Hematology

Article Oncology

Subspecialty Breast Imaging Education in Tanzania; Clinical, Infrastructure, and Logistical Paradigms for Best Practices in the Low- and Middle-Income Settings

Toma S. Omofoye, Anganile Kalinga, Ramapriya Ganti, Frank J. Minja, Timothy B. Rooney

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Article Oncology

Smart Solutions to Address the Global Gap in Radiation Oncology Through Trainee Engagement and Partnerships with Industry

Cecilia Felix Penido Mendes de Sousa, Jared Pasetsky, Gustavo Nader Marta, Megan Kassick, Fabio Ynoe Moraes, Luqman K. Dad

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Article Oncology

Breast Cancer Disparities and Innovations A Focus on Kosovo

Mary D. Chamberlin, Dafina Ademi Islami, Shqiptar Demaci, Richard J. Barth Jr

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Article Oncology

More Drugs Versus More Data: The Tug of War on Cancer in Low- and Middle-Income Countries

Mary Chamberlin, Christopher Booth, Gabriel A. Brooks, Achille Manirakiza, Fidel Rubagumya, Verna Vanderpuye

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Review Oncology

Breast Cancer and Lifestyle Factors: Umbrella Review

Ilir Hoxha, Fitim Sadiku, Lot Hoxha, Midhet Nasim, Marie Anne Christine Buteau, Krenare Grezda, Mary D. Chamberlin

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Review Oncology

Lung Cancer and Lifestyle Factors: Umbrella Review

Jeta Bunjaku, Arber Lama, Tawanda Pesanayi, Jeton Shatri, Mary Chamberlin, Ilir Hoxha

Summary: The evidence suggests that lifestyle factors such as alcohol and coffee intake may increase the risk of lung cancer, while tea intake may have a protective effect. However, the quality of evidence is currently low and further research is needed.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Article Oncology

Education and Training Models for Remote Learning

Victoria E. Forbes, Mary D. Chamberlin, Vincent Dusabejambo, Tim Walker, Steve P. Bensen, Norrisa Haynes, Kathryn Nunes, Veauthyelau Saint-Joy, Frederick L. Makrauer

Summary: Global health education needs to adapt to the challenges we face, such as inequities and pandemics. Virtual teaching models are effective in delivering global health education and improving outcomes through bidirectional learning and equitable partnerships.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Article Oncology

Diagnostic Accuracy of Biomarkers and International Ovarian Tumor Analysis Simple Rules in Diagnosis of Ovarian Cancer

Tefta Isufaj Haliti, Ilir Hoxha, Rubena Mojsiu, Rohini Mandal, Goksu Goc, Kreshnike Dedushi Hoti

Summary: The IOTA Simple Rules have high diagnostic performance in distinguishing between benign and malignant adnexal masses, providing a reliable tool for early diagnosis of ovarian cancer.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Article Oncology

Disparities in Cancer Control in Central America and the Caribbean

Anne Christine Buteau, Alicia Castelo-Loureiro, Regina Barragan-Carrillo, Suyapa Bejarano, Alba J. Kihn-Alarcon, Enrique Soto-Perez-de-Celis

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Article Oncology

Breast Cancer in India Screening, Detection, and Management

Prarthna V. Bhardwaj, Renuka Dulala, Senthil Rajappa, Chandravathi Loke

Summary: The management of breast cancers in India needs greater emphasis on awareness, early detection, standard pathologic testing, and cost-effective solutions. With standardized management, outcomes similar to those of developed countries can be expected. Additionally, clinical trials aimed at a more diverse population in LMICs like India should be undertaken.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2024)

Review Oncology

cGAS-STING at the crossroads in cancer therapy

Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma

Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2024)

Article Hematology

Exploration of rotational thromboelastometry (ROTEM) to characterize the coagulation profiles of newly diagnosed pediatric leukemia patients

Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya

Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.

THROMBOSIS RESEARCH (2024)

Review Oncology

Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet candidate for immunotherapy of human malignancies

Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak

Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2024)

Review Oncology

Advances, opportunities and challenges in developing therapeutic cancer vaccines

Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu

Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2024)

Review Hematology

Comparison of important factors to patients recovering from pulmonary embolism and items covered in patient-reported outcome measures: A mixed-methods systematic review

Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen

Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.

THROMBOSIS RESEARCH (2024)

Review Oncology

Potential applications of ferroptosis inducers and regulatory molecules in hematological malignancy therapy

Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu

Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2024)

Article Hematology

Adhesive properties of plasma-circulating and platelet-derived microvesicles from healthy individuals

E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev

Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.

THROMBOSIS RESEARCH (2024)

Letter Hematology

Recent monthly mortality for pulmonary embolism in the US

Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro

THROMBOSIS RESEARCH (2024)

Letter Hematology

Severe clinical picture in a cohort of six Brazilian children with hemoglobin Sβ-thalassemia IVS-I-5 G>A

Marcos Borato Viana, Erica Louback Oliveira, Andre Rolim Belisario

BLOOD CELLS MOLECULES AND DISEASES (2024)

Article Hematology

Molecular and clinical characterization of two unrelated families with factor V deficiency, including a novel nonsense variant (p.Gln1532*)

Ke Zhang, Longying Ye, Yanhui Jin, Yuan Chen, Shuting Jiang, Haixiao Xie, Lihong Yang, Mingshan Wang

Summary: This study investigated two pedigrees with FV deficiency and identified three mutations that may have deleterious effects on the function and structure of FV.

BLOOD CELLS MOLECULES AND DISEASES (2024)