Engineering, Biomedical

Article Acoustics

Quartz tuning forks resonance frequency matching for laser spectroscopy sensing

Yufei Ma, Yinqiu Hu, Shunda Qiao, Ziting Lang, Xiaonan Liu, Ying He, Vincenzo Spagnolo

Summary: This paper reports on the performance of quartz tuning fork (QTF) based laser spectroscopy sensing using multiple QTFs. Two resonance frequency matching methods are proposed to avoid degradation of sensor performance. Experimental results validate the effectiveness of the proposed methods.

PHOTOACOUSTICS (2022)

Article Biology

Colorectal polyp region extraction using saliency detection network with neutrosophic enhancement

Keli Hu, Liping Zhao, Sheng Feng, Shengdong Zhang, Qianwei Zhou, Xiaozhi Gao, Yanhui Guo

Summary: In this paper, a novel method called NeutSS-PLP is proposed for polyp region extraction in colonoscopy images using a short connected saliency detection network with neutrosophic enhancement. Experimental results on two public datasets demonstrate the effectiveness of the proposed method for polyp extraction.

COMPUTERS IN BIOLOGY AND MEDICINE (2022)

Article Engineering, Biomedical

Electrospun strong, bioactive, and bioabsorbable silk fibroin/poly (L-lactic-acid) nanoyarns for constructing advanced nanotextile tissue scaffolds

Jiao Liu, Tao Li, Hao Zhang, Wenwen Zhao, Lijun Qu, Shaojuan Chen, Shaohua Wu

Summary: This study presents an integrated electrospinning system for fabricating nanofibrous textiles with excellent properties, which is of great significance in the field of tissue engineering and regenerative medicine.

MATERIALS TODAY BIO (2022)

Article Engineering, Biomedical

Wound microenvironment self-adaptive hydrogel with efficient angiogenesis for promoting diabetic wound healing

Zijian Shao, Tianyu Yin, Jinbo Jiang, Yang He, Tao Xiang, Shaobing Zhou

Summary: A self-adaptive multifunctional hydrogel with self-healing property and injectability has been developed for treating diabetic wounds. The hydrogel can react with high glucose and hydrogen peroxide to alleviate oxidative stress and release drugs. In animal experiments, the hydrogel accelerates angiogenesis and wound closure. This self-adaptive multifunctional hydrogel shows potential for the treatment of diabetic wounds.

BIOACTIVE MATERIALS (2023)

Article Engineering, Biomedical

Infection microenvironment-related antibacterial nanotherapeutic strategies

Zhe Wang, Xingyun Liu, Yanwen Duan, Yong Huang

Summary: The emergence and spread of antibiotic resistance is a major challenge in public health. There is an urgent need to discover novel agents against multidrug-resistant bacteria. Nano antibacterial agents have shown potent antibacterial effects by targeting the unique microenvironment of bacterial infections. The development of innovative nano-antibacterial agents could provide powerful weapons against drug-resistant bacteria in the foreseeable future.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Endoscope image mosaic based on pyramid ORB

Ziyan Zhang, Lixiao Wang, Wenfeng Zheng, Lirong Yin, Rongrong Hu, Bo Yang

Summary: This paper introduces an improved ORB algorithm using Gaussian Pyramid for endoscopic image mosaic, which achieves high accuracy, efficiency, and real-time performance.

BIOMEDICAL SIGNAL PROCESSING AND CONTROL (2022)

Article Engineering, Biomedical

Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Shenwu Zhang, Jing Wang, Zhiqiang Kong, Xinxin Sun, Zhonggui He, Bingjun Sun, Cong Luo, Jin Sun

Summary: Immunotherapy is a promising cancer treatment, but its efficacy for immune-cold tumors is not satisfactory. Photodynamic therapy can effectively induce immunogenic cell death, and the use of nanotechnology enhances the effectiveness of cancer immunotherapy. This article reviews recent advances in photodynamic therapy, nanotechnology, and immunogenic cell death, and discusses the prospects and challenges in this field.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration

Qiaomei Tang, Bing Lu, Jian He, Xiao Chen, Qiuli Fu, Haijie Han, Chenqi Luo, Houfa Yin, Zhenwei Qin, Danni Lyu, Lifang Zhang, Min Zhou, Ke Yao

Summary: In this study, a novel approach based on exosomes and a thermosensitive hydrogel was developed for the treatment of corneal diseases. This method effectively reduces scar formation and accelerates the healing process by promoting the repair of damaged corneal epithelium and stromal layer.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Toward higher-performance bionic limbs for wider clinical use

Dario Farina, Ivan Vujaklija, Rickard Branemark, Anthony M. J. Bull, Hans Dietl, Bernhard Graimann, Levi J. Hargrove, Klaus-Peter Hoffmann, He (Helen) Huang, Thorvaldur Ingvarsson, Hilmar Bragi Janusson, Kristleifur Kristjansson, Todd Kuiken, Silvestro Micera, Thomas Stieglitz, Agnes Sturma, Dustin Tyler, Richard F. Ff Weir, Oskar C. Aszmann

Summary: This Perspective discusses the development and clinical application of high-performance bionic limbs, emphasizing the use of different technologies, such as osseointegration, neural signal amplification, and muscle sensors, to create better performing bionic limbs.

NATURE BIOMEDICAL ENGINEERING (2023)

Review Engineering, Biomedical

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

Masoud Sarraf, Erfan Rezvani Ghomi, Saeid Alipour, Seeram Ramakrishna, Nazatul Liana Sukiman

Summary: Commercially pure titanium and titanium alloys are widely used in biomedical applications due to their excellent mechanical properties, corrosion resistance, biocompatibility, and antibacterial properties. Future research will focus on advanced manufacturing technologies, effects of alloying elements on biocompatibility, and the role of titanium in regenerative and nanomedicine applications.

BIO-DESIGN AND MANUFACTURING (2022)

Article Engineering, Biomedical

Massively parallel functional photoacoustic computed tomography of the human brain

Shuai Na, Jonathan J. Russin, Li Lin, Xiaoyun Yuan, Peng Hu, Kay B. Jann, Lirong Yan, Konstantin Maslov, Junhui Shi, Danny J. Wang, Charles Y. Liu, Lihong Wang

Summary: Massively parallel ultrasonic transducers arranged hemispherically around the human head enable functional photoacoustic computed tomography of the human brain with a 10-cm-diameter field of view and spatial and temporal resolutions of 350 µm and 2 s, respectively.

NATURE BIOMEDICAL ENGINEERING (2022)

Article Engineering, Biomedical

Computational Contact Pressure Prediction of CoCrMo, SS 316L and Ti6Al4V Femoral Head against UHMWPE Acetabular Cup under Gait Cycle

J. Jamari, Muhammad Imam Ammarullah, Gatot Santoso, S. Sugiharto, Toto Supriyono, Akbar Teguh Prakoso, Hasan Basri, Emile van der Heide

Summary: This study computationally evaluated the contact pressure between UHMWPE acetabular cup and metal femoral head, and found that Ti6Al4V-on-UHMWPE can reduce cumulative contact pressure.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

Article Engineering, Biomedical

A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Zhilin Li, Hao Cai, Zhiqian Li, Long Ren, Xuelei Ma, Hongyan Zhu, Qiyong Gong, Hu Zhang, Zhongwei Gu, Kui Luo

Summary: To improve the response rate of immune checkpoint inhibitors in immunosuppressive cancers, a self-amplified biomimetic nanosystem was constructed to induce immunogenic cell death at tumor sites. The nanosystem effectively reverses the immunosuppressive tumor microenvironment, leading to distinctive inhibition of tumor growth and metastasis when combined with immune checkpoint inhibitors.

BIOACTIVE MATERIALS (2023)

Article Engineering, Biomedical

Controlling Droplet Impact Velocity and Droplet Volume: Key Factors to Achieving High Cell Viability in Sub-Nanoliter Droplet-based Bioprinting

Wei Long Ng, Xi Huang, Viktor Shkolnikov, Guo Liang Goh, Ratima Suntornnond, Wai Yee Yeong

Summary: A study utilizing a thermal inkjet system to dispense sub-nanoliter cell-laden droplets identified droplet impact velocity and droplet volume as significant factors affecting the viability and proliferation of printed cells. Increasing cell concentration leads to slower impact velocity, improving cell viability, while a minimum droplet volume of 20 nL helps mitigate evaporation-induced cell damage. Control of droplet impact velocity and volume is crucial for viability and proliferation of printed human primary cells in sub-nanoliter bioprinting.

INTERNATIONAL JOURNAL OF BIOPRINTING (2022)

Article Engineering, Biomedical

Iterative reconstruction of low-dose CT based on differential sparse

Siyu Lu, Bo Yang, Ye Xiao, Shan Liu, Mingzhe Liu, Lirong Yin, Wenfeng Zheng

Summary: This paper proposes a discriminative sparse transform iterative reconstruction algorithm for low-dose CT images, which introduces a priori image and global constraint term to reduce noise and artifacts, improve image quality, and overcome the dependence on prior images and registration problems in traditional methods.

BIOMEDICAL SIGNAL PROCESSING AND CONTROL (2023)

Review Engineering, Biomedical

Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery

Mahsa Janmohammadi, Zahra Nazemi, Amin Orash Mahmoud Salehi, Amir Seyfoori, Johnson John, Mohammad Sadegh Nourbakhsh, Mohsen Akbari

Summary: Cellulose-based scaffolds have great potential in bone tissue engineering due to their non-toxicity, biocompatibility, renewable nature, and low cost. They can deliver growth factors and antibiotics directly to the site of impaired bone tissue to promote tissue repair. This review focuses on the various types of cellulose-based composite scaffolds used for bone drug delivery systems and bone regeneration, highlighting their physicochemical, mechanical, and biological properties.

BIOACTIVE MATERIALS (2023)

Review Computer Science, Interdisciplinary Applications

Application of explainable artificial intelligence for healthcare: A systematic review of the last decade (2011-2022)

Hui Wen Loh, Chui Ping Ooi, Silvia Seoni, Prabal Datta Barua, Filippo Molinari, U. Rajendra Acharya

Summary: This study focuses on the application areas of XAI technology in healthcare, emphasizing the need for more attention from the XAI research community in detecting abnormalities in 1D biosignals and identifying key text in clinical notes.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2022)

Article Engineering, Biomedical

Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

Heng Mei, Shengsheng Cai, Dennis Huang, Huile Gao, Jun Cao, Bin He

Summary: This review discusses strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy. Optimizing the intrinsic physicochemical properties and external modification are key methods.

BIOACTIVE MATERIALS (2022)

Article Engineering, Biomedical

A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

Zhaoyuan Guo, Zhuangzhuang Zhang, Nan Zhang, Wenxia Gao, Jing Li, Yuji Pu, Bin He, Jing Xie

Summary: In this study, a composite antibacterial hydrogel PDA-PAM/Mg2+ was developed for accelerated wound healing. This hydrogel showed excellent self-healing and tissue adhesive properties, as well as photothermal antibacterial functions. It demonstrated efficient bacteria inhibition and enhanced wound healing in a rat model.

BIOACTIVE MATERIALS (2022)

Article Engineering, Biomedical

Tetrahedral framework nucleic acids-based delivery of microRNA-155 inhibits choroidal neovascularization by regulating the polarization of macrophages

Xin Qin, Lirong Xiao, Ni Li, Chen Hou, Wenman Li, Jiajie Li, Naihong Yan, Yunfeng Lin

Summary: In this study, we developed a new DNA-based drug called T-155, which improved the symptoms of choroidal neovascularization by regulating the polarization of macrophages.

BIOACTIVE MATERIALS (2022)