Materials Science, Biomaterials

Article Materials Science, Biomaterials

Facile one-pot synthesis of flower-like ellagic acid microparticles incorporating anti-microbial peptides for enhanced wound healing

Guo Zhang, Yu Wang, Hua Qiu, Lei Lu

Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.

JOURNAL OF MATERIALS CHEMISTRY B (2024)

Article Materials Science, Biomaterials

Transparent silk fibroin film-facilitated infected-wound healing through antibacterial, improved fibroblast adhesion and immune modulation

Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan

Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.

JOURNAL OF MATERIALS CHEMISTRY B (2024)

Review Materials Science, Biomaterials

Recent advances in fabricating injectable hydrogels via tunable molecular interactions for bio-applications

Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng

Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.

JOURNAL OF MATERIALS CHEMISTRY B (2024)

Article Engineering, Biomedical

Characterization of gelatin-based wound dressing biomaterials containing increasing coconut oil concentrations

Mehlika Karamanlioglu, Serap Yesilkir-Baydar

Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2024)

Article Engineering, Biomedical

Cell culture design for homogeneous proliferation of cells in three-dimensional nonwoven polymer scaffolds

Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata

Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2024)

Article Engineering, Biomedical

The role of chitosan in enhancing the solubility and antibacterial activity of emodin against drug-resistant bacteria

Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen

Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2024)

Article Materials Science, Biomaterials

Nanofibrous polycaprolactone-polyethylene glycol-based scaffolds embedded with pamidronate: fabrication and characterization

Remya K. Rajan, Sunitha Chandran, Annie John, Ramesh Parameswaran

Summary: This study outlines the fabrication and characterization of pamidronate (PDS) embedded nanofibrous scaffolds based on polycaprolactone/polycaprolactone-polyethyleneglycol-polycaprolactone (PCL/CEC) blends for osteoporotic bone defect management. The electrospinning technique was utilized to fabricate PDS-loaded scaffolds, and the effect of PDS on the blends was evaluated in terms of surface morphology, wettability, biodegradability, and in vitro cytocompatibility. The results showed that the PCL/CEC-PDS scaffolds had a fibroporous architecture, appropriate mechanical properties, and the ability to support cell growth, indicating their potential for managing osteoporotic bone defects.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2024)

Review Materials Science, Biomaterials

Minireview: biocompatibility of engineered biomaterials, their interaction with the host cells, and evaluation of their properties

Angelica Jimenez-Rosales, Stefani Cortes-Camargo, Pedro Estanislao Acuna-Avila

Summary: The immune response to drug-delivering systems and implanted medical devices based on biomaterials is complex, and the goal is to design biomaterials that can respond to stimuli, preserve tissue function, and optimize cellular structures. Understanding the material's structure and location, as well as the severity of damage and other factors, is crucial in developing biocompatible biomaterials.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2024)

Article Engineering, Biomedical

Synthesis, characterization, and antibacterial activity of chitosan-chelated silver nanoparticles

Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng

Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2024)

Article Materials Science, Biomaterials

Recent advances in polymeric hydrogel nanoarchitectures for drug delivery applications

Christopher Igwe Idumah, I. C. Nwuzor, S. R. Odera, U. J. Timothy, U. Ngenegbo, F. A. Tanjung

Summary: This paper presents recent advancements in drug delivery applications of polymeric hydrogel nanoarchitectures and hydrogel derivatives, including the incorporation of nanoparticulates and the enhancement of the chemical, biological, electrical, and mechanical properties of hydrogels. The application of magnetically responsive and smart hydrogels as drug delivery systems is also discussed.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2024)

Article Materials Science, Biomaterials

Insight into the fabrication, characterization, and in vitro cytotoxicity studies approaches of halloysite-based functional anhydride containing polymer nanocomposites

Kubra Aydin, Handan Sevim, Hatice Kaplan Can

Summary: This study aims to develop a new dental material by designing, synthesizing, and characterizing nanocomposites, and evaluate their cytotoxic effects on human gingival fibroblasts. The results of this research will contribute to a better understanding of the properties and safety of this material, providing reference for clinical applications in dentistry.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2024)

Article Materials Science, Biomaterials

Electrospun PCL/fibrin scaffold as a bone implant improved the differentiation of human adipose-derived mesenchymal stem cells into osteo-like cells

Fatemeh Daliri Shadmehri, Ehsan Karimi, Ehsan Saburi

Summary: Bone tissue engineering utilizes polymeric scaffolds and stem cells to create a supportive matrix resembling the in vivo environment for bone repair. The study found that a composite matrix of polycaprolactone and fibrin enhanced the differentiation of adipose-derived stem cells into osteo-like cells.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2024)

Article Engineering, Biomedical

Development of kojic acid loaded collagen-chitosan nanoparticle as skin lightener product: in vitro and in vivo assessment

Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi

Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2024)

Article Biophysics

Analysis of surfactant production by Bacillus cereus GX7 and optimization of fermentation conditions

Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue

Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

Functional surfaces for exosomes capturing and exosomal microRNAs analysis

Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli

Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

Graphene oxide-doped chiral dextro-hydrogel promotes peripheral nerve repair through M2 polarization of macrophages

Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng

Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Engineering, Biomedical

Surface characteristics of 3D printed PEEK polymer using atomic force microscopy

Chithambaram Karunanithi, Senthilnathan Natarajan

Summary: High-performance polymer three-dimensional printing is widely used in biomedical applications, but the surface quality of the printed parts greatly affects their performance. This study investigates the impact of printing parameters on the surface roughness of PEEK specimens and measures the roughness using atomic force microscopy. The results show that the printing parameters significantly affect the surface roughness of the PEEK specimens.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2024)

Article Biophysics

Conductive 3D Ti3C2Tx MXene-Matrigel hydrogels promote proliferation and neuronal differentiation of neural stem cells

Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian

Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

Effect of the oxygenic groups on activated carbon on its hemocompatibility

Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong

Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

A dual-functional strontium-decorated titanium implants that guides the immune response for osseointegration of osteoporotic rats

Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang

Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)