Medical Laboratory Technology

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Article Plant Sciences

Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity

Tian Liu, Yuqi Ma, Hui Zhao, Pengli Wang, Yan Niu, Yuehuan Hu, Xi Shen, Mingxia Zhang, Bing Yan, Jun Yu

Summary: This study evaluated the protective role of hawthorn leaves flavonoids (HLF) in cardiac remodelling under simulated microgravity. The results showed that HLF can reverse the decline in cardiac function and structure caused by simulated microgravity, and it exerts its protective effect by enhancing the NPRA-cGMP-PKG pathway and suppressing the calcineurin-NFAT pathway.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Sodium tanshinone IIA sulphate inhibits angiogenesis in lung adenocarcinoma via mediation of miR-874/eEF-2K/TG2 axis

Bu Wang, Fang Zou, Gu Xin, Bao-Li Xiang, Jian-Qing Zhao, Sheng-Fang Yuan, Xiu-Long Zhang, Zhi-Hua Zhang

Summary: This study found that sodium tanshinone IIA sulphate (STS) extracted from Salvia miltiorrhiza Bunge has an anti-tumor effect on lung adenocarcinoma, inhibiting cell proliferation, migration, invasion, and angiogenesis. This effect may be mediated by the miR-874/eEF-2K/TG2 pathway. STS could be a promising drug to fight against lung cancer and effectively reverse drug resistance when combined with classical anticancer drugs.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Identification of natural compound garcinone E as a novel autophagic flux inhibitor with anticancer effect in nasopharyngeal carcinoma cells

Dan Wei, Luolin Wang, Shunmei Lei, Han Zhang, Caihua Dong, Yao Ke, Yuting Su, Xiaoying Chen, Lianping Xia, Xiaoyang Kong, Fuqiang Yin, Xia Liu

Summary: The compound Garcinone E (GE) inhibits the proliferation and metastasis of nasopharyngeal carcinoma (NPC) cells by blocking autophagic flux, suggesting it has potential as a chemotherapeutic agent for NPC treatment.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Vitexin suppresses the proliferation, angiogenesis and stemness of endometrial cancer through the PI3K/AKT pathway

Cuixia Liang, Yongjie Jiang, Lizhu Sun

Summary: The study showed that vitexin has inhibitory effects on the development of endometrial cancer and clarified its potential mechanism. Vitexin can inhibit cell proliferation, angiogenesis, and stemness capacity, and it also blocks tumor growth of endometrial cancer in vivo.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Sanguinarine inhibits melanoma invasion and migration by targeting the FAK/PI3K/AKT/mTOR signalling pathway

Xiaoyi Qi, Yonglan Chen, Sha Liu, Li Liu, Zehui Yu, Ling Yin, Lu Fu, Mingming Deng, Sicheng Liang, Muhan Lu

Summary: This study revealed the antimetastatic effect of SAG on melanoma and identified the underlying molecular mechanisms through the inhibition of the PI3K-AKT signaling pathway. Results showed that SAG inhibited the proliferation, migration, and invasion of melanoma cells and effectively suppressed tumor growth in a xenograft model. These findings offer a theoretical foundation for the clinical application of SAG in antitumor therapy.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Tormentic acid, a triterpenoid isolated from the fruits of Chaenomeles speciose, protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway

Jun-Yu He, Jie Li, Yuan-Yuan Zhang, Hai-Bo He, Yu-Min He, Dao-Xiang Xu, Xiao Wang, Hao-Yang Wu, Ji-Hong Zhang, Hasan Jahid, Akter Sadia, Hui-Fan Yu, Jun-Zhi Wang, Kun Zou

Summary: This study demonstrates that tormentic acid (TA) has a protective effect on animals and cells with gastric damage, promoting cell proliferation and migration and improving gastric mucosal injury. Therefore, TA may be a potential clinical drug candidate for the treatment of gastric mucosal lesions.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Mechanistic exploration of Yiqi Liangxue Shengji prescription on restenosis after balloon injury by integrating metabolomics with network pharmacology

Tianshi Mao, Long Xie, Yanqiong Guo, Xiang Ji, Jie Wan, Xiaoyun Cui, Qian Fan, Wei Liu, Shuai Wang, Wenbo Han, Qian Lin, Wenhao Jia

Summary: This study investigated the pharmacological mechanism of YQLXSJ on restenosis using metabolomics and network pharmacology. Results showed that YQLXSJ decreased intimal thickness and had potential in preventing and treating restenosis by improving metabolic disorders.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11

Jianjie Rong, Chuanyong Li, Qiang Zhang, Guangfeng Zheng, Weijian Fan, Zhichang Pan, Shuming Shi

Summary: This study confirms that HSYA can improve symptoms in a mouse model of T2DM/AS and elucidates the underlying mechanisms. HSYA effectively reduces atherosclerotic plaque formation in the T2DM/AS mouse model and inhibits HUVEC ferroptosis, while upregulating GSH-Px, SLC7A11, and GPX4 expression and inhibiting ACSL4 expression. Furthermore, HSYA downregulates miR-429 expression, further regulating SLC7A11 expression.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Exploring the mechanisms of action of Zengye decoction (ZYD) against Sjogren's syndrome (SS) using network pharmacology and animal experiment

Jiake Yu, Shuying Wang, Jie Yang, Wuxinrui Huang, Beikang Tang, Weijun Peng, Jing Tian

Summary: This study investigates the mechanisms of Zengye decoction (ZYD) against Sjogren's syndrome (SS). It is found that ZYD has anti-inflammatory and anti-apoptotic effects, providing a theoretical basis for the treatment of SS with ZYD.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids

Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Arifah Abdul Kadir, Syahriel Abdullah, Roro Azizah, Lilis Sulistyorini

Summary: The chloroform extract of Bauhinia purpurea leaves has significant antioxidant and hepatoprotective effects. It can treat liver diseases by activating the endogenous enzyme antioxidant defense system.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Punicalagin attenuates ventricular remodeling after acute myocardial infarction via regulating the NLRP3/caspase-1 pathway

Jian-fei Peng, Xiao-ni Zhao, Meng Zhang, Jing-ya Li, Chun-chun Zhao, Shu-shu Wang, Jia-li Wang, Hui Shi, Peng Zhou, Liang Wang

Summary: The study investigates the role and mechanism of punicalagin in preventing and treating ventricular remodeling after acute myocardial infarction (AMI). The results show that punicalagin improves cardiac function, alleviates cardiac pathological changes, and reduces cardiomyocyte apoptosis by inhibiting the overexpression of NLRP3, caspase-1, and GSDMD.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Optimization of the proportions of advantageous components in the hypolipidemic '' bioequivalent substance system '' of Jiang-Zhi-Ning and its mechanism of action

Yumiao Li, Yan Zhang, Yu Zhang, Tianfeng Lin, Yanyan Gao, Yuan Cai, Chang Zhou, Leyi Yang, Bin Liu, Shifen Dong, Yanyan Jiang

Summary: This study confirms the hypolipidemic effects of Jiang-Zhi-Ning and explores its underlying mechanism using in vitro and in vivo experiments.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury

En Hu, Teng Li, Zhilin Li, Hong Su, Qiuju Yan, Lei Wang, Haigang Li, Wei Zhang, Tao Tang, Yang Wang

Summary: Hydroxysafflor yellow A (HSYA) promotes recovery from traumatic brain injury (TBI) by enhancing neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, as well as the BDNF and STAT3/GAP43 axis.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway

Hui Zhang, Huihua Wang, Qing Zhang, Hui Wang, Yuhang Zhu, Fangfang Wang, Jun Lin, Jue Zhou, Fan Qu

Summary: This study investigated the effects of Bu-Shen-Tian-Jing formulations (BSTJFs) on ovarian granulosa cells exposed to DEHP and determined the potential molecular mechanisms. The results showed that BSTJFs might have therapeutic potential on oxidative stress and mitochondrial damage through the HDAC3/HSP90AA pathway, which encourages further clinical trials.

PHARMACEUTICAL BIOLOGY (2023)

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Correction Plant Sciences

Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood-brain barrier pathway (vol 59, pg 910, 2021)

L. Zhang, L. Wang, L. Huang, Y. Zhao, H. Ding, B. Li, L. Wen, W. Xiong, Y. Liu, T. Zhang, L. Zhang, L. Wu, Q. Xu, Y. Fan, Y. Wei, Q. Yin, Y. Chen, T. Zhang, Z. Yan

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα

Zhenhua Wu, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Yaobang Bai, Zhigang Guo

Summary: This study found that metformin has a protective effect against ferroptosis in cardiac ischemia and reperfusion (I/R) injury.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Lantana camara leaf extract ameliorates memory deficit and the neuroinflammation associated with scopolamine-induced Alzheimer's-like cognitive impairment in zebrafish and mice

Veronica Amoah, Paul Atawuchugi, Yakubu Jibira, Augustine Tandoh, Paul Poku Sampene Ossei, George Sam, George Ainooson

Summary: The hydroethanolic leaf extract of Lantana camara (LCE) has a prophylactic effect on short-term memory deficit and neuroinflammation induced by scopolamine in zebrafish and mice. LCE improved cognitive impairment and reduced inflammatory response.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

JianPi-QingHua formula attenuates nonalcoholic fatty liver disease by regulating the AMPK/SIRT1/NF-κB pathway in high-fat-diet-fed C57BL/6 mice

Jing Tian, Mengjie Cai, Shenyi Jin, Qingguang Chen, Jiahui Xu, Qiuyue Guo, Zihui Yan, Xu Han, Hao Lu

Summary: A study on mice with NAFLD induced by a high-fat diet found that JianPi-QingHua formula (JPQH), a Chinese herbal formula, has a significant hepatoprotective effect. It can reduce body weight, adipose mass, blood glucose, and liver weight, as well as decrease the levels of serum triglycerides, cholesterol, and liver injury markers. In addition, JPQH can improve liver histopathological changes, reduce lipid accumulation, and suppress inflammatory responses. The study suggests that JPQH protects against HFD-induced NAFLD by regulating the SIRT1/AMPK/NF-kappa B pathway.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Prediction of the mechanisms of action of Qutan Huoxue decoction in non-alcoholic steatohepatitis (NASH): a network pharmacology study and experimental validation

Xia Wu, Yurong Zhang, Ding Zheng, Yue Yin, Mengyun Peng, Jing Wang, Xiaoning Zhu

Summary: This study used network pharmacology to predict the potential pathways of Qutan Huoxue decoction (QTHX) and experimentally verified that it treats non-alcoholic steatohepatitis (NASH) by activating the SCOS1/NF-kappa B/TLR4 pathway, thus exerting hepatoprotective effects.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Modified Zhibai Dihuang pill alleviated urinary tract infection induced by extended-spectrum β-lactamase Escherichia coli in rats by regulating biofilm formation

Kaifa Chen, Yongsheng Zhu, Hongwei Su, Hao Jiang, Xin Liu

Summary: Through animal experiments, it was found that modified Zhibai Dihuang pill (MZD), a traditional Chinese medicine, has certain therapeutic effects on urinary tract infections caused by drug-resistant Escherichia coli, reducing white blood cell count, alleviating inflammation and renal fibrosis, inhibiting biofilm formation, and decreasing the expression of related genes.

PHARMACEUTICAL BIOLOGY (2023)

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