Integrative & Complementary Medicine

99.8K Papers

Article Plant Sciences

Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy

Zhiguo Mao, Liyu Tian, Jiao Liu, Qian Wu, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto

Summary: This study found that LIG improves mitochondrial function by promoting PINK1/Parkin-mediated mitophagy and alleviates neuronal injury in cerebral ischemia reperfusion injury.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Quercetin promotes cutaneous wound healing in mice through Wnt/β-catenin signaling pathway

Yuhui Mi, Lei Zhong, Saijian Lu, Po Hu, Yang Pan, Xuelin Ma, Binghui Yan, Zhenhuan Wei, Guangming Yang

Summary: The study aimed to evaluate the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and to reveal the mechanisms involved, including the Wnt/beta-catenin pathway and TERT.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Integrative & Complementary Medicine

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Yasaman Taheri, Cristina Quispe, Jesus Herrera-Bravo, Javad Sharifi-Rad, Shahira M. Ezzat, Rana M. Merghany, Shabnum Shaheen, Lubna Azmi, Abhay Prakash Mishra, Bilge Sener, Mehtap Kilic, Surjit Sen, Krishnendu Acharya, Azadeh Nasiri, Natalia Cruz-Martins, Patrick Valere Tsouh Fokou, Alibek Ydyrys, Zhandos Bassygarayev, Sevgi Durna Dastan, Mohammed M. Alshehri, Daniela Calina, William C. Cho

Summary: This review provides an overview of the medicinal use, chemical composition, pharmacological properties, and safety profile of Urtica dioica, highlighting its potential clinical value.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Plant Sciences

Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo

Song Yang, Fangyu Li, Shuyan Lu, Limei Ren, Shuai Bian, Meichen Liu, Daqing Zhao, Siming Wang, Jiawen Wang

Summary: This study investigated the anti-inflammatory, anti-oxidative, and autophagy regulatory mechanisms of ginseng root extract (GRE) in LPS-treated RAW264.7 cells. The results showed that GRE significantly reduced levels of nitric oxide, TNF-alpha, and IL-6 while also decreasing NF-kappa B activity and MAPK phosphorylation. Furthermore, GRE induced autophagy via the Akt-mTOR signaling pathway, relieving excessive oxidation, mitochondrial dysfunction, and inflammation.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Integrative & Complementary Medicine

Resveratrol' biotechnological applications: Enlightening its antimicrobial and antioxidant properties

Javad Sharifi-Rad, Cristina Quispe, Alessandra Durazzo, Massimo Lucarini, Eliana B. Souto, Antonello Santini, Muhammad Imran, Ashaimaa Y. Moussa, Nada M. Mostafa, Mohamed El-Shazly, Bilge Sener, Mauricio Schoebitz, Miquel Martorell, Abhijit Dey, Daniela Calina, Natalia Cruz-Martins

Summary: This narrative review provides a brief outline of the historical perspectives of resveratrol and an extensive overview of various approaches and contemporary developments on the bioavailability, pharmacodynamics, and pharmacokinetics of this nutraceutical, as well as its biotechnological applications and drug formulations.

JOURNAL OF HERBAL MEDICINE (2022)

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Article Integrative & Complementary Medicine

Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial

Wajiha Mahjabeen, Dilshad Ahmed Khan, Shakil Ahmed Mirza

Summary: Resveratrol supplementation improves glycemic control, reduces insulin resistance, and has significant beneficial effects on chronic inflammation, oxidative stress, and associated microRNA expression in diabetic patients.

COMPLEMENTARY THERAPIES IN MEDICINE (2022)

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Article Integrative & Complementary Medicine

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

Fahadul Islam, Saikat Mitra, Mohamed H. Nafady, Mohammad Tauhidur Rahman, Vineet Tirth, Aklima Akter, Talha Bin Emran, Amany Abdel-Rahman Mohamed, Ali Algahtani, Sanad S. El-Kholy

Summary: The study explored the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models, showing significant effects in reducing sleeping time induced by thiopental sodium and managing blood glucose levels in alloxan-induced diabetic mice. These results suggest the potential medicinal value of L. coromandelica.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Plant Sciences

Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway

Jia-Shang Li, Tao Ji, Shu-Lan Su, Yue Zhu, Xing-Ling Chen, Er-Xin Shang, Sheng Guo, Da-Wei Qian, Jin-Ao Duan

Summary: Alkaloids, flavonoids, and polysaccharides from mulberry leaves have been shown to significantly lower blood glucose and lipid levels by regulating glucose, amino acid, and lipid metabolism, while compounds like 1-DNJ and QG exhibit strong antidiabetic effects through various mechanisms in different cell types.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Integrative & Complementary Medicine

What is the influence of grape products on liver enzymes? A systematic review and meta-analysis of randomized controlled trials

Sadia Ghaffar, Mehak Ali Naqvi, Adeela Fayyaz, Mohammed Kadhem Abid, Kakhramon Najmiddinovich Khayitov, Abduladheem Turki Jalil, Fahad Alsaikhan, Ali Thaeer Hammid, Moaed E. Al-Gazally, Vida Mohammadparast, Behrooz Jannat, Mehran Nouri

Summary: The systematic review and meta-analysis found that grape products had no significant effect on liver enzymes in adults. However, due to the limited number of studies included, further research is needed to evaluate the potential of grape products as a complementary treatment for improving liver enzymes.

COMPLEMENTARY THERAPIES IN MEDICINE (2022)

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Article Plant Sciences

Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway

Hang Chen, Ji Zhu, Yifei Le, Jieli Pan, Ying Liu, Zhijun Liu, Cui Wang, Xiaobing Dou, Dezhao Lu

Summary: Salidroside has been shown to have cardioprotective effects against doxorubicin-induced cardiomyopathy by activating AMPK-dependent signaling pathways. It reduces ferroptotic cell death and shows potential as a novel treatment for DIC.

PHYTOMEDICINE (2022)

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Review Integrative & Complementary Medicine

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Noor-E-Tabassum, Rajib Das, Mashia Subha Lami, Arka Jyoti Chakraborty, Saikat Mitra, Trina Ekawati Tallei, Rinaldi Idroes, Amany Abdel-Rahman Mohamed, Md. Jamal Hossain, Kuldeep Dhama, Gomaa Mostafa-Hedeab, Talha Bin Emran

Summary: Ginkgo biloba is an ancient plant with diverse bioactive components and has been used for therapeutic purposes in various diseases. However, long-term or high-dose use of Ginkgo biloba may cause adverse effects, and severe drug interactions have been reported when combined with other medications. Further experimentation is needed to confirm the safety and efficacy of Ginkgo biloba.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Plant Sciences

Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway

Xiangming Liu, Yiming Ma, Lijuan Luo, Dandan Zong, Herui Li, Zihang Zeng, Yanan Cui, Weiwei Meng, Yan Chen

Summary: DHQ significantly reverses cigarette smoke-induced ferroptosis via a Nrf2-dependent signaling pathway, exerting protective effects in both in vivo mouse models and in vitro cell cultures.

PHYTOMEDICINE (2022)

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Article Integrative & Complementary Medicine

Use of complementary and alternative medicine in general population during COVID-19 outbreak: A survey in Iran

Mahlagha Dehghan, Alireza Ghanbari, Fatemeh Ghaedi Heidari, Parvin Mangolian Shahrbabaki, Mohammad Ali Zakeri

Summary: This study investigated the use of complementary and alternative medicine (CAM) during the COVID-19 epidemic in Iran. The results showed that a majority of participants used at least one type of CAM, with dietary supplements, prayer, and herbal medicines being the most commonly used. CAMs were mainly used for prevention of transmission and reducing anxiety.

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2022)

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Review Plant Sciences

A review of the traditional use of southern African medicinal plants for the treatment of inflammation and inflammatory pain

Gugulethu P. Khumalo, Ben Erik Van Wyk, Yunjiang Feng, Ian E. Cock

Summary: Traditional medicinal plants from southern Africa are commonly used to treat inflammation and pain-related ailments, but there is still a lack of research on their anti-inflammatory properties and further studies are needed.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Integrative & Complementary Medicine

Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells

Seshu Vardhan, Suban K. Sahoo

Summary: This study used in silico molecular docking to search for potential phytochemicals and drugs as adjuvant therapies for COVID-19 by inhibiting the proteolytic cleavage activity of furin and TMPRSS2. The results showed that phytochemicals like limonin and gedunin, as well as the drug nafamostat, exhibited high inhibitory activity.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2022)

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Review Plant Sciences

Catharanthus roseus (L.) G. Don: A review of its ethnobotany, phytochemistry, ethnopharmacology and toxicities

Sunil Kumar, Bikarma Singh, Ramesh Singh

Summary: Catharanthus roseus is a traditional medicinal plant used in the treatment of cancer and diabetes, containing various compounds with pharmacological activities. Research has shown that extracts and compounds from this plant exhibit potential anticancer and antidiabetic properties, but caution is needed as toxicity can occur beyond a certain limit.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Network pharmacology-based approach to understand the effect and mechanism of Danshen against anemia

Shan He, Tianqi Wang, Congwei Shi, Zhenguo Wang, Xianjun Fu

Summary: The study found that Danshen has 115 chemical targets related to anemia, with its treatment mechanism significantly linked to the Jak-STAT signaling pathway. Experimental results showed that Danshen extracts could enhance red blood cell count, cardiac output, and blood flow velocity, with Danshen aqueous extract exhibiting a wider range of anti-anemia effects and lower toxicity.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Integrative & Complementary Medicine

Immunity against COVID-19: Potential role of Ayush Kwath

Shankar Gautam, Arun Gautam, Sahanshila Chhetri, Urza Bhattarai

Summary: The study reviewed the role of immunity in the pathogenesis of COVID-19 and the effects of Ayush Kwath on the virus and immune regulation, suggesting its potential effectiveness in controlling viral infections.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2022)

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Review Integrative & Complementary Medicine

Gallic Acid: A Potential Anti-Cancer Agent

Yuan Jiang, Jin Pei, Yan Zheng, Yu-jing Miao, Bao-zhong Duan, Lin-fang Huang

Summary: Gallic acid (GA) is a natural botanic phenolic compound with therapeutic properties against inflammation, obesity, and cancer. Recent studies have shown that GA can inhibit cancer progression by targeting various biological pathways, making it a promising candidate for anti-cancer therapy. Further research is needed to explore its potential in treating different types of cancer such as lung, prostate, stomach, and colon adenocarcinoma.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2022)

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Article Plant Sciences

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sanjib Senapati, Sandeep Malampati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Benjamin Chun-Kit Tong, King-Ho Cheung, Jie-Qiong Tan, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Ju-Xian Song, Min Li

Summary: The study found that protopine (PRO) reduces abnormal tau protein in the brains of Alzheimer's disease (AD) patients, improving memory and cognition. The research confirmed the pharmacokinetics of PRO and its mechanism of action through experiments.

PHYTOMEDICINE (2022)

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Integrative & Complementary Medicine

Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy

Quercetin promotes cutaneous wound healing in mice through Wnt/β-catenin signaling pathway

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo

Resveratrol' biotechnological applications: Enlightening its antimicrobial and antioxidant properties

Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway

What is the influence of grape products on liver enzymes? A systematic review and meta-analysis of randomized controlled trials

Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway

Use of complementary and alternative medicine in general population during COVID-19 outbreak: A survey in Iran

A review of the traditional use of southern African medicinal plants for the treatment of inflammation and inflammatory pain

Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells

Catharanthus roseus (L.) G. Don: A review of its ethnobotany, phytochemistry, ethnopharmacology and toxicities

Network pharmacology-based approach to understand the effect and mechanism of Danshen against anemia

Immunity against COVID-19: Potential role of Ayush Kwath

Gallic Acid: A Potential Anti-Cancer Agent

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

Related Categories

Top Journals

AMERICAN JOURNAL OF CHINESE MEDICINE

Chinese Medicine

Journal of Integrative Medicine-JIM

Chinese Journal of Natural Medicines

Journal of Traditional and Complementary Medicine

World Journal of Traditional Chinese Medicine

BMC Complementary Medicine and Therapies

COMPLEMENTARY THERAPIES IN MEDICINE

Integrative Medicine Research