Infectious Diseases

453.2K Papers

Follow See full results

Review Immunology

Microbiome diversity is a modifiable virulence factor for cryptosporidiosis

Georgina. R. Hurle, Julii Brainard, Kevin. M. Tyler

Summary: Infection of Cryptosporidium spp. causes significant harm to immunosuppressed individuals and children under 5 years old. The severity of the disease depends on the genotypes of both the parasite and the host, the immune status of the host, and the gut environment or microbiome. Studies have shown that infection leads to reduced bacterial diversity in larger animal models, supporting recent findings that probiotics or naturally diverse gut microbiomes can prevent or minimize pathology caused by gastrointestinal pathogens.

VIRULENCE (2023)

添加到收藏夹

Article Immunology

Uncovering the hidden threat: The widespread presence of chromosome-borne accessory genetic elements and novel antibiotic resistance genetic environments in Aeromonas

Fangzhou Chen, Ting Yu, Zhe Yin, Peng Wang, Xiuhui Lu, Jiaqi He, Yali Zheng, Dongsheng Zhou, Bo Gao, Kai Mu

Summary: This study comprehensively investigates the genomic characteristics of chromosome-borne accessory genetic elements in antibiotic-resistant Aeromonas strains and uncovers novel genetic environments associated with antibiotic resistance.

VIRULENCE (2023)

添加到收藏夹

Article Immunology

African swine fever virus protein p17 promotes mitophagy by facilitating the interaction of SQSTM1 with TOMM70

Boli Hu, Guifang Zhong, Shuxiang Ding, Kang Xu, Xiran Peng, Weiren Dong, Jiyong Zhou

Summary: African swine fever virus (ASFV) uses its protein p17 to induce mitophagy, leading to the degradation of mitochondria and inhibition of host innate immunity.

VIRULENCE (2023)

添加到收藏夹

Article Immunology

PepO and CppA modulate Streptococcus sanguinis susceptibility to complement immunity and virulence

Livia A. Alves, Hassan Naveed, Eduardo M. Franco, Maira Terra Garcia, Victor A. Freitas, Juliana C. Junqueira, Debora C. Bastos, Thais L. S. Araujo, Tsute Chen, Renata O. Mattos-Graner

Summary: This study investigated the functions of endopeptidase O (PepO) and a C3-degrading protease (CppA) in the systemic virulence of Streptococcus sanguinis. The results showed that these two proteins play important roles in the resistance and invasiveness of S. sanguinis.

VIRULENCE (2023)

添加到收藏夹

Article Immunology

Amphibian Hymenochirus boettgeri as an experimental model for infection studies with the chytrid fungus Batrachochytrium dendrobatidis

Tamilie Carvalho, Catherine Si, Rebecca A. Clemons, Evelyn Faust, Timothy Y. James

Summary: Model organisms are crucial in research, providing important insights for other species. This study suggests using the amphibian species Hymenochirus boettgeri as a model organism for the study of chytridiomycosis and demonstrates its dose- and genotype-dependent response, as well as reproducibility in experimental conditions.

VIRULENCE (2023)

添加到收藏夹

Article Immunology

Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition

Xiaowu Jiang, Guijun Yu, Lexin Zhu, Abubakar Siddique, Dongbo Zhan, Linhua Zhou, Min Yue

Summary: This study revealed the role of peptidyl-prolyl isomerase (PrsA), a critical virulence factor of Streptococcus suis type 2 (SS2), in cell death. Pyroptosis and necroptosis were found to be involved in cell death stimulated by PrsA, and specific inhibitors for these pathways alleviated the fatal effect. Furthermore, the N-terminal or C-terminal domains of PrsA were critical for inducing cell death and inflammation.

VIRULENCE (2023)

添加到收藏夹

Retraction Immunology

撤稿声明: A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway (Retraction of Vol 12, art no 2240210, 2023)

Peng Du, Shi-Jun Li, David M. Ojcious, Kai-Xuan Li, Wei-Lun Hu, Xu'ai Lin, Ai-Hua Sun, Jie Yan

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

Cross-species infection potential of avian influenza H13 viruses isolated from wild aquatic birds to poultry and mammals

Weiyang Sun, Menglin Zhao, Zhijun Yu, Yuanguo Li, Xinghai Zhang, Na Feng, Tiecheng Wang, Hongmei Wang, Hongbin He, Yongkun Zhao, Songtao Yang, Xianzhu Xia, Yuwei Gao

Summary: Wild aquatic birds are the primary hosts of H13 avian influenza viruses, and this study analyzed the genetic characteristics of two strains isolated from wild birds in China. It was found that both strains can efficiently replicate in poultry cells and mammalian cells. In vivo experiments showed that the viruses can infect specific pathogen-free chickens and mice, with one strain demonstrating a higher replication ability in chickens. However, they do not replicate well in turkeys and quails. The study also identified a positive antibody rate against H13 AIVs in farm chickens, indicating a potential risk of transmission from wild aquatic birds to poultry or mammals in the future.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia

Yacui Wang, Xiaoran Yu, Fang Liu, Xue Tian, Shuting Quan, Anxia Jiao, Xuemei Yang, Xi Zeng, Weiwei Jiao, Hui Qi, Fang Xu, Qinjing Li, Shuping Liu, Baoping Xu, Lin Sun, Adong Shen

Summary: We analyzed the microbial community in bronchoalveolar lavage fluid samples from children with Mycoplasma pneumoniae pneumonia (MPP) and found significant differences in diversity compared to a control group. The abundance of Tenericutes and Mycoplasma was significantly increased in the MPP group. Using Mycoplasma abundance as a diagnostic method, we achieved high sensitivity and specificity. Our study also revealed a correlation between Mycoplasma abundance and disease severity in children with MPP.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

Magnetic resonance imaging of human variegated squirrel bornavirus 1 (VSBV-1) encephalitis reveals diagnostic pattern indistinguishable from Borna disease virus 1 (BoDV-1) encephalitis but typical for bornaviruses

Monika Huhndorf, Julia Juhasz, Mike P. Wattjes, Andreas Schilling, Stefan Schob, Ingmar Kaden, Guenter Klass, Dennis Tappe

Summary: Human bornavirus encephalitis is a new disease caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). Brain MRI scans of VSBV-1 encephalitis patients revealed characteristic T2 hyperintense lesions in the limbic system, basal ganglia, and brainstem. Sinusitis and early limbic system involvement suggest an olfactory route of VSBV-1 entry. Imaging techniques may be useful for early presumptive diagnosis when molecular and serological testing is not available.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

Emergence of an ancient and pathogenic mammarenavirus

Xue-Lian Luo, Shan Lu, Chuan Qin, Mang Shi, Xiao-Bo Lu, Lu Wang, Sang Ga, Dong Jin, Xin-Li Ma, Jing Yang, Yan Dai, Lin-Lin Bao, Yan-Peng Cheng, Ya-Jun Ge, Yi-Bo Bai, Wen-Tao Zhu, Ji Pu, Hui Sun, Yu-Yuan Huang, Ming-Chao Xu, Wen-Jing Lei, Kui Dong, Cai-Xin Yang, Yi-Fan Jiao, Qi Lv, Feng-Di Li, Jianguo Xu

Summary: Emerging zoonoses of wildlife origin pose a significant threat to human health, and the Qinghai-Tibet Plateau is an important hotspot for such diseases. In this study, a novel arenavirus named plateau pika virus (PPV) was identified and characterized from plateau pikas. PPV strains could replicate in mammalian cells and led to tremors, sudden death, and inflammatory brain lesions in IFN alpha beta R-/- mice. Serological surveys also found PPV-specific IgG antibodies in a small percentage of outpatients in the region where PPV was isolated. Phylogenetic analysis revealed that PPV is distinct from known mammarenaviruses and originated millions of years ago.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

The role of dendritic cells in COVID-19 infection

Xuying Wang, Fei Guan, Heather Miller, Maria G. Byazrova, Fabio Cndotti, Kamel Benlagha, Niels Olsen Saraiva Camara, Jiahui Lei, Alexander Filatov, Chaohong Liu

Summary: COVID-19, caused by SARS-CoV-2, is a major infectious threat to global public health. Dendritic cells play important roles in viral transmission and clinical progression, and understanding their mechanisms and immunological characteristics in SARS-CoV-2 infection is crucial.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

Post-exposure prophylaxis with SA58 (anti-SARS-COV-2 monoclonal antibody) nasal spray for the prevention of symptomatic COVID-19 in healthy adult workers: a randomized, single-blind, placebo-controlled clinical study*

Rui Song, Gang Zeng, Jianxing Yu, Xing Meng, Xiaoyou Chen, Jing Li, Xiaoliang Xie, Xiaojuan Lian, Zhiyun Zhang, Yunlong Cao, Weidong Yin, Ronghua Jin

Summary: This study evaluated the efficacy of a new Anti-SARS-COV-2 monoclonal antibody (SA58) Nasal Spray for post-exposure prophylaxis against COVID-19. The results showed that SA58 Nasal Spray was effective in preventing symptomatic COVID-19 and SARS-CoV-2 infection, and it was well-tolerated.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5

Minrun Duan, Huixin Duan, Yaling An, Tianyi Zheng, Shengfeng Wan, Hui Wang, Xin Zhao, Lianpan Dai, Kun Xu, George F. Gao

Summary: The Omicron variants of concern have shown resistance to early-approved COVID-19 vaccines. Boosting with the chimeric Delta-Omicron RBD-dimer vaccine greatly enhances immune responses and neutralizing activity against all tested SARS-CoV-2 variants.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

Efficacy and safety of an innovative short-course regimen containing clofazimine for treatment of drug-susceptible tuberculosis: a clinical trial

Xubin Zheng, Xuwei Gui, Lan Yao, Jun Ma, Yifan He, Hai Lou, Jin Gu, Ruoyan Ying, Liping Chen, Qin Sun, Yidian Liu, Chih-Ming Ho, Bai-Yu Lee, Daniel L. Clemens, Marcus A. Horwitz, Xianting Ding, Xiaohui Hao, Hua Yang, Wei Sha

Summary: In a preclinical study, a new antituberculosis drug regimen showed promising results in achieving relapse-free cure in a shorter time. This study aimed to evaluate the efficacy and safety of a four-month regimen compared to a standard six-month regimen in patients with drug-susceptible tuberculosis. The results showed that the short-course regimen had lower sputum culture conversion rates and higher incidence of hepatitis, but it demonstrated desired efficacy in the per-protocol population. This study provides the first evidence in humans that a short-course approach can potentially shorten the treatment time for tuberculosis.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

Rift Valley fever virus modulates apoptosis and immune response during infection of human astrocytes

Jordan Quellec, Aurelie Pedarrieu, Camille Piro-Megy, Jonathan Barthelemy, Yannick Simonin, Sara Salinas, Catherine Cetre-Sossah

Summary: Rift Valley fever (RVF) is a zoonotic disease that causes epidemics in Africa, the Arabic Peninsula, and islands of the South West of the Indian Ocean. It mainly affects livestock but also has severe clinical manifestations in humans, including neurological disorders. The impact of RVFV infection on the human CNS is still poorly understood.

EMERGING MICROBES & INFECTIONS (2023)

添加到收藏夹

Article Immunology

Identification of miRnas with possible prognostic roles for HAM/TSP

Daniela Raguer Valadao de Souza, Rodrigo Pessoa, Youko Nukui, Juliana Pereira, Rosa Nascimento Marcusso, Augusto Cesar Penalva de Oliveira, Jorge Casseb, Alberto Jose da Silva Duarte, Patricia Bianca Clissa, Sabri Saeed Sanabani

Summary: In this study, researchers used Illumina MPS technology to investigate the expression profile of global noncoding RNA in HAM/TSP patients. They found differential expression of certain short RNAs, including miRNAs, which have the potential to be used as biomarkers for predicting the pathogenesis of HAM/TSP.

VIRULENCE (2023)

添加到收藏夹

Article Immunology

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Ying Li, Chaoqun Chen, Liu Cong, Shanshan Mao, Mingzhu Shan, Zibing Han, Jiayi Mao, Zhiyu Xie, Zuobin Zhu

Summary: This study identified a maleimide compound (MPD) that effectively inhibits various virulence factors of C. albicans, including adhesion, filamentation, and biofilm formation. MPD has low cytotoxicity, hemolytic activity, and drug resistance development. In a Galleria mellonella-C. albicans infection model, MPD treatment significantly prolonged the survival time of infected larvae. Mechanism research revealed that MPD increased farnesol secretion, which inhibited the Ras1-cAMP-Efg1 pathway and subsequently inhibited the virulence factors. This study suggests the potential application of MPD in overcoming fungal infections in clinics.

VIRULENCE (2023)

添加到收藏夹

Article Immunology

A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway

Rene Bergmann, Wieland Schroedl, Uwe Mueller, Christoph Georg Baums

Summary: This study found that SzM_C2 inhibits complement activation through a mechanism other than fibrinogen and non-immune immunoglobulin binding. The expression of SzM_C2 is necessary for recruiting purified human or equine C1q to the bacterial surface.

VIRULENCE (2023)

添加到收藏夹

Review Immunology

Pathogenicity and virulence of human adenovirus F41: Possible links to severe hepatitis in children

Roger J. Grand

Summary: There are multiple species of human adenoviruses, and species A and F primarily infect the gastrointestinal tract, causing diarrhea in children. Limited understanding of these viruses is due to difficulties in laboratory propagation. Recent research on the structure of HAdV-F41 revealed unique characteristics that may contribute to its ability to infect intestinal cells. HAdV-F41 has been implicated in a recent outbreak of severe acute hepatitis.

VIRULENCE (2023)

添加到收藏夹

«
1
2
3
4
5
»

See full results

Related Categories

Anesthesiology (212.5K) Audiology & Speech-Language Pathology (1.7K) Clinical Neurology (1.3M) Critical Care Medicine (338.4K) Dentistry, Oral Surgery & Medicine (340.8K) Dermatology (413.6K) Emergency Medicine (142.9K) Endocrinology & Metabolism (751.7K) Gastroenterology & Hepatology (856.4K) Geriatrics & Gerontology (226.3K) Gerontology (158.2K) Health Care Sciences & Services (433.8K) Hematology (653.3K) Immunology (896.7K) Integrative & Complementary Medicine (99.8K) Medical Ethics (26.6K) Medical Informatics (100.5K) Medical Laboratory Technology (108K) Medicine, General & Internal (1.3M) Medicine, Legal (48.4K) Medicine, Research & Experimental (710K) Nursing (297.8K) Obstetrics & Gynecology (559.8K) Oncology (1.8M) Ophthalmology (452.2K) Orthopedics (359.5K) Otorhinolaryngology (166K) Pediatrics (655.3K) Peripheral Vascular Disease (595.7K) Pharmacology & Pharmacy (1.3M) Primary Health Care (59.2K) Psychiatry (755.1K) Radiology, Nuclear Medicine & Medical Imaging (799.4K) Rehabilitation (249.2K) Rheumatology (300.3K) Surgery (1.3M) Toxicology (333.1K) Transplantation (309.7K) Tropical Medicine (112.2K) Urology & Nephrology (567K) Veterinary Sciences (455.3K)

© Peeref 2019-2024. All rights reserved.