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Article Plant Sciences

Angelica sinensis polysaccharides alleviate the oxidative burden on hematopoietic cells by restoring 5-fluorouracil-induced oxidative damage in perivascular mesenchymal progenitor cells

Yilin Niu, Hanxianzhi Xiao, Biyao Wang, Ziling Wang, Kunhang Du, Yaping Wang, Lu Wang

Summary: This study investigated the protective antioxidative effects of Angelica sinensis polysaccharide (ASP) on perivascular mesenchymal progenitors (PMPs) and their interactions with hematopoietic cells. The results showed that ASP improved the oxidative balance in PMPs, promoted osteogenic differentiation, and increased the expression of key genes. Additionally, the ASP-treated feeder layer alleviated senescence of hematopoietic cells and delayed premature senescence of 5-FU-treated cells by down-regulating Wnt/beta-catenin signaling. These findings provide a new strategy for alleviating myelosuppressive stress.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Prevention of seminal vesicle damage by Mucuna pruriens var. pruriens seed extract in chronic unpredictable mild stress mice

Sitthichai Iamsaard, Somboon Kietinun, Jintana Sattayasai, Kingkan Bunluepuech, Alexander Tsang-Hsien Wu, Pannawat Choowong-In

Summary: This study investigates the preventive effects of Thai Mucuna pruriens (T-MP) seed extract against seminal vesicle damage, apoptotic and Nrf2 protein expression in mice under chronic unpredictable mild stress (CUMS). The results show that T-MP extract can improve seminal epithelial damage and secretion of fluid containing essential substances and proteins in CUMS mice, increase the expression of AR and TyrPho proteins, inhibit seminal vesicular apoptosis through the suppression of Hsp70 and caspase expression, and increase Nrf2 expression. This study demonstrates that T-MP seeds have antiapoptotic properties and can be used to enhance seminal plasma quality.

PHARMACEUTICAL BIOLOGY (2023)

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Review Plant Sciences

Advances for pharmacological activities of Polygonum cuspidatum-A review

Jia Ke, Meng-Ting Li, Shuyang Xu, Jianpeng Ma, Ming-Yuan Liu, Yan Han

Summary: This article reviews the pharmacological action and clinical applications of Polygonum cuspidatum and its extracts. It highlights the anti-inflammatory, antioxidation, anticancer, and heart protection effects of Polygonum cuspidatum. The potential of Polygonum cuspidatum in treating various diseases, such as arthritis and ulcerative colitis, is also discussed.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Nanocurcumin preserves kidney function and haematology parameters in DMBA-induced ovarian cancer treated with cisplatin via its antioxidative and anti-inflammatory effect in rats

Melva Louisa, Erico Wanafri, Wawaimuli Arozal, Ni Made Dwi Sandhiutami, Ahmad Muhammad Basalamah

Summary: This study found that using nanocurcumin in combination with cisplatin in ovarian cancer rats can provide additional benefits to kidney function and haematological parameters, compared to using cisplatin alone.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Anti-neuroinflammatory effects of alkaloid-enriched extract from Huperzia serrata on lipopolysaccharide-stimulated BV-2 microglial cells

Thu Kim Dang, Seong-Min Hong, Vui Thi Dao, Phuong Thi Thu Tran, Hiep Tuan Tran, Giang Hoang Do, Thanh Nguyen Hai, Hang Thi Nguyet Pham, Sun Yeou Kim

Summary: The alkaloid-enriched extract of Huperzia serrata (Thunb.) Trevis (Lycopodiaceae) has been found to have anti-neuroinflammatory effects on LPS-stimulated BV-2 cells. Pre-treatment with the extract was more effective in suppressing inflammation compared to post-treatment. The extract regulates the MAPK signaling pathway to alleviate neuroinflammation.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway

Guolei Zhang, BoFan Lu, Enhui Wang, Wei Wang, Zheng Li, Lili Jiao, Hui Li, Wei Wu

Summary: This study investigated the antifatigue effect of Panax ginseng on chronic fatigue rats. The results showed that the extract of P. ginseng significantly prolonged the swimming time of rats, reduced blood lipids, and improved energy metabolism, effectively relieving chronic fatigue.

PHARMACEUTICAL BIOLOGY (2023)

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Review Plant Sciences

Efficacy and safety of Tripterygium glycosides as an add-on treatment in adults with chronic urticaria: a systematic review and meta-analysis

Ming Li, Yan Li, Lujing Xiang

Summary: This study evaluated the efficacy and safety of Tripterygium glycosides (TG) combined with H1-antihistamine (H1-AH) in treating chronic urticaria (CU). The results showed that TG plus H1-AH was more effective in improving cure rate, total efficacy rate, reducing pruritus, wheal number and wheal size, and decreasing serum level of immunoglobulin E (IgE), compared to H1-AH alone. The incidence of adverse events between the two groups was not significantly different.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Regulation of bone and fat balance by Fructus Ligustri Lucidi in ovariectomized mice

Xiaoyan Qin, Qiu Wei, Ran An, Yun Yang, Mingqi Cai, Xiaoling Han, Haoping Mao, Xiumei Gao

Summary: This study investigates the anti-osteoporotic effects of an ethanol extract of FLL in ovariectomized mice and explores the underlying mechanism. The results show that FLL prevents bone loss and improves bone microstructure by modulating bone and fat balance, suggesting its potential as a therapeutic agent for postmenopausal osteoporosis.

PHARMACEUTICAL BIOLOGY (2023)

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Correction Plant Sciences

Zhizhu decoction alleviates slow transit constipation by regulating aryl hydrocarbon receptor through gut microbiota (vol 61, pg 111, 2023)

Y. Wen, Y. Zhan, S. Tang, F. Liu, R. Wu, P. Kong, Q. Li, X. Tang

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Integrating serum metabolomics and network analysis to explore the antidepressant activity of crocin in rats with chronic unexpected mild stress-induced depression

Yan Luo, Ziyan Zhong, Huan Li, Le Wang, Dongwei Guo, Xuanqi Dong, Jian Liu, Mingxia Xie, Mei Wu, Yun Xiang, Xi Zhang, Pan Meng

Summary: This study elucidates the mechanism of crocin in treating depression by affecting metabolic pathways, improving body weight, sucrose preference, and reducing immobilization time.

PHARMACEUTICAL BIOLOGY (2023)

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Review Plant Sciences

Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets

Zhouman He, Jia Yuan, Yuanwen Zhang, Runfeng Li, Meilan Mo, Yutao Wang, Huihui Ti

Summary: This article provides comprehensive and promising approaches to the medical community in the fight against COVID-19 by reviewing potential plant-derived anti-SARS-CoV-2 inhibitors. The study identified seven traditional Chinese medicines with unique advantages in regulating the immune system for treating COVID-19, as well as natural plant compounds that could potentially serve as SASR-Cov-2 inhibitors.

PHARMACEUTICAL BIOLOGY (2023)

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Review Plant Sciences

Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis

Xurui Jia, Jie Chen, Ruiou Huang, Dawei Wang, Xing Wang

Summary: This study investigated the effect of Context Chaihu Jia Longgu Muli Decoction (CLMD) combined with antidepressants on multimorbidity with depression (MMD). The results showed that CLMD combined with antidepressants can significantly reduce depression levels, increase the effective rate, improve stroke severity and sleep quality, lower the levels of 5-HT, DA, NE, and IL-1β, and reduce the occurrence of adverse reactions. The study concludes that CLMD combined with antidepressants has a synergistic effect and is an effective option for the treatment of MMD.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1

Jiacheng Gao, Yuhang Wang, Zirui Jia, Jiaming Xue, Tingting Zhou, Guo Zu

Summary: EGCG promotes intestinal epithelial cell proliferation and improves barrier function after I/R injury in vitro and in vivo through the activation of Nurr1.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

A standardized extract of Echinacea purpurea containing higher chicoric acid content enhances immune function in murine macrophages and cyclophosphamide-induced immunosuppression mice

Heggar Venkataramana Sudeep, Kuluvar Gouthamchandra, Illuri Ramanaiah, Amritha Raj, Puttaswamy Naveen, Kodimule Shyamprasad

Summary: This study investigated the immunomodulatory effects of Echinacea purpurea extract with enriched chicoric acid content. The extract showed antioxidant activity and increased nitric oxide production and cytokine release in cells. It also improved immune organ indices and serum cytokine levels in mice.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Clerodendranthus spicatus inhibits epithelial-mesenchymal transition of renal tubular cells through the NF-kappa B/Snail signalling pathway in hyperuricaemia nephropathy

Shouhai Wu, Meixia Yan, Junyi Liu, Yizhen Li, Ruimin Tian, Chuang Li, Lihuang Huang, Zhisheng Lu, Peng Xu, Wei Mao

Summary: The traditional Chinese medicinal herb, Clerodendranthus spicatus, can reduce serum uric acid and ameliorate renal function in the treatment of hyperuricaemic nephropathy. In vivo and in vitro studies showed that Clerodendranthus spicatus inhibits fibrosis in renal cells, leading to the protection of renal function.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Glucocorticoid receptors involved in ginsenoside compound K ameliorate adjuvant arthritis by inhibiting the glycolysis of fibroblast-like synoviocytes via the NF-kappa B/HIF-1 alpha pathway

Yating Wang, Xiurong Bao, Hao Xian, Fang Wei, Yining Song, Siyu Zhao, Yujie Zhang, Yumeng Wang, Ying Wang

Summary: This study investigates the role and potential mechanisms of ginsenoside metabolite compound K (CK) in the treatment of rheumatoid arthritis (RA). The results demonstrate that CK can reduce arthritis symptoms and inhibit inflammation-related genes and pathways. These findings contribute to the understanding of the molecular mechanism of CK in treating RA.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone-fat balance in osteoporosis by adipocyte-derived exosomes

Lining Wang, Yalan Pan, Mengmig Liu, Jie Sun, Li Yun, Pengcheng Tu, Chengjie Wu, Ziceng Yu, Zhitao Han, Muzhe Li, Yang Guo, Yong Ma

Summary: WSTLZT exerts anti-osteoporosis effect through SPRY2 via the MAKP signaling pathway by miR-122-5p carried by adipocyte-derived exosomes.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Protective effects of vitamin D3 (cholecalciferol) on vancomycin-induced oxidative nephrotoxic damage in rats

Rouba Yasser Al-Sroji, Shaza Al-Laham, Ahmad Almandili

Summary: This study tested the antioxidant effect of vitamin D-3 in the prevention of VCM-induced nephrotoxicity. The results showed that vitamin D-3 can reduce lipid peroxidation, creatinine, and urea levels, improve kidney histopathology, and prevent VCM nephrotoxicity.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy

Mingyue Ma, Na Wei, Jieren Yang, Tingting Ding, Anping Song, Lerong Chen, Shuguo Zheng, Huanhuan Jin

Summary: This study aimed to investigate the effect of Schisandrin B (Sch B) on activated hepatic stellate cells (HSCs) senescence in hepatic fibrosis and its underlying mechanism. The results showed that Sch B could alleviate hepatic fibrosis and promote the senescence of activated HSCs, possibly through the induction of NCOA4-mediated ferritinophagy to enhance the aging process.

PHARMACEUTICAL BIOLOGY (2023)

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Article Plant Sciences

Sanziguben polysaccharides improve diabetic nephropathy in mice by regulating gut microbiota to inhibit the TLR4/NF-κB/NLRP3 signalling pathway

Fan Wang, Chang Liu, LingZhi Ren, YanYang Li, HongMei Yang, Yang Yu, WeiPing Xu

Summary: This study aimed to clarify the potential mechanism of Sanziguben polysaccharides (SZP) in improving chronic diabetic nephropathy (DN). The results showed that SZP significantly reduced urine albumin excretion, normalized blood glucose and renal damage in DN mice. Furthermore, SZP regulated gut microbiota and inhibited the TLR4/NF-kappa B/NLRP3 pathway, alleviating DN.

PHARMACEUTICAL BIOLOGY (2023)

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