Integrative & Complementary Medicine

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Review Plant Sciences

Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

Fabiolla Rocha Santos Passos, Heitor Gomes Araujo-Filho, Brenda Souza Monteiro, Saravanan Shanmugam, Adriano Antunes de Souza Araujo, Jackson Roberto Guedes da Silva Almeida, Parimelazhagan Thangaraj, Lucindo Jose Junior Quintans, Jullyana de Souza Siqueira Quintans

Summary: This review summarizes preclinical studies on the anti-inflammatory activity of steroidal saponins through the modulation of inflammatory cytokines. The results show that steroidal saponins and sapogenins have anti-inflammatory, antinociceptive, and antioxidant effects, and they mainly modulate inflammatory cytokines through the Nf-Kappa B, TLR4, and MAPKs pathways.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway

Yuying Wang, Xiaoqing Sang, Rui Shao, Honglin Qin, Xuanhao Chen, Zhifeng Xue, Lin Li, Yu Wang, Yan Zhu, Yanxu Chang, Xiumei Gao, Boli Zhang, Han Zhang, Jian Yang

Summary: Xuanfei Baidu Decoction has protective effects against acute inflammation and pulmonary fibrosis by inhibiting the IL-6/STAT3 signaling pathway to protect against macrophage-induced inflammation and pulmonary fibrosis.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Integrative & Complementary Medicine

Ayurvedic clinical profile of COVID-19 - A preliminary report

Rammanohar Puthiyedath, Sushila Kataria, Unnikrishnan Payyappallimana, Prasad Mangalath, Vasudevan Nampoothiri, Pooja Sharma, Manish Kumar Singh, Kuldeep Kumar, Naresh Trehan

Summary: This paper aims to develop an Ayurvedic clinical profile of COVID-19 through literature review and analysis of clinical data, with the goal of developing standalone and integrative treatment approaches. Preliminary findings indicate that COVID-19 can be understood from an Ayurvedic perspective as a vatakapha dominant sannip nipatajvara of agantu origin with pittanubandha. Further research and collaboration with allopathic physicians is needed to refine and expand upon this preliminary clinical profile.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2022)

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Review Integrative & Complementary Medicine

Historical perspectives on using sham acupuncture in acupuncture clinical trials

Stephen Birch, Myeong Soo Lee, Tae-Hun Kim, Terje Alraek

Summary: Trials of acupuncture in the West initially lacked proper textbooks, leading to faulty assumptions and adoption of problematic research methods; with improvements in trial methodology, new sham treatments were developed and used, but without adequate physiological studies or examination of international acupuncture practices.

INTEGRATIVE MEDICINE RESEARCH (2022)

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Review Plant Sciences

Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification

Yabin Gao, Hang Fan, Anzheng Nie, Kang Yang, Haiyan Xing, Zhiqing Gao, Liujie Yang, Zheng Wang, Linqi Zhang

Summary: This paper reviews the research progress on the pharmacokinetics, physiological and pathological processes of aconitine, and discusses promising research directions and detoxification methods.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Plant Sciences

Leaves, seeds and exocarp of Ginkgo biloba L. (Ginkgoaceae): A Comprehensive Review of Traditional Uses, phytochemistry, pharmacology, resource utilization and toxicity

Yanxia Liu, Huawei Xin, Yunchao Zhang, Fengyuan Che, Na Shen, Yulei Cui

Summary: This review summarizes the traditional uses, phytochemistry, pharmacology, resource utilization, and toxicity research progress of Ginkgo biloba leaves, seeds, and exocarp. Ginkgo biloba has been used for treating cardiovascular and cerebrovascular diseases, Alzheimer's disease, and other diseases. However, it also contains toxic compounds.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Plant Sciences

Isatidis Radix and Isatidis Folium: A systematic review on ethnopharmacology, phytochemistry and pharmacology

Jiao Chen, Zongping Zhu, Tianhui Gao, Yi Chen, Qingsong Yang, Chaomei Fu, Yaning Zhu, Fang Wang, Wan Liao

Summary: Isatidis Radix (Banlangen) and Isatidis Folium (Daqingye) have been commonly used as traditional edible-medicinal herbs for detoxifying and treating influenza and viral infectious diseases. Recent studies have confirmed their effectiveness in antiviral, antibacterial, and immune diseases, with differences in their pharmacological properties. Further comprehensive studies are needed for their utilization.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Integrative & Complementary Medicine

Ethnobotany, Phytochemistry, Biological Activities, and Health-Promoting Effects of the Genus Bulbophyllum

Javad Sharifi-Rad, Cristina Quispe, Abdelhakim Bouyahya, Naoual El Menyiy, Nasreddine El Omari, Md Shahinozzaman, Mim Ara Haque Ovey, Niranjan Koirala, Mamata Panthi, Andrea Ertani, Silvana Nicola, Natallia Lapava, Jesus Herrera-Bravo, Luis A. Salazar, Sushil Changan, Manoj Kumar, Daniela Calina

Summary: This review discusses the therapeutic potential of Bulbophyllum spp. biocompounds by examining the phytochemistry and preclinical pharmacology data. Pharmacological studies have shown that various phytoconstituents in Bulbophyllum species have different biological health-promoting activities, such as antimicrobial, antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Clinical trials are needed to confirm these activities observed in preclinical studies.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Review Plant Sciences

Therapeutic effect of baicalin on inflammatory bowel disease: A review

Xian Wang, Long Xie, Jiaying Long, Kai Liu, Jing Lu, Youdan Liang, Yi Cao, Xiaolin Dai, Xiaofang Li

Summary: This review compiled the efficacy of baicalin in treating inflammatory bowel disease, showing that its mechanisms mainly include anti-inflammation, antioxidant, immune regulation, maintenance of intestinal barrier, and maintenance of intestinal flora balance.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Role of medicinal plants from North Western Himalayas as an efflux pump inhibitor against MDR AcrAB-TolC Salmonella enterica serovar typhimurium: In vitro and In silico studies

Jyoti Mehta, Rajan Rolta, Kamal Dev

Summary: The study aimed to identify phytochemicals from traditional medicinal plants in the North-Western Himalayas that could inhibit the efflux pump activity of Salmonella typhimurium, leading to increased sensitivity to antibiotics at reduced dosages. Results showed that lariciresinol from Zingiber officinale could potentially serve as an efflux pump inhibitor, enhancing antibacterial potency and showing good binding affinity with bacterial targets.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Plant Sciences

A review of the immunomodulatory activities of polysaccharides isolated from Panax species

Yeye Hu, Yang He, Zhiqiang Niu, Ting Shen, Ji Zhang, Xinfeng Wang, Weicheng Hu, Jae Youl Cho

Summary: This article reviews the composition and structural characteristics of purified Panax polysaccharides and discusses their immunomodulatory activities both in vivo and in vitro. Panax polysaccharides can enhance the immune response by activating immune cells and increasing immune indices. Additionally, they have potential therapeutic effects in treating cancer, sepsis, and osteoporosis.

JOURNAL OF GINSENG RESEARCH (2022)

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Article Integrative & Complementary Medicine

In silico evaluation of the compounds of the ayurvedic drug, AYUSH-64, for the action against the SARS-CoV-2 main protease

Thrigulla Saketh Ram, Manne Munikumar, Vankudavath Naik Raju, Parasannanavar Devaraj, Naveen Kumar Boiroju, Rajkumar Hemalatha, P. V. V. Prasad, Manohar Gundeti, Brijesh S. Sisodia, Sharad Pawar, G. P. Prasad, Mukesh Chincholikar, Sumeet Goel, Anupam Mangal, Sudesh Gaidhani, N. Srikanth, K. S. Dhiman

Summary: The study evaluated the compounds in AYUSH-64 drug against SARS-CoV-2, with findings showing 35 compounds had good binding energies and Akuammicine N-Oxide was the most effective compound with strong affinity and interactions. These results suggest that AYUSH-64 could be a potential candidate for managing COVID-19.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2022)

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Article Plant Sciences

A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

Xiaojing Zhang, Zhenzhen Liu, Shuaipeng Chen, Hang Li, Lin Dong, Xueyan Fu

Summary: TBSE activates the Bax/Bcl2 and caspase-9/caspase-3 cascade to induce apoptosis of human colon cancer cells in a dose-dependent manner, which is closely linked to the inhibition of the PI3K/Akt/mTOR signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway

Yang Zhang, Shan Liu, Jiu-Long Ma, Chen Chen, Peng Huang, Jia-Hua Ji, Di Wu, Li-Qun Ren

Summary: Apocynum venetum L. leaf extract alleviates doxorubicin-induced cardiomyocyte apoptosis by suppressing oxidative stress and apoptosis through the AKT/Bcl-2 signaling pathway.

PHYTOMEDICINE (2022)

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Review Plant Sciences

Recent progress (2015-2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer

Zuan Lin, Rongfang Xie, Chenhui Zhong, Jianyong Huang, Peiying Shi, Hong Yao

Summary: This study reviewed the pharmacological effects and mechanisms of Rb1 against cardiovascular and nervous system diseases, diabetes, and their complications, providing insights into the potential therapeutic effects of Rb1 against diseases and offering further predictive analysis.

JOURNAL OF GINSENG RESEARCH (2022)

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Review Integrative & Complementary Medicine

Banana Peels: A Waste Treasure for Human Being

Wafaa M. Hikal, Hussein A. H. Said-Al Ahl, Amra Bratovcic, Kirill G. Tkachenko, Javad Sharifi-Rad, Miroslava Kacaniova, Mohammed Elhourri, Maria Atanassova

Summary: In recent years, scientists have shown increased interest in agricultural waste, particularly banana peels, for their bioactive properties. This review article focuses on the antioxidant and antimicrobial activities of banana peels, highlighting their potential as natural antioxidants and pharmaceutical resources. It is concluded that banana peels can be successfully utilized in various industries, including food and pharmaceuticals, offering new avenues for research.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Plant Sciences

Curcumin inhibits the invasion and metastasis of triple negative breast cancer via Hedgehog/Gli1 signaling pathway

Mengjie Li, Tingting Guo, Jiayi Lin, Xia Huang, Qiaodan Ke, Yujian Wu, Chunping Fang, Chenxia Hu

Summary: Curcumin, the main pharmacological component extracted from Curcuma longa L, has been found to inhibit proliferation and metastasis of TNBC cells via the Hedgehog/Gli1 pathway, providing potential therapeutic strategies for TNBC.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Plant Sciences

Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels

Long You, Seunghwa Cha, Mi-Yeon Kim, Jae Youl Cho

Summary: The immune system plays a crucial role in the human body, with immunomodulation being its main function. Ginsenosides, derived from ginseng, have both immunostimulatory and immunosuppressive effects.

JOURNAL OF GINSENG RESEARCH (2022)

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Article Integrative & Complementary Medicine

AYUSH 64, a polyherbal Ayurvedic formulation in Influenza-like illness - Results of a pilot study

Manohar S. Gundeti, Laxman W. Bhurke, Pallavi S. Mundada, Sanjay Murudkar, Ashita Surve, Ramavatar Sharma, Sunita Mata, Rakesh Rana, Richa Singhal, Neera Vyas, Shruti Khanduri, B. S. Sharma, N. Srikanth, K. S. Dhiman

Summary: This study aimed to evaluate the safety and efficacy of AYUSH-64 in clinically diagnosed ILI patients. The results showed that AYUSH-64 played a positive role in alleviating ILI symptoms, reducing medication usage frequency, and promoting patient recovery through safe intervention.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2022)

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Article Integrative & Complementary Medicine

Evaluation of potency of the selected bioactive molecules from Indian medicinal plants with MPro of SARS-CoV-2 through in silico analysis

Pinku Halder, Upamanyu Pal, Pranab Paladhi, Saurav Dutta, Pallab Paul, Samudra Pal, Debasmita Das, Agnish Ganguly, Ishita Dutta, Sayarneel Mandal, Anirban Ray, Sujay Ghosh

Summary: This study used in silico molecular docking approach to investigate whether phytochemicals from Indian spices and medicinal plants can be used as alternative therapeutic agents to synthetic drugs.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2022)

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