Immunology

896.7K Papers

Follow See full results

Article Immunology

Memory deficits and hippocampal cytokine expression in a rat model of ADHD

Lucy G. Anderson, Eleftheria Vogiatzoglou, Shi Tang, Sarah Luiz, Turley Duque, James P. Ghaly, Jared J. Schwartzer, Jena B. Hales, Marta Sabariego

Summary: This study investigated the potential connections between memory, neuroimmunology, and ADHD in both male and female animals using spontaneously hypertensive rats (SHR). The findings suggest that SHR exhibit deficits in spatial working memory and memory for elapsed time, as well as some differences in hippocampal cytokine concentrations. These findings contribute to a better understanding of the neurobiological basis of ADHD in both sexes and may inform future research aimed at developing effective treatments for the disorder.

BRAIN BEHAVIOR & IMMUNITY-HEALTH (2024)

添加到收藏夹

Article Fisheries

Distribution and spatiotemporal development of organised lymphoid tissues in the chicken intestinal tract

Safieh Zeinali, Kate Sutton, Lonneke Vervelde

Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2024)

添加到收藏夹

Article Fisheries

Mechanisms of type I interferon production by chicken TLR21

Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson

Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2024)

添加到收藏夹

Article Immunology

Choroid plexus volume is increased in mood disorders and associates with circulating inflammatory cytokines

Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti

Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.

BRAIN BEHAVIOR AND IMMUNITY (2024)

添加到收藏夹

Article Fisheries

Identification of an essential role against shrimp pathogens of prophenoloxidase activating enzyme 1 (PPAE1) from Fenneropenaeus merguiensis hemocytes

Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng

Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2024)

添加到收藏夹

Review Immunology

Imaging findings can't mean everything in the era of immunotherapy: a case report and literature review

Xiangye Zhao, Kewei Ma, Xiaobo Ma, Xu Wang, Chao Sun, Shi Qiu, Ye Guo, Zhiguang Yang, Yunpeng Liu, Yinghui Xu

Summary: Immunotherapy may lead to pseudoprogression, where tumors initially grow but shrink with continued treatment. This article reports a case of pseudoprogression in a lung cancer patient receiving immunotherapy, and reviews the mechanisms, clinical manifestations, and prognostic indicators of pseudoprogression.

IMMUNOTHERAPY (2024)

添加到收藏夹

Article Immunology

Toripalimab and fruquintinib therapy for colorectal cancer after failed multiline chemotherapies: a case report

Ling-zhijie Kong, Ying Zheng, Kaichun Li

Summary: Treatment options for metastatic colorectal cancer are limited after second-line chemotherapy failure. In this case report, a 59-year-old male patient achieved remarkable response to fruquintinib and toripalimab combination therapy after multiple lines of chemotherapy failed. The patient had partial response within 3 months and complete response of pulmonary masses within 12 months. The combination of fruquintinib and PD-1 inhibitors improves the prognosis of metastatic colorectal cancer, with a progression-free survival of over 17 months.

IMMUNOTHERAPY (2024)

添加到收藏夹

Article Fisheries

The expression, function, and network regulation of circDNAJB6 in chicken macrophages under lipopolysaccharide (LPS) stimulation

Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun

Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2024)

添加到收藏夹

Article Immunology

Unlocking the role of EIF5A: A potential diagnostic marker regulating the cell cycle and showing negative correlation with immune infiltration in lung adenocarcinoma

Zipeng Yang, Hao Yuan, Houjing He, Shuting Qi, Xiaojing Zhu, Xiaoyu Hu, Mengyuan Jin, Xiu-Xiang Zhang, Zi-Guo Yuan

Summary: In this study, EIF5A was found to be significantly upregulated in LUAD. We constructed a MAZ-hsa-miR-424-3p-EIF5A transcriptional network and investigated the potential mechanism of EIF5A in LUAD. By exploring the cAMP signaling pathway and the cell cycle, we demonstrated that EIF5A regulates the cell cycle in LUAD by inhibiting the cAMP/PKA/CREB signaling pathway, and it is negatively correlated with immune infiltrates in LUAD.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

The combination of tetracyclines effectively ameliorates liver fibrosis via inhibition of EphB1/2

Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang

Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

NMAAP1 regulated macrophage polarizion into M1 type through glycolysis stimulated with BCG

Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan

Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

Protective effect of arctiin against Toxoplasma gondii HSP70-induced allergic acute liver injury by disrupting the TLR4-mediated activation of cytosolic phospholipase A2 and platelet-activating factor

Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao

Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

Comprehensive transcriptomic analyses identify the immunosuppressive effects of LLDT-8 in ART-treated SIV-infected rhesus macaques

Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li

Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

The persistence and antitumor efficacy of CAR-T cells are modulated by tonic signaling within the CDR

Jincai Zhou, Feifei Shi, Xinran Luo, Bixia Lei, Zhongjun Shi, Chenyu Huang, Yuting Zhang, Xiaopei Li, Huajing Wang, Xian -Yang Li, Xiaowen He

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

Identification of immunological characteristics and cuproptosis-related molecular clusters in primary Sjogren's syndrome

Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang

Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier

Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan

Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

MMP-9 inhibition alleviates postoperative cognitive dysfunction by improving glymphatic function via regulating AQP4 polarity

Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang

Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

Histone deacetylase 3 inhibition alleviates 2,4-dinitrochlorobenzene-in-duced atopic dermatitis via epigenetically upregulating Nrf2/HO-1 signaling pathway

Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou

Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke

Guangtian Wang, Zhihui Li, Peng Lin, Huishu Zhang, Yanyan Wang, Tongshuai Zhang, Hui Wang, Heming Li, Lexun Lin, Yuehui Zhao, Lina Jia, Yang Chen, Hong Ji, Wenran Zhao, Zhongqiu Fu, Zhaohua Zhong

Summary: This study demonstrates the neuroprotective effects of si-Smox and its antioxidant properties in preserving BBB integrity and promoting angiogenesis in ischemic stroke. Activation of the Nrf2 pathway plays a key role in these effects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

Article Immunology

Identifying the critical oncogenic mechanism of LDHA based on a prognostic model of T-cell synthetic drivers

Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du

Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.

INTERNATIONAL IMMUNOPHARMACOLOGY (2024)

添加到收藏夹

«
1
2
3
4
5
»

See full results

Related Categories

Anesthesiology (212.5K) Audiology & Speech-Language Pathology (1.7K) Clinical Neurology (1.3M) Critical Care Medicine (338.4K) Dentistry, Oral Surgery & Medicine (340.8K) Dermatology (413.6K) Emergency Medicine (142.9K) Endocrinology & Metabolism (751.7K) Gastroenterology & Hepatology (856.4K) Geriatrics & Gerontology (226.3K) Gerontology (158.2K) Health Care Sciences & Services (433.8K) Hematology (653.3K) Infectious Diseases (453.2K) Integrative & Complementary Medicine (99.8K) Medical Ethics (26.6K) Medical Informatics (100.5K) Medical Laboratory Technology (108K) Medicine, General & Internal (1.3M) Medicine, Legal (48.4K) Medicine, Research & Experimental (710K) Nursing (297.8K) Obstetrics & Gynecology (559.8K) Oncology (1.8M) Ophthalmology (452.2K) Orthopedics (359.5K) Otorhinolaryngology (166K) Pediatrics (655.3K) Peripheral Vascular Disease (595.7K) Pharmacology & Pharmacy (1.3M) Primary Health Care (59.2K) Psychiatry (755.1K) Radiology, Nuclear Medicine & Medical Imaging (799.4K) Rehabilitation (249.2K) Rheumatology (300.3K) Surgery (1.3M) Toxicology (333.1K) Transplantation (309.7K) Tropical Medicine (112.2K) Urology & Nephrology (567K) Veterinary Sciences (455.3K)

© Peeref 2019-2024. All rights reserved.