Article
Engineering, Biomedical
Mi Zhang, Wenhui Hu, Chenhui Cai, Yu Wu, Jianmei Li, Shiwu Dong
Summary: Inflammatory arthritis is a leading cause of disability in the elderly, and the available treatment options are limited. To address this issue, researchers propose using stimuli-responsive nanomaterials to manage inflammatory arthritis, releasing therapeutic medications by triggering pathological changes.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Jiao Liu, Tao Li, Hao Zhang, Wenwen Zhao, Lijun Qu, Shaojuan Chen, Shaohua Wu
Summary: This study presents an integrated electrospinning system for fabricating nanofibrous textiles with excellent properties, which is of great significance in the field of tissue engineering and regenerative medicine.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Zijian Shao, Tianyu Yin, Jinbo Jiang, Yang He, Tao Xiang, Shaobing Zhou
Summary: A self-adaptive multifunctional hydrogel with self-healing property and injectability has been developed for treating diabetic wounds. The hydrogel can react with high glucose and hydrogen peroxide to alleviate oxidative stress and release drugs. In animal experiments, the hydrogel accelerates angiogenesis and wound closure. This self-adaptive multifunctional hydrogel shows potential for the treatment of diabetic wounds.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Zhe Wang, Xingyun Liu, Yanwen Duan, Yong Huang
Summary: The emergence and spread of antibiotic resistance is a major challenge in public health. There is an urgent need to discover novel agents against multidrug-resistant bacteria. Nano antibacterial agents have shown potent antibacterial effects by targeting the unique microenvironment of bacterial infections. The development of innovative nano-antibacterial agents could provide powerful weapons against drug-resistant bacteria in the foreseeable future.
Article
Engineering, Biomedical
Shenwu Zhang, Jing Wang, Zhiqiang Kong, Xinxin Sun, Zhonggui He, Bingjun Sun, Cong Luo, Jin Sun
Summary: Immunotherapy is a promising cancer treatment, but its efficacy for immune-cold tumors is not satisfactory. Photodynamic therapy can effectively induce immunogenic cell death, and the use of nanotechnology enhances the effectiveness of cancer immunotherapy. This article reviews recent advances in photodynamic therapy, nanotechnology, and immunogenic cell death, and discusses the prospects and challenges in this field.
Article
Engineering, Biomedical
Qiaomei Tang, Bing Lu, Jian He, Xiao Chen, Qiuli Fu, Haijie Han, Chenqi Luo, Houfa Yin, Zhenwei Qin, Danni Lyu, Lifang Zhang, Min Zhou, Ke Yao
Summary: In this study, a novel approach based on exosomes and a thermosensitive hydrogel was developed for the treatment of corneal diseases. This method effectively reduces scar formation and accelerates the healing process by promoting the repair of damaged corneal epithelium and stromal layer.
Article
Materials Science, Biomaterials
Minmin Li, Shihai Yin, Mingzi Lin, Xuelin Chen, Ying Pan, Yanqiong Peng, Jianbo Sun, Abhinav Kumar, Jianqiang Liu
Summary: With the increasing prevalence of bone defects caused by accidents, diseases, and surgeries, the treatment of bone defects presents challenges in terms of long treatment duration, high costs, and uncontrollable outcomes, affecting the physical, mental, and financial aspects of patients. Metal organic frameworks (MOFs) have emerged as a new class of bone replacement materials due to their porous nature and diverse structures, providing potential solutions for bone therapy and repair.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
J. Jamari, Muhammad Imam Ammarullah, Gatot Santoso, S. Sugiharto, Toto Supriyono, Akbar Teguh Prakoso, Hasan Basri, Emile van der Heide
Summary: This study computationally evaluated the contact pressure between UHMWPE acetabular cup and metal femoral head, and found that Ti6Al4V-on-UHMWPE can reduce cumulative contact pressure.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Zhilin Li, Hao Cai, Zhiqian Li, Long Ren, Xuelei Ma, Hongyan Zhu, Qiyong Gong, Hu Zhang, Zhongwei Gu, Kui Luo
Summary: To improve the response rate of immune checkpoint inhibitors in immunosuppressive cancers, a self-amplified biomimetic nanosystem was constructed to induce immunogenic cell death at tumor sites. The nanosystem effectively reverses the immunosuppressive tumor microenvironment, leading to distinctive inhibition of tumor growth and metastasis when combined with immune checkpoint inhibitors.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Wei Long Ng, Xi Huang, Viktor Shkolnikov, Guo Liang Goh, Ratima Suntornnond, Wai Yee Yeong
Summary: A study utilizing a thermal inkjet system to dispense sub-nanoliter cell-laden droplets identified droplet impact velocity and droplet volume as significant factors affecting the viability and proliferation of printed cells. Increasing cell concentration leads to slower impact velocity, improving cell viability, while a minimum droplet volume of 20 nL helps mitigate evaporation-induced cell damage. Control of droplet impact velocity and volume is crucial for viability and proliferation of printed human primary cells in sub-nanoliter bioprinting.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Review
Engineering, Biomedical
Mahsa Janmohammadi, Zahra Nazemi, Amin Orash Mahmoud Salehi, Amir Seyfoori, Johnson John, Mohammad Sadegh Nourbakhsh, Mohsen Akbari
Summary: Cellulose-based scaffolds have great potential in bone tissue engineering due to their non-toxicity, biocompatibility, renewable nature, and low cost. They can deliver growth factors and antibiotics directly to the site of impaired bone tissue to promote tissue repair. This review focuses on the various types of cellulose-based composite scaffolds used for bone drug delivery systems and bone regeneration, highlighting their physicochemical, mechanical, and biological properties.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Heng Mei, Shengsheng Cai, Dennis Huang, Huile Gao, Jun Cao, Bin He
Summary: This review discusses strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy. Optimizing the intrinsic physicochemical properties and external modification are key methods.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Zhaoyuan Guo, Zhuangzhuang Zhang, Nan Zhang, Wenxia Gao, Jing Li, Yuji Pu, Bin He, Jing Xie
Summary: In this study, a composite antibacterial hydrogel PDA-PAM/Mg2+ was developed for accelerated wound healing. This hydrogel showed excellent self-healing and tissue adhesive properties, as well as photothermal antibacterial functions. It demonstrated efficient bacteria inhibition and enhanced wound healing in a rat model.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xin Qin, Lirong Xiao, Ni Li, Chen Hou, Wenman Li, Jiajie Li, Naihong Yan, Yunfeng Lin
Summary: In this study, we developed a new DNA-based drug called T-155, which improved the symptoms of choroidal neovascularization by regulating the polarization of macrophages.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Nil Kanatha Pandey, Wei Xiong, Lingyun Wang, Wei Chen, Brian Bui, Jian Yang, Eric Amador, Mingli Chen, Christina Xing, Aseem Atul Athavale, Yaowu Hao, Wirya Feizi, Lloyd Lumata
Summary: The study presents the significance of AIEgen-mediated microwave dynamic therapy (MWDT) for cancer treatment, which helps to overcome the limitations of conventional PDT and reduce the side effects of MW radiation.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Muzhe Li, Han Yin, Zineng Yan, Huiyun Li, Jiang Wu, Yue Wang, Fu Wei, Guangzhao Tian, Chao Ning, Hao Li, Cangjian Gao, Liwei Fu, Shuangpeng Jiang, Mingxue Chen, Xiang Sui, Shuyun Liu, Zhiwei Chen, Quanyi Guo
Summary: The limited ability of articular cartilage to repair itself is hindered by inflammatory problems. Immune response plays a crucial role in both promoting cartilage repair and accelerating cartilage degradation. Multi-dimensional regulation of the inflammatory microenvironment is needed for cartilage regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Guangqiang Li, Xiaoyan Zhong, Xianwen Wang, Fei Gong, Huali Lei, Yangkai Zhou, Chengfei Li, Zhidong Xiao, Guoxi Ren, Liang Zhang, Zhiqiang Dong, Zhuang Liu, Liang Cheng
Summary: This study develops defective MXene nanosheets as efficient and safe sonosensitizers for photothermal-enhanced sonodynamic therapy, extending the biomedical application of MXene-based nanoplatforms.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yongzhi Cui, Yuanyuan Guo, Li Kong, Jingyu Shi, Ping Liu, Rui Li, Yongtao Geng, Weihang Gao, Zhiping Zhang, Dehao Fu
Summary: The complex pathogenesis of osteoporosis makes it difficult to treat with conventional therapies. Researchers have developed an exosome delivery system based on exosomes secreted by mesenchymal stem cells derived from induced pluripotent stem cells. By modifying a bone-targeting peptide, the system can specifically deliver siRNA to osteoblasts and enhance therapeutic effects.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Tejal Patil, Dinesh K. Patel, Sayan Deb Dutta, Keya Ganguly, Tuhin Subhra Santra, Ki-Taek Lim
Summary: Nanocellulose, a biopolymer with superior physicochemical properties, has attracted wide attention from researchers. It can be extracted from various sources and can be chemically modified for biomedical applications.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xueying Ge, Raymond Wong, Anee Anisa, Shengqian Ma
Summary: Reducing the size of metal-organic framework (MOF) composites to the nanoscale has presented unique opportunities for enhanced properties. MOF-based nanocomposites offer limitless possibilities for biomedical applications. This review focuses on the recent development, classification, and construction methods of MOF-based nanocomposites for biomedical applications.
