Medical Informatics

Article Computer Science, Interdisciplinary Applications

MA-RECON: Mask-aware deep-neural-network for robust fast MRI k-space interpolation

Nitzan Avidan, Moti Freiman

Summary: This study aims to enhance the generalization capabilities of DNN-based MRI reconstruction methods for undersampled k-space data. By introducing a mask-aware DNN architecture and training method, the under-sampled data and mask are encoded within the model structure, leading to improved performance. Rigorous testing on the widely accessible fastMRI dataset reveals that this approach demonstrates better generalization capabilities and robustness compared to traditional DNN methods.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

Masked autoencoders with handcrafted feature predictions: Transformer for weakly supervised esophageal cancer classification

Yunhao Bai, Wenqi Li, Jianpeng An, Lili Xia, Huazhen Chen, Gang Zhao, Zhongke Gao

Summary: This study proposes an effective MIL method for classifying WSI of esophageal cancer. The use of self-supervised learning for feature extractor pretraining enhances feature extraction from esophageal WSI, leading to more robust and accurate performance. The proposed framework outperforms existing methods, achieving an accuracy of 93.07% and AUC of 95.31% on a comprehensive dataset of esophageal slide images.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

Spatio-temporal layers based intra-operative stereo depth estimation network via hierarchical prediction and progressive training

Ziyang Chen, Laura Cruciani, Elena Lievore, Matteo Fontana, Ottavio De Cobelli, Gennaro Musi, Giancarlo Ferrigno, Elena De Momi

Summary: In this paper, a deep learning-based approach is proposed to recover 3D information of intra-operative scenes, which can enhance the safety of robot-assisted surgery by implementing depth estimation using stereo images.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

The impact of osteoporosis and diabetes on fracture healing under different loading conditions

Enhao Zhang, Saeed Miramini, Lihai Zhang

Summary: This study investigates the combined effects of osteoporosis and diabetes on fracture healing process by developing numerical models. The results show that osteoporotic fractures have higher instability and disruption in mesenchymal stem cells' proliferation and differentiation compared to non-osteoporotic fractures. Moreover, when osteoporosis coexists with diabetes, the healing process of fractures can be severely impaired.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

Novel ensemble feature selection techniques applied to high-grade gastroenteropancreatic neuroendocrine neoplasms for the prediction of survival

Anna Jenul, Henning Langen Stokmo, Stefan Schrunner, Geir Olav Hjortland, Mona-Elisabeth Revheim, Oliver Tomic

Summary: This study evaluates the application of modern ensemble feature selection techniques for predicting overall survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms. The results demonstrate that these feature selectors provide accurate predictions and integrating expert knowledge can improve the stability of the feature set. WHO Performance Status, Albumin, Platelets, Ki-67, Tumor Morphology, Total MTV, Total TLG, and SUVmax are identified as the most stable and predictive features in this study.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Information Systems

Patients' perceptions, experiences, and satisfaction with e-prescribing system: A cross-sectional study

Jahanpour Alipour, Roxana Sharifian, Javid Dehghan Haghighi, Mehrnaz Hashemzehi, Afsaneh Karimi

Summary: This study investigated patients' perceptions of the e-prescribing system. The majority of patients were aware of e-prescribing, and preferred it over traditional prescriptions. Patients reported overall positive satisfaction and relatively positive perceptions and experiences with the e-prescribing system.

INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS (2024)

Article Computer Science, Interdisciplinary Applications

Deep reinforcement learning-based control of chemo-drug dose in cancer treatment

Hoda Mashayekhi, Mostafa Nazari, Fatemeh Jafarinejad, Nader Meskin

Summary: In this study, a novel model-free adaptive control method based on deep reinforcement learning (DRL) is proposed for cancer chemotherapy drug dosing. The method models the state variables and control action in their original infinite spaces, providing a more realistic solution. Numerical analysis shows the superior performance of the proposed method compared to the state-of-the-art RL-based approach.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

Numerical study of hemodynamic changes in the Circle of Willis after stenosis of the internal carotid artery

Hao Sun, Bao Li, Liyuan Zhang, Yanping Zhang, Jincheng Liu, Suqin Huang, Xiaolu Xi, Youjun Liu

Summary: In cases of moderate stenosis in the internal carotid artery, the A1 segment of the anterior cerebral artery or the posterior communicating artery within the Circle of Willis may show a hemodynamic environment with high OSI and low TAWSS, increasing the risk of atherosclerosis development and stenosis in the CoW.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

A novel scoring approach for the Wolf Motor Function Test in stroke survivors using motion-sensing technology and machine learning: A preliminary study

Bo Sheng, Xiaohui Chen, Jian Cheng, Yanxin Zhang, Shane (Sheng Quan) Xie, Jing Tao, Chaoqun Duan

Summary: In this study, a novel scoring approach for motor function assessment was proposed, which utilized a motion tracking system and an intelligent scoring system to objectively and accurately evaluate upper-limb motor function in stroke survivors, aiding physiotherapists in making individualized treatment decisions.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Information Systems

Longitudinal dynamic clinical phenotypes of in-hospital COVID-19 patients across three dominant virus variants in New York

Matthew Ho, Todd J. Levy, Ioannis Koulas, Kyriaki Founta, Kevin Coppa, Jamie S. Hirsch, Karina W. Davidson, Alex C. Spyropoulos, Theodoros P. Zanos

Summary: This study identified clinical phenotypes of hospitalized COVID-19 patients and investigated their longitudinal dynamics throughout the pandemic. Four distinct clinical phenotypes were associated with different mortality rates and showed variability across different viral variants. Factors such as sex, race/ethnicity, and treatment modalities revealed significant differences between the observed phenotypes. This methodology has the potential to guide evidence-based treatment strategies in a dynamic fashion.

INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS (2024)

Article Computer Science, Information Systems

A pediatric telecardiology system that facilitates integration between hospital-based services and community-based primary care

Savina Mannarino, Valeria Calcaterra, Giulia Fini, Andrea Foppiani, Antonio Sanzo, Martina Pisarra, Gabriele Infante, Marta Marsilio, Irene Raso, Sara Santacesaria, Gianvincenzo Zuccotti

Summary: This study introduces an innovative pediatric telecardiology system, seamlessly integrated with a hospital telemedicine platform, which enhances patient management in the community. The results demonstrate the system's value as a diagnostic tool to facilitate the execution, transmission, and reporting of ECG data between primary care pediatrician clinics and the hospital.

INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS (2024)

Article Computer Science, Interdisciplinary Applications

A calibration and uncertainty quantification analysis of classical, fractional and multiscale logistic models of tumour growth

Nikolaos M. Dimitriou, Ece Demirag, Katerina Strati, Georgios D. Mitsis

Summary: This study investigates the performance of mathematical models of tumour growth through integrating multiscale measurements. The results demonstrate that incorporating multiscale measurements can improve model performance, particularly when high-dose treatment is involved.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Artificial Intelligence

Predicting stroke outcome: A case for multimodal deep learning methods with tabular and CT Perfusion data

Balazs Borsos, Corinne G. Allaart, Aart van Halteren

Summary: The study demonstrates the feasibility of predicting functional outcomes for ischemic stroke patients and the usability of multimodal deep learning architectures for this purpose.

ARTIFICIAL INTELLIGENCE IN MEDICINE (2024)

Article Computer Science, Artificial Intelligence

Depression detection for twitter users using sentiment analysis in English and Arabic tweets

Abdelmoniem Helmy, Radwa Nassar, Nagy Ramdan

Summary: This study utilizes machine learning models to detect depression symptoms in Arabic and English texts, and provides manually and automatically annotated tweet corpora. The study also develops an application that can detect tweets with depression symptoms and predict depression trends.

ARTIFICIAL INTELLIGENCE IN MEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

HCTMFS: A multi-modal feature selection framework with higher-order correlated topological manifold for ESRDaMCI

Chaofan Song, Tongqiang Liu, Haifeng Shi, Zhuqing Jiao

Summary: This study proposed a multi-modal feature selection framework for classifying end-stage renal disease associated with mild cognitive impairment (ESRDaMCI) patients and identifying discriminative brain regions. Brain networks were constructed using structural and functional imaging data, and node efficiency and clustering coefficient were extracted as features. The results showed that this framework outperformed existing methods in terms of diagnostic accuracy.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

A hybrid few-shot multiple-instance learning model predicting the aggressiveness of lymphoma in PET/CT images

Caiwen Xu, Jie Feng, Yong Yue, Wanjun Cheng, Dianning He, Shouliang Qi, Guojun Zhang

Summary: A hybrid few-shot multiple-instance learning model was developed to successfully predict lymphoma aggressiveness in PET/CT images, showcasing the potential of artificial intelligence in medical applications with limited samples.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

CASMatching strategy for automated detection and quantification of carotid artery stenosis based on digital subtraction angiography

Aziguli Wulamu, Jichang Luo, Saian Chen, Han Zheng, Tao Wang, Renjie Yang, Liqun Jiao, Taohong Zhang

Summary: In this paper, a quantitative method for predicting morphological indices of carotid stenosis is proposed. The method adopts a two-stage pipeline, first using an object detection model to locate suitable regions for predicting the indices, and then using a regression model to make the predictions. Experimental results show that the proposed method improves the detection performance of normal vascular segments and achieves high accuracy in predicting the morphological indices.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Review Computer Science, Information Systems

Interdisciplinary collaboration in critical care alarm research: A bibliometric analysis

Louis Agha-Mir-Salim, Lucas McCullum, Enrico Dahnert, Yanick-Daniel Scheel, Ainsley Wilson, Marianne Carpio, Carmen Chan, Claudia Lo, Lindsay Maher, Corinna Dressler, Felix Balzer, Leo Anthony Celi, Akira-Sebastian Poncette, Michele M. Pelter

Summary: Alarm fatigue is a significant issue in the intensive care unit, and collaboration between nurses and engineers is crucial for finding solutions. However, the current research lacks sufficient involvement of nurses, leading to a lack of successful real-world solutions.

INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS (2024)

Article Computer Science, Interdisciplinary Applications

Brain network classification based on dynamic graph attention information bottleneck

Changxu Dong, Dengdi Sun

Summary: This article introduces a novel framework called the dynamic graph attention information bottleneck (DGAIB) to improve information exchange in brain network computations. By optimizing the brain graph structure and enhancing the feature aggregation of brain states, this framework achieves good performance in brain network classification tasks.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)

Article Computer Science, Interdisciplinary Applications

Simulation of coronary capillary transit time based on full vascular model of the heart

Haifeng Wang, Lei Fan, Jenny S. Choy, Ghassan S. Kassab, Lik Chuan Lee

Summary: Capillary transit time is an important factor in gas exchange between the heart and other organs. Researchers have developed a computational framework that can predict the hemodynamics of the entire coronary network and calculate capillary transit time using virtual tracers. The model predictions align with experimental measurements and indicate that coronary artery stenosis leads to longer capillary transit time.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2024)