Medical Laboratory Technology

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Article Plant Sciences

Network pharmacology approach and experimental verification of Dan-Shen Decoction in the treatment of ischemic heart disease

Difei Gong, Tianyi Yuan, Ranran Wang, Shuchan Sun, Awaguli Dawuti, Shoubao Wang, Guanhua Du, Lianhua Fang

Summary: This study validates the efficacy of Dan-Shen Decoction in treating ischemic heart disease (IHD) and explores its potential mechanisms by integrating network pharmacology analyses and experimental verification. The results suggest that the anti-IHD effect of Dan-Shen Decoction may be closely associated with multiple targets and biological processes.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells

Rui-Yi Yang, Jia-Yi Tan, Zhe Liu, Xiao-Ling Shen, Ying-Jie Hu

Summary: The natural lignan LAF from Arctium lappa Linne has been found to inhibit tumor cell growth in vitro and in vivo. However, its role in cell cycle regulation remains unknown.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Da-Yuan-Yin decoction polyphenol fraction attenuates acute lung injury induced by lipopolysaccharide

Lengqiu Guo, Yun Yang, Jie Yuan, Huiling Ren, Xiaolei Huang, Meng Li, Long Xia, Xiaogang Jiang, Daofeng Chen, Jian Zhang

Summary: This study investigates the therapeutic effects of Da-Yuan-Yin on acute lung injury (ALI) and reveals its potential targets through network pharmacology combined with animal experiments.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Therapeutic effects of Bombax ceiba flower aqueous extracts against loperamide-induced constipation in mice

Liuping Wang, Shiyuan Xie, Xuan Jiang, Caini Xu, Youqiong Wang, Jianfang Feng, Bin Yang

Summary: This study investigated the therapeutic effect of Bombax ceiba flower aqueous extracts (BCE) against loperamide-induced constipation and characterized the chemical composition of BCE. The results showed that BCE treatment could increase faecal water and number, improve gastrointestinal transit rate, and reduce first black-stool defecation time, suggesting its potential for the treatment of constipation.

PHARMACEUTICAL BIOLOGY (2023)

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Correction Plant Sciences

Sanguinarine inhibits melanoma invasion and migration by targeting the FAK/PI3K/AKT/mTOR signalling pathway (vol 61, pg 696, 2023)

X. Qi, Y. Chen, S. Liu, L. Liu, Z. Yu, L. Yin, L. Fu, M. Deng, S. Liang, M. Lu

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Effects of puerarin on the intervertebral disc degeneration and biological characteristics of nucleus pulposus cells

Hengtao Tang, Song Zhang, Xinchang Lu, Tongyu Geng

Summary: Puerarin (PU) can delay the progression of intervertebral disc degeneration (IDD) by inhibiting activation of the TLR4/NF-kappa B pathway.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

The effective constituent puerarin, from Pueraria lobata, inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p/IGF1 pathway

Jianpeng Li, Yanan Li, Xiangke Yuan, Dengfeng Yao, Zongyue Gao, Zhaoyang Niu, Zheng Wang, Yue Zhang

Summary: The study found that puerarin, a compound extracted from Pueraria lobata, can inhibit the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p/IGF1 pathway. This suggests that puerarin may have a beneficial effect in the treatment of atherosclerosis and offers a novel therapy option.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Gastric protective effect of Alpinia officinarum flavonoids: mediating TLR4/NF-κB and TRPV1 signalling pathways and gastric mucosal healing

Kaiwen Lin, Tang Deng, Huijuan Qu, Hongya Ou, Qifeng Huang, Bingmiao Gao, Xiaoliang Li, Na Wei

Summary: This study investigated the protective mechanism of total flavonoid of Alpinia officinarum Hance (FAOH) on acetic acid-induced chronic gastric ulcers (GU) in rats and ethanol-induced GES-1 cell damage. The results showed that FAOH reduced the area of gastric ulcers, reversed cell apoptosis, and decreased inflammation and oxidative stress.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway

Jin Ding, Baowei Lu, Lumei Liu, Zixuan Zhong, Neng Wang, Bonan Li, Wen Sheng, Qinghu He

Summary: This study investigated the ferroptosis resistance of the traditional Chinese medicine Guilu-Erxian-Glue (GLEXG) in improving semen quality in the oligoasthenospermia (OAS) rat model. The results showed that high-dose GLEXG significantly improved sperm concentration and motility, mitigated testicular histopathology, and activated the Keap1/Nrf2/GPX4 pathway to reduce oxidative stress and iron levels, and restore sperm mitochondrial morphology and potential. Targeting ferroptosis may be a novel approach for OAS therapy.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Antinociceptive activity of doliroside B

Xishan Bai, Yanhong Li, Yuxiao Li, Min Li, Ming Luo, Kai Tian, Mengyuan Jiang, Yong Xiong, Ya Lu, Yukui Li, Haibo Yu, Xiangzhong Huang

Summary: This study found that doliroside B (DB) and its disodium salt (DBDS) can be used to treat pain by inhibiting COX-1 activity and reducing the production of NO, iNOS, and IL-6, exerting anti-inflammatory and neuroprotective effects.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC2 pathway activation

Zhi Guo, Xuan Yang, Meizhu Wu, Aling Shen, Jiapeng Li, Xiuli Zhang, Ying Cheng, Qiurong Xie, Jun Peng

Summary: This study investigated the therapeutic efficiency of gastrodin as an antihypertensive and determined the mechanisms underlying its effects. The results showed that gastrodin lowered blood pressure, suppressed vascular contraction, and inhibited activation of the MLCK/p-MLC2 pathway, demonstrating its therapeutic efficacy as an antihypertensive.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis

Xiaoyuan Xu, Xiaohua Xu, Xiaoshuang Wang, Ling Shen

Summary: Baicalin has the potential to alleviate the symptoms of PCOS by regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axes.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Effects of Tiaopi Xiezhuo decoction on constipation and gut dysbiosis in patients with peritoneal dialysis

Yu Peng, Yuting Zeng, Tingting Zheng, Xiaoning Xie, Jianfeng Wu, Lizhe Fu, Fuhua Lu, La Zhang, Yang Chen, Xusheng Liu, Lei Wang

Summary: This study investigated the regulatory effect of Tiaopi Xiezhuo decoction (TXD) on gut dysbiosis in constipation patients with peritoneal dialysis (PD). The results showed that TXD treatment for 3 months improved constipation symptoms in PD patients, increased the abundance of certain bacteria in the gut microbiota, and correlated with the improvement of constipation. These findings suggest that TXD may alleviate constipation by modulating gut dysbiosis in PD patients.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis

Ying Feng, Han Dong, Liyan Zheng

Summary: Ligustrazine was found to inhibit inflammation in Endometriosis (EMs) by regulating the STAT3/IGF2BP1/RELA axis. These findings propose a new agent against EMs and support the development of ligustrazine-based treatment strategies for EMs.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Acacetin-loaded microemulsion for transdermal delivery: preparation, optimization and evaluation

Yajing Wang, Qian Chen, Xianfeng Huang, Xiaojing Yan

Summary: Acacetin-loaded microemulsion was prepared and evaluated for efficient pharmacokinetics and non-invasive transdermal delivery. The optimized formulation showed improved solubility and skin absorption efficiency of acacetin, providing a new option for drug delivery.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

PI3K/AKT/SERBP-1 pathway regulates Alisma orientalis beverage treatment of atherosclerosis in APOE-/- high-fat diet mice

Ruiyi Liu, Yan Sun, Dong Di, Xiyuan Zhang, Boran Zhu, Haoxin Wu

Summary: This study used network pharmacology and in vivo experiments to demonstrate the potential therapeutic effects of Alisma orientalis beverage (AOB) in treating atherosclerosis (AS). The findings suggest that AOB improves blood lipids and inhibits the PI3K/AKT/SREBP-1 pathway in the liver, providing new evidence for the clinical application of AOB in the treatment of AS.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. refractum var. torquatum with bioactivity studies

Tuba Kusman Saygi, Nur Tan, Guelbahar Ozge Alim Toraman, Caglayan Unsal Gurer, Osman Tugay, Gulacti Topcu

Summary: This study isolated and identified several bioactive alkaloids from Glaucium grandiflorum Boiss. & Huet. subsp. refractum var. torquatum and G. corniculatum (L.) Rudolph var. corniculatum. The alkaloid extracts showed strong acetylcholinesterase inhibitory and antioxidant activities. Tertiary amine extracts from both plants exhibited great potential as therapeutic agents for Alzheimer's disease.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression

Ji-hong Yuan, Yu Ma, Ling-hong Yuan, Jing-jing Gong, Ling-li Xu, Lv Wang, Yong-mei Jin

Summary: This study investigates whether baicalein can attenuate lung fibrosis by regulating lung fibroblast senescence. The results suggest that baicalein can mitigate lung fibrosis, fibroblast senescence, and activation of the TGF-beta 1/Smad signaling pathway.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Qingyi granules ameliorate severe acute pancreatitis in rats by modulating the gut microbiota and serum metabolic aberrations

Juying Jiao, Jianjun Liu, Fei Luo, Mengxue Shang, Chen Pan, Bing Qi, Liang Zhao, Peiyuan Yin, Dong Shang

Summary: The study aims to elucidate the role of gut microbiota-mediated metabolism in the therapeutic effects of Qingyi granules. The results showed that Qingyi granules can modulate the composition of gut microbiota, restore metabolic abnormalities, and improve pancreatic pathological damage in patients with severe acute pancreatitis. This suggests that Qingyi granules can ameliorate acute pancreatitis by regulating gut microbiota and metabolic abnormalities.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Plantamajoside alleviates acute sepsis-induced organ dysfunction through inhibiting the TRAF6/NF-κB axis

Daili Feng, Ruying Guo, Wei Liao, Jiancheng Li, Song Cao

Summary: The study investigated the role of Plantamajoside in regulating sepsis-induced organ dysfunction and potential mechanisms. The results showed that Plantamajoside suppressed organ injury induced by sepsis by regulating the TRAF6/NF-kappa B axis, suggesting it as a novel strategy for sepsis-caused damage in the future.

PHARMACEUTICAL BIOLOGY (2023)

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