Article
Plant Sciences
Borui Yu, Mengqi Zhou, Zhaocheng Dong, Huijuan Zheng, Yuxue Zhao, Jingwei Zhou, Chao Zhang, Fudong Wei, Guoyong Yu, Wei Jing Liu, Hongfang Liu, Yaoxian Wang
Summary: This study investigated the mechanism of the modified Shen-Yan-Fang-Shuai formula (M-SYFSF) against diabetic nephropathy (DN) through network pharmacological analysis and biological experiments. The results showed that M-SYFSF likely reduces inflammation in DN by inhibiting the MAPK pathway, providing a theoretical basis for its clinical application in the treatment of DN.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Jiani Liu, Li Li, Xue Han, Yue Chen, Juanjuan Diao
Summary: This study aimed to investigate the effect and mechanism of the Chinese herbal formula Lok on asthma airway remodelling, and provide new insights for the prevention and treatment of asthma. The results demonstrated that Lok effectively inhibited cell proliferation and migration, and reduced inflammation and airway remodelling. These findings provide a theoretical basis and potential treatment possibilities for the application of Lok in asthma treatment.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Fei Mu, Rui Lin, Xueyan Lu, Meina Zhao, Jiaxin Zhao, Shaojie Huang, Chao Guo, Yue Guan, Haiyue Zhang, Miaomiao Xi, Jingwen Wang, Haifeng Tang
Summary: This study aimed to elucidate the protective effects of styrax on ischemic stroke and its underlying mechanisms. The results showed that styrax could improve the symptoms of ischemic stroke rats by intervening with energy metabolism and glutamine metabolism. This finding helps us better understand the mechanism of styrax and promote its clinical application.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Cheng Fan, Jin-Xin Wang, Zhang-E. Xiong, Shan-Shan Hu, Ao-Jia Zhou, Ding Yuan, Chang-Cheng Zhang, Zhi-Yong Zhou, Ting Wang
Summary: This study evaluated the neuroprotective effects of Panax japonicus saponins (SPJ) on aging rats. The results showed that SPJ improved neuronal degeneration, mitochondrial morphology, and regulated the expression levels of Mfn2, Opa1, and Drp1 proteins. These findings suggest that SPJ may be a potential therapeutic agent for neurodegenerative disorders.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Xiujuan Qin, Huiyu Chen, Xiaoli Zhu, Xianjin Xu, Jiarong Gao
Summary: This study aimed to investigate the molecular mechanism of traditional Chinese medicine, Qi Teng Xiao Zhuo granule (QTXZG), on chronic glomerulonephritis (CGN) using proteomics. The results showed that QTXZG can promote mitochondrial autophagy by affecting the Rab7/Pink1/Parkin pathway, thereby exerting therapeutic effects.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Yanqi Cao, Jinfeng Liang, Chunguo Wang, Xuejie Bao, Siqi Li, Qi Liu, Bin Zeng, David Humberto Lopez, Ruoxi Yu
Summary: This study found that Qing Cuo Formula (QCF) is effective in treating damp-heat acne. Low-dose QCF can significantly reduce serum levels of androgens and inflammatory cytokines, and network pharmacology analysis identified active compounds and targets related to acne treatment. This study provides evidence for further research on the potential of QCF in treating other conditions related to damp-heat constitution.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Plant Sciences
Meng Qiao, Chao Lei, Chaoren Tan, Cuncun Lu, Zijia Chen, Qiang Zhang, Zhifei Wang
Summary: This study assessed the efficacy and safety of berberine for premature ventricular contractions (PVCs). The results showed that berberine combined with antiarrhythmic drugs had a higher effective rate with no significant adverse reactions. Berberine alone had no significant difference in effective rate but had a lower incidence of adverse reactions and recurrence rate. Overall, berberine is an effective and safe adjunctive therapy for PVCs.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Yuan-zhen Hao, Li-feng Cen, Ting Wang, Tong Yi, Xun-long Shi, Hui-juan Duan, Zhi Dai, Hai-yan Zhu, Jian-guo Tang
Summary: This study investigated the therapeutic effect of 999 XiaoErGanMao granules (XEGMG) on lung and intestine injury in H1N1 influenza virus-infected mice. The results showed that XEGMG can mitigate body weight loss, reduce lung index and pathological damage, and decrease the release of inflammatory cytokines. XEGMG can also protect goblet cells in the colon, maintain intestinal barrier, and regulate the major flora.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Chao Yuan, Huan Zhang, Cuicui Sun, Kai Zhang
Summary: This meta-analysis study on the treatment of sudden hearing loss (SHL) found that adjuvant Ginkgo biloba extract (GBE) therapy was more effective than general treatments (GT) alone, suggesting its potential clinical feasibility in SHL.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Plant Sciences
Yi-Dan Kong, Ying Qi, Na Cui, Zhi-Hong Zhang, Na Wei, Chang-Fu Wang, Yuan-Ning Zeng, Yan-Ping Sun, Hai-Xue Kuang, Qiu-Hong Wang
Summary: Polygonum hydropiper L. (PH), a traditional Chinese medicine, has a pungent flavor and mild drug properties, and has been used to treat various diseases for a long time. Research from 2020 to 2022 has shown that PH extracts, flavonoids, and volatile oil components have diverse bioactivities, including antibacterial, antifungal, insecticidal, antioxidant, and anti-inflammatory effects. However, further research is needed to establish scientific and reasonable evaluation standards and mechanisms of action for active constituents from PH.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Ya-nan Liu, Jie Chen, Xinhao Xu, Yingying Hu, Jin-yu Hu, Ren-ai Xu, Guanyang Lin
Summary: This study establishes a method for determining the concentration of derazantinib in rat plasma and investigates the drug-drug interaction between derazantinib and naringin. The results suggest that the metabolism of derazantinib is not significantly affected by naringin, allowing for their safe concomitant administration.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Yuan Luo, Zhenyuan Tan, Yun Ye, Xiaocong Ma, Guihua Yue
Summary: This study investigates the potential mechanism by which Qiqilian (QQL) capsule improves hypertension-induced vascular endothelial dysfunction (VED), and finds that QQL effectively attenuates endothelial injury and inflammation by inhibiting excessive autophagy, which serves as a potential therapeutic strategy for hypertension.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Kaixia Xu, Guang Lu, Qianjin Feng, Shuangchao Chen, Yonghui Wang
Summary: This study found that protocatechuic acid has a therapeutic effect on liver injury induced by type 2 diabetes, and the potential mechanism may be through the modulation of NF-kappa B and Wnt1/beta-catenin pathways to alleviate insulin resistance, lipid accumulation, oxidative stress, and inflammation in liver tissues.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Xingyu Lv, Yuqi Lin, Xi Zhu, Xiujun Cai
Summary: In this study, it was found that Isoalantolactone (IAL), a compound derived from Inula helenium L., has inhibitory effects on gallbladder cancer (GBC). IAL can inhibit the proliferation, migration, and invasion of GBC cells, promote cell apoptosis, and exert its effects by inhibiting the ERK signaling pathway. Animal experiments also confirmed that IAL can suppress the growth of gallbladder tumors.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Plant Sciences
Andrzej M. M. Woyda-Ploszczyca
Summary: This review provides an overview of the toxicity of atractyloside/carboxyatractyloside, which is mainly attributed to the inhibition of mitochondrial ADP/ATP carriers. The study also suggests that these glycosides may have effects on other target proteins.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Tianrui Zhang, Wulin Liang, Wenjing Ou, Mingqian Zhang, Shuang Cui, Shuofeng Zhang
Summary: This study found that daphnetin can alleviate neuropathic pain by inhibiting inflammation and astrocyte activation in the spinal cord, providing theoretical support for its clinical treatment.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Yiqiao Gao, Yixin Zhang, Wei Liu, Nan Zhang, Qinghe Gao, Jingfang Shangguan, Na Li, Ying Zhao, Yanlong Jia
Summary: The traditional Chinese medicine Danggui Buxue Decoction (DBD) alleviates myelosuppression after chemotherapy by regulating beta-hydroxybutyric acid (beta-OHB) metabolism and suppressing oxidative stress.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Xianheng Zhang, Jian Liu, Yanqiu Sun, Qin Zhou, Xiang Ding, Xiaolu Chen
Summary: The study found that Huangqin Qingrechubi capsule (HQC) improved lipid metabolism disorder and inflammatory response in patients with gouty arthritis (GA) by regulating the lncRNA H19/APN/PI3K/AKT pathway, suggesting that maintaining lipid metabolism stability may be an effective way to alleviate GA.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Plant Sciences
Sabrina Adorisio, Isabella Muscari, Alessandra Fierabracci, Trinh Thi Thuy, Maria Cristina Marchetti, Emira Ayroldi, Domenico Vittorio Delfino
Summary: This article reviews the antiproliferative, pro-apoptotic, anti-inflammatory, and antioxidant effects of bergamot. Studies have shown that different forms of bergamot can affect several mechanisms, leading to anti-proliferative and pro-apoptotic effects, as well as anti-inflammatory and antioxidant effects. Therefore, the rational use of bergamot in clinical applications is of great importance.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Lingxue Liu, Zhangning Yu, Jing Chen, Benchen Liu, Changhui Wu, Ye Li, Jianhua Xu, Peng Li
Summary: In this study, it was found that Lucialdehyde B (LB), an effective triterpenoid from Ganoderma lucidum, has antiproliferative and pro-apoptotic effects on nasopharyngeal carcinoma CNE2 cells. LB inhibits cell proliferation, induces cell cycle arrest, and promotes mitochondrial-dependent apoptosis. It also regulates ROS levels, calcium aggregation, and the Ras/ERK signaling pathway. These findings suggest that LB has potential as a clinical drug candidate for nasopharyngeal carcinoma treatment.
PHARMACEUTICAL BIOLOGY
(2023)
