Instruments & Instrumentation

Article Chemistry, Analytical

Nitrogen-doped carbon dot and DNA tetrahedron nanostructure based electrochemiluminescence aptasensor for AFB1 detection

Ying Li, Pengyue Song, Qingbin Xu, Wenjuan Wu, Nan Long, Jiabo Wang, Lidong Zhou, Ruile Pan, Weijun Kong

Summary: An electrochemiluminescence (ECL) aptasensor with aptamer, N-doped carbon dots (NCDs), and DNA tetrahedral nanostructure (DTN) was developed for ultra-sensitive detection of aflatoxin B1 (AFB1). The sensor exhibited excellent sensitivity, with a low detection limit and wide linear concentration range, as well as high accuracy and recovery in spiked Coix seed matrices. The successful application of the sensor in actual samples confirmed its practicality as a universal platform for trace contaminant detection by altering aptamers.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Multi-interfacial bio-hybrid hydrogel engineering of Alg-Cys polymer coupled with Au nanoparticles as hierarchical excellent electrocatalyst for the detection of prostate cancer drug in human biological fluids

Ragu Sasikumar, Byungki Kim

Summary: In recent years, there has been an increase in the number of patients with prostate cancer, leading to a greater need for monitoring and detecting the anticancer drug, flutamide, in the human body. Researchers have developed a novel electrocatalyst based on Alg-Cys-AuNPs for the detection of flutamide, which exhibits excellent detection performance and is suitable for real-time industrial applications.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Improved deep bidirectional recurrent neural network for learning the cross-sensitivity rules of gas sensor array

Zhen Wang, Yanhao Li, Xiangnan He, Rui Yan, Zhemin Li, Yadong Jiang, Xian Li

Summary: In this study, an improved deep BRNN model was developed to solve the cross-sensitivity problem of chemical gas sensor array, achieving a recognition accuracy of 98.93%.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Dual-channel foldable microfluidic paper-based parallel enzymatic reaction systems for simultaneous visual colorimetric detecting acetylcholinesterase and α-glucosidase together with screening inhibitors

Jinju Xu, Chaoying Tong, Yuanxin Cao, Ziyi Qin, Chunhui Liao, Yuxia Chen, Shuyun Shi, Ying Guo

Summary: In this study, a dual-channel foldable microfluidic paper-based parallel enzymatic reaction system was fabricated for simultaneous detection of AChE and alpha-Glu, as well as screening inhibitors. The developed platform provides a convenient, efficient, sensitive, and specific method for point-of-care testing of disease and development of drugs.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

The fluorescence turn-on detection of cardiac troponin T via folic acid-capped gold nanoclusters/manganese dioxide nanosheets

S. Madanan Anju, Susan Varghese, K. Abraham Merin, Ali Ibrahim Shkhair, Greeshma Rajeevan, Geneva Indongo, Sony George

Summary: Researchers have developed a novel nano couple platform for detecting cardiac biomarkers. By utilizing immunocomplex formation between antigen and antibody, the pre-quenched fluorescence of monoclonal antibody conjugated nano fluorophore was successfully lighted up. This system selectively detects the presence of cardiac troponin-T (cTnT) by giving an enhanced fluorescence signal proportional to the concentration of cTnT antigen, achieved by disrupting the direct contact of the cluster and two-dimensional sheet through specific antigen-antibody interaction forming an immunocomplex.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

An iridium complex-based probe for phosphorescent lifetime-elongated imaging of nitroreductase in living cells

Yibiao Jin, Donghao Hu, Jiamiao Yin, Kuangshi Sun, Lijun Chen, Shujuan Liu, Fuyou Li, Qiang Zhao

Summary: In this study, an iridium-based probe decorated with a p-nitrophenyl group was designed and investigated for the detection and imaging of nitroreductase (NTR). The probe showed selective and precise detection of NTR using photoluminescence lifetime imaging (PLIM) within living cells.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Individually-addressable composite microneedle electrode array by mold-and-place method for glucose detection

Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu

Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

A nanozipper structured efficient FRET probe for ratiometric detection of ATP based on target-induced cycling amplification

Hong Ran Tao, Hang Yan, Zhe Sun, Ya Bin Cui, Nian Bing Li, Hong Qun Luo

Summary: In this study, a ratiometric fluorescence DNA nanozipper was developed for highly sensitive detection of ATP. The sensing strategy showed a linear response to ATP concentration and could detect low concentrations, demonstrating promising application potential in biological samples.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

A biomimetic flexible sensor inspired by Albuca namaquensis for simultaneous high stretchability and strength

Jianhua Fan, Xiaohua Li, Cheng Ma, Qun Wang, Changchao Zhang, Lu Wang, Yang Xia, Zhiwu Han

Summary: In this study, a new type of flexible sensory electronic device is developed, which demonstrates excellent performance in high-intensity and high-stretchability scenarios. By employing a combination of flexible materials and biomimetic design, researchers successfully achieved a substrate with high mechanical strength and large elongation capacity, along with impressive electrical conductivity. Based on this innovation, they established an online testing platform for human-machine interaction that can accommodate substantial deformations at joint interfaces, allowing for synchronization and emulation of extensive tensile movements between mechanical prosthetics and human articulations.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Early detection of Alzheimer's disease by measuring amyloid beta-42 concentration in human serum based on liquid crystals

Houriyeh Sohrabnavi, Mohammad Mohammadimasoudi, Hassan Hajghassem

Summary: This article reports a liquid crystal-based biosensor for the detection of the main biomarker of Alzheimer's disease, amyloid beta protein. The sensor has a fast response time, high specificity, and a low detection limit.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Ultra-large Sn3O4 nanosheets with Sn2+defect for highly efficient hydrogen sensing

Yuyang Liu, Shiqi Chen, Bing Xiao, Jifeng Chu, Hongkang Wang, Yukun Chen, Tianhao Yao, Aijun Yang, Xiaogang Han, Mingzhe Rong, Xiaohua Wang

Summary: In this study, ultra-large micro-sized Sn3O4 nanosheet hierarchies were prepared and found to possess excellent hydrogen sensing performance and stability. The superior performance of the material was verified through theoretical calculations and practical applications.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Gas-phase odor mixture quantification based on relative comparison method using multiple olfactory receptors

Hongchao Deng, Hidefumi Mitsuno, Eri Kuroda, Sawako Niki, Ryohei Kanzaki, Takamichi Nakamoto

Summary: The study proposes a gas-phase odor biosensor for odor mixture quantification based on the relative comparison method, which utilizes cells expressing ORs, liquid thickness control, and liquid exchange. The method overcomes the challenges of biosensor drift and nonlinearity, demonstrating high precision and efficiency in detecting odor mixtures.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Direct Z-scheme NiTiO3/polyaniline heterojunction based photoelectrochemical aptasensor for the efficient detection of ochratoxin A in corn and soil

Qingfa Gong, Shuyun Meng, Dong Liu, Tianyan You

Summary: In this study, a sensitive PEC apta-sensor was constructed based on a direct Z-scheme heterojunction for the detection of ochratoxin A (OTA). By manipulating the conductivity and hydrophilicity of the materials, the separation of charge carriers and amplification of PEC signal were achieved, enabling the detection of OTA. The developed aptasensor exhibited a wide linear detection range and low detection limit, as well as good selectivity and stability.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Colorimetric detection of glyphosate by its competitive reaction against Ponceau 4R for copper ion

Bo-Chuan Hsieh, Yan-Ting Li

Summary: Glyphosate monitoring is crucial for environmental protection, biodiversity, human health, and food safety. This study presents an automated screening method using a cost-effective and stable chromophore probe for accurate and rapid quantification of glyphosate in real environmental samples.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Endowing an amphiphilic aggregation-induced emission molecule with turn-on fluorescence in both latent fingerprints development and antibiotics detection

Dongdong Liu, Mengpei Wang, Jicao Han, Zhengyu Zhang, Xi Wang

Summary: By decorating tetraphenylethene (TPE) backbones with hydrophilic pyridine ethanol-related groups, a series of novel amphiphilic TPE-based pyridinium salts were synthesized and used as water-soluble turn-on fluorescence probes for latent fingerprint development and antibiotic detection. The method has many advantages, including water solubility, low working concentration, ease of operation, good stability, high safety, high contrast, high sensitivity, and high selectivity.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

In-situ growth of hydrogen-bonded organic framework on conductive PEDOT:PSS polymer to realize conductivity-enhanced electrochemiluminescence for fabricating ultrasensitive biosensor

Mei-Ling Lu, Xin-Yue Zhang, Jun-Qi Song, Qiu-Yi Peng, Han-Xiao Xiao, Yang Yang, Wen-Bin Liang, Shaoguang Sun, Ruo Yuan, Dong-Rong Xiao

Summary: This research demonstrates that the electrical conductivity of HOF-based ECL materials can be significantly improved, leading to enhanced ECL performance. A conductive HOF composite was prepared by growing H3TATB-HOF on a highly conductive PEDOT:PSS polymer, resulting in a remarkable increase in ECL intensity. By combining this improved ECL property with a 3D DNA walker amplification strategy, an ultrasensitive ECL biosensor for microRNA-21 detection was designed.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

A fluorescence analysis model for assessing the water stability of porphyrinic metal-organic frameworks

Kun Yu, Huining Chai, Huayue Sun, Xianxin Xiang, Huili Zhao, Mingwei Tian, Lijun Qu, Guangyao Zhang, Xueji Zhang

Summary: The interactions between water molecules and PMOFs with 15 metal nodes were studied and assessed using the fluorescence method in this study. A model for evaluating the water stability of PMOFs was established, and PMOFs were categorized into three groups based on their fluorescence intensity and kinetic performance in ethanol with different water contents. The water-sensitive magnesium node PMOF showed high sensitivity for detecting trace water in organic media.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Ultrasensitive, dynamic, and online monitoring photonic sensors for protein conformation

Xuyang Zhao, Yuxiang Li, Qi Wang, Man Luo, Yi Zhou, Zhihe Guo, Xiang Wu

Summary: A label-free optical detection method with ultrahigh sensitivity and tunable range was developed to monitor protein conformation changes. The biosensor prototype, constructed with overlapping capillaries, successfully monitored the structural variations of silk proteins. This ultrasensitive biosensor has significant potential for clinical diagnosis, healthcare, pharmaceutical screening, and food security.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Fast responding and highly selective chemoresistive humidity sensor based on hydrated V2O5 nanobelts for real-time breath monitoring

Tae Hoon Eom, Sang Eun Lee, Yeong Jae Kim, Sungkyun Choi, Gi Baek Nam, Jung-El Ryu, Tae Hyung Lee, Jin Wook Yang, Sung Hwan Cho, Seung Ju Kim, Sang Eon Jun, Seonyong Lee, Seungsoo Kim, Hee Jung Park, Ho Won Jang

Summary: Chemoresistive humidity sensors based on ultrathin V2O5•nH2O nanobelts show promising performance in real-time breath monitoring, with rapid response and recovery, as well as excellent selectivity to humidity.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

Article Chemistry, Analytical

Matrix redox interference-free nanozyme-amplified detection of Hg2+using thiol-modified phosphatase-mimetic nanoceria

Panwang Hu, Jinjin Liu, Changkun Xia, Bangxiang Liu, Hengjia Zhu, Xiangheng Niu

Summary: Given the significant threats of heavy metals to ecological systems and human health, monitoring them is crucial. This study designs a non-redox nanozyme for detecting Hg2+ without interference from redox substances. The approach demonstrates highly sensitive and specific measurement of Hg2+ with excellent reliability and practicability. It is the first study to detect Hg2+ using phosphatase-mimicking nanozymes, inspiring exploration of new analytical methods with non-redox nanozymes.

SENSORS AND ACTUATORS B-CHEMICAL (2024)