Dermatology

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Article Dermatology

Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases

A. Catala, C. Munoz-Santos, C. Galvan-Casas, M. Roncero Riesco, D. Revilla Nebreda, A. Sola-Truyols, P. Giavedoni, M. Llamas-Velasco, C. Gonzalez-Cruz, X. Cubiro, R. Ruiz-Villaverde, S. Gomez-Armayones, M. P. Gil Mateo, D. Pesque, O. Marcantonio, D. Fernandez-Nieto, J. Romani, N. Iglesias Pena, L. Carnero Gonzalez, J. Tercedor-Sanchez, G. Carretero, T. Masat-Tico, P. Rodriguez-Jimenez, A. M. Gimenez-Arnau, M. Utrera-Busquets, E. Vargas Laguna, A. G. Angulo Menendez, E. San Juan Lasser, M. Iglesias-Sancho, L. Alonso Naranjo, I Hiltun, E. Cutillas Marco, I Polimon Olabarrieta, S. Marinero Escobedo, X. Garcia-Navarro, M. J. Calderon Gutierrez, G. Baeza-Hernandez, L. Bou Camps, T. Toledo-Pastrana, A. Guilabert

Summary: This study investigated cutaneous reactions after SARS-CoV-2 vaccination, finding that most were mild to moderate, but severe cases were also reported. Understanding these reactions can help healthcare professionals and reassure patients.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Dermatology

Monkeypox outbreak in Spain: clinical and epidemiological findings in a prospective cross-sectional study of 185 cases

Alba Catala, Petunia Clavo-Escribano, Josep Riera-Monroig, Gemma Martin-Ezquerra, Pablo Fernandez-Gonzalez, Leonor Revelles-Penas, Ana Simon-Gozalbo, Francisco Jose Rodriguez-Cuadrado, Vanessa Guilera Castells, Francisco Javier de la Torre Gomar, Alicia Comunion-Artieda, Laura de Fuertes de Vega, Jose Luis Blanco, Susana Puig, Angela Maria Garcia-Minarro, Esther Fiz Benito, Carlos Munoz-Santos, Juan Bosco Repiso-Jimenez, Cristina Lopez Llunell, Carmen Ceballos-Rodriguez, Victor Garcia Rodriguez, Juan Luis Castano Fernandez, Irene Sanchez-Gutierrez, Ricardo Calvo-Lopez, Emilio Berna-Rico, Belen De Nicolas-Ruanes, Francesca Corella Vicente, Eloy Jose Tarin Vicente, Laura de la Fernandez de la Fuente, Nuria Riera-Marti, Miguel Angel Descalzo-Gallego, Merce Grau-Perez, Ignacio Garcia-Doval, Irene Fuertes

Summary: This article documents the clinical and epidemiological characteristics of monkeypox cases in the 2022 outbreak in Spain. Most cases started with localized papules and later developed into generalized skin lesions with systemic symptoms. Sexual contact is the most likely mode of transmission, particularly associated with high-risk behaviors.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Dermatology

Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040

Melina Arnold, Deependra Singh, Mathieu Laversanne, Jerome Vignat, Salvatore Vaccarella, Filip Meheus, Anne E. Cust, Esther de Vries, David C. Whiteman, Freddie Bray

Summary: Despite preventable cases, cutaneous melanoma remains the most serious skin cancer worldwide. Understanding the scale and profile of the disease is crucial to focus and strengthen global prevention efforts. The study reveals that melanoma is more frequent among males and is estimated to significantly increase by 2040 if current rates continue.

JAMA DERMATOLOGY (2022)

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Article Dermatology

Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients

S. Georgin-Lavialle, B. Terrier, A. F. Guedon, M. Heiblig, T. Comont, E. Lazaro, V Lacombe, L. Terriou, S. Ardois, J-D Bouaziz, A. Mathian, G. Le Guenno, A. Aouba, R. Outh, A. Meyer, M. Roux-Sauvat, M. Ebbo, L. P. Zhao, A. Bigot, Y. Jamilloux, V Guillotin, E. Flamarion, P. Henneton, G. Vial, V Jachiet, J. Rossignol, S. Vinzio, T. Weitten, J. Vinit, C. Deligny, S. Humbert, M. Samson, N. Magy-Bertrand, T. Moulinet, R. Bourguiba, T. Hanslik, C. Bachmeyer, M. Sebert, M. Kostine, B. Bienvenu, P. Biscay, E. Liozon, L. Sailler, F. Chasset, A. Audemard-Verger, E. Duroyon, G. Sarrabay, F. Borlot, C. Dieval, T. Cluzeau, P. Marianetti, H. Lobbes, G. Boursier, M. Gerfaud-Valentin, J. Jeannel, A. Servettaz, S. Audia, M. Larue, B. Henriot, B. Faucher, J. Graveleau, B. Sainte Marie, J. Galland, L. Bouillet, C. Arnaud, L. Ades, F. Carrat, P. Hirsch, P. Fenaux, O. Fain, P. Sujobert, O. Kosmider, A. Mekinian

Summary: VEXAS syndrome is a newly described autoinflammatory syndrome associated with somatic mutations of UBA1. It presents a wide range of clinical features, with different prognostic profiles identified, and the UBA1 p.Met41Leu mutation is associated with a better prognosis.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Review Dermatology

Cutaneous findings following COVID-19 vaccination: review of world literature and own experience

T. Gambichler, S. Boms, L. Susok, H. Dickel, C. Finis, N. Abu Rached, M. Barras, M. Stuecker, D. Kasakovski

Summary: Skin reactions following COVID-19 vaccination can vary from mild injection-site discomfort to severe allergic reactions and autoimmune-mediated conditions. These immune responses may be attributed to molecular mimicry between SARS-CoV-2 components and human proteins.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Dermatology

Dupilumab provides rapid and sustained improvement in SCORAD outcomes in adults with moderate-to-severe atopic dermatitis: combined results of four randomized phase 3 trials

S. Barbarot, A. Wollenberg, J. Silverberg, M. Deleuran, G. Pellacani, J. C. Armario-Hita, Z. Cheng, B. Shumel, L. Eckert, A. Gadkari, Y. Lu, A. B. Rossi

Summary: In adults with moderate-to-severe atopic dermatitis, treatment with Dupilumab, either alone or in combination with topical corticosteroids, leads to rapid and sustained improvements in SCORing Atopic Dermatitis (SCORAD) and its component scores.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Article Dermatology

Clinical and pathologic correlation of cutaneous COVID-19 vaccine reactions including V-REPP: A registry-based study

Devon E. McMahon, Carrie L. Kovarik, William Damsky, Misha Rosenbach, Jules B. Lipoff, Anisha Tyagi, Grace Chamberlin, Ramie Fathy, Rosalynn M. Nazarian, Seemal R. Desai, Henry W. Lim, Bruce H. Thiers, George J. Hruza, Lars E. French, Kimberly Blumenthal, Lindy P. Fox, Esther E. Freeman

Summary: This study investigated histopathologic features and clinical correlations of cutaneous reactions after COVID-19 vaccination, proposing the concept of V-REPP (vaccine-related eruption of papules and plaques) and 12 other reaction patterns. Despite limitations in available biopsy reports, the research provided new insights into skin reactions following vaccination.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Review Dermatology

COVID-19/SARS-CoV-2 virus spike protein-related delayed inflammatory reaction to hyaluronic acid dermal fillers: a challenging clinical conundrum in diagnosis and treatment

Girish Gilly Munavalli, Rachel Guthridge, Siri Knutsen-Larson, Amy Brodsky, Ethan Matthew, Marina Landau

Summary: This study presents the first reported cases of delayed inflammatory reactions to hyaluronic acid dermal fillers after exposure to the COVID-19 spike protein. The mechanism of action for this reaction is likely multifactorial, potentially involving binding and blockade of ACE2 receptors by the SARS-CoV-2 virus spike protein. Management of these cases varied depending on the underlying cause, with different approaches taken for cases related to COVID-19 infection versus vaccination.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2022)

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Article Dermatology

Comorbidity screening in hidradenitis suppurativa: Evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations

Amit Garg, Neeta Malviya, Andrew Strunk, Shari Wright, Afsaneh Alavi, Raed Alhusayen, Ali Alikhan, Steven D. Daveluy, Isabelle Delorme, Noah Goldfarb, Wayne Gulliver, Iltefat Hamzavi, Tarannum Jaleel, Alexa B. Kimball, Joslyn S. Kirby, Mark G. Kirchhof, Janice Lester, Hadar Lev-Tov, Michelle A. Lowes, Robert Micheletti, Lauren A. Orenstein, Vincent Piguet, Christopher Sayed, Jerry Tan, Haley B. Naik

Summary: This study aims to provide evidence-based screening recommendations for comorbidities associated with HS. Screening recommendations were made based on the consistency and quality of existing studies, disease prevalence and magnitude of association, as well as benefits, harms, and feasibility of screening. A total of 30 comorbidities were recommended for screening in order to improve patients' quality of life and health status.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Article Dermatology

Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis Analysis of Follow-up Data From the Measure Up 1 and Measure Up 2 Randomized Clinical Trials

Eric L. Simpson, Kim A. Papp, Andrew Blauvelt, Chia-Yu Chu, H. Chih-Ho Hong, Norito Katoh, Brian M. Calimlim, Jacob P. Thyssen, Albert S. Chiou, Robert Bissonnette, Linda F. Stein Gold, Colleen Wegzyn, Xiaofei Hu, Meng Liu, John Liu, Allan R. Tenorio, Alvina D. Chu, Emma Guttman-Yassky

Summary: The study evaluated the long-term efficacy and safety of upadacitinib treatment in patients with atopic dermatitis over 52 weeks. Results showed that patients continuing the 15 mg and 30 mg doses maintained efficacy at week 52, with a favorable benefit-risk profile and sustained efficacy responses.

JAMA DERMATOLOGY (2022)

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Article Dermatology

Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID-19 vaccination

Valerie Larson, Roy Seidenberg, Avrom Caplan, Nooshin K. Brinster, Shane A. Meehan, Randie H. Kim

Summary: This retrospective case series reviewed cutaneous adverse reactions to mRNA-based COVID-19 vaccines, identifying various skin manifestations including injection-site reactions, generalized eruptions, and eczematous dermatitis. The study suggests that dermatopathologists should be aware of potential cutaneous adverse reactions to COVID-19 vaccines, with histopathological patterns ranging from mixed-cell infiltrates to epidermal spongiosis and interface changes.

JOURNAL OF CUTANEOUS PATHOLOGY (2022)

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Article Dermatology

Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial

April W. Armstrong, Melinda Gooderham, Richard B. Warren, Kim A. Papp, Bruce Strober, Diamant Thaci, Akimichi Morita, Jacek C. Szepietowski, Shinichi Imafuku, Elizabeth Colston, John Throup, Sudeep Kundu, Steve Schoenfeld, Misti Linaberry, Subhashis Banerjee, Andrew Blauvelt

Summary: This study compared the efficacy and safety of deucravacitinib with placebo and apremilast in adults with moderate to severe plaque psoriasis. The results showed that deucravacitinib was more effective than placebo and apremilast in reducing symptoms and improving skin lesions, and the adverse event rates were similar among the three drugs.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2023)

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Review Emergency Medicine

Autophagy and skin wound healing

Haiyue Ren, Feng Zhao, Qiqi Zhang, Xing Huang, Zhe Wang

Summary: The article discusses the role of autophagy in wound healing, including its anti-infection and inflammation regulatory functions in the inflammatory phase, its promotion of cell survival, angiogenesis, and cell differentiation in the proliferative phase, and its impact on hypertrophic scar formation in the remodeling phase. The article also highlights the association between autophagy and refractory diabetic wounds, and suggests that understanding autophagy regulation and molecular mechanisms can provide novel strategies for wound healing treatment.

BURNS & TRAUMA (2022)

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Article Cell Biology

Chronic wounds: Treatment consensus

Elof Eriksson, Paul Y. Liu, Gregory S. Schultz, Manuela M. Martins-Green, Rica Tanaka, Dot Weir, Lisa J. Gould, David G. Armstrong, Gary W. Gibbons, Randy Wolcott, Oluyinka O. Olutoye, Robert S. Kirsner, Geoffrey C. Gurtner

Summary: The Wound Healing Foundation (WHF) organized a virtual meeting to establish a consensus on the best treatment for chronic wounds. The meeting covered topics such as diagnosis, debridement, infection control, dressings, grafting, pain management, oxygen treatment, outcomes, and future needs. Key takeaways included the need for simplified wound care, the potential benefits of telemonitoring, and the importance of defining patient expectations.

WOUND REPAIR AND REGENERATION (2022)

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Review Dermatology

Systemic Immunomodulatory Treatments for Atopic Dermatitis Update of a Living Systematic Review and Network Meta-analysis

Aaron M. Drucker, Deanna E. Morra, David Prieto-Merino, Alexandra G. Ellis, Zenas Z. N. Yiu, Bram Rochwerg, Sonya Di Giorgio, Bernd W. M. Arents, Tim Burton, Phyllis Spuls, Jochen Schmitt, Carsten Flohr

Summary: In this study, a network meta-analysis was conducted to compare the efficacy and safety assessments of systemic treatments for atopic dermatitis. The results indicated that abrocitinib and upadacitinib had slightly higher scores than dupilumab, while upadacitinib at a daily dose of 15 mg showed similar scores to dupilumab.

JAMA DERMATOLOGY (2022)

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Article Dermatology

2021 European guideline on the management of Mycoplasma genitalium infections

J. S. Jensen, M. Cusini, M. Gomberg, H. Moi, J. Wilson, M. Unemo

Summary: Mycoplasma genitalium infection is responsible for a significant number of cases of non-chlamydial non-gonococcal urethritis in men and is associated with cervicitis and pelvic inflammatory disease in women. Transmission occurs through direct mucosal contact. Asymptomatic infections are common. Diagnosis is achieved through nucleic acid amplification testing, including investigation for macrolide resistance mutations.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Dermatology

Our contemporary understanding of the aetiology of pressure ulcers/pressure injuries

Amit Gefen, David M. Brienza, Janet Cuddigan, Emily Haesler, Jan Kottner

Summary: The third edition of the Clinical Practice Guideline on Prevention and Treatment of Pressure Ulcers/Injuries, published in 2019, provides clinicians with updated evidence-based guidance on pressure ulcers. The guideline also discusses the etiology, classification, and future research needs related to pressure ulcers. Research shows that sustained soft tissue deformations can lead to cell death, tissue damage, and the formation of pressure ulcers/pressure injuries. In order to prevent pressure ulcers, it is important to minimize deformations in tissues by reducing peak strain/stress values or decreasing exposure time.

INTERNATIONAL WOUND JOURNAL (2022)

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Article Dermatology

Anti-interleukin-23 for psoriasis in elderly patients: guselkumab, risankizumab and tildrakizumab in real-world practice

A. Ruggiero, G. Fabbrocini, E. Cinelli, S. S. Ocampo Garza, E. Camela, M. Megna

Summary: The study indicated that three anti-IL-23 therapies are promising, safe, and effective options for elderly patients with psoriasis, with no significant differences found between them. However, more data is required to confirm these results and understand their role in the management of this patient group. Limitations of the study included small sample size and varied follow-up durations.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2022)

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Review Dermatology

Therapeutic advances in wound healing

Andre Oliveira, Sandra Simoes, Andreia Ascenso, Catarina Pinto Reis

Summary: This review provides an overview of recent technologies/therapies for skin regeneration, including wound dressings, skin substitutes, exogenous growth factor based therapy and systemic therapy. The benefits, risks, clinical use, and availability of each therapy are addressed. Furthermore, future trends in wound care, such as novel formulations using metallic nanoparticles and topical insulin, are discussed.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Review Dermatology

Emerging treatment strategies in wound care

Marjan Mirhaj, Sheyda Labbaf, Mohamadreza Tavakoli, Alexander Marcus Seifalian

Summary: Wound healing is a complex process, and the current treatment strategies face challenges. Dressings and skin substitutes are the most effective, convenient, and cost-effective method for treating chronic wounds, and advances in materials science offer hope for treatment. There is a need to improve current treatment strategies to meet the increasing demands of the aging population and diabetes-related wounds.

INTERNATIONAL WOUND JOURNAL (2022)

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