Article
Genetics & Heredity
Mohamed Taha, Mohamed Moussa Mohamed Ibrahim, Heba Sedrak
Summary: This study examines the associations between gene-gene interactions and haplotypes and the risk of coronary artery disease. The findings suggest that gene-gene interactions may play a significant role in the risk of myocardial infarction and unstable angina.
Article
Genetics & Heredity
Ashvinkumar Katral, Firoz Hossain, Rajkumar U. Zunjare, Rashmi Chhabra, T. Vinutha, Hriipulou Duo, Bhupender Kumar, Chikkappa G. Karjagi, Sherry R. Jacob, Sushil Pandey, Chirravuri N. Neeraja, Sujata Vasudev, Vignesh Muthusamy
Summary: This study characterized the genetic basis and protein-protein interaction network of kernel oil in maize by analyzing the functional polymorphism of genes such as dgat1-2, fatb, and wri1a in 292 maize inbreds. The results showed that these genes play important roles in oil content and composition in maize.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Qing-Lin Li, Hua Zheng, Zhi Luo, Li-Xiang Wu, Peng-Cheng Xu, Jia-Cheng Guo, Yu-Feng Song, Xiao-Ying Tan
Summary: This study deciphered the full-length cDNA sequences of seven lipid metabolic genes in yellow catfish and investigated their expression and response to high-fat and bile acid diets. The results provide a foundation for further exploration into the function and regulatory mechanisms of these genes in fish.
Article
Genetics & Heredity
Anna Argoty-Pantoja, Rafael Velazquez-Cruz, Jorge Salmeron, Berenice Rivera-Paredez
Summary: This study proposes a systematic procedure for identifying SNP candidates for complex traits. By reviewing literature, analyzing signaling pathways and gene-gene interaction networks, SNPs with high frequency and multiple associations with signaling pathways were selected. Seven SNPs were genotyped in a cohort study, and a positive association with hypertension incidence was observed.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Yanan Huang, Helu Liu, Yang Zhou, Zaiqing Lu, Yujin Pu, Haibin Zhang
Summary: In this study, an Oxidative squalene cyclase (OSC) gene derived from the deep-sea holothurian Chiridota sp. was cloned and functionally characterized. The Chiridota sp. OSC was found to catalyze 2,3-Oxidosqualene into parkeol and exhibited higher relative enzymatic activity and stability under high pressure compared to a shallow-sea holothurian.
Article
Genetics & Heredity
Soren Drud-Heydary Nielsen, Navid Sahebekhtiari, Ziyu Huang, Jette Feveile Young, Martin Kroyer Rasmussen
Summary: This study analyzed the secretion of miRNAs and proteins during the proliferation and differentiation of satellite cells in vitro, revealing differential secretion of these molecules. The findings suggest that the secreted molecules may play a role in the regulation of muscle development pathways.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Yuepeng Cao, Zhuo Zou, Xuhong Wu, Weijian Li, Zhen Lu, Jiawei Hu, Liu Yang
Summary: This study reveals the role of LUCAT1 in bladder cancer (BC) and its impact on ferroptosis. LUCAT1 acts as a regulator in BC, promoting cell proliferation, migration, and invasion while inhibiting ferroptosis. Mechanistically, LUCAT1 binds to IGF2BP1, which governs STAT3 mRNA stability.
Article
Genetics & Heredity
Chaoying Wang, Jianghui He, Chunyue Chen, Wenjun Luo, Xitong Dang, Liang Mao
Summary: Human esophageal cancer related gene-4 (ECRG-4) plays a role as a tumor suppressor and also maintains homeostasis in the cardiovascular system. It is covalently bound to the cell surface, signaling the maintenance of homeostasis, and activates inflammatory and tissue proliferative responses upon tissue injury. ECRG-4 is highly expressed in the heart and vasculature, involved in cardiac rate/rhythm control, cardiotoxicity, and cardiovascular diseases. Therefore, ECRG-4 has the potential to be a novel therapeutic target for maintaining cardiovascular system homeostasis.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Letter
Genetics & Heredity
Fang Chen, Dong-Zhi Li
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2024)
Article
Ecology
Jorge Pena, Aviad Heifetz, Georg Noldeke
Summary: Cooperation usually becomes harder to sustain as groups become larger, but in some cases, increasing group size can increase the probability of cooperation. The expected payoff and the probability of provision of the public good vary with the cost of cooperation.
THEORETICAL POPULATION BIOLOGY
(2024)
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Lena Dhara, Anusri Tripathi
Summary: This study explores the contribution of beta-lactamase/quinolone resistant genes and other factors to the development of ESBL and quinolone resistant pathogenic bacteria. It reveals that the presence of these resistance genes, efflux pump upregulation, and porin loss/reduction contribute to the development of antibiotic resistance. Overall, the study provides important insights into the mechanisms behind the emergence of these resistant bacteria. Rating: 8/10
Article
Genetics & Heredity
Mona Ahmed Abbas, Heba Maged Abo Shady, Ola Hamdy Ahmed Elshafey, Nevein M. Al-Sheikh
Summary: This study evaluated the association between the expression levels of p53, miRNA-21, and lncRNA-TCL6 and the risk and severity of preeclampsia in pregnant women. The results showed that these genes were dysregulated in preeclampsia compared to normal pregnancy, highlighting the role of apoptosis in its development. P53 was identified as a prognostic marker for preeclampsia, distinguishing between mild and severe cases.
