerged as a potential alternative treatment option, but there are challenges and limitations that need to be addressed. Further research is needed to optimize the protocols and evaluate the clinical benefits and risks of stem cell therapy for pulmonary fibrosis.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2024)

Article Medicine, General & Internal

Psychological impact of first admission with cardiovascular disease in a tertiary hospital in Oman

Ahmed Al-Maskari, Ghanima Al-Zaabi, Hafsa A. AL-Mamari, Manar Al-mawali, Sunil K. Nadar

Summary: This study found a significant proportion of patients in Oman admitted for the first time due to ACS or CHF experienced moderate to severe anxiety and depression, with higher rates among CHF patients. Healthcare providers should pay closer attention to the psychological well-being of these patients.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2024)

Review Medicine, General & Internal

Stair-climbing interventions on cardio-metabolic outcomes in adults: A scoping review

Anang M. Ghosal, Baskaran Chandrasekaran

Summary: This scoping review explores the physiological and therapeutic effects of stair-climbing interventions on adult cardio-metabolic disease risk factors. The results show that stair climbing improves aerobic capacity and serum biomarkers, reducing the risk of cardio-metabolic diseases. In addition, stair climbing has positive effects on indicators such as body composition, blood pressure, cholesterol levels, and insulin sensitivity.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2024)

Article Medicine, General & Internal

Sleep profile and its correlation with clinical variables in fibromyalgia syndrome: A cross-sectional study

Reepa A. Ughreja, Prem Venkatesan, Dharmanand B. Gopalakrishna, Yogesh P. Singh, R. Vani Lakshmi

Summary: A scarcity of literature exists on sleep quality in fibromyalgia syndrome (FMS) in Indian patients. The current study aimed to describe the sleep profile in FMS patients with poor sleep quality in urban Bangalore and determine the relationship between poor sleep and FMS variables. The results showed that sleep disturbance is highly prevalent in FMS patients, particularly in females with increasing FMS severity and duration. Sleep quality was found to be significantly correlated with both somatic and psychological variables. Further studies are needed to evaluate predictors of poor sleep in FMS patients.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2024)

Article Medicine, General & Internal

Expression of programmed death-ligand 1, IRF1 and CD8 T lymphocyte infiltration in a primary subset of breast cancer patients in Sudan

Shahenaz S. Salih, Mohammed S. Abdelaziz, Ibtehal M. Abdelhag, Altaf S. Mosad

Summary: This study investigated the protein expression of PD-L1 in breast cancer tissues and its association with estrogen status, IRF-1 expression, and CD8 T lymphocyte infiltration. The results showed a significant association between PD-L1 and CD8, and IRF-1 was found to induce higher levels of PD-L1 expression. PD-L1 was also found to impact cell proliferation, as reflected by the Ki67 index. There was an inverse association between PD-L1 and ER status. The findings suggest that PD-L1, along with IRF-1 and CD8, could serve as potential biomarkers for predicting immune therapy response in breast cancer patients.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2024)

Article Medicine, General & Internal

Anatomical variation in the sphenoidal sinuses in patients with chronic rhinosinusitis: A CT scan study

Vinodhini Periyasamy, Radhakrishnan Sumana, Anupama Doddappaiah, Rathinasabapathy Mythilikrishnan

Summary: This study evaluated the association between anatomical variations of the sphenoidal sinuses and chronic rhinosinusitis using CT scans. The results showed a significant correlation between anatomical variations in male participants and an increased risk of chronic rhinosinusitis. Understanding these anatomical variations can assist surgeons in determining the surgical boundaries during sphenoidal sinus surgeries.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2024)

Article Medicine, General & Internal

Morphometric measurements of mandible to determine stature and sex: A postmortem study

Nehala C. Hamza, Chandni Gupta, Vikram Palimar

Summary: This study investigated the relationship between mandibular dimensions and stature and sex identification. The results showed that bicondylar width was strongly correlated with stature, while mandibular angle was useful for determining sex.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2024)

Article Medicine, General & Internal

Fever of Unknown Origin

Kathleen Ryan

Summary: Fevers of unknown origin (FUO) present a diagnostic challenge, with a wide range of potential causes including infectious, autoimmune, and malignant. Some adolescents with FUO may never have an identifiable etiology, but the prognosis is generally favorable in the absence of red flag symptoms.

MEDICAL CLINICS OF NORTH AMERICA (2024)

Article Medicine, General & Internal

Attaining Diagnostic Excellence How the Structure and Function of a Rare Disease Service Contribute to Ending the Diagnostic Odyssey

Brett J. Bordini, Ryan D. Walsh, Donald Basel, Tejaswini Deshmukh

MEDICAL CLINICS OF NORTH AMERICA (2024)

Article Medicine, General & Internal

Monogenetic Etiologies of Diabetes

Bethany Auble, Justin Dey

MEDICAL CLINICS OF NORTH AMERICA (2024)

Article Medicine, General & Internal

Monogenic Etiology of Hypertension

Vaishali Singh, Scott K. Van Why

Summary: Hypertension in adolescents is rare, and evaluation for identifiable causes beyond primary hypertension is necessary. Common causes of hypertension in this age group are usually acquired or congenital renal or vascular diseases. If these etiologies are not found, exploration for rare causes, including monogenic hypertension, should be pursued.

MEDICAL CLINICS OF NORTH AMERICA (2024)

Review Primary Health Care

Educational interventions in childhood asthma: A systematic review

Eva Benito-Ruiz, Maria Perez-Corral, Isabel Blazquez-Ornat, Enrique Ramon-Arbues, Isabel Anton-Solanas, Carlos Navas-Ferrer

Summary: This systematic review analyzes educational interventions in pediatric asthmatic patients and highlights the importance of correct inhalation technique and self-management education in improving the treatment outcomes for these patients. On-site demonstration and delivery of recommendations or multimedia interventions are the most prevalent types of educational interventions. Results show the significance of periodic review of the technique.

ATENCION PRIMARIA (2024)

Article Medicine, General & Internal

Foot and Ankle Injuries with the Rise of Pickleball

Elise Elegeert, Allison J. Justice, Robert Martin Shipman, Aaron J. Guyer, Jason Beaver

Summary: With the increasing popularity of pickleball, it is important to be familiar with the common injuries associated with this sport in order to accurately diagnose acute or chronic injuries in patients.

PHYSICIAN ASSISTANT CLINICS (2024)

Article Medicine, General & Internal

The Upper Extremity From Shoulder to Wrist

Melissa Shaffron

PHYSICIAN ASSISTANT CLINICS (2024)

Editorial Material Medicine, General & Internal

General Orthopedics

Kim Zuber, Jane S. Davis

PHYSICIAN ASSISTANT CLINICS (2024)

Article Medicine, General & Internal

Numbness and Tingling, Where Is It Coming From? A Peripheral Neuropathy Overview for the New Orthopedic, Neurology, and Rehabilitation Clinician

Amy Dix, Stephanie Kubiak

Summary: The diagnosis and treatment of mono- and polyneuropathy is a crucial aspect of orthopedic management. Orthopedic providers should be aware of the risk of iatrogenic nerve injury during surgery and the presence of underlying neuropathies, such as diabetes, which can complicate postoperative outcomes. Interdisciplinary collaboration between orthopedic and neurology providers, along with the involvement of occupational therapists, plays a significant role in diagnosing and treating neuropathy conditions.

PHYSICIAN ASSISTANT CLINICS (2024)

Article Medicine, General & Internal

Osteoarthritis of the Knee

Jodiann Williams, Kerby Pierre-Louis

PHYSICIAN ASSISTANT CLINICS (2024)

Article Medicine, General & Internal

Topics in Pediatric Orthopedics

Amy L. Noyes, Victoria Gentile, Katherine Holmes

Summary: Pediatric orthopedics is a unique subspecialty that requires understanding of bone development and physiological norms at different stages of childhood. Thorough history-taking, physical examination skills, and the prevention of future complications are crucial for prompt diagnosis and timely treatment. This review highlights key topics that clinicians may encounter when treating children with orthopedic complaints.

PHYSICIAN ASSISTANT CLINICS (2024)

Article Medicine, General & Internal

Approach to Idiopathic Anaphylaxis in Adolescents

Jeanne E. Conner, Joshua A. Steinberg

Summary: Diagnosis of anaphylaxis should involve comprehensive consideration, including detailed history and objective findings. Using diagnostic criteria and considering rare triggers, as well as evaluating for mast cell disorders, can aid in the diagnosis. Referral to specialists may be necessary.

MEDICAL CLINICS OF NORTH AMERICA (2024)

Article Medicine, General & Internal

Hemophagocytic Lymphohistiocytosis in Adolescents and Young Adults Genetic Predisposition and Secondary Disease

Alejandra Escobar Vasco, Julie -Ann Talano, Larisa Broglie

Summary: HLH is a rare but fatal disease, and maintaining a high level of suspicion is crucial for patients with evidence of hyperinflammation. Adolescents with HLH should undergo genetic evaluation for familial HLH, and primary immune deficiencies and dysregulation disorders should also be considered. Early diagnosis and treatment are necessary to prevent morbidity and mortality related to HLH's hyperinflammation.

MEDICAL CLINICS OF NORTH AMERICA (2024)