Medical Informatics

Article Mathematical & Computational Biology

Inverse probability of treatment weighting with generalized linear outcome models for doubly robust estimation

Erin E. Gabriel, Michael C. Sachs, Torben Martinussen, Ingeborg Waernbaum, Els Goetghebeur, Stijn Vansteelandt, Arvid Sjolander

Summary: There is a concerning trend in the applied literature to believe that the combination of a propensity score and an adjusted outcome model automatically results in a doubly robust estimator and to misuse more complex established doubly robust estimators. This article introduces a simple alternative method and aims to help readers understand why it is doubly robust. It also provides examples and code for implementation.

STATISTICS IN MEDICINE (2023)

Article Computer Science, Interdisciplinary Applications

IoT-based COVID-19 detection using recalling-enhanced recurrent neural network optimized with golden eagle optimization algorithm

S. Karthick, N. Gomathi

Summary: The development of Internet of Medical Things (IoMT) with deep learning has opened up new possibilities in healthcare, particularly during the COVID-19 pandemic. This paper proposes RERNN-GEO, a deep learning method based on IoT, which utilizes the Gray-Level Co-Occurrence Matrix (GLCM) window adaptive algorithm for accurate diagnosis of COVID-19 using chest X-ray images.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2023)

Article Computer Science, Interdisciplinary Applications

A feature engineering-based machine learning technique to detect and classify lung and colon cancer from histopathological images

Indu Chhillar, Ajmer Singh

Summary: Lung and colon cancers are prevalent and lethal tumors. This study aims to develop an accurate and interpretable machine learning technique for automated classification of these cancers from histopathology images. Texture and color features are extracted using Haralick and Color histogram algorithms, then passed into the Light Gradient Boosting Machine (LightGBM) classifier. Experimental results show high accuracy and good performance of the proposed technique in classifying lung and colon cancer images.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2023)

Article Health Care Sciences & Services

Race-ethnicity and sex differences in 1-year survival following percutaneous coronary intervention among Medicare fee-for-service beneficiaries

Samuel T. Savitz, Kristine Falk, Sally C. Stearns, Lexie R. Grove, Donald E. Pathman, Joseph S. Rossi

Summary: The existing literature on the differences in survival following percutaneous coronary intervention (PCI) based on patient sex, race-ethnicity, and socioeconomic characteristics (SEC) is limited. This study aimed to evaluate the differences in 1-year survival after PCI based on sex and race-ethnicity, and to explore the influence of SEC on these differences. The findings indicate that women are more likely to undergo PCI in the setting of acute myocardial infarction (AMI) and have less transition to outpatient care. Black patients experience higher 1-year mortality following PCI, which can be explained by differences in baseline comorbidities, county medical resources, and state of residence.

JOURNAL OF EVALUATION IN CLINICAL PRACTICE (2023)

Review Computer Science, Information Systems

A scoping review of empathy recognition in text using natural language processing

Vishal Anand Shetty, Shauna Durbin, Meghan S. Weyrich, Airin Denise Martinez, Jing Qian, David L. Chin

Summary: This article provides a scoping review of studies on empathy recognition in text using natural language processing (NLP) and identifies an approach to identifying physician empathic communication over patient portal messages. The review finds variations in definitions of empathy and common settings where empathy is studied. NLP methods show promise in handling empathy-related tasks, but challenges remain in precisely defining and measuring empathy in text.

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION (2023)

Article Health Care Sciences & Services

Privacy-preserving analysis of time-to-event data under nested case-control sampling

Lamin Juwara, Yi Archer Yang, Ana M. Velly, Paramita Saha-Chaudhuri

Summary: Analyses of distributed data networks of rare diseases are challenging due to privacy and ethical concerns. We propose a privacy-preserving data analysis technique by pooling individual records of covariates at recruiting sites. Our method shows good performance in simulations and analysis of real data.

STATISTICAL METHODS IN MEDICAL RESEARCH (2023)

Article Mathematical & Computational Biology

Accommodating misclassification effects on optimizing dynamic treatment regimes with Q-learning

Yasin Khadem Charvadeh, Grace Y. Yi

Summary: This article investigates the impact of ignoring misclassification in binary covariates on the determination of optimal decision rules in dynamic treatment regimes and demonstrates its negative effects on Q-learning through empirical studies. The authors propose two correction methods to address the misclassification effects and find that these methods successfully mitigate bias in parameter estimation.

STATISTICS IN MEDICINE (2023)

Article Computer Science, Interdisciplinary Applications

Semi-supervised breast cancer pathology image segmentation based on fine-grained classification guidance

Kai Sun, Yuanjie Zheng, Xinbo Yang, Xinyuan Chen, Weikuan Jia

Summary: Breast cancer pathological image segmentation is important in quantifying tumor regions and providing treatment guidance. This study proposes a semi-supervised learning model based on classification-guided segmentation, which achieves outstanding segmentation performance.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2023)

Article Computer Science, Interdisciplinary Applications

Design and analysis of a compatible exoskeleton rehabilitation robot system based on upper limb movement mechanism

Yuansheng Ning, Hongbo Wang, Ying Liu, Qi Wang, Yu Rong, Jianye Niu

Summary: This paper proposes an upper limb exoskeleton rehabilitation robot system for shoulder-elbow-wrist joint rehabilitation training. The robot's model was guided by establishing a motion equivalent model, designing the robot mechanism configuration, and optimizing the structural parameters and human-machine compatibility. The results demonstrate that the rehabilitation robot can cover the motion range of upper limb joints, meet the needs of trajectory training, and maintain low human-machine interaction pressures during training.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2023)

Review Health Care Sciences & Services

Utilization of smart devices and the evolution of customized healthcare services focusing on big data: a systematic review

Youn Sun Son, Ki Han Kwon

Summary: The combination of smart devices and big data enables personalized healthcare and promotes health, making it an important direction for the future healthcare industry.

MHEALTH (2023)

Review Health Care Sciences & Services

Wearable heart rate variability and atrial fibrillation monitoring to improve clinically relevant endpoints in cardiac surgery -a systematic review

Liliane Zillner, Martin Andreas, Markus Mach

Summary: This systematic review highlights the potential of heart rate variability (HRV) and atrial fibrillation (AF) monitoring by wearable health monitoring devices as a diagnostic tool in cardiac surgery patients. HRV is found to be a predictor for sudden cardiac death, mortality after acute myocardial infarction (AMI), and postoperative atrial fibrillation (POAF). Continuous monitoring via wearables is also shown to be effective in capturing significant cardiac events that would otherwise have been missed.

MHEALTH (2023)

Article Computer Science, Information Systems

Brain Activity is Influenced by How High Dimensional Data are Represented: An EEG Study of Scatterplot Diagnostic (Scagnostics) Measures

Ronak Etemadpour, Sonali Shintree, A. Duke Shereen

Summary: Visualization and visual analytic tools enhance data perception and aid decision making. Scatterplot matrices (SPLOM) are commonly used for visualizing multidimensional datasets, but they become unwieldy for high dimensional data. The Graph-theoretic Scatterplot Diagnostic (Scagnostics) method extracts a subset of scatterplots with salient features and manageable size to improve human decision making. In this study, EEG was used to observe brain activity during decision making based on scatterplots created with different visual measures.

JOURNAL OF HEALTHCARE INFORMATICS RESEARCH (2023)

Article Health Care Sciences & Services

Prediction of atrial fibrillation from at-home single-lead ECG signals without arrhythmias

Matteo Gadaleta, Patrick Harrington, Eric Barnhill, Evangelos Hytopoulos, Mintu P. Turakhia, Steven R. Steinhubl, Giorgio Quer

Summary: Early identification of atrial fibrillation (AF) is crucial in reducing the risk of serious cardiovascular outcomes. This study developed a model using a deep learning approach to predict the near-term risk of AF based on electrocardiogram (ECG) data. The model showed high accuracy in predicting AF over a two-week period, providing a potential digital strategy for improving diagnosis and treatment initiation.

NPJ DIGITAL MEDICINE (2023)

Article Mathematical & Computational Biology

Multiply robust estimation of natural indirect effects with multiple ordered mediators

An-Shun Tai, Sheng-Hsuan Lin

Summary: This study proposes a method of using multiply robust estimators to infer natural indirect effects in the presence of multiple ordered mediators. The method is shown to be robust to model misspecification and has been validated through simulations and an illustrative example.

STATISTICS IN MEDICINE (2023)

Article Mathematical & Computational Biology

Combining Mendelian randomization with the sibling comparison design

Arvid Sjolander, Thomas Frisell, Sara Oberg, Yunzhang Wang, Sara Hagg

Summary: This article explores the combination of Mendelian randomization (MR) and sibling comparison design, discussing the feasibility and bias issues, and provides theoretical results and conclusions based on real data.

STATISTICS IN MEDICINE (2023)

Article Mathematical & Computational Biology

Optimal weighted Bonferroni tests and their graphical extensions

Dong Xi, Yao Chen

Summary: This article proposes an optimization algorithm for multiple objectives in clinical trials, focusing on the optimal weighted Bonferroni split. The study investigates the behavior of disjunctive power and conjunctive power as optimization objectives and proposes an efficient algorithm based on constrained nonlinear optimization and multiple starting points. The algorithm is applied to graphical approaches, providing a practical reference for optimal graphical strategies in clinical trials.

STATISTICS IN MEDICINE (2023)

Correction Medical Informatics

The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey (vol 21, 282, 2021)

J. A. Andrews, M. P. Craven, A. R. Lang, B. Guo, R. Morriss, C. Hollis

BMC MEDICAL INFORMATICS AND DECISION MAKING (2023)

Article Medical Informatics

LCRNet: local cross-channel recalibration network for liver cancer classification based on CT images

Qiang Fang, Yue Yang, Hao Wang, Hanxi Sun, Jiangming Chen, Zixiang Chen, Tian Pu, Xiaoqing Zhang, Fubao Liu

Summary: Liver cancer is the leading cause of mortality worldwide. In this paper, a novel neural network architecture called LCRNet is proposed to improve the accuracy of liver cancer diagnosis by considering global context features and building local dependencies between channels.

HEALTH INFORMATION SCIENCE AND SYSTEMS (2023)

Review Medical Informatics

Machine learning for the prediction of sepsis-related death: a systematic review and meta-analysis

Yan Zhang, Weiwei Xu, Ping Yang, An Zhang

Summary: Machine learning methods show relatively favorable accuracy in predicting mortality risk in sepsis patients, highlighting the need for updating prediction scoring systems based on existing machine learning approaches.

BMC MEDICAL INFORMATICS AND DECISION MAKING (2023)

Article Medical Informatics

Self-supervised neural network-based endoscopic monocular 3D reconstruction method

Ziming Zhang, Wenjun Tan, Yuhang Sun, Juntao Han, Zhe Wang, Hongsheng Xue, Ruoyu Wang

Summary: Based on deep learning, this study addresses the problem of inconsistent brightness between frames in endoscopic 3D reconstruction, and introduces attention modules and inter-layer losses to handle the complexity of endoscopic scenes in clinical surgeries. The developed framework can better simulate the mapping relationship between adjacent frames during endoscope motion and exhibits good generalization performance.

HEALTH INFORMATION SCIENCE AND SYSTEMS (2023)