Instruments & Instrumentation

Article Chemistry, Analytical

DNA walker-powered SERS logic aptasensors for accurate imaging and identification of tumor cells

Chen Dong, Jingrong Xiong, Yeran Wang, Jing Liang, Chenlong Yan, Huiming Lv, Jingjing Zhang, Chunyuan Song, Lianhui Wang

Summary: In this study, a DNA walker-powered SERS logic aptasensor was proposed for accurate identification of tumor cells. The aptasensor can sensitively and specifically image membrane proteins on single live cells, enabling logical analysis for cancer cell classification and subtypes.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Nanocasting technique for imprinting a natural leaf pattern on biomimetic polyaniline to yield an artificial hierarchical surface structure for gas sensing

Kun-Hao Luo, Yu-Han Hung, Aamna Bibi, Yi-Min Li, Chuan Hu, Jui-Ming Yeh

Summary: This study focuses on the synthesis and utilization of a novel biomimetic material, Bio-PANI, for H2S gas sensing applications. The Bio-PANI coating exhibits a larger specific surface area and better electrochemical performances compared to conventional PANI coating. The Bio-PANI-coated sensor shows higher response and better stability.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Enhanced performance of electro-responsive PVC gel actuators prepared by advanced rapid thermal melting technique

Yuwei Wu, Min Yu, Chengbo Tian, David Vokoun, Runqi Hu, Hengzao Ge, Hao Zhang, Ivo Stachiv

Summary: This study proposes a new method for fabricating PVC gel using a thermal melting approach, which significantly improves its actuation performance while reducing fabrication time and cost.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

An APE1-mediated isothermal target cycling amplification for label-free and rapid detection of miRNA

Mengxu Sun, Yanxin Zhang, Juan Xie, Ya Zhang, Ting Huang, Minmin Li, Jin-Xiang Chen, Zong Dai, Jun Chen

Summary: This study developed a highly efficient and sensitive miRNA detection method by combining APE1-mediated isothermal target cycling amplification system with magnetic separation. The label-free and rapid detection of miRNA was achieved through the recognition and cleavage of AP probes by APE1, and the fluorescence measurement of G4/ThT. The method showed high specificity and sensitivity, and demonstrated its application in detecting miR-1246 in serum samples from breast cancer patients and normal people.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Classification of circulating tumor cell clusters by morphological characteristics using convolutional neural network-support vector machine

Junhyun Park, Seongmin Ha, Jaejeung Kim, Jae-Woo Song, Kyung-A. Hyun, Tohru Kamiya, Hyo-Il Jung

Summary: In this study, a hybrid algorithm was developed for accurate classification of CTC clusters without immunofluorescence staining, providing a powerful tool for cancer diagnosis and prognosis.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Low-temperature gas sensor with good long-term stability based on Co3O4/ Ti3C2TX heterojunction

Zhe Liu, Xichao Mo, Shuhao Tian, Jie Chen, Yanpeng Liu, Haiyang Wu, Yawei Zhao, Yanrong Wang, Shanglong Peng

Summary: This study demonstrates the fabrication of Co3O4/MX7.5 heterojunction using electrostatic adsorption and calcination strategies, and shows its potential for detecting ethanol at a relatively low temperature with long-term stability.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Colorimetric detection of glucose with smartphone-coupled μPADs: harnessing machine learning algorithms in variable lighting environments

Solaleh Ghateii, Amir Jahanshahi

Summary: Recent advances in microfluidic paper-based analytical devices have shown great potential for point-of-care testing, particularly for monitoring glucose levels in diabetes patients. However, the practical application of smartphone-coupled devices has been hindered by variability in ambient lighting conditions. In this study, a machine learning-based algorithm and flash/no-flash technic were developed to address the issue, resulting in accurate monitoring of plasma glucose levels across a wide range and in various lighting conditions.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Dual-channel colorimetric sensor based on metal ion mediated color transformation of AuNPs to identify the authenticity and origin of Atractylodis Macrocephalae Rhizoma

Yue Wu, Rui Liu, Zediao Huang, Hengye Chen, Xiangyu Zhao, Yanmin Rao, Rongxian Bai, Wanjun Long, Jian Yang, Wei Lan, Haiyan Fu

Summary: In this study, a dual-channel colorimetric sensor was constructed to identify the authenticity and origin of Atractylodis Macrocephalae Rhizoma (AMR) using metal ions mediated color transformation of gold nanoparticles (AuNPs). The sensor accurately classified AMR samples from different origins and their counterfeits based on significantly different color transformations.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

CO gas sensing characteristics of BaSnO3 epitaxial films prepared by PLD: The effect of film thickness

Shikha Shrivastava, Debashrita Mahana, Simran Nehra, Sunil Gangwar, Sandeep Singh, C. S. Yadav, Senthil Kumar Muthusamy, Anjana Dogra

Summary: In this study, the perovskite Barium Stannate (BaSnO3) thin films were investigated for CO gas sensing application. The electrical properties and gas sensing response of BaSnO3 thin films were improved by reducing the film thickness. The 90 nm thick film exhibited a higher gas sensing response at a lower temperature due to the presence of numerous grains and grain boundaries facilitating the adsorption and desorption of oxygen species.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Surface motifs regulated aggregation induced emission in AuAg nanoclusters combined with Ce(III)/Ce(IV) catalytic cyclic amplification strategy for sensitive bioanalysis

Xuelin Zhang, Hui Dong, Hui Zhou, Yueyuan Li, Qing Liu, Hongyou Cui, Shujun Wang, Yueyun Li, Qin Wei

Summary: By regulating the surface motifs of metal nano-clusters (MNCs) based on aggregation-induced emission (AIE) strategy, a highly efficient luminescent probe AuAg NCs was designed. The introduction of Ag(I) resulted in denser surface patterns, reducing the non-radiative energy dissipation. Additionally, the spontaneous catalytic cycle amplification strategy improved the electrochemiluminescence (ECL) efficiency of AuAg NCs. The biosensor showed a wide linear relationship range and low detection limit using cardiac troponin I as a model.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Fabrication of ZnO-SnO2 heterojunction inverse opal photonic balls for chemiresistive acetone sensing

Feihu Li, Junjie Jing, Jinkun Li, Shuni Li, Siyu Ye, Xinru Song, Zili Zhan, Yeguang Zhang

Summary: In this study, ZnO-SnO2 heterojunction three-dimensional inverse opal photonic crystal balls (IOPB) were fabricated via rapid and liquid waste-free spray drying. The IOPBs showed higher response and faster response/recovery times compared to pure SnO2 sensors, as well as good selectivity and long-term stability.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

TASER: A flexible approach for nucleic acid detection using a molecular converter

Yu Jin Park, Dong-Yeon Song, Dong-Myung Kim

Summary: Advancing expeditious and highly responsive in vitro diagnostic techniques is crucial for ensuring the effectiveness of disease prevention and control measures. This study utilizes the translational machinery to transform target nucleic acids into easily quantifiable proteins, offering a versatile pathway for adaptable and cost-effective nucleic acid testing.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Transformer oil-dissolved methane detection based on non-adiabatic tapered fiber using polyacrylate and cryptophane-A overlay deposition

Yukun Wang, Guoming Ma, Dan Gao, Yuan Wang, Yangyang Xie, Xunbo Gao, Houxian Du, Junting Ji

Summary: This paper proposed a methane sensor based on the evanescent field of the non-adiabatic tapered optical fiber (NATOF) for high-sensitivity in-situ detection of transformer oil-dissolved methane. The sensor exhibited a detection sensitivity of 9.8 pm/ppm and a detection limit of 2.35 ppm, with excellent reversibility validated through cyclic experiments.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Development of highly sensitive plasmonic biosensors encoded with gold nanoparticles on M13 bacteriophage networks

Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo

Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Single-atom Cu-attached MOFs as peroxide-like enzymes to construct dual-mode immunosensors for detection of breast cancer typing in serum

Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo

Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

MATLAB-assisted visual ratiometric fluorescence sensing of tetracycline based on antenna effect

Ruimei Zhang, Yuxin Guo, Jiawei Huang, Hongchang Li, Ruizhi Wen, Wenlei Wang

Summary: This study established a rapid method for the detection of tetracycline (TC) by utilizing sodium alginate-protected gold nanoclusters (SA-AuNCs) and europium ions (Eu3+). The proposed method showed a linear relationship over a wide range of TC concentrations, with a low detection limit and high recovery rates. Additionally, color information extracted from fluorescence images taken with a smartphone was analyzed using MATLAB, enabling semi-quantitative detection of TC in real samples without the need for time-consuming pretreatment or expensive instruments.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Review Chemistry, Analytical

A review on photonic crystal fiber based fluorescence sensing for chemical and biomedical applications

Baptiste Moeglen Paget, Keertana Vinod Ram, Shuyan Zhang, Jayakumar Perumal, Sylvain Vedraine, Georges Humbert, Malini Olivo, U. S. Dinish

Summary: Photonic crystal fibers (PCFs) have unique light-guiding properties and have been widely studied for biomedical applications. PCF-based fluorescence sensors offer highly sensitive detection of biomolecules at low sample volumes. This review discusses recent advancements in fluorescence detection using different PCF configurations and compares them with conventional fluorescence methods. Prospective applications of PCF-based fluorescence sensing and their potential use as optofluidic biopsy needles for clinically relevant biomarker detection are also discussed.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Machine-learning-assisted sensor array for detecting COVID-19 through simulated exhaled air

Quan Zou, Toshio Itoh, Woosuck Shin, Makoto Sawano

Summary: This study tests the classification performance of a sensing system using simulated VOC gases and finds that the AIST sensors have better sensing ability than commercial sensors. An artificial neural network is developed to predict gas concentration with excellent performance. This study provides a promising method for rapidly screening respiratory diseases.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

S-vacancies mediated piezo-phototronic effect for high-performance self-powered photoelectrochemical sensing based on CdS nanorod array/ Ce-metal-organic framework heterojunction

Ding Jiang, Jinghan Jiang, Xiaojiao Du, Xueling Shan, Wenchang Wang, Hiroshi Shiigi, Zhidong Chen

Summary: In this study, a self-powered photoelectrochemical sensing platform was developed for sensitive detection of tetra-cycline (TC). The platform combined sulfur-vacancy engineered CdS nanorod arrays with Ce-metal-organic frameworks to enhance the photocurrent and facilitate electron transfer. The sensing system based on this platform showed linear detection of TC and demonstrated good anti-interference ability and stability.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Rational design of α-glucosidase activated near-infrared fluorescent probe and its applications in diagnosis and treatment of diabetes

Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng

Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.

SENSORS AND ACTUATORS B-CHEMICAL (2024)